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Cited by 662

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Volumetric Dilution, Rather Than Sequestration Best Explains the Low Vitamin D Status of Obesity

Open access
Drincic, Andjela T., Armas, Laura A.G., van Diest, Eileen E., Heaney, Robert P.·2012·Obesity
DOI 10.1038/oby.2011.404
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Abstract

Vitamin D status is known to be poor in obese individuals; there is no consensus as to the reason. Cross‐sectional study of the relation between serum 25‐hydroxyvitamin D (25(OH)D) concentration and body size in the baseline data from unsupplemented adults entering two study cohorts in our research unit, N = 686. Regression analyses of body size variables against serum 25(OH)D concentration, using both linear and hyperbolic models. The fit to a hyperbolic model of 25(OH)D against body weight completely removed the obesity‐related component of inter‐individual variability in serum 25(OH)D concentration. The hyperbolic fit using total body weight was significantly better than any linear model, and specifically better than any using BMI. Dilution of ingested or cutaneously synthesized vitamin D in the large fat mass of obese patients fully explains their typically low vitamin D status. There is no evidence for sequestration of supplemental or endogenous cholecalciferol. Vitamin D replacement therapy needs to be adjusted for body size if desired serum 25(OH)D concentrations are to be achieved.

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Metadata

Authors
Drincic, A. T., Armas, L. A. G., van Diest, E. E., & Heaney, R. P.
Venue
Obesity
Publisher
Wiley
Published
2012-07
Volume
20
Issue
7
Pages
1444-1448
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
DOI
10.1038/oby.2011.404
OpenAlex
W2049268743
Cited by
662
References
2
FWCI
25.56
Type
journal article
Language
en
Open access
bronze

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