Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1–42)-induced rat model of Alzheimer's disease

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

The rat brain in stereotaxic coordinates

Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824 · see citing works

Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

Paglia, D. E., & Valentine, W. N. (1967) · PubMed · Cited by 10,776 · see citing works

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

[43] Malondialdehyde determination as index of lipid Peroxidation

Draper, H. H., & Hadley, M. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86135-i · Cited by 4,291 · see citing works

Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

Bustin, S. A. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250169 · Cited by 3,844 · see citing works

Oxidative DNA damage: mechanisms, mutation, and disease

Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

Chomczyński, P. (1993) · PubMed · Cited by 2,788 · see citing works

[38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay

Reznick, A. Z., & Packer, L. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33041-7 · Cited by 2,455 · see citing works

A simple method for determination of serum catalase activity and revision of reference range

Góth, L. (1991) · Clinica Chimica Acta · doi:10.1016/0009-8981(91)90067-m · Cited by 2,391 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease

Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355 · see citing works

Metabolism and functions of glutathione in brain

Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702 · see citing works

Apoptosis in neurodegenerative disorders

Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605 · see citing works

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

Virág, L., & Szabó, C. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.375 · Cited by 1,373 · see citing works

Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management

Woolf, C. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-8-200404200-00010 · Cited by 1,134 · see citing works

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114 · see citing works

Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD + into a nuclear signalPreprint

Kim, M. Y., Zhang, T., & Kraus, W. L. (2005) · Genes & Development · doi:10.1101/gad.1331805 · Cited by 803 · see citing works

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., & Mattson, M. P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06920.2000 · Cited by 784 · see citing works

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2642 · Cited by 611 · see citing works

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

Shall, S., & de MURCIA, G. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00016-1 · Cited by 534 · see citing works

Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease

Marcus, D. L., Thomas, C., Rodriguez, C., Simberkoff, K., Tsai, J. S., Strafaci, J. A., & Freedman, M. L. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6750 · Cited by 513 · see citing works

Protection against reactive oxygen species by selenoproteins

Steinbrenner, H., & Sies, H. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.014 · Cited by 513 · see citing works

Poly (ADP-ribose) polymerase, nitric oxide and cell death

Pieper, A. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01292-4 · Cited by 512 · see citing works

The importance of neuritic plaques and tangles to the development and evolution of AD

Tiraboschi, P., Hansen, L. A., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129697.01779.0a · Cited by 477 · see citing works

Parthanatos, a messenger of death

David, K. K. (2009) · Frontiers in Bioscience · doi:10.2741/3297 · Cited by 450 · see citing works

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

Lovell, M. A., Xie, C., & Markesbery, W. R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00235-9 · Cited by 449 · see citing works

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

Keller, J. N., Pang, Z., Geddes, J. W., Begley, J. G., Germeyer, A., Waeg, G., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010273.x · Cited by 439 · cited 2× · see citing works

Safety of high-dose nicotinamide: a review

Knip, M., Douek, I. F., Moore, W. P. T., Gillmor, H. A., McLean, A. E. M., Bingley, P. J., & Gale, E. A. M. (2000) · Diabetologia · doi:10.1007/s001250051536 · Cited by 423 · see citing works

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

Zhang, Y., McLaughlin, R., Goodyer, C., & LeBlanc, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110119 · Cited by 418 · see citing works

Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

Green, K. N., Steffan, J. S., Martinez-Coria, H., Sun, X., Schreiber, S. S., Thompson, L. M., & LaFerla, F. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3203-08.2008 · Cited by 404 · cited 1× · see citing works

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z.-Q., Simbulan-Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Guastella, D. B., Dawson, V. L., & Dawson, T. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5774 · Cited by 382 · see citing works

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

Selkoe, D. J. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-8-200404200-00047 · Cited by 381 · see citing works

Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic

Ferraris, D. V. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100012m · Cited by 375 · see citing works

Elevation of Glutathione as a Therapeutic Strategy in Alzheimer Disease

Pocernich, C., & Butterfield, D. (2011) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2011.10.003 · Cited by 333 · see citing works

Role of Oxidative Stress in the Progression of Alzheimer's Disease

Rukhsana Sultana, A., & Butterfield, D. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1222 · Cited by 327 · see citing works

Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons

Paradis, E., Douillard, H., Koutroumanis, M., Goodyer, C. G., & LeBlanc, A. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07533.1996 · Cited by 325 · see citing works

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

de la Monte, S. M., Sohn, Y. K., & Wands, J. R. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00131-7 · Cited by 307 · see citing works

Poly(ADP‐ribose)

Bürkle, A. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04864.x · Cited by 294 · see citing works

Protein Oxidation and Lipid Peroxidation in Brain of Subjects with Alzheimer's Disease: Insights into Mechanism of Neurodegeneration from Redox Proteomics

Rukhsana Sultana, A., Marzia Perluigi, A., & Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2021 · Cited by 259 · see citing works

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease

Love, S., Barber, R., & Wilcock, G. K. (1999) · Brain · doi:10.1093/brain/122.2.247 · Cited by 254 · see citing works

Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

Liu, D., Pitta, M., Jiang, H., Lee, J.-H., Zhang, G., Chen, X., Kawamoto, E. M., & Mattson, M. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.020 · Cited by 238 · see citing works

Nicotinamide is a potent inhibitor of proinflammatory cytokines

Ungerstedt, J. S., Blombäck, M., & Söderström, T. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02031.x · Cited by 222 · see citing works

Poly(ADP‐ribose) polymerase‐1 activity promotes NF‐κB‐driven transcription and microglial activation: implication for neurodegenerative disorders

Chiarugi, A., & Moskowitz, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01684.x · Cited by 216 · see citing works

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

Mandir, A. S., Poitras, M. F., Berliner, A. R., Herring, W. J., Guastella, D. B., Feldman, A. B., Poirier, G. G., Wang, Z., Dawson, T. M., & Dawson, V. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08005.2000 · Cited by 213 · see citing works

Poly(ADP-ribose) Polymerase-1 in the Nervous System

Ha, H. C., & Snyder, S. H. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0324 · Cited by 196 · see citing works

Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain

Maiese, K., & Chong, Z. Z. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00078-6 · Cited by 187 · see citing works

Decreased base excision repair and increased helicase activity in Alzheimer's disease brain

Lovell, M. A., Xie, C., & Markesbery, W. R. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02335-5 · Cited by 174 · see citing works

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

Abeti, R., Abramov, A. Y., & Duchen, M. R. (2011) · Brain · doi:10.1093/brain/awr104 · Cited by 172 · see citing works

Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid β-peptide (1–42) into rat brain: Implications for Alzheimer’s disease

Debra Boyd-kimball, A., Rukhsana Sultana, A., Poon, H. F., Lynn, B. C., Casamenti, F., Pepeu, G., Klein, J. B., & Butterfield, D. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.022 · Cited by 166 · see citing works

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.

Flood, J. F., Morley, J. E., & Roberts, E. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3363 · Cited by 164 · see citing works

Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer’s patients

Cecchi, C., Fiorillo, C., Sorbi, S., Latorraca, S., Nacmias, B., Bagnoli, S., Nassi, P., & Liguri, G. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01049-3 · Cited by 159 · see citing works

Neurovascular function in Alzheimer's disease patients and experimental models

Nicolakakis, N., & Hamel, E. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.43 · Cited by 156 · see citing works

Role of p53 in Neurodegenerative Diseases

Chang, J. R., Ghafouri, M., Mukerjee, R., Bagashev, A., Chabrashvili, T., & Sawaya, B. E. (2011) · Neurodegenerative Diseases · doi:10.1159/000329999 · Cited by 145 · see citing works

Diagnosis and biomarkers of predementia in Alzheimer's disease

Forlenza, O. V., Diniz, B. S., & Gattaz, W. F. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-89 · Cited by 145 · see citing works

Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus

MacGibbon, G. A., Lawlor, P. A., Sirimanne, E. S., Walton, M. R., Connor, B. J., Young, D., Williams, C. E., Gluckman, P. D., Faull, R. L. M., Hughes, P. E., et al. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01351-0 · Cited by 140 · see citing works

The Sirtuin Inhibitor Nicotinamide Enhances Neuronal Cell Survival During Acute Anoxic Injury Through AKT, BAD, PARP, and Mitochondrial Associated "Anti-Apoptotic" Pathways

Chong, Z. Z., Lin, S., Li, F., & Maiese, K. (2005) · Current Neurovascular Research · doi:10.2174/156720205774322584 · Cited by 126 · see citing works

Poly(ADP-Ribose) Polymerases: Homology, Structural Domains and Functions. Novel Therapeutical Applications

Nguewa, P., Fuertes, M. A., Valladares, B., Alonso‐Moreno, C., & Pérez, J. M. (2004) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2004.01.001 · Cited by 119 · see citing works

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Sonnen, J. A., Breitner, J. C. S., Lovell, M. A., Markesbery, W. R., Quinn, J. F., & Montine, T. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.022 · Cited by 103 · see citing works

Relationship between red blood cell antioxidant enzymatic system status and lipoperoxidation during the acute phase of malaria

Beauvieux, M.-C., Peuchant, E., Dumon, M. F., Receveur, M. C., Bras, M. L., & Clerc, M. (1995) · Clinical Biochemistry · doi:10.1016/0009-9120(94)00071-3 · Cited by 96 · see citing works

Proteomics in animal models of Alzheimer's and Parkinson's diseases

Robinson, R. A. S., Owen, J. B., & Butterfield, D. A. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.003 · Cited by 81 · see citing works

Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

Cenini, G., Sultana, R., Memo, M., & Butterfield, D. A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.015 · Cited by 79 · see citing works

Oxidants and antioxidants revisited. New concepts of oxidative stress

Packer, L., & Cadenas, E. (2007) · Free Radical Research · doi:10.1080/10715760701490975 · Cited by 78 · see citing works

Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease

Abeti, R., & Duchen, M. R. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0895-x · Cited by 78 · see citing works

Post-treatment with nicotinamide (vitamin B3) reduces the infarct volume following permanent focal cerebral ischemia in female Sprague–Dawley and Wistar rats

Sakakibara, Y., Mitha, A. P., Ogilvy, C. S., & Maynard, K. I. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00854-5 · Cited by 76 · see citing works

Induction of oxidative stress by L‐2‐hydroxyglutaric acid in rat brain

Latini, A., Scussiato, K., Rosa, R. B., Leipnitz, G., Llesuy, S., Belló‐Klein, A., Dutra‐Filho, C. S., & Wajner, M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10735 · Cited by 69 · see citing works

Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system

Li, S., Cui, N., Zhang, C., Zhao, X., Yu, S.-F., & Xie, K. (2005) · Toxicology · doi:10.1016/j.tox.2005.08.018 · Cited by 69 · see citing works

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains

Cascella, R., Conti, S., Tatini, F., Evangelisti, E., Scartabelli, T., Casamenti, F., Wilson, M. R., Chiti, F., & Cecchi, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.012 · Cited by 68 · see citing works

Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.

Chambon, C., Wegener, N., Gravius, A., & Danysz, W. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.024 · Cited by 64 · see citing works

Alzheimer’s disease and Alzheimer’s dementia: distinct but overlapping entities

Blass, J. P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00036-2 · Cited by 62 · see citing works

Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide

Li, F. (2004) · Frontiers in bioscience · doi:10.2741/1412 · Cited by 61 · see citing works

Evaluation of the poly(ADP‐ribose) polymerase‐1 gene variants in Alzheimer's disease

Liu, H., Lin, W., Wu, B., Liu, S. R., Wang, W., Tsai, C., Lee, C., & Tsai, F. (2010) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20379 · Cited by 54 · see citing works

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

Zampagni, M., Wright, D., Cascella, R., D’Adamio, G., Casamenti, F., Evangelisti, E., Cardona, F., Goti, A., Nacmias, B., Sorbi, S., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.012 · Cited by 54 · see citing works

Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase

Wu, G., Nan, C., Rollo, J. C., Huang, X., & Tian, J. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-16 · Cited by 52 · see citing works

Propentofylline protects β-amyloid protein-induced apoptosis in cultured rat hippocampal neurons

Koriyama, Y., Chiba, K., & Mohri, T. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02789-9 · Cited by 48 · see citing works

GPI 6150 Prevents H2O2 Cytotoxicity by Inhibiting Poly(ADP-ribose) Polymerase

Zhang, J., Lautar, S. L., Huang, S. H., Ramsey, C., Cheung, A., & Li, J.-H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3816 · Cited by 44 · see citing works

Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide

Pandya, K. G., Patel, M. R., & Lau‐Cam, C. A. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-s1-s16 · Cited by 42 · see citing works

Poly ADP-ribose polymerase-1 and health

Kirkland, J. B. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009280 · Cited by 40 · see citing works

Mechanism of amyloid β protein induced neuronal cell death: current concepts and future perspectives

Behl, C., & Sagara, Y. (1997) · Springer eBooks · doi:10.1007/978-3-7091-6844-8_14 · Cited by 35 · see citing works

Inhibitory effects of ascorbic acid on dopamine uptake by rat striatal synaptosomes: relationship to lipid peroxidation and oxidation of protein sulfhydryl groups

Morel, P., Fauconneau, B., Page, G., Mirbeau, T., & Huguet, F. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)00080-7 · Cited by 33 · see citing works

Correlation between (3H) dopamine specific uptake and (3H) GBR 12783 specific binding during the maturation of rat striatum

Bonnet, J.-J., & Costentin, J. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90563-8 · Cited by 33 · see citing works

Intrinsic Mechanisms of Poly(ADP-Ribose) Neurotoxicity: Three Hypotheses

Chiarugi, A. (2005) · NeuroToxicology · doi:10.1016/j.neuro.2005.01.012 · Cited by 32 · see citing works

Chapter 27 Amyloid β-peptides injection into the cholinergic nuclei: morphological, neurochemical and behavioral effects

Pepeu, G., Giovannelli, L., Casamenti, F., Cali, C., & Bartolini, L. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62111-1 · Cited by 26 · see citing works

Neurodegenerative Disorders and Cholesterol

Michikawa, M. (2004) · Current Alzheimer Research · doi:10.2174/1567205043331983 · Cited by 23 · see citing works

Potential neuroprotective effect of γ-glutamylcysteine ethyl ester on rat brain against kainic acid-induced excitotoxicity

Yalçın, A., Armağan, G., Turunç, E., Konyalıoğlu, S., & Kanıt, L. (2010) · Free Radical Research · doi:10.3109/10715761003645964 · Cited by 16 · see citing works

Effect ofγ-glutamylcysteine ethylester on the levels ofc-fosmRNA expression, glutathione and reactive oxygen species formation in kainic acid excitotoxicity

Turunç, E., Kanıt, L., & Yalçın, A. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01122.x · Cited by 11 · see citing works

Beneficial effects of melatonin on morphological changes in postnatal cerebellar tissue owing to epileptiform activity during pregnancy in rats: Light and immunohistochemical study

Uyanıkgil, Y., Turgut, M., Ateş, U., Baka, M., & Yurtseven, M. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.07.004 · Cited by 11 · see citing works

Influence of penicillin-induced epileptic activity during pregnancy on postnatal hippocampal nestin expression in rats: light and electron microscopic observations

Baka, M., Uyanıkgil, Y., Yurtseven, M., & Turgut, M. (2004) · Child s Nervous System · doi:10.1007/s00381-004-1010-7 · Cited by 10 · see citing works

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works

NAD+ homeostasis in health and disease

Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627 · see citing works

Mitophagy and Neuroprotection

Lou, G., Palikaras, K., Lautrup, S., Scheibye‐Knudsen, M., Tavernarakis, N., & Fang, E. F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.07.002 · Cited by 450 · see citing works

Oxidative and nitrative stress in neurodegeneration

Cobb, C. A., & Cole, M. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.020 · Cited by 300 · see citing works

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Braidy, N., Berg, J., Clement, J., Khorshidi, F., Poljak, A., Jayasena, T., Grant, R., & Sachdev, P. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7269 · Cited by 286 · see citing works

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Cai, Q., & Jeong, Y. Y. (2020) · Cells · doi:10.3390/cells9010150 · Cited by 263 · see citing works

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

Martire, S., Mosca, L., & D’Erme, M. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.04.001 · Cited by 228 · see citing works

Neuronal cell death mechanisms in Alzheimer’s disease: An insight

Goel, P., Chakrabarti, S., Goel, K., Bhutani, K., Chopra, T., & Bali, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937133 · Cited by 235 · see citing works

Modulating NAD+ metabolism, from bench to bedside

Katsyuba, E., & Auwerx, J. H. (2017) · The EMBO Journal · doi:10.15252/embj.201797135 · Cited by 224 · see citing works

Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease

Nand, S., Singh, C., Singh, A., Singh, M. P., & Singh, S. P. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01945-y · Cited by 213 · see citing works

The Influence of Nicotinamide on Health and Disease in the Central Nervous System

Fricker, R. A., Green, E. L., Jenkins, S. I., & Griffin, S. M. (2018) · International Journal of Tryptophan Research · doi:10.1177/1178646918776658 · Cited by 200 · see citing works

Apoptotic Pathways and Alzheimer’s Disease: Probing Therapeutic Potential

Sharma, V., Singh, T. G., Singh, S., Garg, N., & Dhiman, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03418-7 · Cited by 197 · see citing works

Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age‐related disorders

Srivastava, S. (2016) · Clinical and Translational Medicine · doi:10.1186/s40169-016-0104-7 · Cited by 193 · see citing works

Apoptosis and its therapeutic implications in neurodegenerative diseases

Erekat, N. S. (2021) · Clinical Anatomy · doi:10.1002/ca.23792 · Cited by 163 · see citing works

Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer’s disease: A neuropharmacological review of their bioactive constituents

Gorji, N., Moeini, R., & Memariani, Z. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.003 · Cited by 154 · see citing works

The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update

Song, Q., Zhou, X., Xu, K., Liu, S., Zhu, X., & Yang, J. J. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.08.008 · Cited by 122 · see citing works

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

Prakash, A. K., & Kumar, A. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.036 · Cited by 116 · see citing works

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

McGurk, L., Mojsilovic‐Petrovic, J., Deerlin, V. M. V., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B., & Bonini, N. M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0586-1 · Cited by 112 · see citing works

Cell Death Mechanisms of Neurodegeneration

Fan, J., Dawson, T. M., & Dawson, V. L. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_16 · Cited by 112 · see citing works

Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases

Park, H., Kam, T., Dawson, T. M., & Dawson, V. L. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2019.12.009 · Cited by 105 · see citing works

WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family

Maiese, K. (2014) · Current Neurovascular Research · doi:10.2174/1567202611666140912115107 · Cited by 103 · see citing works

Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases

Fernández‐Moriano, C., González‐Burgos, E., & Gómez-Serranillos, M. P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/408927 · Cited by 94 · see citing works

Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

Thapa, K., Khan, H., Sharma, U., Grewal, A. K., & Singh, T. G. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118975 · Cited by 92 · see citing works

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

Zheng, M., Cai, J., Liu, Z., Shu, S., Wang, Y., Tang, C., & Dong, Z. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14285 · Cited by 91 · see citing works

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

Zhang, Y., & Zhao, J. (2015) · DNA and Cell Biology · doi:10.1089/dna.2014.2738 · Cited by 88 · see citing works

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

Salech, F., Ponce, D. P., Paula-Lima, A. C., SanMartín, C. D., & Behrens, M. I. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00255 · Cited by 89 · see citing works

Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties

Zarei, I., Brown, D. G., Nealon, N. J., & Ryan, E. P. (2017) · Rice · doi:10.1186/s12284-017-0157-2 · Cited by 87 · see citing works

Coffee intake and decreased amyloid pathology in human brain

Kim, J. W., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Jung, G., Lee, H. N., Sohn, B. K., Lee, J.-Y., Kim, Y. K., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0604-5 · Cited by 86 · see citing works

Taking aim at Alzheimer’s disease through the mammalian target of rapamycin

Maiese, K. (2014) · Annals medicus · doi:10.3109/07853890.2014.941921 · Cited by 76 · see citing works

Parthanatos in the pathogenesis of nervous system diseases

Wang, X., & Ge, P. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.049 · Cited by 75 · see citing works

Resveratrol Inhibits Trophoblast Apoptosis through Oxidative Stress in Preeclampsia-Model Rats

Zou, Y., Zuo, Q., Huang, S., Yu, X., Jiang, Z., Zou, S., Fan, M., & Sun, L. (2014) · Molecules · doi:10.3390/molecules191220570 · Cited by 75 · see citing works

Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2

Sarkar, B., Dhiman, M., Mittal, S., & Mantha, A. K. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0093-2 · Cited by 73 · see citing works

Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes

Pérez‐González, A., Alvarez-Idaboy, J. R., & Galano, A. (2015) · Journal of Molecular Modeling · doi:10.1007/s00894-015-2758-2 · Cited by 72 · see citing works

N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model

More, J., Galusso, N., Veloso, P., Montecinos, L., Finkelstein, J. P., Sánchez, G., Bull, R., Valdés, J. L., Hidalgo, C., & Paula-Lima, A. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00399 · Cited by 71 · see citing works

Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities

Xu, X., Sun, B., & Zhao, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106314 · Cited by 70 · see citing works

Forsythiaside Protects Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis in PC12 Cell

Huang, C., Lin, Y., Su, H., & Ye, D. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1461-5 · Cited by 68 · see citing works

Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus

Hosseini, L., Farokhi-Sisakht, F., Badalzadeh, R., Khabbaz, A., Mahmoudi, J., & Sadigh‐Eteghad, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.037 · Cited by 66 · see citing works

Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts

Campbell, J. M. (2022) · Nutrients · doi:10.3390/nu14153231 · Cited by 62 · see citing works

Upregulation effects of Tanshinone IIA on the expressions of NeuN, Nissl body, and IκB and downregulation effects on the expressions of GFAP and NF-κB in the brain tissues of rat models of Alzheimer’s disease

Li, J., Wen, P., Li, W., & Zhou, J. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000419 · Cited by 61 · see citing works

B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?

Moretti, R., & Peinkhofer, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225797 · Cited by 57 · see citing works

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity

Brady, P. N., Goel, A., & Johnson, M. A. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-18 · Cited by 58 · see citing works

Regeneration in the nervous system with erythropoietin

Maiese, K. (2015) · Frontiers in bioscience · doi:10.2741/4408 · Cited by 54 · see citing works

NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo

Wang, X., He, H., Xiong, X., Zhou, S., Wang, W., Feng, L., Han, R., & Xie, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668491 · Cited by 54 · see citing works

The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice

Gao, B., Chi, L., Tu, P., Gao, N., & Lü, K. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00179 · Cited by 52 · see citing works

Amelioration of bleomycin-induced pulmonary fibrosis by chlorogenic acid through endoplasmic reticulum stress inhibition

Wang, Y., Dong, J., Nie, J., Zhu, J., Wang, H., Chen, Q., Chen, J., Xia, J.-M., & Shuai, W. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1393-z · Cited by 51 · see citing works

New Insights for nicotinamide Metabolic disease autophagy and mTOR

Maiese, K. (2020) · Frontiers in bioscience · doi:10.2741/4886 · Cited by 53 · see citing works

Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review

Dailah, H. G. (2022) · Molecules · doi:10.3390/molecules27217207 · Cited by 50 · see citing works

Perinatal asphyxia: CNS development and deficits with delayed onset

Herrera‐Marschitz, M., Neira-Peña, T., Rojas-Mancilla, E., Espina-Marchant, P., Esmar, D., Perez, R. S., Muñoz, V., Gutierrez-Hernandez, M., Rivera, B., Simola, N., et al. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00047 · Cited by 50 · see citing works

New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation

Liu, C., & Fang, Y. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.028 · Cited by 50 · see citing works

Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis

Farajdokht, F., Amani, M., Mirzaei, F., Alihemmati, A., Mohaddes, G., & Babri, S. (2017) · EXCLI journal · doi:10.17179/excli2017-526 · Cited by 48 · see citing works

Anti-acetylcholinesterase and Antioxidant Activities of Inhaled Juniper Oil on Amyloid Beta (1–42)-Induced Oxidative Stress in the Rat Hippocampus

Cioancă, O., Hăncianu, M., Mihăşan, M., & Hriţcu, L. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1550-0 · Cited by 47 · see citing works

Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling

Xiao, Y. M., Dai, Y., Li, L., Geng, F., Xu, Y., Wang, J., Wang, S., & Zhao, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111651 · Cited by 45 · see citing works

Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1-42 (Aβ 1-42 ) induced neurotoxicity in PC12 cells

Koh, E.-J., Kim, K.-J., Choi, J., Kang, D.-H., & Lee, B.-Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.02.057 · Cited by 43 · see citing works

Programming Apoptosis and Autophagy with Novel Approaches for Diabetes Mellitus

Maiese, K. (2015) · Current Neurovascular Research · doi:10.2174/1567202612666150305110929 · Cited by 43 · see citing works

Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: past, present, and future

Hu, M.-L., Pan, Y.-R., Yong, Y.-Y., Liu, Y., Yu, L., Qin, D.-L., Qiao, G., Law, B. Y.-K., Wu, J.-M., Zhou, X.-G., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102078 · Cited by 44 · see citing works

PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols

Maluchenko, N. V., Feofanov, A. V., & Studitsky, V. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111441 · Cited by 42 · see citing works

Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)-Induced Toxicity

Yalcin, A., Soddu, E., Turunc Bayrakdar, E., Uyanikgil, Y., Kanit, L., Armagan, G., Rassu, G., Gavini, E., & Giunchedi, P. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.05.017 · Cited by 37 · see citing works

Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review

Gindri, I. M., Ferrari, G. A., Pinto, L. P. S., Bicca, J. M., dos Santos, Í. K., Dallacosta, D., & Roesler, C. R. D. M. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00242.2023 · Cited by 37 · see citing works

Pyridine Dinucleotides from Molecules to Man

Fessel, J. P., & Oldham, W. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7120 · Cited by 35 · see citing works

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

McGurk, L., Rifai, O. M., & Bonini, N. M. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.05.004 · Cited by 36 · see citing works

Defective Autophagy and Mitophagy in Alzheimer’s Disease: Mechanisms and Translational Implications

Chen, J., He, H., Ye, Q., Feng, F., Wang, W., Gu, Y., Han, R., & Xie, C. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02487-7 · Cited by 36 · see citing works

Neuroprotective effect of mogrol against Aβ1–42-induced memory impairment neuroinflammation and apoptosis in mice

Chen, G., Liu, C., Meng, G., Zhang, C., Chen, F., Tang, S., Hong, H., & Zhang, C. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13056 · Cited by 34 · see citing works

Protective Effects of Phillyrin on H2O2-induced Oxidative Stress and Apoptosis in PC12 Cells

Wei, T., Tian, W., Yan, H., Shao, G., & Xie, G. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0091-4 · Cited by 34 · see citing works

N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons

Cho, C. H., Kim, E.-A. L., Kim, J., Choi, S. Y., Yang, S.-J., & Cho, S. (2016) · Free Radical Research · doi:10.3109/10715762.2016.1167277 · Cited by 34 · see citing works

Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver

Mahmoud, Y. I., & Mahmoud, A. A. (2016) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2016.05.003 · Cited by 33 · see citing works

Nicotinamide reverses behavioral impairments and provides neuroprotection in 3˗nitropropionic acid induced animal model ofHuntington’s disease: implication of oxidative stress˗ poly(ADP˗ ribose) polymerase pathway

Sidhu, A., Diwan, V., Kaur, H., Bhateja, D., Singh, C. K., Sharma, S., & Padi, S. S. V. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0297-0 · Cited by 32 · see citing works

Synaptosome as a tool in Alzheimer’s disease research

Ahmad, F., & Liu, P. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147009 · Cited by 33 · see citing works

Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1–42) induced neurotoxicity in animal model of Alzheimer’s disease

Som, S., Antony, J., Dhanabal, S. P., & Ponnusankar, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-021-00880-8 · Cited by 32 · see citing works

Boosting mitochondrial health to counteract neurodegeneration

Burtscher, J., Romani, M., Bernardo, G., Popa, T., Ziviani, E., Hummel, F. C., Sorrentino, V., & Millet, G. P. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102289 · Cited by 34 · see citing works

Ex vivo protective effects of nicotinamide and 3‐aminobenzamide on rat synaptosomes treated with Aβ(1–42)

Turunç, E., Armağan, G., Uyanıkgil, Y., Kanıt, L., Koylu, E. O., & Yalçın, A. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3049 · Cited by 31 · see citing works

Dihuang-Yinzi Alleviates Cognition Deficits via Targeting Energy-Related Metabolism in an Alzheimer Mouse Model as Demonstrated by Integration of Metabolomics and Network Pharmacology

Han, G., Zhen, W., Dai, Y., Yu, H., Li, D., & Ma, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.873929 · Cited by 30 · see citing works

Acute sources of mitochondrial NAD+ during respiratory chain dysfunction

Chinopoulos, C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113218 · Cited by 29 · see citing works

LncRNA XIST knockdown attenuates Aβ25-35-induced toxicity, oxidative stress, and apoptosis in primary cultured rat hippocampal neurons by targeting miR-132.

Wang, X., Wang, C., Geng, C.-H., & Zhao, K. (2018) · Europe PMC (PubMed Central) · Cited by 30 · see citing works

SIRT1‐mediated amelioration of oxidative stress in kidney of alcohol‐aflatoxin‐B1‐induced hepatocellular carcinoma by resveratrol is catalase dependent and GPx independent

Rawat, D., Shrivastava, S., Naik, R. A., Chhonker, S. K., & Koiri, R. K. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22576 · Cited by 29 · see citing works

Thermodynamics and Intermolecular Interactions of Nicotinamide in Neat and Binary Solutions: Experimental Measurements and COSMO-RS Concentration Dependent Reactions Investigations

Cysewski, P., Przybyłek, M., Kowalska, A., & Tymorek, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147365 · Cited by 28 · see citing works

Mitochondrial mechanisms in Alzheimer’s disease: Quest for therapeutics

Kalani, K., Chaturvedi, P., Chaturvedi, P., Verma, V. K., Lal, N., Awasthi, S. K., & Kalani, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103547 · Cited by 28 · see citing works

Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer’s Disease

Wu, Z., & Nakanishi, H. (2015) · Journal of Immunology Research · doi:10.1155/2015/471342 · Cited by 27 · see citing works

Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide

Zheng, C., Li, Y., Wu, X., Gao, L., & Chen, X. (2024) · Nutrients · doi:10.3390/nu16142354 · Cited by 26 · see citing works

Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases

Bhatt, V., & Tiwari, A. K. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2057849 · Cited by 27 · see citing works

Anthranilic acid as a secondary antioxidant: Implications to the inhibition of OH production and the associated oxidative stress

Francisco‐Márquez, M., Aguilar-Fernández, M., & Galano, A. (2015) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2015.09.025 · Cited by 25 · see citing works

Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics

Bajaj, S., & Mahesh, R. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09170-1 · Cited by 23 · see citing works

Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer’s Disease: A Systematic Review of Preclinical Studies

Hosseini, L., Mahmoudi, J., Pashazadeh, F., Salehi‐Pourmehr, H., & Sadigh‐Eteghad, S. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01842-6 · Cited by 22 · see citing works

Recent advances in preventing neurodegenerative diseases

Chou, S.-C., Aggarwal, A., Dawson, V. L., Dawson, T. M., & Kam, T. (2021) · Faculty Reviews · doi:10.12703/r/10-81 · Cited by 24 · see citing works

Nicotinamide Improves Functional Recovery via Regulation of the RAGE/JNK/NF-κB Signaling Pathway after Brain Injury

Alam, S., Réhman, S. U., & Kim, M. O. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020271 · Cited by 22 · see citing works

Simvastatin inhibits the apoptosis of hippocampal cells in a mouse model of Alzheimer's disease

Hu, X., Song, C., Fang, M., & Li, C. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5620 · Cited by 20 · see citing works

KHG21834 attenuates glutamate-induced mitochondrial damage, apoptosis, and NLRP3 inflammasome activation in SH-SY5Y human neuroblastoma cells

Yang, S.-J., Han, A. R., Kim, E.-A., Yang, J. W., Ahn, J., Na, J.-M., & Cho, S. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172412 · Cited by 20 · see citing works

Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort

Initiative, A. D. N., Wang, C., Meng, X., Li, J., Zhang, Q., Chen, F., Liu, W., Wang, Y., Cheng, S., Yao, X., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-3798-z · Cited by 20 · see citing works

Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice

Kim, E. J., & Yang, S. J. (2017) · Clinical Nutrition Research · doi:10.7762/cnr.2017.6.2.130 · Cited by 19 · see citing works

Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders

Maiese, K. (2021) · Current Neurovascular Research · doi:10.2174/1567202617999210104220334 · Cited by 19 · see citing works

Poly(ADP-ribosylation) and neurodegenerative disorders

Basello, D. A., & Scovassi, A. I. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.07.005 · Cited by 19 · see citing works

Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation

Sriram, C. S., Jangra, A., Kasala, E. R., Bodduluru, L. N., & Bezbaruah, B. K. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.07.001 · Cited by 19 · see citing works

Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer

Kim, Y., Lee, H., Woo, J. J., Wang, Y., Kim, K., Choi, S., Jang, J., Kim, Y., Park, I. A., Han, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03322-7 · Cited by 19 · see citing works

Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers

Dong, R., Denier‐Fields, D. N., Lu, Q., Suridjan, I., Kollmorgen, G., Wild, N., Betthauser, T. J., Carlsson, C. M., Asthana, S., Johnson, S. C., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.04.009 · Cited by 18 · see citing works

Bioinorganic Chemistry of Micronutrients Related to Alzheimer’s and Parkinson’s Diseases

Kola, A., Nencioni, F., & Valensin, D. (2023) · Molecules · doi:10.3390/molecules28145467 · Cited by 18 · see citing works

Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain

Chaubey, K., Vázquez-Rosa, E., Tripathi, S., Shin, M.-K., Yu, Y. J., Dhar, M., Chakraborty, S., Yamakawa, M., Wang, X.-M., Sridharan, P. S., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102535 · Cited by 24 · see citing works

Mitochondrial One-Carbon Metabolism and Alzheimer’s Disease

Yu, Y., & Martins, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126302 · Cited by 17 · see citing works

Sobriety and Satiety: Is NAD+ the Answer?

Braidy, N., Villalva, M. D., & van Eeden, S. (2020) · Antioxidants · doi:10.3390/antiox9050425 · Cited by 17 · see citing works

Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury

Cai, W.-B., Zhao, Y., Liu, L., Cheng, Q., Wang, J., Shi, X., Liu, Y. Z., Qiao, X., Zhu, Y., Chen, C., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.033 · Cited by 16 · see citing works

Ex vivo protective effects of nicotinamide and 3‐aminobenzamide on rat synaptosomes treated with Aβ(1–42)

Turunç, E., Armağan, G., Uyanıkgil, Y., Kanıt, L., Koylu, E. O., & Yalçın, A. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3049 · Cited by 31 · see citing works

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

Salech, F., Ponce, D. P., Paula-Lima, A. C., SanMartín, C. D., & Behrens, M. I. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00255 · Cited by 89 · see citing works

Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease

Abeti, R., & Duchen, M. R. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0895-x · Cited by 78 · see citing works

PARP-1 drives metabolic changes in Alzheimer's disease models

Martire, S., Fuso, A., Correani, V., Fabrizi, C., MASCI, A., Fontana, M., Perkins, N., MOSCA, L., Maras, B., & D’Erme, M. (2014) · IRIS Research product catalog (Sapienza University of Rome)

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

Abeti, R., Abramov, A. Y., & Duchen, M. R. (2011) · Brain · doi:10.1093/brain/awr104 · Cited by 172 · see citing works