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The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

The effects of low-fat, high-carbohydrate diets vs. low-carbohydrate, high-fat diets on weight, blood pressure, serum liquids and blood glucose: a systematic review and meta-analysis

Yang, Qing, Lang, Xinyue, Li, Wei, Liang, Yan·2022·European Journal of Clinical Nutrition
DOI 10.1038/s41430-021-00927-0
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Abstract

Our aim was to determine the relative effectiveness of two dietary macronutrient patterns (LFHC (low-fat, high-carbohydrate) diets and LCHF (low-carbohydrate, high-fat) diets) on weight loss and cardiovascular risk factors. We searched four databases including MEDLINE, EMBASE, Cochrane Library, and Web of Science to identify the eligible studies on March 13, 2020. Randomized clinical trials (RCT) were included which compared the effect of two diets (LFHC and LCHF) on weight loss, blood pressure, serum liquids, and blood glucose in overweight or obesity adults. Standardized mean difference (SMD) and 95% confidence interval (CI) were used for the pooled results. This paper included eleven studies involving 739 participants. Compared with LFHC diets, LCHF diets had a greater effect on weight loss (SMD = -1.01 kg; 95% CI -1.99 to -0.04, p = 0.04) and HDL-cholesterol changes (SMD = 0.82 mmol/l; 95% CI 0.43 to 1.21, p < 0.0001), but a smaller effect on total cholesterol decrease (SMD = 0.63 mmol/l; 95% CI 0.18-1.08, p = 0.006) and LDL-cholesterol decrease (SMD = 0.59 mmol/l; 95% CI 0.11-1.18, p = 0.05). Between the two groups, changes in lean mass, fat mass, systolic blood pressure, diastolic blood pressure, triglycerides, and glucose were non-significant. To conclude, both diets are effective for weight control and reduction of cardiovascular risk factors. And further studies with long-term follow-up are needed to confirm our results.

Overview

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Crossref · 10.1038/s41430-021-00927-0

Cites

18 of 18 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • Several systematic reviews and meta-analyses over the past decade have unanimously shown that low-carbohydrate diets produce superior weight loss to low-fat diets, with mean differences ranging 1.01-2.64 kg.

    “Several systematic reviews and meta-analyses over the past decade have examined the effects of LCDs, unanimously showing superior weight loss to LFDs [136,138–145], with mean differences ranging 1.01–2.64 kg.”

    From International Society of Sports Nutrition position stand: diets for body weight reduction (2026) · cites this paper as [144]

Citations

Cites

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Research works printed but not linked: 26

  1. Bradley U, Spence M, Courtney CH, McKinley MC, Ennis CN, McCance DR. et al. Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial. Diabetes. 2009;58:2741–48. · DOI
  2. García Gabarra A, Castellà Soley M, Calleja Fernández A. [Recommended energy and nutrients intakes in the European Union: 2008-2016]. Nutr Hosp. 2017;34:490–8. · DOI
  3. Smart NA, Marshall BJ, Daley M, Boulos E, Windus J, Baker N. et al. Low-fat diets for acquired hypercholesterolaemia. Cochrane Database Syst Rev. 2011;2:Cd007957
  4. Seid H, Rosenbaum M. Low carbohydrate and low-fat diets: what we don’t know and why we should know It. Nutrients. 2019;11:2749. · DOI · Paper page
  5. Hall KD. A review of the carbohydrate-insulin model of obesity. Eur J Clin Nutr. 2017;71:323–6. · DOI · Paper page
  6. Bo S, Fadda M, Fedele D, Pellegrini M, Ghigo E, Pellegrini N. A critical review on the role of food and nutrition in the energy balance. Nutrients 2020;12:1161. · DOI
  7. Ludwig DS, Friedman MI. Increasing adiposity consequence or cause of overeating?. JAMA. 2014;311:2167–8. · DOI · Paper page
  8. Taubes G. The science of obesity: what do we really know about what makes us fat? An essay by Gary Taubes. BMJ. 2013;346:f1050. · DOI
  9. Clar C, Al-Khudairy L, Loveman E, Kelly SA, Hartley L, Flowers N. et al. Low glycaemic index diets for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017;7:Cd004467
  10. Naude CE, Schoonees A, Senekal M, Young T, Garner P, Volmink J. Low carbohydrate versus isoenergetic balanced diets for reducing weight and cardiovascular risk: a systematic review and meta-analysis. PLoS ONE. 2014;9:e100652 · DOI · Paper page
  11. Hu T, Bazzano LA. The low-carbohydrate diet and cardiovascular risk factors: evidence from epidemiologic studies. Nutr Metab Cardiovasc Dis. 2014;24:337–43. · DOI · Paper page
  12. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264–9. w264. · DOI · Paper page
  13. Kriston L. Dealing with clinical heterogeneity in meta-analysis. Assumptions, methods, interpretation. Int J Methods Psychiatr Res. 2013;22:1–15. · DOI
  14. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34. · DOI · Paper page
  15. DerSimonian R, Laird N. Meta-analysis in clinical trials revisited. Contemp Clin Trials. 2015;45:139–45. · DOI · Paper page
  16. Aude YW, Agatston AS, Lopez-Jimenez F, Lieberman EH, Marie Almon N, Hansen M. et al. The national cholesterol education program diet vs a diet lower in carbohydrates and higher in protein and monounsaturated fat: a randomized trial. Arch Intern Med. 2004;164:2141–6. · DOI · Paper page
  17. Fleming RM. The effect of high-, moderate-, and low-fat diets on weight loss and cardiovascular disease risk factors. Prev Cardiol. 2002;5:110-8. · DOI
  18. Hu T, Yao L, Reynolds K, Whelton PK, Niu T, Li S. et al. The effects of a low-carbohydrate diet vs. a low-fat diet on novel cardiovascular risk factors: a randomized controlled trial. Nutrients. 2015;7:7978–94. · DOI
  19. Petrisko M, Kloss R, Bradley P, Birrenkott E, Spindler A, Clayton ZS, et al. Biochemical, anthropometric, and physiological responses to carbohydrate-restricted diets versus a low-fat diet in obese adults: a randomized crossover trial. J Med. Food 2020;23:206-14. · DOI
  20. Ruth MR, Port AM, Shah M, Bourland AC, Istfan NW, Nelson KP. et al. Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects. Metab: Clin Exp. 2013;62:1779–87. · DOI
  21. Tay J, Brinkworth GD, Noakes M, Keogh J, Clifton PM. Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. J Am Coll Cardiol. 2008;51:59–67. · DOI · Paper page
  22. Utz W, Engeli S, Haufe S, Kast P, Böhnke J, Haas V. et al. Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women. Int J Cardiol. 2013;167:905–9. · DOI
  23. Bueno NB, de Melo IS, de Oliveira SL, da Rocha Ataide T. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. 2013;110:1178–87. · DOI · Paper page
  24. Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88:1617–23. · DOI · Paper page
  25. Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the atkins, ornish, weight watchers, and zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005;293:43–53. · DOI · Paper page
  26. Tipton KD. Efficacy and consequences of very-high-protein diets for athletes and exercisers. Proc Nutr Soc. 2011;70:205–14. · DOI

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Metadata

Authors
Yang, Q., Lang, X., Li, W., & Liang, Y.
ORCID
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2021-06-24
Volume
76
Issue
1
Pages
16-27
ISSN
  • 0954-3007
  • 1476-5640
DOI
10.1038/s41430-021-00927-0
Cited by
45
References
18
Language
en
Licence

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