The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks
Open accessAbstract
Enhancing or restoring enzymatic function in cells is highly desirable in applications ranging from ex vivo cellular manipulations to enzyme replacement therapies in humans. However, because enzymes degrade in biological milieus, achieving long-term enzymatic activities can be challenging. Herein we report on the in cellulo properties of nanofactories that consist of antioxidative enzymes encapsulated in metal–organic frameworks (MOFs). We demonstrate that, while free enzymes display weak activities for only a short duration, these efficient nanofactories protect human cells from toxic reactive oxygen species for up to a week. Remarkably, these results are obtained in spite of the nanofactories being localized in lysosomes, acidic organelles that contain a variety of proteases. The long-term persistence of the nanofactories is attributed to the chemical stability of MOF in low pH environment and to the protease resistance provided by the protective cage formed by the MOF around the encapsulated enzymes.
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Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Metal–Organic Framework-Based Enzyme Biocomposites
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Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Incorporation of biomolecules in Metal-Organic Frameworks for advanced applications
An, H., Li, M., Gao, J., Zhang, Z., Ma, S., & Chen, Y. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.01.001 · Cited by 336
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Metadata
- Authors
- Lian, X., Erazo-Oliveras, A., Pellois, J.-P., & Zhou, H.-C.
- Venue
- Nature Communications
- Published
- 2017-12-12
- Volume
- 8
- Issue
- 1
- Pages
- 2075-2075
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2774855349
- Cited by
- 172
- References
- 7
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lian, X., Erazo-Oliveras, A., Pellois, J.-P., & Zhou, H.-C. (2017). High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks. Nature Communications. https://doi.org/10.1038/s41467-017-02103-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
