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Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Open access
Gao, Shuai, Wei, Guoguang, Zhang, Sihang, Zheng, Binbin, Xu, Jiaojiao, Chen, Gaoxian, Li, Mingwang, Song, Shaoli, Fu, Wei, Xiao, Zeyu, Lu, Wei·2019·Nature Communications

Abstract

Fluorophores with donor-acceptor-donor groups with the emission spanning the second near-infrared window (NIR-II) have recently received great attention for biomedical application. Yet, the mechanism underlying the equilibrium between fluorescence (radiative decay) and photothermal effect (non-radiative decay) of these fluorophores remains elusive. Here, we demonstrate that a lipophilic NIR-II fluorophore, BPBBT, possesses both twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) characteristics. Human serum albumin (HSA) binds to BPBBT, which changes the planarity of the fluorophore and restricts its intramolecular rotation. The binding results in alteration to the equilibrium between AIE and TICT state of BPBBT, tailoring its fluorescence and photothermal efficiency. Under the guidance of intraoperative NIR-II fluorescence image, the prepared HSA-bound BPBBT nanoparticles delineate primary orthotopic mouse colon tumor and metastatic lesions with dimensions as small as 0.5 mm × 0.3 mm, and offer photothermal ablation therapy with optimized timing, dosing and area of the laser irradiation.

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Metadata

Authors
Gao, S., Wei, G., Zhang, S., Zheng, B., Xu, J., Chen, G., Li, M., Song, S., Fu, W., Xiao, Z., & Lu, W.
Venue
Nature Communications
Published
2019-05-17
Volume
10
Issue
1
Pages
2206-2206
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2946107233
Cited by
317
References
47
FWCI
13.63
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. https://app.cochat.ai/papers/10.1038/s41467-019-10056-9
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Gao, S., Wei, G., Zhang, S., Zheng, B., Xu, J., Chen, G., Li, M., Song, S., Fu, W., Xiao, Z., & Lu, W. (2019). Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nature Communications. https://doi.org/10.1038/s41467-019-10056-9

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