Evolving perspectives on the sources of the frequency-following response
Open accessAbstract
The auditory frequency-following response (FFR) is a non-invasive index of the fidelity of sound encoding in the brain, and is used to study the integrity, plasticity, and behavioral relevance of the neural encoding of sound. In this Perspective, we review recent evidence suggesting that, in humans, the FFR arises from multiple cortical and subcortical sources, not just subcortically as previously believed, and we illustrate how the FFR to complex sounds can enhance the wider field of auditory neuroscience. Far from being of use only to study basic auditory processes, the FFR is an uncommonly multifaceted response yielding a wealth of information, with much yet to be tapped.
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Recent research suggests cortical contribution to FFR, originally thought to only come from subcortical regions.
“Further, methodologically, spatial information has become crucial for cABR, given recent research has suggested cortical contribution to FFR, originally thought to only come from subcortical regions [46].”
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Altered processing of communication signals in the subcortical auditory sensory pathway in autism
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- Authors
- Coffey, E. B. J., Nicol, T., White-Schwoch, T., Chandrasekaran, B., Krizman, J., Skoe, E., Zatorre, R. J., & Kraus, N.
- Affiliations
- Centre for Research on Brain Language and Music (CA)
- Northwestern University (US)
- University of Pittsburgh (US)
- University of Connecticut (US)
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Coffey, Emily B. J.
- ORCID
- Venue
- Nature Communications
- Published
- 2019-11-06
- Volume
- 10
- Issue
- 1
- Pages
- 5036-5036
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6834633
- OpenAlex
- W2982822984
- Cited by
- 207
- References
- 125
- Citations by year
- 2026: 21 · 2025: 21 · 2024: 37 · 2023: 34 · 2022: 31 · 2021: 41 · 2020: 20 · 2019: 1 · 2018: 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC015504, R01DC013315)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- frequency-following response, cortical sources, auditory neuroscience, neuroplasticity
- MeSH terms
- Auditory Cortex, Auditory Perception, Brain, Evoked Potentials, Auditory, Humans, Learning, Memory, Sound, Evoked Potentials, Auditory, Brain Stem
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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