Neurons along the auditory pathway exhibit a hierarchical organization of prediction error
Open accessAbstract
Perception is characterized by a reciprocal exchange of predictions and prediction error signals between neural regions. However, the relationship between such sensory mismatch responses and hierarchical predictive processing has not yet been demonstrated at the neuronal level in the auditory pathway. We recorded single-neuron activity from different auditory centers in anaesthetized rats and awake mice while animals were played a sequence of sounds, designed to separate the responses due to prediction error from those due to adaptation effects. Here we report that prediction error is organized hierarchically along the central auditory pathway. These prediction error signals are detectable in subcortical regions and increase as the signals move towards auditory cortex, which in turn demonstrates a large-scale mismatch potential. Finally, the predictive activity of single auditory neurons underlies automatic deviance detection at subcortical levels of processing. These results demonstrate that prediction error is a fundamental component of singly auditory neuron responses.
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Several paradigms shown in this article have been already used for investigations of MMN in non-human animals.
“Several paradigms shown in this article have been already used for investigations of MMN in non-human animals (49–51).”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [51]
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Stimulus-Specific Prediction Error Neurons in Mouse Auditory Cortex
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Large-scale interactions in predictive processing: oscillatory versus transient dynamics
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Auditory Mismatch Negativity Under Predictive Coding Framework and Its Role in Psychotic Disorders
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Predictive Coding, Variational Autoencoders, and Biological Connections
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Inverted central auditory hierarchies for encoding local intervals and global temporal patterns
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Diverse functions of the auditory cortico-collicular pathway
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Behavior-relevant top-down cross-modal predictions in mouse neocortex
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Deviance detection in physiologically identified cell types in the rat auditory cortex
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Self-citationWhat can we learn from inactivation studies? Lessons from auditory cortex
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Self-citationNeural Substrates and Models of Omission Responses and Predictive Processes
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Spontaneous beat synchronization in rats: Neural dynamics and motor entrainment
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Brain predictive coding processes are associated to COMT gene Val158Met polymorphism
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Predictive learning shapes the representational geometry of the human brain
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Implicit Memory for Complex Sounds in Higher Auditory Cortex of the Ferret
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Mismatch-negativity (MMN) in animal models: Homology of human MMN?
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Omission responses in local field potentials in rat auditory cortex
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Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys
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Self-citationNovelty Processing in the Auditory System: Detection, Adaptation or Expectation?
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Self-citationAcetylcholine modulates the precision of prediction error in the auditory cortex
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Decoding of Envelope vs. Fundamental Frequency During Complex Auditory Stream Segregation
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A Critical Review of the Deviance Detection Theory of Mismatch Negativity
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Robust multisensory deviance detection in the mouse parietal associative area
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Alzheimer’s Disease, Hearing Loss, and Deviance Detection
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A multimodal cortical network of sensory expectation violation revealed by fMRI
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Change detection in the primate auditory cortex through feedback of prediction error signals
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Natural ITD statistics predict human auditory spatial perception
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Emergence of prediction error along the human auditory hierarchy
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Somatosensory omissions reveal action‐related predictive processing
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Two Prediction Error Systems in the Nonlemniscal Inferior Colliculus: Spectral and Nonspectral
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Self-citationAbnormal Auditory Processing and Underlying Structural Changes in 22q11.2 Deletion Syndrome
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Hierarchical musical instrument separation
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Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortexPreprint
Jamali, S., Bagur, S., Brémont, E., van Kerkoerle, T., Dehaene, S., & Bathellier, B. (2024) · eLife · doi:10.7554/elife.102702 · Cited by 16 · see citing works
- Authors
- Parras, G. G., Nieto-Diego, J., Carbajal, G. V., Valdés-Baizabal, C., Escera, C., & Malmierca, M. S.
- Affiliations
- Instituto de Investigación Biomédica de Salamanca (ES)
- Institut de Recerca Sant Joan de Déu (ES)
- Universidad de Salamanca (ES)
- Corresponding author
- Malmierca, Manuel S.
- Venue
- Nature Communications
- Published
- 2017-12-15
- Volume
- 8
- Issue
- 1
- Pages
- 2148-2148
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5732270
- OpenAlex
- W2774201964
- Cited by
- 344
- References
- 75
- Citations by year
- 2026: 38 · 2025: 33 · 2024: 55 · 2023: 60 · 2022: 39 · 2021: 29 · 2020: 50 · 2019: 25 · 2018: 14
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Gredos (University of Salamanca) (publishedVersion, cc-by)
- Hispana (publishedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Generalitat de Catalunya (SGR 2014, SGR2014-177)
- Junta de Castilla y León
- European Social Fund (2007–2013)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Embodied and Extended Cognition
- Keywords
- prediction error, auditory pathway, single-unit activity, auditory cortex, subcortical auditory processing, mismatch response, deviance detection, sensory prediction, auditory adaptation
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