Altered processing of communication signals in the subcortical auditory sensory pathway in autism
Open accessAbstract
Autism spectrum disorder (ASD) is characterised by social communication difficulties. These difficulties have been mainly explained by cognitive, motivational, and emotional alterations in ASD. The communication difficulties could, however, also be associated with altered sensory processing of communication signals. Here, we assessed the functional integrity of auditory sensory pathway nuclei in ASD in three independent functional magnetic resonance imaging experiments. We focused on two aspects of auditory communication that are impaired in ASD: voice identity perception, and recognising speech‐in‐noise. We found reduced processing in adults with ASD as compared to typically developed control groups (pairwise matched on sex, age, and full‐scale IQ) in the central midbrain structure of the auditory pathway (inferior colliculus [IC]). The right IC responded less in the ASD as compared to the control group for voice identity, in contrast to speech recognition. The right IC also responded less in the ASD as compared to the control group when passively listening to vocal in contrast to non‐vocal sounds. Within the control group, the left and right IC responded more when recognising speech‐in‐noise as compared to when recognising speech without additional noise. In the ASD group, this was only the case in the left, but not the right IC. The results show that communication signal processing in ASD is associated with reduced subcortical sensory functioning in the midbrain. The results highlight the importance of considering sensory processing alterations in explaining communication difficulties, which are at the core of ASD.
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Altered voice processing in ASD seems to be present already at the midbrain level of the auditory pathway.
“Interestingly, a recent study show altered voice processing in ASD which seems to be present already at the midbrain level of the auditory pathway (Schelinski et al. 2022).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Schelinski et al. 2022
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Self-citationLópez-Barroso, D., & de Diego‐Balaguer, R. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00476 · Cited by 51 · see citing works
Schelinski, S., & von Kriegstein, K. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-04244-1 · Cited by 48 · see citing works
Self-citationAbrams, D. A., Padmanabhan, A., Chen, T., Odriozola, P., Baker, A. E., Kochalka, J., Phillips, J. M., & Menon, V. (2019) · eLife · doi:10.7554/elife.39906 · Cited by 46 · see citing works
A neural mechanism for recognizing speech spoken by different speakers
Kreitewolf, J., Gaudrain, É., & von Kriegstein, K. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.005 · Cited by 44 · see citing works
Abstract rules drive adaptation in the subcortical sensory pathway
Tabas, A., Mihai, P. G., Kiebel, S. J., Trampel, R., & von Kriegstein, K. (2020) · eLife · doi:10.7554/elife.64501 · Cited by 44 · see citing works
Self-citationPeterson, D. C., & Schofield, B. R. (2007) · Hearing Research · doi:10.1016/j.heares.2007.06.009 · Cited by 44 · see citing works
Auditory, tactile, and audiotactile information processing following visual deprivation
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Angelis, V. D., Martino, F. D., Moerel, M., Santoro, R., Hausfeld, L. G., & Formisano, E. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.020 · Cited by 41 · see citing works
Right hemisphere ventral stream for emotional prosody identification
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VOCAL PITCH DURING SIMULATED EMOTION.
Fairbanks, G., & Pronovost, W. (1938) · Science · doi:10.1126/science.88.2286.382 · Cited by 39 · see citing works
Voice identity discrimination in schizophrenia
Chhabra, S., Badcock, J. C., Maybery, M. T., & Leung, D. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.08.006 · Cited by 38 · see citing works
Zimmerman, R., Smith, A., Fech, T., Mansour, Y., & Kulesza, R. J. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05729-7 · Cited by 37 · see citing works
Schelinski, S., Riedel, P., & von Kriegstein, K. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.09.031 · Cited by 37 · see citing works
Self-citationThe role of glottal pulse rate and vocal tract length in the perception of speaker identity
Gaudrain, É., Li, S., Ban, V. S., & Patterson, R. D. (2009) · Interspeech (USB) · doi:10.21437/interspeech.2009-54 · Cited by 29 · see citing works
Hemispheric asymmetries in subcortical visual and auditory relay structures in congenital deafness
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Developmental phonagnosia: Linking neural mechanisms with the behavioural phenotype
Roswandowitz, C., Schelinski, S., & von Kriegstein, K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.064 · Cited by 24 · see citing works
Self-citationImpaired Subcortical Detection of Auditory Changes in Schizophrenia but Not in Major Depression
Gaebler, A. J., Zweerings, J., Koten, J. W., König, A. A., Turetsky, B. I., Zvyagintsev, M., & Mathiak, K. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz027 · Cited by 24 · see citing works
Functional Mapping of the Human Auditory Cortex
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van der Kruk, Y., Wilson, W. J., Perrykkad, K., Downing, C., Harper‐Hill, K., & Ashburner, J. K. (2017) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-017-0111-7 · Cited by 22 · see citing works
Structural abnormalities of the right inferior colliculus in schizophrenia
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Borowiak, K., Schelinski, S., & von Kriegstein, K. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.09.019 · Cited by 17 · see citing works
Self-citationSchelinski, S., & von Kriegstein, K. (2022) · Brain and Behavior · doi:10.1002/brb3.2848 · Cited by 13 · see citing works
Self-citationSchelinski, S., & von Kriegstein, K. (2021) · doi:10.31234/osf.io/rf8tp · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
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A systematic review on speech-in-noise perception in autism
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- Authors
- Schelinski, S., Tabas, A., & von Kriegstein, K.
- Affiliations
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Faculty of Psychology, Chair of Cognitive and Clinical Neuroscience Technische Universität Dresden Dresden Germany
- Corresponding author
- Schelinski, Stefanie
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2022-01-17
- Volume
- 43
- Issue
- 6
- Pages
- 1955-1972
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC8933247
- OpenAlex
- W4220683378
- Cited by
- 24
- References
- 125
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 3
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Human Brain Mapping (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, cc-by-nc)
- PsyArXiv (OSF Preprints) (submittedVersion)
- PsyArXiv (OSF Preprints) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- autism spectrum disorder, auditory sensory processing, inferior colliculus, speech perception in noise, social communication deficits, hemispheric lateralization
- MeSH terms
- Autism Spectrum Disorder, Adult, Auditory Pathways, Autistic Disorder, Communication, Humans, Speech
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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