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New views of Arc, a master regulator of synaptic plasticity

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Shepherd, Jason D, Bear, Mark F·2011·Nature Neuroscience
DOI 10.1038/nn.2708PMC PMC8040377
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Abstract

Many proteins have been implicated in synaptic and experience-dependent plasticity. However, few demonstrate the exquisite regulation of expression and breadth of functional importance as the immediate early gene product Arc. Here we review and attempt to synthesize the disparate views of Arc in neuronal function. The main conclusion garnered from this body of work is that Arc is a critical effector molecule downstream of many molecular signaling pathways and that dysregulation of Arc expression can have dire consequences for normal brain function.

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Crossref · 10.1038/nn.2708

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  • Molecular markers of synaptic potentiation like arc, BDNF or CaMKIV are involved in both the potentiation and depression of synaptic strength or other forms of non-Hebbian scaling.

    “Also, molecular markers of synaptic potentiation like arc, BDNF or Calmodulin-dependent-kinase (CaMK) IV are involved in both the potentiation and depression of synaptic strength or other forms of non-Hebbian scaling (1026, 1067), questioning that the relative increase and decrease of these markers across sleep and wakefulness, respectively, is actually related to one specific form of synaptic”

    From About Sleep's Role in Memory (2013) · cites this paper as [1067]

    “A view from the top: information storage” links Arc to both LTP and LTD, and “A view from the bottom: synaptic function” describes its role in homeostatic synaptic scaling (page numbers unavailable). The cited paper does not establish the same combination of roles for BDNF or CaMKIV; it mentions BDNF only in relation to Arc expression. (LLM, conf=0.86)

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Cites

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Research works printed but not linked: 47

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Authors
Shepherd, J. D., & Bear, M. F.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
  • Shepherd, Jason D
  • Bear, Mark F
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2011-01-30
Volume
14
Issue
3
Pages
279-284
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.2708
PMC
PMC8040377
OpenAlex
W1995549311
Cited by
481
References
3
Citations by year
2026: 15 · 2025: 19 · 2024: 22 · 2023: 34 · 2022: 22 · 2021: 43 · 2020: 31 · 2019: 28 · 2018: 48 · 2017: 35 · 2016: 31 · 2015: 31 · 2014: 38 · 2013: 35 · 2012: 35
FWCI
3.72
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Neurological Disorders and Stroke (K99NS076364)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Arc, synaptic plasticity, experience-dependent plasticity, immediate early genes, neuronal signaling pathways, neurological disorders, brain function
MeSH terms
Animals, Homeostasis, Humans, Neuronal Plasticity, Neurons, RNA, Messenger, Synapses, Visual Cortex, Signal Transduction, Immediate-Early Proteins, Receptors, AMPA

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