Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

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Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

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Plant-Derived Bioactive Compounds and Potential Health Benefits: Involvement of the Gut Microbiota and Its Metabolic Activity

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In vitro Antimicrobial Activity and the Mechanism of Berberine Against Methicillin-Resistant Staphylococcus aureus Isolated from Bloodstream Infection Patients

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Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR’s cholesterol-decreasing efficacy in patients

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Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota

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Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism

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Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action

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Antibiotic-perturbed microbiota and the role of probiotics

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Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

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Berberine ameliorates ovariectomy-induced anxiety-like behaviors by enrichment in equol generating gut microbiota

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Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways

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Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

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Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases

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Berberine influences multiple diseases by modifying gut microbiota

Yang, F., Gao, R., Luo, X., Liu, R., & Xiong, D. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1187718 · Cited by 70 · see citing works

The mechanism of berberine alleviating metabolic disorder based on gut microbiome

Wang, H., Zhang, H., Gao, Z., Zhang, Q., & Gu, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854885 · Cited by 69 · see citing works

The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo

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Berberis dictyophylla F. inhibits angiogenesis and apoptosis of diabetic retinopathy via suppressing HIF-1α/VEGF/DLL-4/Notch-1 pathway

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The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials

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Gut Microbiota and Antidiabetic Drugs: Perspectives of Personalized Treatment in Type 2 Diabetes Mellitus

Liu, W., Luo, Z., Zhou, J., & Sun, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.853771 · Cited by 62 · see citing works

Effect of traditional Chinese medicine on gut microbiota in adults with type 2 diabetes: A systematic review and meta-analysis

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The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case‐Control Study of Gestational Diabetes Mellitus

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Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine

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Network pharmacology provides new insights into the mechanism of traditional Chinese medicine and natural products used to treat pulmonary hypertension

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Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation

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Effects of Berberine on Atherosclerosis

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Mechanisms of traditional Chinese medicine in modulating gut microbiota metabolites-mediated lipid metabolism

Li, Y., Ji, X., Wu, H., Xiang, L., Zhang, H., & Tang, D. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114207 · Cited by 55 · see citing works

Natural anti-cancer products: insights from herbal medicine

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Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study

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A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

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Gut Microbiota‐Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

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Increased circulating butyrate and ursodeoxycholate during probiotic intervention in humans with type 2 diabetes

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Biologically active isoquinoline alkaloids covering 2019–2022

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Convergent evolution of berberine biosynthesis

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Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives

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Adjunctive Probio-X Treatment Enhances the Therapeutic Effect of a Conventional Drug in Managing Type 2 Diabetes Mellitus by Promoting Short-Chain Fatty Acid-Producing Bacteria and Bile Acid Pathways

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Mulberry leaf polysaccharides ameliorate glucose and lipid metabolism disorders via the gut microbiota-bile acids metabolic pathway

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Addressing the preventive and therapeutic perspective of berberine against diabetes

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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications

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Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial

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Berberine improves liver injury induced glucose and lipid metabolic disorders via alleviating ER stress of hepatocytes and modulating gut microbiota in mice

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Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus

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Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Huang, J., Huang, N., Mao, Q., Shi, J., & Qiu, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1130253 · Cited by 42 · see citing works

Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy via the miR‑18a‑3p/Gsdmd pathway

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Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice

Wang, X., Zhang, J., Wang, S., Song, Z., Sun, H., Wu, F., Lin, X., Jin, K., Jin, X., Wang, W.-T., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175782 · Cited by 43 · see citing works

Diabetes and gut microbiota

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Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Yang, S., Li, D., Yu, Z., Li, Y., & Wu, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.709629 · Cited by 40 · see citing works

Simiao Wan modulates the gut microbiota and bile acid metabolism during improving type 2 diabetes mellitus in mice

Chen, Y., Zhu, L., Hu, W., Wang, Y., Wen, X., & Yang, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154264 · Cited by 40 · see citing works

Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications

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Common mechanisms of Gut microbe-based strategies for the treatment of intestine-related diseases: based on multi-target interactions with the intestinal barrier

Chen, K., Wang, H., Yang, Y., Tang, C., Sun, X., Zhou, J., Liu, S., Li, Q., Zhao, L., & Gao, Z. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02299-5 · Cited by 45 · see citing works

Antidiabetic Properties of Plant Secondary Metabolites

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Baicalin ameliorates multidrug-resistant Pseudomonas aeruginosa induced pulmonary inflammation in rat via arginine biosynthesis

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Consideration of Gut Microbiome in Murine Models of Diseases

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Intestinal Microbiota—A Promising Target for Antiviral Therapy?

Yang, M., Yang, Y., He, Q., Zhu, P., Liu, M., Xu, J., & Zhao, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676232 · Cited by 41 · see citing works

Berberine Improves Vascular Dysfunction by Inhibiting Trimethylamine-N-oxide via Regulating the Gut Microbiota in Angiotensin II-Induced Hypertensive Mice

Wang, Z., Wu, F., Zhou, Q., Qiu, Y., Zhang, J., Tu, Q., Zhou, Z., Shao, Y., Xu, S., Wang, Y., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.814855 · Cited by 37 · see citing works

Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms

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Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation

Xie, Z., Liu, X., Huang, X., Liu, Q., Yang, M., Huang, D., Zhao, P., Tian, J., Wang, X., & Hou, J. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174526 · Cited by 36 · see citing works

Probiotics and synbiotics for glycemic control in diabetes: A systematic review and meta-analysis of randomized controlled trials

Baroni, I., Fabrizi, D., Luciani, M., Magon, A., Conte, G., Angeli, G. D., Paglione, G., Ausili, D., & Caruso, R. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.03.006 · Cited by 35 · see citing works

Emerging frontiers of antibiotics use and their impacts on the human gut microbiome

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Emerging trends and research foci of berberine on tumor from 2002 to 2021: A bibliometric article of the literature from WoSCC

Yuan, R., Tan, Y., Sun, P., Qin, B., & Liang, Z. C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1122890 · Cited by 34 · see citing works

Mechanisms of bariatric surgery for weight loss and diabetes remission

Yin, M., Wang, Y., Han, M., Liang, R., Li, S., Wang, G., & Gang, X. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13443 · Cited by 34 · see citing works

Gut microbiota and healthy longevity

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Metabolic diseases in the East Asian populations

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A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens

Dehau, T., Cherlet, M., Croubels, S., Immerseel, F. V., & Goossens, E. (2023) · mSystems · doi:10.1128/msystems.01239-22 · Cited by 35 · see citing works

Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites

Dehau, T., Cherlet, M., Croubels, S., Van De Vliet, M., Goossens, E., & Van Immerseel, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1281090 · Cited by 33 · see citing works

Role of Fenugreek, Cinnamon, Curcuma longa, Berberine and Momordica charantia in Type 2 Diabetes Mellitus Treatment: A Review

Cortez-Navarrete, M., Pérez-Rubio, K. G., & Escobedo-Gutiérrez, M. D. J. (2023) · Pharmaceuticals · doi:10.3390/ph16040515 · Cited by 39 · see citing works

Efficacy of fecal microbiota transplantation in type 2 diabetes mellitus: a systematic review and meta-analysis

Yang, Y., Yan, J., Li, S., Liu, M., Han, R., Wang, Y., Wang, Z., & Wang, D. (2023) · Endocrine · doi:10.1007/s12020-023-03606-1 · Cited by 33 · see citing works

Berberine and health outcomes: an overview of systematic reviews

Shi, L.-J., Wang, W., Jing, C., Hu, J. Y., & Liao, X. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04872-4 · Cited by 36 · see citing works

Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway

Sui, M., Jiang, X., Sun, H., Liu, C., & Fan, Y. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s313068 · Cited by 32 · see citing works

Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes

Hu, X., Zhou, R., Li, H., Zhao, X., Sun, Y., Fan, Y., & Zhang, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.805812 · Cited by 32 · see citing works

Network pharmacology, molecular docking, and experimental pharmacology explored Ermiao wan protected against periodontitis via the PI3K/AKT and NF-κB/MAPK signal pathways

Xia, Z., Li, Q., & Tang, Z. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115900 · Cited by 32 · see citing works

Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

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Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma

Chen, P., Yang, C., Ren, K., Xu, M., Pan, C., Ye, X., & Li, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1504948 · Cited by 32 · see citing works

The gut-cardiovascular connection: new era for cardiovascular therapy

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Integrated Traditional Chinese Medicine Improves Functional Outcome in Acute Ischemic Stroke: From Clinic to Mechanism Exploration With Gut Microbiota

Guo, Q., Ni, C., Li, L., Li, M., Jiang, X., Gao, L. Q., Zhu, H., & Song, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.827129 · Cited by 31 · see citing works

Preventive Effect of Berberine on Postoperative Atrial Fibrillation

Zhang, J., Wang, Y., Jiang, H., Tao, D., Zhao, K., Yin, Z., Han, J., Xin, F., Jin, Y., & Wang, H. (2022) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.122.011160 · Cited by 29 · see citing works

Design of probiotic delivery systems and their therapeutic effects on targeted tissues

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Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke

Shih, C., Liao, W., Ke, H., Kuo, C.-W., Tsao, C., Tsai, W., Chiu, Y., Huang, H.-C., & Wu, C.-C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114565 · Cited by 27 · see citing works

Berberine alleviates type 2 diabetic symptoms by altering gut microbiota and reducing aromatic amino acids

Yao, Y., Chen, H., Yan, L., Wang, W., & Wang, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110669 · Cited by 66 · see citing works

Probiotics Plus Berberine as an Anti-Diabetic Regimen in Patients with Type 2 Diabetes, Particularly in the Elderly: A Multicentre Randomised Controlled TrialPreprint

Zhang, Y., Gu, Y., Wang, S., Ma, J., Gu, X., Xue, Y., Huang, S., Yang, J., Chen, L., Chen, G., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3204706 · Cited by 1 · see citing works

Multi-target regulation of intestinal microbiota by berberine to improve type 2 diabetes mellitus

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Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

Zhao, J., Li, Y., Sun, M., Yu, C., Li, J.-Y., Wang, S.-H., Yang, D., Guo, C., Du, X., Zhang, W., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i8.708 · Cited by 74 · see citing works

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