The spatial and temporal structure of neural activity across the fly brain
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Abstract
What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate.
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- Authors
- Schaffer, E. S., Mishra, N., Whiteway, M. R., Li, W., Vancura, M. B., Freedman, J., Patel, K. B., Voleti, V., Paninski, L., Hillman, E. M. C., Abbott, L. F., & Axel, R.
- Affiliations
- Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Schaffer, Evan S.
- ORCID
- Venue
- Nature Communications
- Published
- 2023-09-11
- Volume
- 14
- Issue
- 1
- Pages
- 5572-5572
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10495430
- OpenAlex
- W4386605566
- Cited by
- 53
- References
- 76
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 12 · 2023: 9 · 2022: 8
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation (DGE 16?44869, 1707398)
- Howard Hughes Medical Institute
- Simons Foundation (542951, 543023)
- Gatsby Charitable Foundation (DBI-1707398, 1707398)
- National Institutes of Health (1uf1ns108213-01)
- National Institute of Neurological Disorders and Stroke (U01NS094296)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Drosophila brain, neuronal activity, spontaneous behavior, running, grooming, neuronal clusters, microcircuits
- MeSH terms
- Animals, Brain, Drosophila, Grooming, Neurons, Knowledge
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