Cited by 195Nanoplatforms for cancer theranosticsQuantum Dots Synthesis And PropertiesLuminescence Properties of Advanced Materials

A phosphorescent probe for in vivo imaging in the second near-infrared window

Chang, Baisong, Li, Daifeng, Ren, Ying, Qu, Chunrong, Shi, Xiaojing, Liu, Ruiqi, Liu, Hongguang, Tian, Jie +3 more·2021·Nature Biomedical Engineering

Abstract

In the second near-infrared spectral window (NIR-II; with wavelengths of 1,000-1,700 nm), in vivo fluorescence imaging can take advantage of reduced tissue autofluorescence and lower light absorption and scattering by tissue. Here, we report the development and in vivo application of a NIR-II phosphorescent probe that has lifetimes of hundreds of microseconds and a Stokes shift of 430 nm. The probe is made of glutathione-capped copper-indium-selenium nanotubes, and in acidic environments (pH 5.5-6.5) switches from displaying fluorescence to phosphorescence. In xenograft models of osteosarcoma and breast cancer, intravenous or intratumoral injections of the probe enabled phosphorescence imaging at signal-to-background ratios, spatial resolutions and sensitivities higher than NIR-II fluorescence imaging with polymer-stabilized copper-indium-sulfide nanorods. Phosphorescence imaging may offer superior imaging performance for a range of biomedical uses.

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Crossref · 10.1038/s41551-021-00773-2

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Authors
Chang, B., Li, D., Ren, Y., Qu, C., Shi, X., Liu, R., Liu, H., Tian, J., Hu, Z., Sun, T., & Cheng, Z.
Affiliations
  • Wuhan University of Technology (CN)
  • Stanford Medicine (US)
  • Chinese Academy of Sciences (CN)
  • Northeastern University (CN)
Corresponding author
  • Hu, Zhenhua
  • Sun, Taolei
  • Cheng, Zhen
Venue
Nature Biomedical Engineering
Published
2021-08-12
Volume
6
Issue
5
Pages
629-639
ISSN
2157-846X (ISSN-L)
OpenAlex
W3191365619
Cited by
195
References
30
Citations by year
2026: 23 · 2025: 58 · 2024: 46 · 2023: 34 · 2022: 34
FWCI
8.65
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (51803161, 51533007, 61622117)
  • DOE | Office of Science (DE-SC0008397)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
Keywords
phosphorescent probes, NIR-II imaging, second near-infrared window, glutathione capping, osteosarcoma, breast cancer, in vivo fluorescence imaging
MeSH terms
Copper, Humans, Indium, Luminescent Measurements, Nanotubes, Optical Imaging

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