Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging
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Zhang et al. first reported the design of novel indocyanine polymethine fluorophores (Cy15s), achieving record-breaking emission wavelengths beyond 1200 nm.
“Zhang et al. first reported the design of novel indocyanine polymethine fluorophores (Cy15s), achieving record-breaking emission wavelengths beyond 1200 nm (Fig. 14b)101.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
In murine models, SJ-1271-Micelles facilitated high-contrast NIR-IIb vascular imaging, with SNRs of 6.79 (hindlimb), 3.39 (abdomen), and 5.87 (brain).
“In murine models, SJ-1271-Micelles facilitated high-contrast NIR-IIb vascular imaging, with SNRs of 6.79 (hindlimb), 3.39 (abdomen), and 5.87 (brain).”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
Cy15 emission represented the longest wavelength reported for an indocyanine polymethine dye.
“This emission represented the longest wavelength reported for an indocyanine polymethine dye.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
Zhang et al. developed indocyanine pentadecamethine fluorophores (Cy15s) via a π-chain elongation strategy, achieving ultra-long emission wavelengths and enhanced brightness.
“Zhang et al. developed indocyanine pentadecamethine fluorophores (Cy15s) via a π-chain elongation strategy, achieving ultra-long emission wavelengths and enhanced brightness (Fig. 3b)101.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
Cy15 fluorophores displayed absorption and emission maxima at 1241 nm and 1287 nm, respectively.
“The resulting Cy15 fluorophores displayed profoundly red-shifted optical properties, with absorption and emission maxima at 1241 nm and 1287 nm, respectively.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
Tumor-associated vasculature remained clearly detectable 72 h post injection.
“Remarkably, tumor-associated vasculature remained clearly detectable 72 h post injection”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
Following intravenous injection, SJ-1271-Micelles enabled clear discrimination between tumors and adjacent normal tissues in orthotopic 4T1 tumor-bearing mice, with TNR and SNR peaking at 3.0 and 4.76, respectively.
“Following intravenous injection, SJ-1271-Micelles enabled clear discrimination between tumors and adjacent normal tissues in orthotopic 4T1 tumor-bearing mice, with tumor-to-normal tissue ratio (TNR) and SNR peaking at 3.0 and 4.76, respectively.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
SJ-1271 has significant potential for long-term tumor monitoring and vascular localization.
“underscoring the significant potential of SJ-1271 for long-term tumor monitoring and vascular localization.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [101]
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Organic small-molecule NIR-II fluorophores for tumor phototheranostics
Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
“3b) 101 .”
- Authors
- Ge, R.-T., Xiong, F., Chen, Z.-B., Wang, Y., Zheng, L., Zhou, J., Wu, D., & Zhang, S.-Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Wu, Di
- Zhang, Shu-Yu
- Venue
- Chem
- Publisher
- Elsevier BV
- Published
- 2025-07
- Volume
- 11
- Issue
- 7
- Pages
- 102489
- ISSN
- 2451-9294 (ISSN-L)
- OpenAlex
- W4408290752
- Cited by
- 28
- References
- 40
- Citations by year
- 2026: 18 · 2025: 10
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chem (publishedVersion)
- Funders
- Shanghai Jiao Tong University (YG2022ZD021)
- Key Scientific Research Project of Colleges and Universities in Henan Province (24A330005)
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Key Technologies Research and Development Program (2021YFF0701800)
- Shanghai Municipality Science and Technology Commission
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- NIR-II fluorescence imaging, extended π-conjugation, deep tissue imaging, angiography, tissue penetration depth
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