Cited by 33Optical Imaging and Spectroscopy TechniquesNanoplatforms for cancer theranosticsLuminescence Properties of Advanced Materials

Second Near‐Infrared Window Fluorescence Materials for In Vivo Dynamic Multiplexed Imaging

Fan, Fang, Zeng, Keyun, Zhu, Yingying, Zhang, Yuxin, Chen, Yu, Lv, Diya, Jia, Dan, Chai, Yifeng +2 more·2025·Advanced Functional Materials

Abstract

Second near‐infrared (NIR‐II) fluorescence imaging has emerged as a breakthrough technology for accurately revealing complex mechanisms in vivo owing to its high sensitivity, deeper tissue penetration, high spatiotemporal resolution, and high throughput. This review provides a comprehensive overview of NIR‐II fluorescence imaging, specifically focusing on the materials used, including single‐walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare‐earth nanoparticles (RENPs), and organic fluorophores (OFs). It details their development, application, and advantageous performance in NIR‐II fluorescence imaging. Furthermore, this review highlights an approach to dynamic multiplexed NIR‐II fluorescence imaging in vivo that enables multitarget detection, providing a powerful tool for accurately and effectively assessing pathological processes and revealing complex biological mechanisms in vivo. Finally, it explores the aspects of translational medicine for NIR‐II imaging, addressing challenges, and future prospects related to material development, detection equipment, and unmet biomedical applications.

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Crossref · 10.1002/adfm.202422693

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175 of 175 references verified0 citation errors · 0 not checkable

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Authors
Fan, F., Zeng, K., Zhu, Y., Zhang, Y., Chen, Y., Lv, D., Jia, D., Chai, Y., Chen, X., & Li, Q.
Affiliations
  • School of Pharmacy Shanghai 200433 China
  • Chengdu Military General Hospital (CN)
  • Southeast University (CN)
Corresponding author
  • Chen, Xiaofei
  • Li, Quan
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2025-04
Volume
35
Issue
31
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
OpenAlex
W4409079566
Cited by
33
References
175
Citations by year
2026: 24 · 2025: 9
FWCI
19.13
Type
journal article
Language
en
Open access
closed
Locations
Advanced Functional Materials (publishedVersion)
Funders
National Natural Science Foundation of China (82473884, 82204339, 82122066)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
Keywords
single-walled carbon nanotubes, quantum dots, rare earth nanoparticles, organic fluorophores, in vivo imaging, multi-target detection, translational medicine

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