Early detection of pancreatic cancer using DNA-based molecular approaches

Cancer Statistics, 2021

Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21654 · Cited by 16,522 · see citing works

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., et al. (2018) · Science · doi:10.1126/science.aar3247 · Cited by 2,783 · see citing works

Whole genomes redefine the mutational landscape of pancreatic cancer

Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642 · see citing works

Integrated genomic characterization of pancreatic ductal adenocarcinoma

Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019 · see citing works

Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas

Tanaka, M., Fernández-del Castillo, C., Kamisawa, T., Jang, J. Y., Levy, P., Ohtsuka, T., Salvia, R., Shimizu, Y., Tada, M., & Wolfgang, C. L. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.007 · Cited by 1,797 · see citing works

Pancreatitis and the Risk of Pancreatic Cancer

Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753 · see citing works

1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience

Winter, J. M., Cameron, J. L., Campbell, K. A., Arnold, M. A., Chang, D. C., Coleman, J., Hodgin, M. B., Sauter, P. K., Hruban, R. H., Riall, T. S., et al. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2006.08.018 · Cited by 1,491 · see citing works

American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts

Vege, S. S., Ziring, B., Jain, R., Moayyedi, P., Adams, M. A., Dorn, S. D., Dudley-Brown, S. L., Flamm, S. L., Gellad, Z. F., Gruss, C. B., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.015 · Cited by 1,138 · see citing works

Intraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience

Sohn, T., Yeo, C., Cameron, J., Hruban, R., Fukushima, N., Campbell, K., & Lillemoe, K. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000128306.90650.aa · Cited by 915 · see citing works

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer*

Kahlert, C., Melo, S., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J.-H., Weitz, J., Chin, L., Futreal, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.532267 · Cited by 896 · see citing works

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

Basturk, O., Hong, S.-M., Wood, L. D., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Brosens, L. A. A., Fukushima, N., Goggins, M., Hruban, R. H., et al. (2015) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000533 · Cited by 864 · see citing works

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786 · see citing works

Main-Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinical Predictors of Malignancy and Long-term Survival Following Resection

Salvia, R., Castillo, C., Bassi, C., Thayer, S., Falconi, M., Mantovani, W., Pederzoli, P., & Warshaw, A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000124386.54496.15 · Cited by 783 · see citing works

Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma

Groot, V. P., Rezaee, N., Wu, W., Cameron, J. L., Fishman, E. K., Hruban, R. H., Weiss, M. J., Zheng, L., Wolfgang, C. L., & He, J. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002234 · Cited by 757 · see citing works

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.042 · Cited by 741 · see citing works

ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts

Elta, G. H., Enestvedt, B. K., Sauer, B. G., & Lennon, A. M. (2018) · The American Journal of Gastroenterology · doi:10.1038/ajg.2018.14 · Cited by 726 · see citing works

Mucinous Cystic Tumors of the Pancreas

Zamboni, G., Scarpa, A., Bogina, G. S., Iacono, C., Bassi, C., Talamini, G., Sessa, F., Capella, C., Solcia, E., Rickaert, F., et al. (1999) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199904000-00005 · Cited by 679 · see citing works

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678 · see citing works

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

Furukawa, T., Klöppel, G., Adsay, V. N., Albores‐Saavedra, J., Fukushima, N., Horii, A., Hruban, R. H., Kato, Y., Klimstra, D. S., Longnecker, D. S., et al. (2005) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-005-0039-7 · Cited by 663 · see citing works

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E. K., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319352 · Cited by 659 · see citing works

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

Wu, J., Jiao, Y., Molin, M. D., Maitra, A., de Wilde, R. F., Wood, L. D., Eshleman, J. R., Goggins, M., Wolfgang, C. L., Canto, M. I., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118046108 · Cited by 640 · see citing works

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C. J., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M., Allen, P. J., Schattner, M. A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704961114 · Cited by 581 · see citing works

High prevalence of mutantKRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients

Allenson, K., Castillo, J., San Lucas, F. A., Scelo, G., Kim, D. U., Bernard, V., Davis, G., Kumar, T., Katz, M., Overman, M. J., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx004 · Cited by 493 · see citing works

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

Honeyman, J. N., Simon, E. P., Robine, N., Chiaroni-Clarke, R. C., Darcy, D. G., Lim, I. I. P., Gleason, C. E., Murphy, J. M., Rosenberg, B. R., Teegan, L., et al. (2014) · Science · doi:10.1126/science.1249484 · Cited by 491 · see citing works

Comparison of Sanger Sequencing, Pyrosequencing, and Melting Curve Analysis for the Detection of KRAS Mutations

Tsiatis, A. C., Norris-Kirby, A., Rich, R. G., Hafez, M. J., Gocke, C. D., Eshleman, J. R., & Murphy, K. M. (2010) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2010.090188 · Cited by 488 · see citing works

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

Springer, S., Wang, Y., Dal Molin, M., Masica, D. L., Jiao, Y., Kinde, I., Blackford, A., Raman, S. P., Wolfgang, C. L., Tomita, T., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.041 · Cited by 477 · see citing works

Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.

Khalid, A., Zahid, M., Finkelstein, S., Leblanc, J., Kaushık, N., Ahmad, N., Brugge, W., Edmundowicz, S., Hawes, R., & Mcgrath, K. (2009) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2008.07.033 · Cited by 449 · see citing works

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

Furukawa, T., Kuboki, Y., Tanji, E., Yoshida, S., Hatori, T., Yamamoto, M., Shibata, N., Shimizu, K., Kamatani, N., & Shiratori, K. (2011) · Scientific Reports · doi:10.1038/srep00161 · Cited by 442 · see citing works

American Gastroenterological Association Technical Review on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

Scheiman, J. M., Hwang, J. H., & Moayyedi, P. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.014 · Cited by 437 · see citing works

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

Singhi, A. D., McGrath, K., Brand, R. E., Khalid, A., Zeh, H. J., Chennat, J. S., Fasanella, K. E., Papachristou, G. I., Slivka, A., Bartlett, D. L., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313586 · Cited by 405 · see citing works

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3764 · Cited by 403 · see citing works

Model to determine risk of pancreatic cancer in patients with new-onset diabetes

Sharma, A., Kandlakunta, H., Nagpal, S. J. S., Feng, Z., Hoos, W., Petersen, G. M., & Chari, S. T. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.023 · Cited by 394 · see citing works

Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia

van Heek, N. T., Meeker, A. K., Kern, S. E., Yeo, C. J., Lillemoe, K. D., Cameron, J. L., Offerhaus, G. J. A., Hicks, J. L., Wilentz, R. E., Goggins, M. G., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64432-x · Cited by 363 · see citing works

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0402 · Cited by 361 · see citing works

Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

Amato, E., Molin, M. D., Mafficini, A., Yu, J. Q., Malleo, G., Rusev, B. C., Fassan, M., Antonello, D., Sadakari, Y., Castelli, P., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4344 · Cited by 349 · see citing works

Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms

Oyama, H., Tada, M., Takagi, K., Tateishi, K., Hamada, T., Nakai, Y., Hakuta, R., Ijichi, H., Ishigaki, K., Kanai, S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.08.032 · Cited by 319 · see citing works

ACG Practice Guidelines for the Diagnosis and Management of Neoplastic Pancreatic Cysts

Khalid, A., & Brugge, W. R. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01516.x · Cited by 313 · see citing works

Clinicopathological Correlates of Pancreatic Intraepithelial Neoplasia: A Comparative Analysis of 82 Cases With and 152 Cases Without Pancreatic Ductal Adenocarcinoma

Andea, A. A., Sarkar, F. H., & Adsay, V. N. (2003) · Modern Pathology · doi:10.1097/01.mp.0000087422.24733.62 · Cited by 290 · see citing works

Long-term Risk of Pancreatic Malignancy in Patients With Branch Duct Intraductal Papillary Mucinous Neoplasm in a Referral Center

Pergolini, I., Sahora, K., Ferrone, C. R., Morales‐Oyarvide, V., Wolpin, B. M., Mucci, L. A., Brugge, W. R., Mino-Kenudson, M. A., Patiño, M., Sahani, D. V., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.019 · Cited by 280 · see citing works

Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions

Ahmad, N. A., Kochman, M. L., Brensinger, C. M., Brugge, W. R., Faigel, D. O., Gress, F. G., Kimmey, M. B., Nickl, N. J., Savides, T. J., Wallace, M. B., et al. (2003) · Gastrointestinal Endoscopy · doi:10.1067/mge.2003.298 · Cited by 277 · see citing works

Pancreatic Cysts: Pathologic Classification, Differential Diagnosis, and Clinical Implications

Baştürk, O., Çoban, İ., & Adsay, V. N. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.3.423 · Cited by 275 · see citing works

Update on Familial Pancreatic Cancer

Hruban, R. H., Canto, M. I., Goggins, M., Schulick, R. D., & Klein, A. P. (2010) · Advances in Surgery · doi:10.1016/j.yasu.2010.05.011 · Cited by 269 · see citing works

Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Duell, E. J., Lucenteforte, E., Olson, S. H., Bracci, P. M., Li, D., Risch, H. A., Silverman, D. T., Ji, B., Gallinger, S., Holly, E. A., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds140 · Cited by 267 · see citing works

Validation of the American Joint Commission on Cancer (AJCC) 8th Edition Staging System for Patients with Pancreatic Adenocarcinoma: A Surveillance, Epidemiology and End Results (SEER) Analysis

Kamarajah, S. K., Burns, W. R., Frankel, T. L., Cho, C. S., & Nathan, H. (2017) · Annals of Surgical Oncology · doi:10.1245/s10434-017-5810-x · Cited by 254 · see citing works

Screening for Pancreatic Cancer: Why, How, and Who?

Poruk, K. E., Firpo, M. A., Adler, D. G., & Mulvihill, S. J. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e31825ffbfb · Cited by 249 · see citing works

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer

Yang, S., Che, S. P. Y., Kurywchak, P., Tavormina, J. L., Gansmo, L. B., Correa de Sampaio, P., Tachezy, M., Bockhorn, M., Gebauer, F., Haltom, A. R., et al. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1281499 · Cited by 248 · see citing works

Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions

Rhim, A. D., Thege, F. I., Santana, S. M., Lannin, T. B., Saha, T. N., Tsai, S. J., Maggs, L. R., Kochman, M. L., Ginsberg, G. G., Lieb, J. G., II, et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.12.007 · Cited by 230 · see citing works

The Role of Pancreatic Cyst Fluid Molecular Analysis in Predicting Cyst Pathology

Khalid, A., McGrath, K. M., Zahid, M., Wilson, M., Brody, D., SWALSKY, P., Moser, A. J., Lee, K. K., Slivka, A., Whitcomb, D. C., et al. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00409-x · Cited by 223 · see citing works

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Dal Molin, M., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav4772 · Cited by 217 · see citing works

Preoperative<i>GNAS</i>and<i>KRAS</i>Testing in the Diagnosis of Pancreatic Mucinous Cysts

Singhi, A. D., Nikiforova, M. N., Fasanella, K. E., McGrath, K. M., Pai, R. K., Ohori, N. P., Bartholow, T. L., Brand, R. E., Chennat, J. S., Lu, X., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0513 · Cited by 207 · see citing works

Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

Murphy, S. J., Hart, S. N., Lima, J. F., Kipp, B. R., Klebig, M. L., Winters, J. L., Szabo, C., Zhang, L., Eckloff, B. W., Petersen, G. M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.049 · Cited by 199 · see citing works

Circulating tumor cells in locally advanced pancreatic adenocarcinoma: the ancillary CirCe 07 study to the LAP 07 trial

Bidard, F., Huguet, F., Louvet, C., Mineur, L., Bouché, O., Chibaudel, B., Artru, P., Desseigne, F., Bachet, J., Mathiot, C., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt176 · Cited by 192 · see citing works

Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features

Omori, Y., Ono, Y., Tanino, M. A., Karasaki, H., Yamaguchi, H., Furukawa, T., Enomoto, K., Ueda, J., Sumi, A., Katayama, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.10.029 · Cited by 189 · see citing works

Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia

Kanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.016 · Cited by 181 · see citing works

American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data

Singhi, A. D., Zeh, H. J., Brand, R. E., Nikiforova, M. N., Chennat, J. S., Fasanella, K. E., Khalid, A., Papachristou, G. I., Slivka, A., Hogg, M. E., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.12.009 · Cited by 177 · see citing works

Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts

Kanda, M., Knight, S., Topazian, M. D., Syngal, S., Farrell, J. J., Lee, J. D., Kamel, I. R., Lennon, A. M., Borges, M. W., Young, A., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-302823 · Cited by 170 · see citing works

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

Singhi, A. D., Wood, L. D., Parks, E., Torbenson, M. S., Felsenstein, M., Hruban, R. H., Nikiforova, M. N., Wald, A. I., Kaya, C., Nikiforov, Y. E., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.028 · Cited by 167 · see citing works

Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas: Its Histopathologic Difference Between 2 Major Types

Ban, S., Naitoh, Y., Mino-Kenudson, M. A., Sakurai, T., Kuroda, M., Koyama, I., Lauwers, G. Y., & Shimizu, M. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000213305.98187.d4 · Cited by 165 · see citing works

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

Yu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-311166 · Cited by 164 · see citing works

Genetic analyses of isolated high‐grade pancreatic intraepithelial neoplasia (HG‐PanIN) reveal paucity of alterations in TP53 and SMAD4

Hosoda, W., Chianchiano, P. E., Griffin, J. F., Pittman, M. E., Brosens, L. A. A., Noë, M., Yu, J., Shindo, K., Suenaga, M., Rezaee, N., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4884 · Cited by 158 · see citing works

Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts

Nikiforova, M. N., Khalid, A., Fasanella, K. E., McGrath, K. M., Brand, R. E., Chennat, J. S., Slivka, A., Zeh, H. J., Zureikat, A. H., Krasinskas, A. M., et al. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.91 · Cited by 153 · see citing works

Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts

Jones, M., Zheng, Z., Wang, J., Dudley, J. C., Albanese, E., Kadayıfçı, A., Dias-Santagata, D. C., Le, L. P., Brugge, W. R., Castillo, C. F. F.-D., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.06.047 · Cited by 146 · see citing works

IPMNs with co-occurring invasive cancers: neighbours but not always relatives

Felsenstein, M., Noë, M., Masica, D. L., Hosoda, W., Chianchiano, P. E., Fischer, C. G., Lionheart, G., Brosens, L. A. A., Pea, A., Yu, J., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315062 · Cited by 145 · see citing works

Genomic characterization of malignant progression in neoplastic pancreatic cysts

Noë, M., Niknafs, N., Fischer, C. G., Hackeng, W. M., Guthrie, V. B., Hosoda, W., Debeljak, M., Papp, E., Adleff, V., White, J. R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17917-8 · Cited by 144 · see citing works

Pancreatic cysts

Pitman, M. B., Lewandrowski, K. B., Shen, J., et al. (2009) · Cancer Cytopathology · doi:10.1002/cncy.20059 · Cited by 140 · see citing works

Pancreatic Cyst Prevalence and the Risk of Mucin-Producing Adenocarcinoma in US Adults

Gardner, T. B., Glass, L. M., Smith, K. D., Ripple, G. H., Barth, R. J., Klibansky, D. A., Colacchio, T. A., Tsapakos, M. J., Suriawinata, A. A., Tsongalis, G. J., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.103 · Cited by 140 · see citing works

DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma

Vyas, M., Hechtman, J. F., Zhang, Y., Benayed, R., Yavas, A., Aşkan, G., Shia, J., Klimstra, D. S., & Baştürk, O. (2019) · Modern Pathology · doi:10.1038/s41379-019-0398-2 · Cited by 134 · see citing works

Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

Pea, A., Yu, J., Rezaee, N., Luchini, C., He, J. P., Molin, M. D., Griffin, J. F., Fedor, H. L., Fesharakizadeh, S., Salvia, R., et al. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001817 · Cited by 132 · see citing works

Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.06.001 · Cited by 129 · see citing works

Molecular analysis of pancreatic cyst fluid

Shen, J., Brugge, W., DiMaio, C. J., & Pitman, M. (2009) · Cancer · doi:10.1002/cncy.20027 · Cited by 118 · see citing works

Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma

Rezaee, N., Barbon, C., Zaki, A., He, J. P., Salman, B., Hruban, R. H., Cameron, J. L., Herman, J. M., Ahuja, N., Lennon, A. M., et al. (2015) · HPB · doi:10.1016/j.hpb.2015.10.010 · Cited by 117 · see citing works

Cytology from Pancreatic Cysts Has Marginal Utility in Surgical Decision-Making

Maker, A. V., Lee, L., Raut, C. P., Clancy, T. E., & Swanson, R. S. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0110-0 · Cited by 109 · see citing works

Intraductal Tubulopapillary Neoplasm of the Pancreas

Baştürk, O., Adsay, V. N., Askan, G., et al. (2016) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000782 · Cited by 101 · see citing works

Contemporary Management of Localized Resectable Pancreatic Cancer

Kommalapati, A., Tella, S. H., Goyal, G., Ma, W., & Mahipal, A. (2018) · Cancers · doi:10.3390/cancers10010024 · Cited by 99 · see citing works

Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations

Kulemann, B., Rösch, S., Seifert, S., Timme, S., Bronsert, P., Seifert, G. J., Martini, V., Kuvendjiska, J., Glatz, T., Hussung, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04601-z · Cited by 94 · see citing works

From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions

Fischer, C. G., & Wood, L. D. (2018) · The Journal of Pathology · doi:10.1002/path.5154 · Cited by 92 · see citing works

Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma

Baştürk, O., Berger, M. F., Yamaguchi, H., Adsay, V. N., Askan, G., Bhanot, U. K., Zehir, A., Carneiro, F., Hong, S., Zamboni, G., et al. (2017) · Modern Pathology · doi:10.1038/modpathol.2017.60 · Cited by 91 · see citing works

Pancreatoduodenectomy at the Verona Pancreas Institute: the Evolution of Indications, Surgical Techniques, and Outcomes

Bassi, C., Marchegiani, G., Giuliani, T., Gioia, A. D., Andrianello, S., Zingaretti, C. C., Brentegani, G., Pastena, M. D., Fontana, M., Pea, A., et al. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000004753 · Cited by 91 · see citing works

The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma

Matsuda, Y., Furukawa, T., Yachida, S., Nishimura, M., Seki, A., Nonaka, K., Aida, J., Takubo, K., Ishiwata, T., Kimura, W., et al. (2017) · Pancreas · doi:10.1097/mpa.0000000000000786 · Cited by 89 · see citing works

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic <i>KLF4</i> mutations predominantly in low-grade regions

Fujikura, K., Hosoda, W., Felsenstein, M., Song, Q., Reiter, J. G., Zheng, L., Beleva Guthrie, V., Rincon, N., Dal Molin, M., Dudley, J., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-321217 · Cited by 89 · see citing works

Circulating Tumor Cells in Pancreatic Cancer: Current Perspectives

Martini, V., Timme‐Bronsert, S., Fichtner‐Feigl, S., Hoeppner, J., & Kulemann, B. (2019) · Cancers · doi:10.3390/cancers11111659 · Cited by 83 · see citing works

Pancreatic Juice Mutation Concentrations Can Help Predict the Grade of Dysplasia in Patients Undergoing Pancreatic Surveillance

Suenaga, M., Yu, J., Shindo, K., Tamura, K., Almario, J. A., Zaykoski, C., Witmer, P. D., Fesharakizadeh, S., Borges, M., Lennon, A.-M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2463 · Cited by 81 · see citing works

Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer

Canto, M. I., Kerdsirichairat, T., Yeo, C. J., Hruban, R. H., Shin, E. J., Almario, J. A., Blackford, A. L., Ford, M., Klein, A. P., Javed, A. A., et al. (2019) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-019-04230-z · Cited by 80 · see citing works

Cyst Fluid Biomarkers for Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Critical Review from the International Expert Meeting on Pancreatic Branch-Duct-Intraductal Papillary Mucinous Neoplasms

Maker, A. V., Carrara, S., Jamieson, N. B., et al. (2014) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2014.11.001 · Cited by 77 · see citing works

Intraductal Papillary Mucinous Neoplasm of the Pancreas as the Main Focus for Early Detection of Pancreatic Adenocarcinoma

Tanaka, M. (2018) · Pancreas · doi:10.1097/mpa.0000000000001047 · Cited by 76 · see citing works

Intraductal Oncocytic Papillary Neoplasms

Wang, T., Aşkan, G., Adsay, V. N., Allen, P. J., Jarnagin, W. R., Memiş, B., Sigel, C., Seven, İ. E., Klimstra, D. S., & Baştürk, O. (2019) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001226 · Cited by 75 · see citing works

Single‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Guthrie, V. B., Huang, W., Yu, J., Chianchiano, P. E., Hosoda, W., Zhang, H., Zheng, L., Shao, X. M., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5194 · Cited by 62 · see citing works

Genome-Wide Somatic Copy Number Alterations in Low-Grade PanINs and IPMNs from Individuals with a Family History of Pancreatic Cancer

Hong, S., Vincent, A., Kanda, M., Leclerc, J., Omura, N., Borges, M. W., Klein, A. P., Canto, M. I., Hruban, R. H., & Goggins, M. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1075 · Cited by 59 · see citing works

Cyst Fluid Biosignature to Predict Intraductal Papillary Mucinous Neoplasms of the Pancreas with High Malignant Potential

Maker, A. V., Hu, V. H., Kadkol, S. S., Hong, L. K., Brugge, W. R., Winter, J. M., Yeo, C. J., Hackert, T., Büchler, M. W., Lawlor, R. T., et al. (2019) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2019.02.040 · Cited by 52 · see citing works

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

Hata, T., Suenaga, M., Marchionni, L., Macgregor-Das, A. M., Yu, J., Shindo, K., Tamura, K., Hruban, R. H., & Goggins, M. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.03.012 · Cited by 48 · see citing works

Cancerization of the Pancreatic Ducts

Hutchings, D., Waters, K. M., Weiss, M. J., Wolfgang, C. L., Makary, M. A., He, J. P., Cameron, J. L., Wood, L. D., & Hruban, R. H. (2018) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001148 · Cited by 47 · see citing works

GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype

Hata, T., Mizuma, M., Motoi, F., Omori, Y., Ishida, M., Nakagawa, K., Hayashi, H., Morikawa, T., Kamei, T., Furukawa, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74868-2 · Cited by 42 · see citing works

Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors

Elias, K. M., Tsantoulis, P. K., Tille, J., Vitonis, A. F., Doyle, L. A., Hornick, J. L., Kaya, G., Barnes, L., Cramer, D. W., Puppa, G., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5161 · Cited by 41 · see citing works

Commercial Molecular Panels Are of Limited Utility in the Classification of Pancreatic Cystic Lesions

Panarelli, N. C., Sela, R., Schreiner, A. M., Crapanzano, J. P., Klimstra, D. S., Schnoll‐Sussman, F. H., Pochapin, M. B., & Yantiss, R. K. (2012) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31825d534a · Cited by 37 · see citing works

Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen

Sadakari, Y., Kanda, M., Maitani, K., Borges, M. W., Canto, M. I., & Goggins, M. (2014) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2014.14 · Cited by 35 · see citing works

The Added Value of Molecular Testing in Small Pancreatic Cysts

Toll, A. D., Kowalski, T. E., Loren, D. E., & Bibbo, M. (2015) · PubMed · doi:10.6092/1590-8577/3401 · Cited by 34 · see citing works

Early and Sustained Elevation in Serum Pancreatic Amylase Activity

Bannone, E., Marchegiani, G., Balduzzi, A., et al. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000004921 · Cited by 28 · see citing works

Noninvasive Discrimination of Low and High-risk Pancreatic Intraductal Papillary Mucinous Neoplasms

Roth, S., Bose, P., Alhamdani, M. S. S., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004066 · Cited by 25 · see citing works

The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection

Pflüger, M. J., Griffin, J. F., Hackeng, W. M., Kawamoto, S., Yu, J., Chianchiano, P. E., Shin, E., Lionheart, G., Tsai, H., Wang, H., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004427 · Cited by 25 · see citing works

High risk of acute pancreatitis after endoscopic ultrasound-guided fine needle aspiration of side branch intraductal papillary mucinous neoplasms

Siddiqui, A., Shahid, H. M., Shah, A., Khurana, T., Huntington, W., Ghumman, S. S., Loren, D. E., Kowalski, T. E., Laique, S. N., Hayat, U., et al. (2015) · Endoscopic Ultrasound · doi:10.4103/2303-9027.156728 · Cited by 23 · see citing works

Pancreas Cancer Incidence and Pancreas Cancer-Associated Mortality Are Low in National Cohort of 7211 Pancreas Cyst Patients.

Anand, G. S., Youssef, F., Liu, L., et al. (2022) · PubMed · doi:10.1007/s10620-021-06923-5 · Cited by 6 · see citing works

Strategic Planning and Essential Steps for Establishing a Uterine Transplant and Rehabilitation Program

Dorafshar, A. H., Jahromi, A. H., Horen, S. R., et al. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000005301 · Cited by 6 · see citing works

Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works

Notch and Kras in pancreatic cancer: At the crossroads of mutation, differentiation and signaling

Jean–Paul De La, O., & Murtaugh, L. C. (2009) · Cell Cycle · doi:10.4161/cc.8.12.8744 · Cited by 79 · see citing works

Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression

Fujikura, K., Akita, M., Abe‐Suzuki, S., Itoh, T., & Zen, Y. (2017) · Histopathology · doi:10.1111/his.13271 · Cited by 41 · see citing works

Pathobiology of Precursors to Pancreatic Cancer

Oberhuber, G. (2021) · Springer eBooks · doi:10.1007/978-3-030-53786-9_15 · Cited by 1 · see citing works

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.042 · Cited by 741 · see citing works

Kras loss of heterozygosity promotes MAPK dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivityPreprint

Fey, S. K., Najumudeen, A. K., Ford, C. A., Gilroy, K. L., Upstill‐Goddard, R., Chang, D. K.-F., Clark, W., Nixon, C., Barry, S. T., Morton, J. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.29.552598