The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

Microglia Function in the Central Nervous System During Health and Neurodegeneration

Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22

Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,896

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895

Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance

Holle, J. B., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T. U. P., Anandakumar, H., Wimmer, M. I., Vu, D. L., Kuhring, M., Brüning, U., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022030378 · Cited by 60

Immunometabolism in cancer: basic mechanisms and new targeting strategy

Su, R., Shao, Y., Huang, M., Liu, D., Yu, H., & Qiu, Y. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02006-2 · Cited by 62

Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor

Li, X., Lu, C. C., Fan, D., Lu, X., Xia, Y., Zhao, H., Xu, H., Zhu, Y., Li, J., Liu, H., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00131 · Cited by 57

Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients

Ramos-García, N. A., Orozco‐Ibarra, M., Estudillo, E., Elizondo, G., Apo, E. G., Macías‐García, L., Sosa, A. L., & Torres-Ramos, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061983 · Cited by 60

Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?

Panfili, E., Gerli, R., Grohmann, U., & Pallotta, M. T. (2020) · Biomolecules · doi:10.3390/biom10091280 · Cited by 58

Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS

Rothhammer, V., Kenison, J. E., Li, Z., Tjon, E. C., Takenaka, M. C., Chao, C., de Lima, K. A., Borucki, D. M., Kaye, J., & Quintana, F. J. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000946 · Cited by 57

Indole scaffolds as a promising class of the aryl hydrocarbon receptor ligands

Dvořák, Z., Poulíková, K., & Mani, S. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113231 · Cited by 58

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension

Masaki, T., Okazawa, M., Asano, R., Inagaki, T., Ishibashi, T., Yamagishi, A., Umeki-Mizushima, S., Nishimura, M., Manabe, Y., Ishibashi‐Ueda, H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023899118 · Cited by 56

An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

Li, L., Dai, Y., & Xia, Y. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114845 · Cited by 60

Undigested Food and Gut Microbiota May Cooperate in the Pathogenesis of Neuroinflammatory Diseases: A Matter of Barriers and a Proposal on the Origin of Organ Specificity

Riccio, P., & Rossano, R. (2019) · Nutrients · doi:10.3390/nu11112714 · Cited by 60

Metabolic perspective of astrocyte dysfunction in Alzheimer's disease and type 2 diabetes brains

Shen, Z., Li, Z., Yu, M., Tan, K.-L., & Chen, S. X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114206 · Cited by 53

Gut Microbial-Derived Metabolomics of Asthma

Lee‐Sarwar, K. A., Lasky-Su, J. A., Kelly, R. S., Litonjua, A. A., & Weiss, S. T. (2020) · Metabolites · doi:10.3390/metabo10030097 · Cited by 58

The Role of Bacterial Membrane Vesicles in Human Health and Disease

Villageliú, D. N., & Samuelson, D. R. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.828704 · Cited by 58

Immunosuppressive Amino-Acid Catabolizing Enzymes in Multiple Sclerosis

Correale, J. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600428 · Cited by 54

Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response

Vogeley, C., Sondermann, N. C., Woeste, S., Momin, A. A., Gilardino, V., Hartung, F., Heinen, M., Maaß, S. K., Mescher, M., Pollet, M., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106989 · Cited by 55

Role of macrophage AHR/TLR4/STAT3 signaling axis in the colitis induced by non-canonical AHR ligand aflatoxin B1

Zhang, L., Cheng, D., Zhang, J., Tang, H., Li, F., Peng, Y., Duan, X., Meng, E., Zhang, C., Zeng, T., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131262 · Cited by 53

The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis

Huang, W., Rui, K., Wang, X., Peng, N., Zhou, W., Shi, X., Lu, L., Hu, D., & Tian, J. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103049 · Cited by 59

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Segner, H. E., Bailey, C., Tafalla, C., & Bo, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179460 · Cited by 58

Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets

Wnorowski, A., Wnorowska, S., Kurzepa, J., & Parada-Turska, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413497 · Cited by 53

Aryl Hydrocarbon Receptor in Cutaneous Vascular Endothelial Cells Restricts Psoriasis Development by Negatively Regulating Neutrophil Recruitment

Zhu, Z., Chen, J., Lin, Y., Zhang, C., Li, W., Qiao, H., Fu, M., Dang, E., & Wang, G. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.11.022 · Cited by 52

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma

Panitz, V., Končarević, S., Sadik, A., Friedel, D., Bausbacher, T., Trump, S., Farztdinov, V. M., Schulz, S., Sievers, P., Schmidt, S., et al. (2021) · Theranostics · doi:10.7150/thno.60679 · Cited by 52

Dietary Tryptophan-Mediated Aryl Hydrocarbon Receptor Activation by the Gut Microbiota Alleviates Escherichia coli-Induced Endometritis in Mice

Zhao, C., Bao, L., Qiu, M., Feng, L., Chen, L., Liu, Z., Duan, S., Zhao, Y., Wu, K., Zhang, N., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00811-22 · Cited by 53

Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system

Peng, G., & Fadeel, B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114422 · Cited by 54

Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

Zhang, R., Yu, C., Zeh, H. J., Wang, H., Kroemer, G., Klionsky, D. J., Billiar, T. R., Kang, R., & Tang, D. (2023) · Immunity · doi:10.1016/j.immuni.2023.11.001 · Cited by 55

Immune biomarkers link air pollution exposure to blood pressure in adolescents

Prunicki, M. M., Cauwenberghs, N., Ataam, J. A., Movassagh, H., Kim, J. B., Kuznetsova, T., Wu, J. C., Maecker, H. T., Haddad, F., & Nadeau, K. C. (2020) · Environmental Health · doi:10.1186/s12940-020-00662-2 · Cited by 51

Deciphering the cellular mechanisms underlying fibrosis-associated diseases and therapeutic avenues

Miao, H., Wu, X., Zhang, D., Wang, Y., Guo, Y. P., Li, P., Xiong, Q., & Zhao, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105316 · Cited by 54

Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders

Fila, M., Chojnacki, J., Pawlowska, E., Szczepanska, J., Chojnacki, C., & Blasiak, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810134 · Cited by 50

New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression

Dębińska, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112506 · Cited by 52

Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review

Skonieczna‐Żydecka, K., Jakubczyk, K., Maciejewska, D., Janda, K., Kaźmierczak-Siedlecka, K., Kaczmarczyk, M., Łoniewski, I., & Marlicz, W. M. (2020) · Nutrients · doi:10.3390/nu12113369 · Cited by 52

Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression

McGovern, K., Castro, A. C., Cavanaugh, J., Coma, S., Walsh, M., Tchaicha, J. H., Syed, S., Natarajan, P., Manfredi, M. G., Zhang, X. M., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0984 · Cited by 50

Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target

Shi, J., Du, T., Wang, J., Tang, C., Lei, M., Yu, W., Yang, Y., Ma, Y., Huang, P., Chen, H., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf0211 · Cited by 51

Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases

Grishanova, A. Y., & Perepechaeva, M. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136933 · Cited by 53

The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite

Wu, J., Wang, K., Qi, X., Zhou, S., Zhao, S., Lu, M., Nie, Q., Li, M., Han, M., Luo, X., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2024.12.006 · Cited by 50

Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

Zhou, Y.-H., Sun, L. X., Chen, J., Sun, W., Ma, L., Han, Y., Jin, X., Zhao, Q., Li, T., Lu, H., et al. (2019) · mBio · doi:10.1128/mbio.02591-19 · Cited by 51

Dioxins and dioxin-like compounds: toxicity in humans and animals, sources, and behaviour in the environment

Tuomisto, J. (2019) · WikiJournal of Medicine · doi:10.15347/wjm/2019.008 · Cited by 53

Aryl Hydrocarbon Receptor Connects Inflammation to Breast Cancer

Guarnieri, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155264 · Cited by 52

The Aryl Hydrocarbon Receptor in Asthma: Friend or Foe?

Poulain‐Godefroy, O., Bouté, M., Carrard, J., Álvarez-Simón, D., Tsicopoulos, A., & de Nadaï, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228797 · Cited by 57

Uremic Toxins in Organ Crosstalk

Lowenstein, J., & Nigám, S. K. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.592602 · Cited by 49

Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities

Meier, K. H. U., Trouillon, J., Li, H., Lang, M., Fuhrer, T., Zamboni, N., Sunagawa, S., Macpherson, A. J., & Sauer, U. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00802-1 · Cited by 48

Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway

Akhtar, S., Hourani, S., Therachiyil, L., Al‐Dhfyan, A., Agouni, A., Zeidan, A., Shahab Uddin, M. S., & Korashy, H. M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.08.014 · Cited by 49

MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors

Amini, A., Pang, D., Hackstein, C.-P., & Klenerman, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584521 · Cited by 49

Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits

Sanz, M., Mann, B. T., Ryan, P. L., Bosque, A., Pennington, D. J., Hackstein, H., & Soriano-Sarabia, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148988 · Cited by 49

Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction

Lee, B., Lee, S. M., Song, J. W., & Choi, J. W. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.009 · Cited by 49

Host–microbe serotonin metabolism

Nunzi, E., Pariano, M., Costantini, C., Garaci, E., Puccetti, P., & Romani, L. R. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.014 · Cited by 49

Quercetin protected the gut barrier in ulcerative colitis by activating aryl hydrocarbon receptor

Wei, Q., Jiang, H., Zeng, J., Xu, J., Zhang, H., Xiao, E., Lu, Q., & Huang, G. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156633 · Cited by 53

More than a cell biosensor: aryl hydrocarbon receptor at the intersection of physiology and inflammation

Guarnieri, T., Abruzzo, P. M., & Bolotta, A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00493.2019 · Cited by 49

Understanding mast cell heterogeneity at single cell resolution

Cildir, G., Yip, K. H., Pant, H., Tergaonkar, V., Lopez, A. F., & Tumes, D. J. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.04.004 · Cited by 46

Innate immune sensing by epithelial barriers

Constant, D. A., Nice, T. J., & Rauch, I. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.07.014 · Cited by 46

The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target

Benakis, C., & Liesz, A. (2022) · Neurological Research and Practice · doi:10.1186/s42466-022-00222-8 · Cited by 52

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Peng, G., Sinkko, H., Alenius, H. T., Lozano, N., Kostarelos, K., Bräutigam, L., & Fadeel, B. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01260-8 · Cited by 46

Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

Yang, Y., Wang, N., Xu, L., Liu, Y., Huang, L., Gu, M., Wu, Y., Guo, W., & Sun, H. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05616-3 · Cited by 49

Feeding the gut microbiome: impact on multiple sclerosis

Bronzini, M., Maglione, A., Rosso, R., Matta, M., Masuzzo, F., Rolla, S., & Clerico, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1176016 · Cited by 49

Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor

Xing, J., Gumerov, V. M., & Zhulin, I. B. (2023) · Science Advances · doi:10.1126/sciadv.adi4517 · Cited by 44

Crosstalk between Tryptophan Metabolism via Kynurenine Pathway and Carbohydrate Metabolism in the Context of Cardio-Metabolic Risk—Review

Kiluk, M., Lewkowicz, J., Pawlak, D., & Tankiewicz‐Kwedlo, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112484 · Cited by 50

Advances in atopic dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune cells

Nomura, T., & Kabashima, K. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.022 · Cited by 47

What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis

Vanholder, R. C., Nigám, S. K., Burtey, S., & Glorieux, G. (2022) · Toxins · doi:10.3390/toxins14030221 · Cited by 49

High-Throughput Screening for Drug Discovery

Saxena, S. K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.91075 · Cited by 46

The intestinal microenvironment shapes macrophage and dendritic cell identity and function

Filardy, A. A., Ferreira, J. R. M., Rezende, R. M., Kelsall, B. L., & de Oliveira, R. P. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.01.003 · Cited by 50

Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy

Lu, S., Wang, C., Ma, J., & Wang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1456030 · Cited by 49

AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA

Al-Ghezi, Z. Z., Singh, N. P., Mehrpouya‐Bahrami, P., Busbee, P. B., Nagarkatti, M., & Nagarkatti, P. S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02349 · Cited by 47

A genome-wide CRISPR/Cas9 screen reveals that the aryl hydrocarbon receptor stimulates sphingolipid levels

Majumder, S., Kono, M., Lee, Y. T., Byrnes, C., Li, C., Tuymetova, G., & Proia, R. L. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ac119.011170 · Cited by 45

Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

Lai, Y., Babunovic, G. H., Cui, L., Dedon, P. C., Doench, J. G., Fortune, S. M., & Lu, T. K. (2020) · Cell Systems · doi:10.1016/j.cels.2020.08.010 · Cited by 42

Non-Genomic AhR-Signaling Modulates the Immune Response in Endotoxin-Activated Macrophages After Activation by the Environmental Stressor BaP

Großkopf, H., Walter, K., Karkossa, I., von Bergen�, M., & Schubert, K. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.620270 · Cited by 46

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration

Khan, A. S., & Langmann, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01999-8 · Cited by 44

Heavy metals, oxidative stress, and the role of AhR signaling

Kou, Z., Tran, F., & Dai, W. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116769 · Cited by 48

The role of the AHR in host–pathogen interactions

Barreira‐Silva, P., Lian, Y., Kaufmann, S. H. E., & Moura‐Alves, P. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01088-4 · Cited by 44

PM2.5 exacerbates nasal epithelial barrier dysfunction in allergic rhinitis by inducing NLRP3-mediated pyroptosis via the AhR/CYP1A1/ROS axis

Yuan, J., Liao, Z., Zhu, X., Zhu, Y., Wu, S., Guo, L., Fu, Y., & Liu, Y. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138145 · Cited by 44

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

Lima, C., Falcão, M. A. P., da Rosa, J. G. S., Disner, G. R., & Lopes‐Ferreira, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012402 · Cited by 42

Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity

Jiang, X., Wang, J., Lin, L., Du, L., Ding, Y., Zheng, F., Xie, H., Wang, Y., Hu, M., Liu, B., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02042-5 · Cited by 46

Aromatic Amino Acid Metabolites: Molecular Messengers Bridging Immune-Microbiota Communication

Shin, H.-K., & Bang, Y. (2025) · Immune Network · doi:10.4110/in.2025.25.e10 · Cited by 44

Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice

Kahalehili, H. M., Newman, N. K., Pennington, J. M., Kolluri, S. K., Kerkvliet, N. I., Shulzhenko, N., Morgun, A., & Ehrlich, A. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.606441 · Cited by 46

PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma

Shu, G., Chen, M., Liao, W., Fu, L., Lin, M., Gui, C., Cen, J., Lu, J. K., Chen, Z., Wei, J., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2521 · Cited by 43

Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine

Meza‐Perez, S., Liu, M., Silva-Sánchez, A., Morrow, C. D., Eipers, P. G., Lefkowitz, E. J., Ptacek, T., Scharer, C. D., Rosenberg, A. F., Hill, D. D., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.06.003 · Cited by 42

Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease

Wang, Y., Wu, X., Shan, Q.-Y., Yang, Q., Yu, X.-Y., Yang, J., Miao, H., Cao, G., & Zhao, Y. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01598-4 · Cited by 42

Physical Exercise as Kynurenine Pathway Modulator in Chronic Diseases: Implications for Immune and Energy Homeostasis

Joisten, N., Walzik, D., Metcalfe, A. J., Bloch, W., & Zimmer, P. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920938688 · Cited by 46

From Suppressor T Cells to Regulatory T Cells: How the Journey that Began with the Discovery of the Toxic Effects of TCDD Led to Better Understanding of the Role of AhR in Immunoregulation

Singh, N. P., Nagarkatti, M., & Nagarkatti, P. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217849 · Cited by 44

Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds

Kwong, H.-S., Paloni, M., Grandvuillemin, L., Sirounian, S., Ancelin, A., Lai-Kee-Him, J., Grimaldi, M., Carivenc, C., Lancey, C., Ragan, T. J., et al. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168411 · Cited by 40

The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1

Panfili, E., Mondanelli, G., Orabona, C., Gargaro, M., Volpi, C., Belladonna, M. L., Rossini, S., Suvieri, C., & Pallotta, M. T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1134551 · Cited by 40

Uremic Toxin Indoxyl Sulfate Promotes Macrophage-Associated Low-Grade Inflammation and Epithelial Cell Senescence

Ribeiro, A., Liu, F., Srebrzynski, M., Rother, S., Adamowicz, K., Wadowska, M., Steiger, S., Anders, H., Schmaderer, C., Kozieł, J., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098031 · Cited by 40

The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome

Smith, B. C., Sinyuk, M., Jenkins, J. E., Psenicka, M. W., & Williams, J. L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01861-x · Cited by 41

Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain?

Löscher, W., & Gericke, B. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100966 · Cited by 41

Immunosuppressive role of Benzo[a]pyrene in induction of lung cancer in mice

Salem, M. L., El‐Ashmawy, N. E., El-Fattah, E. E. A., & Khedr, E. G. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109330 · Cited by 40

Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling

Barroso, A., Mahler, J. V., Fonseca-Castro, P. H., & Quintana, F. J. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.02.003 · Cited by 40

The Potential Role of the Intestinal Micromilieu and Individual Microbes in the Immunobiology of Chimeric Antigen Receptor T-Cell Therapy

Schubert, M., Rohrbach, R., Schmitt, M. W., & Stein‐Thoeringer, C. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670286 · Cited by 40

IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10

Fang, X., Guo, L., Xing, Z., Shi, L., Liang, H., Li, A., Kuang, C., Tao, B., & Yang, Q. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106132 · Cited by 41

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Wang, Y., Sun, J., Zhu, K., Wang, D., Zhao, X., Zhang, H., Wu, S., Wang, J., & Wang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02764-3 · Cited by 41

The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease

Kumar, K. P., Ooi, J. D., & Goldberg, R. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1291724 · Cited by 42

The aryl hydrocarbon receptor pathway: a linking bridge between the gut microbiome and neurodegenerative diseases

Coretti, L., Buommino, E., & Lembo, F. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1433747 · Cited by 42

The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation

Chen, Z., Dragan, M., Sun, P., Haensel, D., Vu, R., Cui, L., Zhu, P., Yang, N., Shi, Y., & Dai, X. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01264-z · Cited by 44

Pharmacological targeting of BMAL1 modulates circadian and immune pathways

Pu, H., Bailey, L. C., Bauer, L. G., Voronkov, M., Baxter, M. D., Huber, K., Khorasanizadeh, S., Ray, D. W., & Rastinejad, F. (2025) · Nature Chemical Biology · doi:10.1038/s41589-025-01863-x · Cited by 47

Microbiota and metabolites in rheumatic diseases

Tong, Y., Marion, T. N., Schett, G. A., Luo, Y., & Liu, Y. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102530 · Cited by 40

Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation

Wang, M., Hu, H.-H., Chen, Y., Chen, L., Wu, X., & Zhao, Y.-Y. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153323 · Cited by 39

Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway

Gao, S., Guo, K., Chen, Y., Zhao, J., Jing, R., Wang, L., Li, X., Hu, Z., Xu, N., & Li, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.655281 · Cited by 40

Elastin-Derived Peptides in the Central Nervous System: Friend or Foe

Szychowski, K. A., Skóra, B., & Wójtowicz, A. K. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01140-0 · Cited by 40

Escherichia coli small molecule metabolism at the host–microorganism interface

Gatsios, A., Kim, C. S., & Crawford, J. M. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00807-5 · Cited by 43

Thinking inside the box: Current insights into targeting orbital tissue remodeling and inflammation in thyroid eye disease

Gupta, V., Hammond, C. L., Roztocil, E., Gonzalez, M. O., Feldon, S. E., & Woeller, C. F. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2021.08.010 · Cited by 39

Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process

Salminen, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101928 · Cited by 42

CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance, and immune homeostasis

Renga, G., Nunzi, E., Stincardini, C., Pariano, M., Puccetti, M., Pieraccini, G., Serio, C. D., Fraziano, M., Poerio, N., Oikonomou, V., et al. (2024) · Blood · doi:10.1182/blood.2023021380 · Cited by 44

The Aryl Hydrocarbon Receptor: Impact on the Tumor Immune Microenvironment and Modulation as a Potential Therapy

Griffith, B. D., & Frankel, T. L. (2024) · Cancers · doi:10.3390/cancers16030472 · Cited by 45

Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation

Li, L., Xu, Z., Ni, H., Meng, Y., Xu, Y., Xu, H., Zheng, Y., Zhang, Y., Xue, G., & Shang, Y. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.009 · Cited by 39

Control of immune-mediated pathology via the aryl hydrocarbon receptor

Wheeler, M. A., Rothhammer, V., & Quintana, F. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.767723 · Cited by 95

The aryl hydrocarbon receptor and the gut–brain axis

Barroso, A., Mahler, J. V., Fonseca-Castro, P. H., & Quintana, F. J. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00585-5 · Cited by 152

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response

Quintana, F. J. (2012) · Immunology · doi:10.1111/imm.12046 · Cited by 117

Aryl Hydrocarbon Receptor in Health and Disease

Li, H., Fan, Y., Liu, J., Dong, S., Wen, B., Zhang, Y., Wang, X., Duan, X., Hu, Y., Yan, Z., et al. (2025) · MedComm · doi:10.1002/mco2.70426 · Cited by 22

Regulation of the immune response by the aryl hydrocarbon receptor

Gutiérrez-Vázquez, C., & Quintana, F. J. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.012 · Cited by 985