Cited by 1,197Toxic Organic Pollutants ImpactNuclear Receptors and SignalingGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 206 of the 207 references it cites were found in a registry or an index.

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Rothhammer, Veit, Quintana, Francisco J.·2019·Nature Reviews Immunology

DOI 10.1038/s41577-019-0125-8

Open this paper in CoChat — free account

Abstract

The environment, diet, microbiota and body's metabolism shape complex biological processes in health and disease. However, our understanding of the molecular pathways involved in these processes is still limited. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner. In this Review, we summarize our current knowledge of AHR and the transcriptional programmes it controls in the immune system. Finally, we discuss the role of AHR in autoimmune and neoplastic diseases of the central nervous system, with a special focus on the gut immune system, the gut-brain axis and the therapeutic potential of targeting AHR in neurological disorders.

Integrity signals

Registry

Crossref · 10.1038/s41577-019-0125-8

Cites

206 of 206 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Microglia Function in the Central Nervous System During Health and Neurodegeneration
Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,896
Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals
Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895

Show all 207 references

Sorted by citations

Items 701–800 of 999

Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model
Jeong, J., Kim, K.-H., Kim, D., Chandrasekaran, G., Kim, M., Pagire, S. H., Dighe, M., Choi, E. Y., Bak, S.-M., Kim, E., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.07.030 · Cited by 8
Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Furue, M., & Furue, M. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00005 · Cited by 10
Extended Multicomponent Reactions with Indole Aldehydes: Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor
Ghashghaei, O., Pedrola, M., Seghetti, F., Martin, V. V., Zavarce, R., Babiak, M., Nováček, J., Hartung, F., Rolfes, K. M., Haarmann‐Stemmann, T., et al. (2020) · Angewandte Chemie · doi:10.1002/ange.202011253 · Cited by 8
Molecular Evolution of Aryl Hydrocarbon Receptor Signaling Pathway Genes
Bhalla, D., & van Noort, V. (2023) · Journal of Molecular Evolution · doi:10.1007/s00239-023-10124-1 · Cited by 9
Retinoic acid induced cytokines are selectively modulated by liver X receptor activation in zebrafish
Diaz, O. E., Xue, S., Luo, X., Nava-Palacios, J., Appelblom, A., Morales, R. A., Das, S., & Villablanca, E. J. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.02.009 · Cited by 9
Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor
Abuin-Martínez, C., Vidal, R., Gutiérrez‐López, M. D., Pérez‐Hernández, M., Giménez‐Gómez, P., Morales‐Puerto, N., O’Shea, E., & Colado, M. I. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108490 · Cited by 9
The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stressPreprint
Pfänder, P., Hensen, L., Prentzell, M. T., Navas, P. R., Solvay, M., Sadik, A., Sayeeram, D., Rehbein, U., Bausbacher, T., Egger, A.-S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.16.523931 · Cited by 9
Aryl hydrocarbon receptor (AHR): Towards understanding intestinal microbial ligands including vitamin B12 and folic acid as natural antagonists
Bock, K. W. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115658 · Cited by 7
Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway
Hong, G., Zhao, Y., Li, Q., & Liu, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112512 · Cited by 7
The role of aryl hydrocarbon receptor in the occurrence and development of periodontitis
Wu, L., Li, X., Li, J., Wang, Y., Yang, C., Zhao, C., & Gao, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1494570 · Cited by 7
The potential role of AhR/NR4A1 in androgen-dependent prostate cancer: focus on TCDD-induced ferroptosis
Chen, X., Yao, Y., Gong, G., He, T., Ma, C., & Yu, J. (2024) · Biochemistry and Cell Biology · doi:10.1139/bcb-2024-0155 · Cited by 9
Perspective: Pathological transdifferentiation—a novel therapeutic target for cardiovascular diseases and chronic inflammation
Yang, W. Y., Issa, M. B., Saaoud, F., Xu, K., Shao, Y., Lu, Y., Dornas, W. C., Cueto, R., Jiang, X., Wang, H., et al. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1500775 · Cited by 7
Aryl Hydrocarbon Receptor Establishes a Delicate Balance between the Level of the Trace Amine Tryptamine and Monoamine Oxidase Activity in the Brain and Periphery in Health and Conditions such as Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders
Kot, M. (2025) · Current Neuropharmacology · doi:10.2174/011570159x340635241022113450 · Cited by 8
Microbiota and immune dynamics in rheumatoid arthritis: Mechanisms and therapeutic potential
Jin, J., Cai, X., Rao, P., Xu, J. Q., & Li, J. (2025) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2025.102035 · Cited by 8
Zinc amino acid chelate and the Aryl Hydrocarbon Receptor (AHR) cooperate in improving the barrier function of a Caco-2 cell intestinal epithelium
Hu, X., Wang, R., Kille, P., Maret, W., & Högstrand, C. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109909 · Cited by 8
ITE-mediated AhR activation attenuates atherosclerosis by promoting macrophage M2-like polarization through NF-κB/LCN2 pathway suppression
Zheng, Q., Lin, Y., Zeng, L., Chen, S., Chen, L., Lin, X., Zhu, J., Lin, J., Weng, X., & Chai, D. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123715 · Cited by 7
PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial–Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway
Wang, Y., Zheng, B., Xiong, P., Liu, Y., Shu, L., Shen, Y., Lu, T., & Yang, Y. (2025) · Toxics · doi:10.3390/toxics13060488 · Cited by 7
The Skin Microbiome, Microbial Metabolites and the Epidermal Response to Ultraviolet Radiation—Towards Next Generation Suncare
Mercer, S. D., McBain, A. J., & O’Neill, C. A. (2025) · Experimental Dermatology · doi:10.1111/exd.70142 · Cited by 7
Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity
Yagyu, H., Kiuchi, M., Sasaki, A., Itakura, E., Kokubo, K., Iwamura, C., Onodera, A., Aoki, A., Hishiya, T., Tsuji, K., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adp0849 · Cited by 9
Multitarget natural compounds taming NETosis: A translational strategy for cancer and inflammatory diseases
Jia, W., Zhang, J., Shang, Y., & Liu, S. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218103 · Cited by 7
Trimethylamine N-oxide induced cognitive impairment through disruption of blood-brain barrier by inhibiting TGF-β pathway
Liu, Y., Zhang, H.-Y., Hong, X.-Y., Wu, Y., Li, M., & Zheng, H. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111862 · Cited by 7
Subversion of kynurenine-induced AHR activation in CD8 T cells by kynureninase-expressing antigen-presenting cells
Giacomantonio, M., Vijayan, V. V., Nair, P. G., Pathak, G. P., Kennedy, B. E., Paulo, J. A., McMillen, T. S., Banerjee, A., Kumar, V., Sultonova, M., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117149 · Cited by 7
AhR inhibition promotes axon regeneration via a stress–growth switch
Halawani, D., Wang, Y., Li, J., Halperin, D. S., Ni, H., Estill, M. S., Ramakrishnan, A., Shen, L., Sefiani, A., Geoffroy, C. G., et al. (2026) · Nature · doi:10.1038/s41586-026-10295-z · Cited by 14
The effect of apigenin, an aryl hydrocarbon receptor antagonist, in Phthalate‐Exacerbated eosinophilic asthma model
Kim, S., Quoc, Q. L., Park, H., & Shin, Y. S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17804 · Cited by 8
EXPOSURE AND ASSOCIATED HEALTH RISK OF ENDOCRINE DISRUPTION COMPOUNDS
Asenuga, E. R., & Olagunju, A. S. (2023) · African Journal of Health Safety and Environment · doi:10.52417/ajhse.v4i1.332 · Cited by 7
Multi-Fusarium mycotoxin exposure activates Nrf2 and Ahr pathway in the liver of laying hens
Kövesi, B., Kulcsár, S., Ancsin, Z., Erdélyi, M., Zándoki, E., Gömbös, P., Balogh, K., & Mézes, M. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.12.006 · Cited by 9
Fulvic acid modulates mucosal immunity in fish skin: Sustainable aquaculture solution or environmental risk factor?
Lieke, T., Stejskal, V., Behrens, S., Steinberg, C. E. W., & Meinelt, T. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133737 · Cited by 7
Gut microbiota as a modulator of type 1 diabetes: A molecular perspective
Nikola, L., & Iva, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123187 · Cited by 8
In Vitro Evaluation of Aryl Hydrocarbon Receptor Involvement in Feline Coronavirus Infection
Sorbo, L. D., Giugliano, R., Cerracchio, C., Iovane, V., Salvatore, M. M., Serra, F., Amoroso, M. G., Pellegrini, F., Levante, M., Capozza, P., et al. (2025) · Viruses · doi:10.3390/v17020227 · Cited by 7
Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis
Cao, Y. C., Xie, Q., Zheng, Q., Zhang, J., Yao, M., Du, Z., Zhang, L., Hu, T., Zhao, Y., Du, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202412498 · Cited by 7
Tryptophan Metabolism and the Microbiome-Gut-Brain Axis
Clarke, G. A., Villalobos-Manríquez, F., & Marin, D. C. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.13 · Cited by 7
Diet in Intestinal Fibrosis: A Double-Edged Sword
Marion‐Letellier, R., Leboutte, M., Amamou, A., Raman, M., Savoye, G., & Ghosh, S. K. (2021) · Nutrients · doi:10.3390/nu13093148 · Cited by 7
Multi-Walled Carbon Nanotubes Inhibit Potential Detoxification Of Dioxin-Mediated Toxicity by Blocking The Nuclear Translocation Of Aryl Hydrocarbon Receptor
Wei, Y., Sun, H., Zhang, S., Xie, H. Q., Li, C., Zhao, B., & Yan, B. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128458 · Cited by 7
Opioid-Use, COVID-19 Infection, and Their Neurological Implications
Jalodia, R., Antoine, D., Braniff, R. G., Dutta, R. K., Ramakrishnan, S., & Roy, S. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.884216 · Cited by 7
Dung biomass smoke exposure impairs resolution of inflammatory responses to influenza infection
McCarthy, C. E., Duffney, P. F., Nogales, A., Post, C. M., Lawrence, B. P., Martínez‐Sobrido, L., Thatcher, T. H., Phipps, R. P., & Sime, P. J. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116160 · Cited by 9
Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts
Amamou, A., Yaker, L., Leboutte, M., Bôle‐Feysot, C., Savoye, G., & Marion‐Letellier, R. (2022) · Nutrients · doi:10.3390/nu14163253 · Cited by 7
Evolutive emergence and divergence of an Ig regulatory node: An environmental sensor getting cues from the aryl hydrocarbon receptor?
D’Addabbo, P., Frezza, D., & Sulentic, C. E. W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.996119 · Cited by 7
StemRegenin 1 Mitigates Radiation-Mediated Hematopoietic Injury by Modulating Radioresponse of Hematopoietic Stem/Progenitor Cells
Hwang, Y. J., Shin, D., Kim, M., Jang, H., Kim, S., Yang, H., Jang, W. I., Park, S., Shim, S., & Lee, S. B. (2023) · Biomedicines · doi:10.3390/biomedicines11030824 · Cited by 7
Abnormal kynurenine level contributes to the pathological bone features of ankylosing spondylitis
Jeon, C., Jang, Y., Lee, S. H., Weon, S., Park, H., Lee, S., Oh, Y., Choi, S. H., Wang, S. E., Kim, T., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110132 · Cited by 7
Elastin-Derived Peptide VGVAPG Affects Production and Secretion of Testosterone in Mouse Astrocyte In Vitro
Szychowski, K. A., Pomianek, T., & Gmiński, J. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02920-3 · Cited by 7
A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation
Rodríguez, P. N., Hartung, F., Pedrola, M., Coomar, S., Diaz-Moreno, A., Hätälä, A. M., Rolfes, K. M., Sánchez‐Vera, I., Gil, J., Molins, E., et al. (2025) · ACS Central Science · doi:10.1021/acscentsci.5c00194 · Cited by 5
New insights into tryptophan metabolism in ischemic stroke: A promising therapeutic target
Chen, W., Mao, T., Sun, C. H., Ma, R., Dong, Y., Xiong, Y., Bao, W., Han, R., & Wang, L. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111529 · Cited by 10
The role of gut microbiota in neuropathic pain: insights into immune mechanisms
Gong, Z., Zou, J., Fang, Y., Li, J., Luo, Y., Xue, Q., Yu, B., Hua, B., & Liu, Z. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02260-4 · Cited by 10
Tryptophan metabolic gatekeeping in epithelial repair: GPR35-KLF5 circuitry decodes mucosal damage signals for repair programming
Xie, B., Wang, M., Xiao, Y., Zhang, X., Liu, M., Miao, J., Mo, Y., Liu, H., Wang, J., Xu, F., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-025-08237-0 · Cited by 6
Bacterial tryptophan metabolites in cancer and atherosclerosis: insights for a role in immune checkpoint inhibition
Dormans, T., Kroon, J., Rampanelli, E., Nieuwdorp, M., & van Es, N. (2025) · Essays in Biochemistry · doi:10.1042/ebc20253060 · Cited by 6
Integrating host-microbiota metabolic networks: how aromatic amino acids shape immune homeostasis and affect disease progression
Zhang, Y., Zhao, X., Wang, H., Zhang, Z., Shi, H., Wang, Y., & Zhu, S. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01435-6 · Cited by 8
Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity
Ghosh, S., Vanwinkle, Z. M., Bodduluri, S. R., Juin, S. K., Kadari, M., Singh, A., Dryden, G. W., Lawrenz, M. B., Kanneganti, T., Rai, S. N., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73760-3 · Cited by 7
Activation of aryl hydrocarbon receptor by azatyrosine-phenylbutyric hydroxamide inhibits progression of diabetic retinopathy mice
Fitriana, I., Wu, C.-H., Hsu, T.-J., Chan, Y.-J., Li, C.-H., Lee, C., Hsiao, G., & Cheng, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115700 · Cited by 6
Disrupting Development: Unraveling the Interplay of Aryl Hydrocarbon Receptor (AHR) and Wnt/β-Catenin Pathways in Kidney Development Under the Influence of Environmental Pollutants
Mohammadi‐Bardbori, A., Shadboorestan, A., Niknahad, H., Noorafshan, A., Fardid, R., Nadimi, E., Bakhtari, A., & Omidi, M. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-04009-z · Cited by 6
Development of FluoAHRL: A Novel Synthetic Fluorescent Compound That Activates AHR and Potentiates Anti-Inflammatory T Regulatory Cells
Jonić, N., Koprivica, I., Chatzigiannis, C. M., Tsiailanis, A. D., Kyrkou, S. G., Tzakos, E. P., Pavić, A., Dimitrijević, M., Jovanović, A., Jovanović, M. B., et al. (2024) · Molecules · doi:10.3390/molecules29132988 · Cited by 6
The aryl hydrocarbon receptor and FOS mediate cytotoxicity induced by Acinetobacter baumannii
Kew, C., Prieto‐Garcia, C., Bhattacharya, A., Tietgen, M., MacNair, C. R., Carfrae, L. A., Mello-Vieira, J., Klatt, S., Cheng, Y., Rathore, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52118-7 · Cited by 6
An endogenous aryl hydrocarbon receptor ligand induces preeclampsia‐like phenotypes in rats
Zhao, Y., Zhou, C., Zhang, S., Mishra, J. S., Li, H., Lei, W., Wang, K., Kumar, S., & Zheng, J. J. (2024) · The Journal of Physiology · doi:10.1113/jp287503 · Cited by 6
Molecular insights into developmental toxicity induced by PCB77 exposure on zebrafish via integrating transcriptomics with adverse outcome pathway
Chen, Y., Zhao, J., Chen, X., Zong, L., Lu, X., Pan, Y. F., Guan, M., Zhang, J., & Xu, S. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178502 · Cited by 6
3,3′-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury
Dallera, C. A., Pláceres-Uray, F., Mastromatteo-Alberga, P., Torres, M. D., Balleste, A. F., Gorthy, A. S., Rahimzadeh, T. S., Aliancin, I., Dietrich, W. D., Vaccari, J. P. D. R., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00531 · Cited by 6
Naringenin Exhibits Antiglioma Activity Related to Aryl Hydrocarbon Receptor Activity and IL-6, CCL2, and TNF-α Expression
de Santana, M. R., Argolo, D. S., Lima, I. S., dos Santos, C. C., Victor, M. M., Ramos, G. D. S., do Nascimento, R. P., Ulrich, H., & Costa, S. L. (2025) · Brain Sciences · doi:10.3390/brainsci15030325 · Cited by 6
Computational discovery of novel aryl hydrocarbon receptor modulators for psoriasis therapy
Santini, G., Bonati, L., & Motta, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-03626-z · Cited by 8
H3K9 acetylation–NF-κB–AP-1 nexus targeted by ITE limits TNF-α–induced MMP-9 expression in monocytic cells
Bahman, F., Kochumon, S., Malik, M. Z., Akther, N., Jacob, S. P., Drobiova, H., Al‐Mulla, F., & Ahmad, R. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf240 · Cited by 6
The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy: A Population-Based Cohort Study
Tryggvadottir, H., Sandén, E., Björner, S., Bressan, A., Rödström, M. Y., Khazaei, S., Edwards, D. P., Nodin, B., Jirström, K., Isaksson, K., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.642768 · Cited by 7
Protective Effects of Maclurin against Benzo[a]pyrene via Aryl Hydrocarbon Receptor and Nuclear Factor Erythroid 2-Related Factor 2 Targeting
Kim, J., Park, S., Yang, S., Oh, S. W., Kwon, K., Park, S. J., Yu, E., Kim, H., Park, J. Y., Choi, S., et al. (2021) · Antioxidants · doi:10.3390/antiox10081189 · Cited by 6
AhR regulates VEGF expression by promoting STAT1 transcriptional activity, thereby affecting endothelial angiogenesis in acute limb ischemia
Ma, J., Chen, J., Wang, H., Lu, D., & Liang, K. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110253 · Cited by 6
Chlamydia trachomatis relies on the scavenger role of aryl hydrocarbon receptor with detyrosinated tubulin for its intracellular growth, but this is impaired by excess indole
Zhang, S., Funahashi, Y., Tanaka, S., Okubo, T., Thapa, J., Nakamura, S., Higashi, H., & Yamaguchi, H. (2023) · Microbes and Infection · doi:10.1016/j.micinf.2022.105097 · Cited by 6
The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
Linke, C., Freitag, T., Riess, C., Scheffler, J. V., del Moral, K., Schoenwaelder, N., Fiedler, T., Fiebig, A., Kaps, P., Dubinski, D., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02873-2 · Cited by 6
Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets
Kozlakidis, Z., Shi, P., Abarbanel, G., Klein, C. A., & Sfera, A. (2023) · BioTech · doi:10.3390/biotech12020038 · Cited by 7
What Is the Role of the Gut in Wound Infections?
Hyoju, S. K., Machutta, K., Krezalek, M. A., & Alverdy, J. C. (2023) · Advances in Surgery · doi:10.1016/j.yasu.2023.05.002 · Cited by 7
Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution
Bouchard, K. V., & Costin, G. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1256399 · Cited by 6
Investigating the Aryl Hydrocarbon Receptor Agonist/Antagonist Conformational Switch Using Well-Tempered Metadynamics Simulations
Mosa, F. E. S., AlRawashdeh, S., El‐Kadi, A. O. S., & Barakat, K. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c00169 · Cited by 8
Influence of ligand’s directional configuration, chrysenes as model compounds, on the binding activity with aryl hydrocarbon receptor
Kim, T., Zhen, J., Lee, J., Bauer, R. P. C., Lee, C., Kwon, B.-O., Chae, K. H., Hong, S., Giesy, J. P., Chang, G. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70704-9 · Cited by 6
Deschampsia antarctica extract (Edafence®) as a powerful skin protection tool against the aging exposome
Mataix, M., Rodríguez-Luna, A., Gutiérrez-Pérez, M., Milani, M., Gandarillas, A., Espada, J., & Pérez-Davó, A. (2020) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2020.138 · Cited by 6
Targeting the Aryl Hydrocarbon Receptor (AhR): A Review of the In-Silico Screening Approaches to Identify AhR Modulators
Mosa, F. E. S., El‐Kadi, A. O. S., & Barakat, K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99228 · Cited by 8
Genetic diversity and spatial genetic structure in fragmented populations of Solanum spp. from the Brazilian savannah, based on microsatellite loci
de Moura, T. M., Sebbenn, A. M., Chaves, L. J., Coelho, A. S. G., Oliveira, G. C. X., & Kageyama, P. Y. (2009) · Scientia Forestalis · Cited by 6
Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways
Ansari, R. A., Alfuraih, S., Shekh, K., Omidi, Y., Javed, S., & Saghir, S. A. (2023) · Wiley eBooks · doi:10.1002/9781119896258.ch3 · Cited by 6
Indoleamine 2,3-Dioxygenase 1/Aryl Hydrocarbon Receptor Feedback Loop Mediates Anti-inflammation in lipopolysaccharide-stimulated Astrocytes to Dampen Inflammatory Neurotoxicity
Gan, Y., & Lee, Y. (2025) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-24-00089 · Cited by 6
Tryptophan pathway profiling in multiple sclerosis patients treated with ocrelizumab
Ricci, C., Pivetta, M., Martinis, E., Valeri, V., Colliva, C., Giacchè, N., Lorenzut, S., Cargnelutti, D., Frossi, B., & Tonon, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1603663 · Cited by 5
The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice
Yu, Y., Wang, Y., Zhang, J., Li, S., Wang, Y., You, X., Chen, X., Du, M., Xie, L., & Liu, S. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1640149 · Cited by 5
The role of the aryl hydrocarbon receptor in ovarian development, function, xenobiotic metabolism, and disease
Dean, A. E., & Flaws, J. A. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf201 · Cited by 5
Lactucopicrin: A Sesquiterpene Lactone with Anti-Inflammatory Activity Modulates the Crosstalk between NF-kB and AHR Pathways
Ávila‐Gálvez, M. Á., Pinto, C. J. G., Rafael-Pita, C., Silva, I. P., Janowska, A. T., Marinho, S. P., Saitch, R., Lian, Y., Louphrasitthiphol, P., Protze, J., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02294 · Cited by 6
Phytate enhances gut Parasutterella colonization to alleviate radiation injury
Li, Y., Qiu, J., Liu, Z., Xiao, H., Wang, B., Dong, Y., Xiao, Y., Wang, Q., Dong, J., & Cui, M. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.10.009 · Cited by 5
Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy
Yin, J., Yang, S., Liu, Z., Zhao, S., Sun, S., Liu, Z., & Li, Q. (2025) · Advanced Science · doi:10.1002/advs.202508107 · Cited by 6
Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants
Filipovic, D., Qi, W., Kana, O. Z., Marri, D., LeCluyse, E. L., Andersen, M. E., Cuddapah, S., & Bhattacharya, S. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad094 · Cited by 5
Aryl Hydrocarbon Receptor Involvement in the Sodium-Dependent Glutamate/Aspartate Transporter Regulation in Cerebellar Bergmann Glia Cells
Silva-Parra, J., Ramírez-Martínez, L., Palafox-Gómez, C., Sandu, C., López‐Bayghen, E., Vega, L., Elizondo, G., Loaeza‐Loaeza, J., Hernández‐Sotelo, D., Hernández‐Kelly, L. C., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00046 · Cited by 5
Aryl Hydrocarbon Receptor Activation Limits the Fatty Acid Synthesis and Subsequent “miR-193a-3p-HDAC3-FASN” Signals to Alleviate Intestinal Fibrosis
Wu, X., Miao, X., Xue, X., Qiao, S., Dai, Y., & Wei, Z. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00976 · Cited by 5
Modulation of aryl hydrocarbon receptor activity by halogenated indoles
Vrzalová, A., Vrzal, R., Nádvorník, P., Šebela, M., & Dvořák, Z. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117964 · Cited by 5
Cullin-Conciliated Regulation of Plant Immune Responses: Implications for Sustainable Crop Protection
Wang, H., & Xie, Z. (2024) · Plants · doi:10.3390/plants13212997 · Cited by 5
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway
Duah, M., Zheng, F., Shen, J., Xu, Y., Cao, S., Yan, Z., Lan, Q., Wang, Y., Xu, K., & Pan, B. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.12.011 · Cited by 5
Interactions Between Mesenchymal Stem Cells and Microorganisms: Unraveling the Paradox for Enhanced Mesenchymal Stem Cell-Based Therapy
Kord-Parijaee, E., Ferdosi-Shahandashti, E., & Hafezi, N. (2025) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2024.0334 · Cited by 5
Evidence for a Modulatory Effect of a 12‐Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof‐of‐Principle Study
Minato, I., Mena, P. R., Ricciardiello, L., Scaioli, E., Belluzzi, A., Rotondo, E., Derlindati, E., Montanini, B., Michelini, C., Tosi, N., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70067 · Cited by 5
Anti-inflammatory effects of Bifidobacterium infantis M-63 during the early postnatal period in term infants
Xu, C., Odamaki, T., Hiraku, A., Nakata, S., Arai, S., Iwabuchi, N., Tanaka, M., Tsuno, T., & Nakamura, M. (2025) · Pediatric Research · doi:10.1038/s41390-025-04263-y · Cited by 5
Enteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade
Puccetti, M., Pariano, M., Stincardini, C., Fabi, C., Galarini, R., Barola, C., Alabed, H. B. R., Mancini, D. F., Pellegrino, R. M., Garaci, E., et al. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126158 · Cited by 5
Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
Nguyen, P.-T., Nakamura, Y., Tran, N. Q. V., Ishimaru, K., Nguyen, T.-A., Kobayashi, Y., Watanabe-Saito, F., Okuda, T., Nakano, N., & Nakao, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129997 · Cited by 5
The Interplay Between Environmental Pollutants, Gut Microbiota, and Infections
El‐Mansoury, B., Smimih, K., Hamdan, Y. A., Khiat, A. E., Elouali, S., Fatimi, H. E., Draoui, A., Hiba, O. E., & Jayakumar, A. R. (2023) · Advances in human services and public health (AHSPH) book series · doi:10.4018/978-1-7998-9414-8.ch008 · Cited by 5
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis
Yamazaki, T., Kouno, T., Hsu, C. L., Hartmann, P., Mayo, S. L., Zhang, X., Stärkel, P., Bosques‐Padilla, F., Verna, E. C., Abraldeṣ, J. G., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000777 · Cited by 5
Beyond transcription, aryl hydrocarbon receptor plays a protective role in periodontitis by interacting with CaMKII
Zeng, X., Feng, M., Lu, J., Wang, R., Deng, L., Yang, Y., & Luo, L. (2024) · Journal of Periodontology · doi:10.1002/jper.24-0021 · Cited by 6
Regulatory Mechanism of Rosemary Extract (Rosmarinus officinalis) on Human Skin Fibroblasts During Ultraviolet A Photoaging
Mao, F., Wu, Z., Shen, Y., Ren, Y., Yang, M., Li, X., & Zhang, L. (2020) · Iranian Journal of Science and Technology Transactions A Science · doi:10.1007/s40995-020-01028-6 · Cited by 5
Temperature-dependent metabolite orchestration to acute submaximal exercise indicates cardiorespiratory fitness in humans
Hu, Y., Zheng, Y., Wang, Y., Yu, S., Li, M., Zhou, J., Wu, G., Xing, W., Dong, L., Liu, Y., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121284 · Cited by 5
Molecular dynamics simulations depict structural motions of the whole human aryl hydrocarbon receptor influencing its binding of ligands and HSP90
Rosales‐Hernández, M. C., Bello, M., Toledano, J. V., Feregrino, B. C. E., Correa‐Basurto, J., Morales, L. G. F., & Torres-Ramos, M. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2171132 · Cited by 5
Molecular mechanisms associated with multiple sclerosis progression, severity and phenotypePreprint
Kosa, P. F., Lumbard, K., Wang, J., Liang, C., Masvekar, R., Kim, Y., Varosanec, M., Jennings, L. L., & Bielekova, B. (2022) · medRxiv · doi:10.1101/2022.10.14.22281095 · Cited by 5
Dioxins and Dioxin-Like Compounds: Current Challenges in Sensing and Future Perspectives
Muhammad, I., & Ren, T. (2025) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2025.2588709 · Cited by 4
MIR-21 regulating distribution of intestinal flora through TNF-α promotes progression of ulcerative colitis
Yang, K., Liu, X., Niu, T., Zhao, Q., & Gao, F. (2023) · Journal of Medical Biochemistry · doi:10.5937/jomb0-43320 · Cited by 4
Hypervolemia in Dialysis Patients Impairs STAT3 Signaling and Upregulates miR-142-3p: Effects on IL-10 and IL-6
Ulrich, C., Fiedler, R., Herberger, E., Canim, Z., Markau, S., & Girndt, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073719 · Cited by 4
Mechanisms of microbe-mediated immune development in the context of antibiotics and asthma
Donald, K., & Finlay, B. B. (2024) · Frontiers in Allergy · doi:10.3389/falgy.2024.1469426 · Cited by 4

Authors: Rothhammer, V., & Quintana, F. J.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Quintana, Francisco J.
ORCID: Rothhammer, Veit
Quintana, Francisco J.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2019-02-04
Volume: 19
Issue: 3
Pages: 184-197
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-019-0125-8
OpenAlex: W2911968308
Cited by: 1,197
References: 207
Citations by year: 2026: 148 · 2025: 189 · 2024: 179 · 2023: 192 · 2022: 173 · 2021: 160 · 2020: 117 · 2019: 37
FWCI: 11.68
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: aryl hydrocarbon receptor, environmental sensing, immune regulation, gut immune system, gut-brain axis, autoimmune disease, central nervous system tumors, transcriptional programs, microbiota, neurological disorders
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Diet, Environment, Gene Expression Regulation, Humans, Intestines, Signal Transduction, Receptors, Aryl Hydrocarbon, Autoimmune Diseases of the Nervous System, Adaptive Immunity, Molecular Targeted Therapy, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks