The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Neurotoxic reactive astrocytes are induced by activated microglia

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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

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Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands

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Developmental and sexual dimorphic atlas of the prenatal mouse external genitalia at the single-cell level

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Activation of Aryl Hydrocarbon Receptor by ITE Improves Cardiac Function in Mice After Myocardial Infarction

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E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms

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Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism

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Non-Host Factors Influencing Onset and Severity of Celiac Disease

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Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism

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Indole derivatives, microbiome and graft versus host disease

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Sublethal effects of early-life exposure to common and emerging contaminants in birds

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Kynurenine Attenuates Ulcerative Colitis Mediated by the Aryl Hydrocarbon Receptor

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Coexposure to microplastic and Bisphenol A exhacerbates damage to human kidney proximal tubular cells

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Indole-3-propionic acid function through PXR and AhR, molecular signaling pathways, and antitoxic role in underlying diseases

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Pharmacological Modulation of Immune Responses by Nutritional Components

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Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling

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The Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin

Vogeley, C., Rolfes, K. M., Krutmann, J., & Haarmann‐Stemmann, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841721 · Cited by 24

Neuroinflammation: Extinguishing a blaze of T cells

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Cyanidin-3-O-glucoside impacts fecal discharge of polystyrene microplastics in mice: Potential role of microbiota-derived metabolites

Chen, W., Tu, P., Ye, X., Tang, Q., Yu, T., & Zheng, X. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116212 · Cited by 24

Fusobacterium nucleatum promotes proliferation in oesophageal squamous cell carcinoma via AHR / CYP1A1 signalling

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Nanomaterials for antigen-specific immune tolerance therapy

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GPR35‐mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis

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AhR–STAT3–HO‐1/COX‐2 signalling pathway may restrict ferroptosis and improve hMSC accumulation and efficacy in mouse liver

Han, L., Ma, C., Wu, Z., Xu, H., Li, H., & Pan, G. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16208 · Cited by 26

Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs

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Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy

Zhong, H., Liu, T., Shang, Y., Huang, C., & Pan, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117042 · Cited by 24

Metabolic Reprogramming in Respiratory Viral Infections: A Focus on SARS-CoV-2, Influenza, and Respiratory Syncytial Virus

Camps, J., Iftimie, S. M., Jiménez-Franco, A., Castro, A., & Joven, J. (2025) · Biomolecules · doi:10.3390/biom15071027 · Cited by 31

Tryptophan catabolites from microbiota ameliorate immune-mediated hepatitis through activating aryl hydrocarbon receptor of T cells

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Increased AHR Transcripts Correlate With Pro-inflammatory T-Helper Lymphocytes Polarization in Both Metabolically Healthy Obesity and Type 2 Diabetic Patients

Zhao, R., He, Q., Sha, S., Song, J., Qin, J., Liu, P., Sun, Y., Sun, L., Hou, X., & Chen, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01644 · Cited by 23

The aryl hydrocarbon receptor: An environmental effector in the pathogenesis of fibrosis

Shi, Y., Zeng, Z., Yu, J., Tang, B., Tang, R., & Xiao, R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105180 · Cited by 23

The effects of endocrine disruptors on the male germline: an intergenerational health risk

Lombó, M., & Herráez, M. P. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12701 · Cited by 23

Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters

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Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans

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Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation

Bock, K. W. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03134-9 · Cited by 23

More than Meets the Eye: The Aryl Hydrocarbon Receptor is an Environmental Sensor, Physiological Regulator and a Therapeutic Target in Ocular Disease

Hammond, C. L., Roztocil, E., Gupta, V., Feldon, S. E., & Woeller, C. F. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.791082 · Cited by 24

The Aryl Hydrocarbon Receptor Modulates T Follicular Helper Cell Responses to Influenza Virus Infection in Mice

Houser, C. L., & Lawrence, B. P. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100936 · Cited by 24

The key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor

Wu, J., Pang, T., Lin, Z., Zhao, M., & Jin, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.965941 · Cited by 25

The “Superoncogene” Myc at the Crossroad between Metabolism and Gene Expression in Glioblastoma Multiforme

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Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

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Acute exercise impacts AhR and PD-1 levels of CD8+ T-cells—Exploratory results from a randomized cross-over trial comparing endurance versus resistance exercise

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Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond

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Xanthurenic acid: A role in brain intercellular signaling

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Association Between the Gut Microbiota and Alzheimer’s Disease: An Update on Signaling Pathways and Translational Therapeutics

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The Ancestral Environment Shapes Antiviral CD8+ T cell Responses across Generations

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Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials

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Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke‐Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR / AhR Pathway in Mice

Huang, X., Xu, S., Yu, L.-J., Zhou, Y., Zhou, Y., & Liu, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6635080 · Cited by 22

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

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Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach

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Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways

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Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor

Helm, E. Y., & Zhou, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1056267 · Cited by 24

Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

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Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

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Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?

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The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Cirac, A., Tsaktanis, T., Beyer, T., Linnerbauer, M., Andlauer, T. F. M., Grummel, V., Nirschl, L., Lößlein, L., Quintana, F. J., Hemmer, B., et al. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001043 · Cited by 23

Indole-3-aldehyde Alleviates High-Fat Diet-Induced Gut Barrier Disruption by Increasing Intestinal Stem Cell Expansion

Zhang, J., Zhang, R., Chen, Y., Guo, X., Ren, Y., Wang, M., Li, X., Huang, Z., Zhu, W., & Yu, K. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02381 · Cited by 22

Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management

Rangel, M. V. D. S., Lopes, K. G., Qin, X., & Borges, J. P. (2025) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2025.1535152 · Cited by 24

Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells

Almeida-da-Silva, C. L. C., Dakafay, H. M., Liu, K., & Ojcius, D. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147669 · Cited by 21

Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease

Fling, R. R., & Zacharewski, T. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212431 · Cited by 21

Time-course of host cell transcription during the HTLV-1 transcriptional burst

Kiik, H., Ramanayake, S., Miura, M., Tanaka, Y., Melamed, A., & Bangham, C. R. M. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010387 · Cited by 21

Gastrointestinal Microbiome and Multiple Health Outcomes: Umbrella Review

Chang, C., Yuan, X., Zhang, X., Chen, X., & Li, K. (2022) · Nutrients · doi:10.3390/nu14183726 · Cited by 22

Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota

Wen, Y., Zhan, Y., Tang, S., Liu, F., Wu, R., Kong, P., Li, Q., & Tang, X. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2157020 · Cited by 23

Oral administration of nanoformulated indoximod ameliorates ulcerative colitis by promoting mitochondrial function and mucosal healing

Wu, P., Yao, S., Wang, X., Wang, X., Yang, L., Dai, W., Zhang, H., He, B., Wang, X., Wang, S., et al. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122813 · Cited by 21

Host–Microbiome Interactions: Tryptophan Metabolism and Aromatic Hydrocarbon Receptors after Traumatic Brain Injury

Sun, Y., Wang, S., Liu, B., Hu, W., & Zhu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310820 · Cited by 23

Physical exercise and persistent organic pollutants

Liu, C., & Hou, H. S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19661 · Cited by 22

ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques

Lv, J., Yü, P., Wang, Z., Deng, W., Bao, L., Liu, J., Li, F., Zhu, Q., Zhou, N., Lv, Q., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00672-1 · Cited by 21

Lipopolysaccharide-Enhanced Responses against Aryl Hydrocarbon Receptor in FcgRIIb-Deficient Macrophages, a Profound Impact of an Environmental Toxin on a Lupus-Like Mouse Model

Udompornpitak, K., Bhunyakarnjanarat, T., Charoensappakit, A., Dang, C. P., Saisorn, W., & Leelahavanichkul, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084199 · Cited by 21

Nutrition to Optimise Human Health—How to Obtain Physiological Substantiation?

Witkamp, R. F. (2021) · Nutrients · doi:10.3390/nu13072155 · Cited by 25

A potential role for AHR in SARS-CoV-2 pathologyPreprint

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Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short chain fatty acids

McCoubrey, L. E., Ferraro, F., Seegobin, N., Vérin, J., Alfassam, H. A., Awad, A., Marzorati, M., Verstrepen, L., Ghyselinck, J., Munck, J. D., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.039 · Cited by 21

A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease

Summers, B. S., Broome, S. T., Pang, T. W. R., Mundell, H. D., Belic, N. K., Tom, N., Ng, M. L., Yap, M. L., Sen, M. K., Sedaghat, S., et al. (2024) · International Journal of Tryptophan Research · doi:10.1177/11786469241248287 · Cited by 28

The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration

Vellucci, L., Mazza, B., Barone, A., Nasti, A., Simone, G. D., Iasevoli, F., & de Bartolomeis, A. (2025) · Biomolecules · doi:10.3390/biom15050615 · Cited by 23

Aryl Hydrocarbon Receptor in Health and Disease

Li, H., Fan, Y., Liu, J., Dong, S., Wen, B., Zhang, Y., Wang, X., Duan, X., Hu, Y., Yan, Z., et al. (2025) · MedComm · doi:10.1002/mco2.70426 · Cited by 22

Aryl hydrocarbon receptor–targeted therapy for CD4+ T cell–mediated idiopathic pneumonia syndrome in mice

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Combinatory Exposure to Urolithin A, Alternariol, and Deoxynivalenol Affects Colon Cancer Metabolism and Epithelial Barrier Integrity in vitro

Groestlinger, J., Seidl, C., Varga, E., Favero, G. D., & Marko, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.882222 · Cited by 20

Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes

Bishop, S. L., Drikic, M., Wacker, S., Chen, Y. Y., Kozyrskyj, A. L., & Lewis, I. A. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00553-4 · Cited by 19

The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: Multiple sclerosis as a model

Hoffman, K. R., Brownell, Z., Doyle, W. J., & Ochoa‐Repáraz, J. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102957 · Cited by 20

Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential

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Predictive modeling of aryl hydrocarbon receptor (AhR) agonism

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Intestinal interplay of quorum sensing molecules and human receptors

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