Mechanisms of hypoxia signalling: new implications for nephrology

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

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Hypoxia-inducible factors in physiology and medicine

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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A conserved family of prolyl-4-hydroxylases that modify HIF

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Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway

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Oxygen sensing by HIF hydroxylases

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

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PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

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Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

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Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

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HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

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HIF transcription factors, inflammation, and immunity

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Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

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Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

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Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

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Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

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Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

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Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

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Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

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Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma

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Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

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HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

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Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

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HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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Regulation of erythropoiesis by hypoxia-inducible factors

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Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs

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Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

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Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

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Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

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Dynamic DNA methylation across diverse human cell lines and tissuesPreprint

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High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

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Targeting renal cell carcinoma with a HIF-2 antagonist

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

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Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasisPreprint

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Tumour hypoxia causes DNA hypermethylation by reducing TET activity

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Cellular and molecular mechanisms in kidney fibrosis

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Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

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Reactive Oxygen Species Activate the HIF-1α Promoter Via a Functional NFκB Site

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SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia

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The interplay between MYC and HIF in cancer

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JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

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Expression of Hypoxia-Inducible Factor-1α and -2α in Hypoxic and Ischemic Rat Kidneys

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

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Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

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Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

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HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

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HIF activation identifies early lesions in VHL kidneys

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Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

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Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition

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On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

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Oxygen Gradients in the Microcirculation

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Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

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Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

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Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response

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Genetic and Functional Studies Implicate HIF1 α as a 14q Kidney Cancer Suppressor Gene

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Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

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Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

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Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells

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Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2

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Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

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Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

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Identification of the renal erythropoietin-producing cells using transgenic mice

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Hypoxia induces rapid changes to histone methylation and reprograms chromatin

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HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

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