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Decoding myofibroblast origins in human kidney fibrosis
Open accessAbstract
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist 1-3. The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain poorly understood 1,2,4. Here, using single-cell RNA sequencing, we profiled the transcriptomes of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys to map the entire human kidney. This analysis enabled us to map all matrix-producing cells at high resolution, and to identify distinct subpopulations of pericytes and fibroblasts as the main cellular sources of scar-forming myofibroblasts during human kidney fibrosis. We used genetic fate-tracing, time-course single-cell RNA sequencing and ATAC-seq (assay for transposase-accessible chromatin using sequencing) experiments in mice, and spatial transcriptomics in human kidney fibrosis, to shed light on the cellular origins and differentiation of human kidney myofibroblasts and their precursors at high resolution. Finally, we used this strategy to detect potential therapeutic targets, and identified NKD2 as a myofibroblast-specific target in human kidney fibrosis.
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“Recent studies have implicated a range of mesenchymal progenitor cells (MPs) in the initiation and propagation of fibrosis28–30.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [30]
Experimental — accuracy not yet measuredIn the citing paper
“For example, fatty acids amplify the inflammatory response by interacting with transcription factors such as HNF4α and TLRs.155,156”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [156]
In the citing paper
“Fibroblasts, in addition to displaying significant functional heterogeneity, are capable of remarkable degrees of plasticity and phenotype switching during progression and regression of fibrosis30,35,36.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [30]
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Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
Fast unfolding of communities in large networks
Blondel, V. D., Guillaume, J.-L., Lambiotte, R., & Lefebvre, E. (2008) · Journal of Statistical Mechanics: Theory and Experiment · doi:10.1088/1742-5468/2008/10/p10008 · Cited by 21,424
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700
Research works printed but not linked: 2
- Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202–1214 (2015). · DOI · Paper page
- Bushnell, B. BBMap: a Fast, Accurate, Splice-Aware Aligner https://www.osti.gov/biblio/1241166 (2014).
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Items 301–400 of 770
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Shao, X., Yu, L., Li, C., Qian, J., Yang, X., Yang, H., Liao, J., Fan, X., Xu, X., & Fan, X. (2025) · Genome biology · doi:10.1186/s13059-025-03566-x · Cited by 17
Tuleta, I., & Frangogiannis, N. G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00403.2025 · Cited by 16
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Bell, P. T., & Belz, G. T. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01268-4 · Cited by 19
Chang, Y.-T., Chung, M., Chang, C.-H., Chiu, K.-H., Shieh, J., & Wu, M. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2088809 · Cited by 15
Wu, X., Miao, X., Guo, Y., Shao, T., Tang, S., Lin, Y., Xu, Y., Li, N., & Zhang, T. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121412 · Cited by 16
Self-citationKato, M. V., Chen, Z., Das, S., Wu, X., Wang, J., Li, A., Chen, W., Tsark, W. M. K., Tunduguru, R., Lanting, L. L., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1204124 · Cited by 15
Sarkaria, S. M., Zhou, J., Bao, S., Zhao, W., Fang, Y., Que, J., Bhagat, G., Zhang, C., & Ding, L. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.05.002 · Cited by 14
Ito, H., Hirose, T., Sato, S., Takahashi, C., Ishikawa, R., Endo, A., Kamada, A., Oba‐Yabana, I., Kimura, T., Murakami, K., et al. (2023) · Hypertension Research · doi:10.1038/s41440-023-01451-3 · Cited by 15
Goff, S. V., Tessier, A., Napoli, M., Dieryckx, C., Bauer, J., Dussoyer, M., Lagoutte, P., Peyronnel, C., Essayan, L., Kleiser, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43401-0 · Cited by 15
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Goligorsky, M. S. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00526.2023 · Cited by 15
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Yoon, B., Kim, H., Jung, S. W., & Park, J. (2024) · Kidney International · doi:10.1016/j.kint.2024.01.045 · Cited by 14
Wang, Y. L., Jiang, Y., Ni, G., Li, S., Balderson, B., Zou, Q., Liu, H., Jiang, Y., Sun, J., & Ding, X. (2024) · Advanced Science · doi:10.1002/advs.202306703 · Cited by 16
Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells
Sahu, R. K., Xavier, S., Chauss, D., Wang, L., Chew, C., Taylor, R. P., Stallcup, W. B., Ma, J. Z., Kazemian, M., Afzali, B., et al. (2022) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00404.2021 · Cited by 15
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al-Harran, S. A. S. (1990) · Durham e-Theses (Durham University) · Cited by 15
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Self-citationHu, H., Zhang, J., Li, Y., Ding, J., Chen, W., & Guo, Z. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.719980 · Cited by 14
Quatredeniers, M., Serafin, A. S., Benmerah, A., Rausell, A., Saunier, S., & Viau, A. (2023) · Scientific Data · doi:10.1038/s41597-023-02209-9 · Cited by 15
Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects
Zhang, Y., Chen, S., Tian, Y., & Fu, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1407261 · Cited by 16
Raspberry ameliorates renal fibrosis in rats with chronic kidney disease via the PI3K/Akt pathway
Hu, J., Pang, X., Liang, X., Shao, X., Xia, Q., Sun, J., Wang, Y., Wang, G., Li, S., Zha, L., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156589 · Cited by 14
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Xu, J., Wang, Y., Gomez-Salazar, M. A., Hsu, G. C., Negri, S., Li, Z., Hardy, W. R., Ding, L., Péault, B., & James, A. W. (2021) · Stem Cells · doi:10.1002/stem.3436 · Cited by 14
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Spurlin, J. W., Garis, M. R., & Lwigale, P. Y. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00232-9 · Cited by 13
Wang, L.-F., Zha, H., Huang, J., & Shi, L. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5313 · Cited by 13
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Self-citationChen, S., Li, J., Ye, L., Zhang, M., Qiu, Z., Liu, S., Wang, H., Zhu, Y., Song, S., Hou, X., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07154-y · Cited by 13
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Zhao, Y. F., Jia, Q., Hao, G., Lin, H., Gao, Y., Zhang, X., Yan, Z., Li, B., Wu, Y., Zhang, B., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1491315 · Cited by 13
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Arroyo, E. M. P., Yassini, N., Sakiri, E., Russo, G., Bourgeois, S., Mohebbi, N., Amann, K., Joller, N., Wagner, C. A., & Silva, P. H. I. (2022) · Clinical Science · doi:10.1042/cs20220095 · Cited by 13
Fang, C.-Y., Chen, S.-H., Huang, C.-C., Liao, Y., Chao, S., & Yu, C. (2022) · Pharmaceuticals · doi:10.3390/ph15070833 · Cited by 13
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Hotait, Z. S., Cascio, J. N. L., Choos, E. N. D., & Shepard, B. D. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00225.2022 · Cited by 13
Gunawardhana, K. L., Hong, L., Rugira, T., Uebbing, S., Kucharczak, J., Mehta, S. S., Karunamuni, D. R., Cabrera‐Mendoza, B., Gandotra, N., Scharfe, C., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci160036 · Cited by 13
Dai, R., Cheng, M., Peng, C.-Y., Cao, Z.-P., Jin, H., Wang, D., Wang, Y., & Zhang, L. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04338-x · Cited by 12
Breaking the fibrotic code: Nanotechnology-driven advances in renal fibrosis therapy
Liu, M., Li, X., Gao, Y., Wei, Z., Ma, J., Zhang, X., Zhang, X., Chen, K., & Liu, T. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123738 · Cited by 17
Self-citationXu, C., Liu, S., Yang, F., Zhang, K., Li, Y., Zhao, X., Zhang, J., Lu, T., Lu, S., Jiang, Y., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202101441r · Cited by 12
Chen, W., Xu, D., Liu, Q., Wu, Y., Wang, Y., & Yang, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114697 · Cited by 12
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Matsushita, K., Toyoda, T., Akane, H., Morikawa, T., & Ogawa, K. (2023) · Journal of Toxicologic Pathology · doi:10.1293/tox.2023-0111 · Cited by 12
Pellowe, A. S., Wu, M. J., Kang, T.-Y., Chung, T. D., Ledesma-Mendoza, A., Herzog, E. L., Levchenko, A., Odell, I. D., Varga, J., & Gonzalez, A. L. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.02.021 · Cited by 12
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Zhang, F., Hu, Z., Jacob, A., Brenner, M., & Wang, P. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01071-2 · Cited by 12
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Ma, M., Luo, Q., Chen, L., Liu, F., Yin, L., & Guan, B. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04103-5 · Cited by 13
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Inoue, T. (2021) · Clinical and Experimental Nephrology · doi:10.1007/s10157-021-02062-3 · Cited by 12
Shaw, I., O'Sullivan, E. D., Pisco, A. O., Borthwick, G., Gallagher, K., Péault, B., Hughes, J., & Ferenbach, D. A. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0392 · Cited by 12
Fu, H., Gui, Y., Liu, S., Wang, Y., Bastacky, S., Qiao, Y., Zhang, R., Bonin, C. P., Hargis, G. R., Yu, Y., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103112 · Cited by 12
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Ji, F., Liu, Y., Shi, J., Liu, C., Fu, S., Wang, H., Ren, B., Mi, D., Gao, S., & Sun, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.916045 · Cited by 12
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Zhang, F., Fan, L., Zhang, H., Huang, W., Sun, D., Pan, B., Wan, X. H., & Cao, C. (2021) · Journal of Immunology Research · doi:10.1155/2021/5521051 · Cited by 12
Tuechler, N., Burtscher, M. L., Garrido‐Rodríguez, M., Khan, M. M., Türei, D., Tischer, C., Kaspar, S., Schwarz, J., Stein, F., Rettel, M., et al. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00116-2 · Cited by 14
Self-citationPietilä, R. S., Marks, A. M., He, L., Nanavazadeh, S., Quaggin, S. E., Betsholtz, C., & Jeansson, M. (2025) · Journal of Clinical Investigation · doi:10.1172/jci190286 · Cited by 12
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Wu, Z., Lohmöller, J., Kuhl, C. K., Wehrle, K., & Jankowski, J. (2023) · Circulation Research · doi:10.1161/circresaha.123.321765 · Cited by 12
Shen, J., Liang, J., Rejiepu, M., Ma, Z., Zhao, J., Li, J., Zhang, L., Yuan, P., Wang, J., & Tang, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-55613-5 · Cited by 11
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Self-citationLi, Z., Jiang, J., Cai, K., Qiao, Y., Zhang, X., Wang, L., Kang, Y., Wu, X., Zhao, B., Wang, X., et al. (2025) · Bone Research · doi:10.1038/s41413-025-00400-9 · Cited by 11
Self-citationThe kidney stroma in development and disease
Fusco, A. N., Oxburgh, L. H., & Carroll, T. J. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00985-8 · Cited by 11
Ma, J., Huang, Y., Chen, J., Li, Y., Yao, R., Li, X., Liang, Q., Chen, X., Peng, C., Liu, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64447-2 · Cited by 13
Self-citationGerrits, T., Brouwer, I. J., Dijkstra, K. L., Wolterbeek, R., BRUIJN, J. A., Scharpfenecker, M., & Baelde, H. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010646 · Cited by 11
Noonin, C., Itsaranawet, T., & Thongboonkerd, V. (2023) · European journal of medical research · doi:10.1186/s40001-023-01109-3 · Cited by 11
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Wu, M., Jin, Q., Xu, X., Fan, J., Chen, W., Miao, M., Gu, R., Zhang, S., Guo, Y., Huang, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202301753 · Cited by 11
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Jiang, M., Chen, H., & Guo, G. (2021) · Kidney Diseases · doi:10.1159/000517130 · Cited by 12
Chromatin-accessibility estimation from single-cell ATAC data with scOpenPreprint
Li, Z., Kuppe, C., Ziegler, S., Cheng, M., Kabgani, N., Menzel, S., Zenke, M., Kramann, R., & Costa, I. G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/865931 · Cited by 10
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Liu, Y., Ma, Y.-H., Yang, J.-W., Man, J.-W., Wang, H.-B., Li, Y., Liang, C., Cao, J., Chen, S., Li, K.-P., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110834 · Cited by 12
Yang, X., Delsante, M., Daneshpajouhnejad, P., Fenaroli, P., Mandell, K. A. P., Wang, X., Takahashi, S., Halushka, M. K., Kopp, J. B., Levi, M., et al. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.100336 · Cited by 12
Shao, X., Xu, H., Kim, H., ljaz, S., Beier, F., Jankowski, V., Lellig, M., Vankann, L., Werner, J. N., Chen, L., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02131-y · Cited by 11
Self-citationNew approaches to acute kidney injury
Noel, S., Kapoor, R., & Rabb, H. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae265 · Cited by 10
Cheuk, Y. C., Xu, S., Zhu, D., Luo, Y., Chen, T., Chen, J., Li, J., Shi, Y., Zhang, Y., & Rong, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.817402 · Cited by 11
Badal, S. S., Tuhaifi, T. A., Yu, Y., Lopez, D., Plato, C. F., Joly, K. M., Breckenridge, D. G., Yang, H., Liles, J. T., & Fogo, A. B. (2022) · Kidney360 · doi:10.34067/kid.0001032022 · Cited by 10
Buscher, K., Heitplatz, B., Marck, V. V., Song, J., Loismann, S., Rixen, R., Hüchtmann, B., Kurian, S. M., Ehinger, E., Wolf, D., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020121685 · Cited by 11
Ledru, N., Wilson, P. C., Muto, Y., Yoshimura, Y., Wu, H., Asthana, A., Tullius, S. G., Waikar, S. S., Orlando, G., & Humphreys, B. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.29.522232 · Cited by 10
Zhen, X., Sun, Y., Lin, H., Huang, Y., Liu, T., Li, Y., & Peng, H. (2023) · PeerJ · doi:10.7717/peerj.16301 · Cited by 9
PCPE-2 (procollagen C-proteinase enhancer-2): The non-identical twin of PCPE-1
Napoli, M., Bauer, J., Bonod‐Bidaud, C., Goff, S. V., & Moali, C. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.09.001 · Cited by 11
Shang, Y., Wang, Z., Yang, F., Wang, W., Tang, Q., Guo, X., Du, X., Zhang, X., Hao, J., & Lin, H. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00994-6 · Cited by 9
Self-citationGlobal trends and prospects related to macrophage in chronic kidney disease: a bibliometric analysis
Hu, Y., Wang, Y., Hong, H., Chen, Y.-X., Zhou, Q.-Y., Zhu, G., Tang, J., Liu, W., & Wang, L. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2423846 · Cited by 9
Li, H., Li, P., Shen, Q., Zhu, Z., Yang, M., Zhang, X., Yang, M., Weigan, S., & Gong, W. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167741 · Cited by 10
Self-citationJafree, D. J., Perera, C., Ball, M., Tolomeo, D., Pomeranz, G., Wilson, L., Davis, B. M., Mason, W. J., Funk, E. M., Kolatsi‐Joannou, M., et al. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052024 · Cited by 10
Li, B., Qi, J., Cao, Y., Long, Y., Wei, Z., Wang, W., Hu, S., Wang, Y., Zhu, Q., Hu, X. J., et al. (2025) · Advanced Science · doi:10.1002/advs.202411752 · Cited by 10
The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis
Düsing, P., Göbel, I., Ackerschott, A., Reese, L., Giavalisco, P., Dethloff, F., Niepmann, S. T., Stei, M., Beiert, T., Zimmer, S., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf106 · Cited by 9
Connexin mRNA distribution in adult mouse kidneys
Geis, L., Boudriot, F.-F., & Wagner, C. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02608-0 · Cited by 9
Isolation and characterization of peritoneal microvascular pericytes
Tang, L., Shi, J., Yu, M., Shan, Y., Juan, Z., & Sheng, M. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13386 · Cited by 9
Yucha, S. E. V., Quackenbush, D., Chu, T., Lo, F., Sutherland, J. J., Kuzu, G., Roberts, C., Luna, F., Barnes, S. W., Walker, J. R., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277937 · Cited by 9
Wang, H., Li, M., Fei, L., Xie, C., Ding, L., Zhu, C., Zeng, F., & Liu, N. (2023) · Transplantation Proceedings · doi:10.1016/j.transproceed.2022.12.002 · Cited by 9
Bode, M., Herrnstadt, G. R., Dreher, L., Ehnert, N., Kirkerup, P., Lindenmeyer, M. T., Meyer‐Schwesinger, C., Ehmke, H., Köhl, J., Huber, T. B., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21599 · Cited by 9
Self-citationPregizer, S. K., Vreven, T., Mathur, M., & Robinson, L. N. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1176856 · Cited by 9
Shirbaghaee, Z., Sorenson, C. M., & Sheibani, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115333 · Cited by 8
Emerging therapeutic pipelines on kidney fibrosis: challenges in translational research
Granata, S., Barberio, L., D’Agostino, R., Sorace, F., Leone, F., Pellegrino, D., Stallone, G., Provenzano, M., & Zaza, G. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07796-w · Cited by 8
Wang, M., Ji, C., Zhang, Y., Zhang, Z., Zhang, Y., Guo, H., Qiao, N., Zhou, X., Cao, X., Ye, Z., et al. (2022) · Endocrine · doi:10.1007/s12020-022-03155-z · Cited by 8
Metadata
- Authors
- Kuppe, C., Ibrahim, M. M., Kranz, J., Zhang, X., Ziegler, S., Perales-Patón, J., Jansen, J., Reimer, K. C., Smith, J. R., Dobie, R., Wilson-Kanamori, J. R., Halder, M., Xu, Y., Kabgani, N., Kaesler, N., Klaus, M., Gernhold, L., Puelles, V. G., Huber, T. B., Boor, P., Menzel, S., Hoogenboezem, R. M., Bindels, E. M. J., Steffens, J., Floege, J., Schneider, R. K., Saez-Rodriguez, J., Henderson, N. C., & Kramann, R.
- Affiliations
- RWTH Aachen University (DE)
- Sankt-Antonius-Hospital Eschweiler (DE)
- Heidelberg University (DE)
- Radboud University Nijmegen (NL)
- Centre for Inflammation Research (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Erasmus MC Cancer Institute (NL)
- Erasmus MC (NL)
- Corresponding author
- Kramann, Rafael
- ORCID
- Kuppe, Christoph
- Ibrahim, Mahmoud M.
- Kranz, Jennifer
- Zhang, Xiaoting
- Ziegler, Susanne
- Perales-Patón, Javier
- Jansen, Jitske
- Reimer, Katharina C.
- Smith, James R.
- Dobie, Ross
- Wilson-Kanamori, John R.
- Halder, Maurice
- Kaesler, Nadine
- Klaus, Martin
- Puelles, Victor G.
- Huber, Tobias B.
- Boor, Peter
- Hoogenboezem, Remco M.
- Bindels, Eric M. J.
- Floege, Jürgen
- Schneider, Rebekka K.
- Saez-Rodriguez, Julio
- Henderson, Neil C.
- Kramann, Rafael
- Venue
- Nature
- Published
- 2020-11-11
- Volume
- 589
- Issue
- 7841
- Pages
- 281-286
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7611626
- OpenAlex
- W3104014715
- Cited by
- 769
- References
- 86
- Citations by year
- 2026: 147 · 2025: 128 · 2024: 148 · 2023: 139 · 2022: 115 · 2021: 87 · 2020: 3
- FWCI
- 54.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
- Funders
- European Hematology Association
- Wellcome Trust (219542/Z/19/Z, 104366/Z/14/Z)
- British Heart Foundation (RM/17/3/33381, RE/18/5/34216)
- Deutsche Forschungsgemeinschaft (TRR57, SFBTRR219, BO3755/3‐1, TRR219, CRC 1192, SFB‐TRR57, SCHN 1188/5-1, BO3755/6-1, CRU344)
- Bundesministerium für Bildung und Forschung (01GM1901A, STOP‐FSGS 01GM1901A)
- Else Kröner-Fresenius-Stiftung
- RWTH Aachen University (SFBTRR219, O3-11)
- Medical Research Council
- H2020 European Research Council (677448)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- renal fibrosis, myofibroblast origin, chronic kidney disease, pericytes, fibroblasts, proximal tubule, NKD2, cell fate tracing, single-cell transcriptomics, spatial transcriptomics, ATAC-seq
- MeSH terms
- RNA-Seq, Animals, Calcium-Binding Proteins, Cell Differentiation, Extracellular Matrix, Female, Fibroblasts, Fibrosis, Humans, Kidney Tubules, Male, Mesoderm, Case-Control Studies, Cell Lineage, Pericytes, Receptor, Platelet-Derived Growth Factor alpha, Receptor, Platelet-Derived Growth Factor beta, Adaptor Proteins, Signal Transducing, Mice, Renal Insufficiency, Chronic, Myofibroblasts, Single-Cell Analysis, Transcriptome
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