Cited by 308Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsMultiple Sclerosis Research Studies

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The identity and function of microglia in neurodegeneration

Song, Wilbur M., Colonna, Marco·2018·Nature Immunology

DOI 10.1038/s41590-018-0212-1

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Abstract

The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activated cells have been called 'degeneration- or disease-associated microglia' (DAM). These activated microglia can perform different functions and exert both positive effects and negative effects in different mouse disease models. In humans, mutations in genes expressed in microglia are linked to various neurodegenerative diseases. Here we provide an overview of the common microglial response to neurodegeneration and key contributing pathways; delineate the multifaceted functions of activated microglia spanning various diseases; and discuss insights from the study of human disease-associated genes. We argue that strong evidence from both mouse models and human genetics causally links the function of activated microglia to neurodegeneration.

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Self-citation

Authors: Song, W. M., & Colonna, M.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Colonna, Marco
ORCID: Song, Wilbur M.
Colonna, Marco
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2018-09-24
Volume: 19
Issue: 10
Pages: 1048-1058
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/s41590-018-0212-1
OpenAlex: W2891888347
Semantic Scholar: 56fd070c6693804f7ada07ce3ee33529dfa55dbf
Cited by: 308
References: 178
Citations by year: 2026: 21 · 2025: 28 · 2024: 37 · 2023: 49 · 2022: 53 · 2021: 42 · 2020: 42 · 2019: 33 · 2018: 3
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: microglia, neurodegeneration, disease-associated microglia, microglial activation, tissue-resident macrophages, microglial morphology, neurodegenerative disease models, microglial function
MeSH terms: Animals, Humans, Microglia, Neurodegenerative Diseases

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The identity and function of microglia in neurodegeneration

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