T cells in COVID-19 — united in diversity
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The shared target genes and pathways in corresponding cells were previously shown related to death from COVID-19.
“The shared target genes and pathways in corresponding cells were previously shown related to death from COVID-1957–60.”
From ASGARD is a single-cell guided pipeline to aid repurposing of drugs (2023) · cites this paper as [59]
Neutrophil, NK cell, T cell, and monocyte play an important role in COVID-19-related death.
“The population of neutrophil, NK cell, T cell, and monocyte increased in deceased severe COVID patients compared to the cured ones, suggesting the important role of these four types of cells in COVID-19-related death57–60 (Fig. 6b).”
From ASGARD is a single-cell guided pipeline to aid repurposing of drugs (2023) · cites this paper as [59]
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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
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SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
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SARS-CoV-2 infection protects against rechallenge in rhesus macaques
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Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19
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Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19
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Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
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ASGARD is a single-cell guided pipeline to aid repurposing of drugs
He, B., Xiao, Y., Liang, H., Huang, Q., Du, Y., Li, Y., Garmire, D., Sun, D., & Garmire, L. X. (2023) · Nature Communications · doi:10.1038/s41467-023-36637-3 · Cited by 57 · see citing works
- Authors
- Swadling, L., & Maini, M. K.
- Affiliations
- University College London (GB)
- Corresponding author
- Maini, Mala K.
- Venue
- Nature Immunology
- Published
- 2020-09-07
- Volume
- 21
- Issue
- 11
- Pages
- 1307-1308
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W3083285583
- Cited by
- 77
- References
- 13
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 17 · 2022: 20 · 2021: 25 · 2020: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, T cell response, CD4+ T cells, CD8+ T cells, T cell receptor repertoire, epitope mapping, antibody response, disease severity
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, United Kingdom, Humans, Pneumonia, Viral, CD4-Positive T-Lymphocytes, Coronavirus Infections, CD8-Positive T-Lymphocytes, Severe acute respiratory syndrome-related coronavirus, Pandemics
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