The DOI matches its Crossref record; 60 of the 65 references it cites were found in a registry or an index.
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Open accessAbstract
Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phenotypic changes in patients with early/active RA, treatment-refractory/active RA and RA in sustained remission. Each clinical state was characterized by different frequencies of nine discrete phenotypic clusters within four distinct STM subpopulations with diverse homeostatic, regulatory and inflammatory functions. This cellular atlas, combined with deep-phenotypic, spatial and functional analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulations (MerTK pos TREM2 high and MerTK pos LYVE1 pos) with unique remission transcriptomic signatures enriched in negative regulators of inflammation. These STMs were potent producers of inflammation-resolving lipid mediators and induced the repair response of synovial fibroblasts in vitro. A low proportion of MerTK pos STMs in remission was associated with increased risk of disease flare after treatment cessation. Therapeutic modulation of MerTK pos STM subpopulations could therefore be a potential treatment strategy for RA.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, this phenotype is not unique to the fibrotic liver, also being identified in other tissues in the context of sterile injury (32, 33, 38, 110–121) as well as in macrophages surrounding the bile duct in the healthy liver (62).”
From Targeting macrophages in liver fibrosis (2026) · cites this paper as [115]
Citations
Cites
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Self-citationFinak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159
Smolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,553
Self-citationSingle-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377
Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372
Self-citation
Research works printed but not linked: 1
- Firestein, G. S., Gabriel, S. E., McInnes, I. B. & O’Dell, J. R. Kelley and Firestein’s Textbook of Rheumatology 2nd edn (Elsevier, 2016).
Cited by
Sorted by citations
Items 201–300 of 777
Hoffmann, M. H., Kirchner, H., Krönke, G., Riemekasten, G., & Bonelli, M. M. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224092 · Cited by 25
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis
Yang, X., Rong, K., Fu, S., Yang, Y., Liu, S., Zhang, C., Xu, K., Zhang, K., Zhu, Y., Hao, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59579-4 · Cited by 28
An update on novel therapeutic intervention in Rheumatoid arthritis
Shah, P., Siddique, A., Thakkar, A. P., Gharat, S., Godad, A. P., Kale, P. P., & Doshi, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108794 · Cited by 24
Li, Q., Hu, Y.-Z., Gao, S., Wang, P., Hu, Z., & Dai, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155333 · Cited by 24
Huang, D., Jiao, X., Huang, S., Liu, J., Si, H., Qi, D., Pei, X., Lu, D., Wang, Y., & Li, Z. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.06.005 · Cited by 23
The double-edged role and therapeutic potential of TREM2 in atherosclerosis
Zhu, B., Liu, Y., & Peng, D. (2024) · Biomarker Research · doi:10.1186/s40364-024-00675-w · Cited by 28
Renal Mononuclear Phagocytes in Lupus Nephritis
Davidson, A. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11269 · Cited by 22
JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation
Nyirenda, M. H., Nijjar, J. S., Frleta‐Gilchrist, M., Gilchrist, D. S., Porter, D. R., Siebert, S., Goodyear, C. S., & McInnes, I. B. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002671 · Cited by 23
Self-citationNon-genetic Heterogeneity of Macrophages in Diseases—A Medical Perspective
Gessain, G., Blériot, C., & Ginhoux, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613116 · Cited by 24
Khawaja, G., El-Orfali, Y., Shoujaa, A., & Najem, S. A. (2024) · Pharmaceuticals · doi:10.3390/ph17070963 · Cited by 26
Building a modular and multi-cellular virtual twin of the synovial joint in Rheumatoid Arthritis
Zerrouk, N., Augé, F., & Niarakis, A. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01396-y · Cited by 23
Cellular characterisation of advanced osteoarthritis knee synovium
Mimpen, J. Y., Hedley, R., Ridley, A., Baldwin, M. J., Windell, D., Bhalla, A., Ramos‐Mucci, L., Buckley, C. D., Coles, M. C., Alvand, A., et al. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03110-x · Cited by 22
Self-citationPredicting best treatment in rheumatoid arthritis
Lewis, M. (2023) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2023.152329 · Cited by 22
Self-citationScallan, J. P., Bouta, E. M., Rahimi, H., Kenney, H. M., Ritchlin, C. T., Davis, M. J., & Schwarz, E. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.745096 · Cited by 22
Two distinct resident macrophage populations coexist in the ovary
Li, N., Li, Z., Fang, F., Zhu, C., Zhang, W., Lu, Y., Zhang, R., Si, P., Bian, Y., Qin, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007711 · Cited by 22
Gaigeard, N., Cardon, A., Goff, B. L., Guicheux, J., & Boutet, M. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104187 · Cited by 22
New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology
Sandhu, G., & Thelma, B. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.834247 · Cited by 21
Shao, Y., Liu, Y., Liu, Y., Zhu, S., Wu, J., Ma, K., GuoQi, L., Huang, S., Wen, H., Zhang, C., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00392-x · Cited by 23
Current understanding on TREM-2 molecular biology and physiopathological functions
Bharadwaj, S., Groza, Y., Mierzwicka, J. M., & Malý, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112042 · Cited by 23
Zhang, X., Fu, X., Chen, W., Chen, P., Zhu, H. L., Yang, B., Liang, J., & Zeng, F. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03388-w · Cited by 24
Efferocytosis and Its Role in Rheumatic Diseases
Tang, X., Peng, Y., Jiang, Z., Yu, B., Peng, D., Xie, X., Li, F., & Ge, Y. L. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43268 · Cited by 21
Pistorius, K., Ly, L., Souza, P. R., Gómez, E. A., Koenis, D. S., Rodrı́guez, A. R., Foster, J., Sosabowski, J. K., Hopkinson, M., Rajeeve, V., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103974 · Cited by 20
Self-citationFriščić, J., Reinwald, C., Böttcher, M., Houtman, M., Euler, M., Chen, X., Walker, K., Kirchner, P., Zhu, H., Wirth, B., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42378 · Cited by 21
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
Triaille, C., Tilman, G., Sokolova, T., Loriot, A. E., Marchandise, J., Montjoye, S. D., Toukap, A. N., de Bellefon, L. M., Bouzin, C., Galant, C., et al. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224068 · Cited by 20
Liu, Q., Yan, X., Yuan, Y., Li, R., Zhao, Y., Fu, J., Wang, J., & Su, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031577 · Cited by 23
Wang, L., Zhang, L., Chen, F., Li, Q., Zhu, B., Tang, Y., Yang, Z., Cheng, C., Qiu, L., & Ma, L. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04000 · Cited by 20
Tenascin-C promotes bone regeneration via inflammatory macrophages
Ren, Q., Xing, W., Jiang, B., Feng, H., Hu, X., Suo, J., Wang, L., & Zou, W. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-024-01429-9 · Cited by 24
Miyamoto, A. T., Shimagami, H., Kumanogoh, A., & Nishide, M. (2025) · Inflammation and Regeneration · doi:10.1186/s41232-025-00369-2 · Cited by 23
Zhang, Z., Liu, Y., Liang, X., Wang, Q., Xu, M., Yang, X., Tang, J., He, Y., He, Y., Zhang, D., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.043 · Cited by 19
Cui, Y., Feng, Z., Zhao, Q., Dai, H., Yang, Z., Rui, H., & Liu, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1713148 · Cited by 20
Innate immune memory: The evolving role of macrophages in therapy
Damani‐Yokota, P., & Khanna, K. M. (2025) · eLife · doi:10.7554/elife.108276 · Cited by 22
Huang, T., Takashima, Y., Kumar, J., Morales, J., Le, K., Hu, Z., Rubino, S., Trousdale, R. T., Berry, G. J., Goronzy, J. J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.019 · Cited by 24
Xu, H., Li, C., Li, Z., Zhang, L., Wang, G., Xie, R., Jiang, Y., Yuan, Y., & Nie, H. (2021) · Immunology · doi:10.1111/imm.13351 · Cited by 19
Prediction of treatment response: Personalized medicine in the management of rheumatoid arthritis
Wei, M., & Chu, C. (2022) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2021.101741 · Cited by 19
Li, L., Wang, X., Gao, R.-Y., Zhang, B., Liu, Y. L., Zhou, J., Fu, L., & Wang, J. (2022) · Advanced Science · doi:10.1002/advs.202105188 · Cited by 19
Tissue microenvironment dictates inflammation and disease activity in rheumatoid arthritis
Cheng, C., Liao, H., & Wu, C. (2022) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2022.01.026 · Cited by 19
Malange, K. F., Pelaez, J. M. N., Dias, E. V., Lemes, J. B. P., Choi, S., dos Santos, G. G., Yaksh, T. L., & Corr, M. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.1018800 · Cited by 22
Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection
Ciaffaglione, V., & Rizzarelli, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216209 · Cited by 21
Ohashi, Y., Uchida, K., Fukushima, K., Satoh, M., Koyama, T., Tsuchiya, M., Saito, H., Uchiyama, K., Takahira, N., Inoue, G., et al. (2021) · Journal of Orthopaedic Research® · doi:10.1002/jor.25157 · Cited by 19
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis
Zhang, Y., He, X., Yin, D., & Zhang, Y. (2024) · Aging and Disease · doi:10.14336/ad.2024.0514 · Cited by 21
Resolution of inflammation during rheumatoid arthritis
Ye, X., Ren, D., Chen, Q., Shen, J., Wang, B., Wu, S., & Zhang, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1556359 · Cited by 23
Laouteouet, D., Bortolotti, O., Marinèche, L., Hannemann, N., Chambon, M., Glasson, Y., Dumé, A., Lima, J. D., Fournial, M., Touchet, D., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43299 · Cited by 20
Inappropriate treatment response to DMARDs: A pathway to difficult-to-treat rheumatoid arthritis
Guo, H., Li, L., Liu, B., Lu, P., Cao, Z., Ji, X., Li, L., Ouyang, G., Nie, Z., Lü, A., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110655 · Cited by 18
Wu, X., Guo, H., Gao, H., Li, Y., Hu, X., Kowalke, M. A., Li, Y., Wei, Y., Zhao, J., Auger, J. L., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.02.040 · Cited by 17
Mechanism of action of Nrf2 and its related natural regulators in rheumatoid arthritis
Ma, K., Miao, L., Li, B., Yu, W., Liu, F., Liu, K., Li, Y., Huang, C., & Yang, Z. G. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05221-w · Cited by 20
GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica
Jiemy, W. F., Zhang, A., Abdulahad, W. H., Reitsema, R. D., van Sleen, Y., Sandovici, M., Alegria, G. C., Cornec, D., Devauchelle‐Pensec, V., Hémon, P., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.01.004 · Cited by 17
Pan, T., Gao, W., Song, Z., Long, D.-D., Cao, P., Hu, R. M., Chen, D., Zhou, W., Jin, Y., Hu, S., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.021 · Cited by 17
Insights Into the Concept of Rheumatoid Arthritis Flare
Cassione, E. B., Grignaschi, S., Xoxi, B., Luvaro, T., Greco, M. I., Mazzucchelli, I., Bugatti, S., Montecucco, C., & Manzo, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.852220 · Cited by 17
Sang, Y., Li, Y., Xu, L., Chen, J., Li, D., & Du, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1045532 · Cited by 19
Tissue-resident, extravascular Ly6c− monocytes are critical for inflammation in the synovium
Montgomery, A. B., Chen, S. Y., Wang, Y., Gadhvi, G. T., Mayr, M. G., Cuda, C. M., Dominguez, S. T., Makinde, H. M., Gurra, M. G., Misharin, A. V., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112513 · Cited by 17
Self-citationImmunomodulatory Nanoparticles for Modulating Arthritis Flares
Johnson, W. T., McBride, D. A., Kerr, M., Nguyen, A., Zoccheddu, M., Bollmann, M., Wei, X., Jones, R. M., Wang, W., Svensson, M. N. D., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c05298 · Cited by 17
Macrophage re-programming by JAK inhibitors relies on MAFB
López-Navarro, B., Simón‐Fuentes, M., Ríos, I., Schiaffino, M. T., Sánchez, A., Torres‐Torresano, M., Nieto‐Valle, A., Castrejón, I., & Puig‐Kröger, A. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05196-1 · Cited by 20
Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function
Malany, K., Li, X., Vogel, C. F. A., & Ehrlich, A. K. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae050 · Cited by 18
Immune tolerance therapies for autoimmune diseases: Shifting the goalpost to cure
Sharkey, P., & Thomas, R. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102242 · Cited by 18
Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis
Wang, Q., Ji, J., Huang, D., & Gao, C. (2025) · BME Frontiers · doi:10.34133/bmef.0102 · Cited by 18
Wang, L., Hao, M., Xu, Y., Wang, Z., Xie, H., Zhang, B., Zhang, X., Lin, J., Sun, X., Wang, J., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04144-5 · Cited by 16
Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain
Oggero, S., Voisin, M.-B., Picco, F., Huerta, M. Á., Cecconello, C., Burgoyne, T., Perretti, M., & Malcangio, M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2416343122 · Cited by 20
Nikolova‐Ganeva, K., Mihaylova, N., Kechidzhieva, L., Ivanova, K. I., Zarkov, A. S., Parzhanov, D. L., Ivanov, M. M., & Marchev, A. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146813 · Cited by 16
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis
Masuo, Y., Murakami, A., Akamine, R., Iri, O., Uno, S., Murata, K., Nishitani, K., Ito, H., Watanabe, R., Fujii, T., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adt3955 · Cited by 17
Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases
Rao, D. A. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01291-0 · Cited by 19
Gan, P., Wang, R., Deng, R., Wu, H., Bu, Y., Chen, F., Dong, X.-T., & Ke, J.-T. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175271 · Cited by 17
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Fernández, S., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03210-0 · Cited by 16
Zheng, Y., Wang, Y., Qi, B., Lang, Y., Zhang, Z., Ma, J., Lou, M., Liang, X., Chang, Y., Zhao, Q., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1368516 · Cited by 17
Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis
Huynh, N. C., Ling, R., Komagamine, M., Shi, T., Tsukasaki, M., Matsuda, K., Okamoto, K., Asano, T., Muro, R., Pluemsakunthai, W., et al. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00347-0 · Cited by 18
Rheumatoid arthritis: a review of the key clinical features and ongoing challenges of the disease
Matteo, A. D., & Emery, P. (2024) · Panminerva Medica · doi:10.23736/s0031-0808.24.05272-8 · Cited by 16
Ying, Z., Changjun, C., Haocheng, H., Qibin, L., Dailing, C., Teng, L.-S., Xuecheng, S., Gong, M., & Zhang, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113855 · Cited by 19
Liu, H., Li, Q., Chen, Y., Dong, M., Liu, H., Zhang, J., Yang, L., Yin, G., & Xie, Q. (2025) · Arthritis Research & Therapy · doi:10.1186/s13075-025-03481-3 · Cited by 16
Exploring the Role of Macrophages and Their Associated Structures in Rheumatoid Arthritis
Tian, X., Chen, J., Hong, Y., Cao, Y., Xiao, J., & Zhu, Y. (2025) · Journal of Innate Immunity · doi:10.1159/000543444 · Cited by 20
Shen, J., Ma, X., He, Y., Wang, Y., Zhong, T., & Zhang, Y. (2022) · PeerJ · doi:10.7717/peerj.14209 · Cited by 17
Avouac, J., Kay, J., & Choy, E. (2025) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2025.152740 · Cited by 18
Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis
Marzeda, A. M., Schwenzer, A., Didov, B. S., Woolcock, K., Richard, J.-B., Jennings, L. K., Julé, A. M., Yang, N., Davidson, S., Sansom, S. C., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.03.016 · Cited by 15
Self-citationMurakami, A., Akamine, R., Tanaka, S., Murata, K., Nishitani, K., Ito, H., Watanabe, R., Fujii, T., Iwasaki, T., Masuo, Y., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adr3838 · Cited by 15
Wang, Y. Q., Li, Y., Jiang, J., Hong, Y., Gao, S., & Hua, C. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103954 · Cited by 15
Raimondo, M. G., Mohammadian, H., Angeli, M. R., Alivernini, S., Fedorchenko, V., Huang, K., Demmler, R., Rhein, P., Xu, C., Li, Y.-N., et al. (2026) · Nature Immunology · doi:10.1038/s41590-025-02351-z · Cited by 18
Self-citationSustained DMARD-free remission in rheumatoid arthritis – about concepts and moving towards practice
Verstappen, M., & Mil, A. H. M. V. D. H. (2022) · Joint Bone Spine · doi:10.1016/j.jbspin.2022.105418 · Cited by 15
Rouse, J. R., Danner, R., Wahhab, A., Pereckas, M., Nguyen, C. P., McClune, M. E., Steere, A. C., Strle, K., Jutras, B. L., & Lochhead, R. B. (2024) · ACR Open Rheumatology · doi:10.1002/acr2.11710 · Cited by 15
He, Q., Li, R., Yang, H., Li, B., & Zhang, L. (2025) · Small · doi:10.1002/smll.202412491 · Cited by 15
Olsson, A. M., Povoleri, G. A. M., Somma, D., Ridley, M. L., Rizou, T., Lalnunhlimi, S., MacDonald, L., Rajasekhar, M., Martínez-Nuñez, R. T., Kurowska‐Stolarska, M., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab016 · Cited by 14
Self-citationSynovial single-cell heterogeneity, zonation and interactions: a patchwork of effectors in arthritis
Schonfeldova, B., Zec, K., & Udalova, I. A. (2021) · Rheumatology · doi:10.1093/rheumatology/keab721 · Cited by 14
Self-citationTomentosin suppressed M1 polarization via increasing MERTK activation mediated by regulation of GAS6
Di, Y., Bao, Y.-J., Zhu, Z., Sun, S., Tian, F.-X., Wang, F., Yu, G., Zhang, M.-F., Han, J., & Zhou, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116429 · Cited by 14
Metabolite-sensing GPCRs in rheumatoid arthritis
Yang, X., Zhang, W., Wang, L., Zhao, Y., & Wei, W. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.001 · Cited by 14
Zhu, J., Lin, Y., Li, G., He, Y., Su, Z., Tang, Y., Zhang, Y., Xu, Q., Yao, Z., Zhou, H., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.100981 · Cited by 14
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Tang, X., Zhang, Y., Zhang, H., Zhang, N., Dai, Z., Cheng, Q., & Li, Y. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-09001-6 · Cited by 15
Applications of single-cell RNA sequencing in rheumatoid arthritis
Figueiredo, M. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1491318 · Cited by 16
Feng, Y., Tang, Y., Hu, J., Chen, C., Zhong, G., Xiang, C., Chen, N., Bian, J., Shi, S., & Zhang, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141511 · Cited by 14
Stromal cell regulation of inflammatory responses
Friščić, J., & Hoffmann, M. H. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.10.006 · Cited by 13
Inching closer to precision treatment for rheumatoid arthritis
Donlin, L. T. (2022) · Nature Medicine · doi:10.1038/s41591-022-01857-5 · Cited by 14
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04608-9 · Cited by 15
Current state and future directions of basic research in rheumatoid arthritis
Ghang, B., Park, J. K., Ju, J. H., & Han, S. W. (2025) · Journal of Rheumatic Diseases · doi:10.4078/jrd.2024.0151 · Cited by 13
Cai, M., Li, Z., Wen, X., Jin, H., Li, Y., Wu, H., Yang, C., & Chen, Z. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43319 · Cited by 16
Resolution Pharmacology: State-of-the-art and therapeutic landscape
Perretti, M., & Montero‐Melendez, T. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100097 · Cited by 15
Regulation of the innate immune response in rheumatoid arthritis
Muheremu, A., Aierxiding, S., & Gao, J. X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1545625 · Cited by 14
Interleukin-34-regulated T-cell responses in rheumatoid arthritis
Park, H. E., Oh, H., & Baek, J.-H. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1078350 · Cited by 12
Vago, J. P., Valdrighi, N. Y., Blaney‐Davidson, E., Hornikx, D. L. A. H., Neefjes, M., Barba-Sarasua, M. E., Thielen, N. G. M., van den Bosch, M. H. J., van der Kraan, P. M., Koenders, M. I., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16050703 · Cited by 13
Application of Injectable Hydrogels as Delivery Systems in Osteoarthritis and Rheumatoid Arthritis
Zhu, R., Liao, H.-Y., Huang, Y., & Shen, H. (2024) · British Journal of Hospital Medicine · doi:10.12968/hmed.2024.0347 · Cited by 15
Haag, S. M., Xie, S., Eidenschenk, C., Fortin, J., Callow, M. G., Costa, M., Lun, A. T. L., Cox, C., Wu, S. Z., Pradhan, R., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01962-w · Cited by 13
Keskitalo, S., Seppänen, M. R. J., del Sol, A., & Varjosalo, M. T. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.02.011 · Cited by 13
Deng, Z., Yang, W., Zhao, B., Yang, Z., Li, D., & Yang, F. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42881 · Cited by 19
Lee, M. S., Kim, S., Lee, J., Bae, Y., & Lee, S. K. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501471 · Cited by 13
Paoletti, A., Ly, B., Bitoun, S., Nocturne, G., Rivière, É., Manson, J. J., Matucci, A., Pallardy, M. J., de Vries, N., & Xavier Mariette, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.832117 · Cited by 13
Metadata
- Authors
- Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., Attar, M., Gessi, M., Fedele, A. L., Chilaka, S., Somma, D., Sansom, S. N., Filer, A., McSharry, C., Millar, N. L., Kirschner, K., Nerviani, A., Lewis, M. J., Pitzalis, C., Clark, A. R., Ferraccioli, G., Udalova, I., Buckley, C. D., Gremese, E., McInnes, I. B., Otto, T. D., & Kurowska-Stolarska, M.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Arthritis UK (GB)
- Agostino Gemelli University Polyclinic (IT)
- University of Oxford (GB)
- University of Glasgow (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Queen Mary University of London (GB)
- Corresponding author
- Alivernini, Stefano
- ORCID
- Alivernini, Stefano
- MacDonald, Lucy
- Elmesmari, Aziza
- Tolusso, Barbara
- Gigante, Maria Rita
- Petricca, Luca
- Perniola, Simone
- Attar, Moustafa
- Gessi, Marco
- Fedele, Anna Laura
- Chilaka, Sabarinadh
- Somma, Domenico
- Sansom, Stephen N.
- Filer, Andrew
- McSharry, Charles
- Millar, Neal L.
- Kirschner, Kristina
- Nerviani, Alessandra
- Lewis, Myles J.
- Pitzalis, Costantino
- Clark, Andrew R.
- Ferraccioli, Gianfranco
- Udalova, Irina
- Buckley, Christopher D.
- Gremese, Elisa
- McInnes, Iain B.
- Otto, Thomas D.
- Kurowska-Stolarska, Mariola
- Venue
- Nature Medicine
- Published
- 2020-06-29
- Volume
- 26
- Issue
- 8
- Pages
- 1295-1306
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3037615636
- Cited by
- 740
- References
- 65
- Citations by year
- 2026: 143 · 2025: 161 · 2024: 145 · 2023: 106 · 2022: 90 · 2021: 80 · 2020: 14
- FWCI
- 54.63
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.gla.ac.uk
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Funders
- European Hematology Association (TRTH172)
- Kennedy Trust for Rheumatology Research (KENN161704, KENN192004)
- Versus Arthritis (21890, 22253, 22272, 21802)
- Medical Research Council (MR/S025308/1)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, synovial macrophages, macrophage subsets, inflammation, clinical remission, disease flares, tissue repair, macrophage heterogeneity
- MeSH terms
- Mannose Receptor, Arthritis, Rheumatoid, Biopsy, Humans, Inflammation, Joints, Macrophages, Receptors, Cell Surface, Receptors, Immunologic, Synovial Fluid, Synovial Membrane, Cell Lineage, Lectins, C-Type, Mannose-Binding Lectins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review