Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453

2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159

Rheumatoid arthritis

Smolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,553

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339

Tissue-resident macrophages

Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096

S100A8/A9 in Inflammation

Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372

Antibody-sheltered immunological nanonut (AINUT) for rheumatoid arthritis-targeted efficient alleviation

Liu, L., Zhang, Y., Mao, C., Chen, H., Zhang, Y., Wang, J., Fu, C., Lan, X., Wang, W., Liang, X., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101640 · Cited by 13

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation

Flak, M. B., Koenis, D. S., Gonzalez-Nuñez, M., Chopo-Pizarro, A., & Dalli, J. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115348 · Cited by 13

Theaflavin-3,3’-Digallate Ameliorates Collagen-Induced Arthritis Through Regulation of Autophagy and Macrophage Polarization

Zhang, L., Li, W., Hou, Z., Wang, Z., Zhang, W., Liang, X., Wu, Z., Wang, T., Liu, X., Peng, X., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s374802 · Cited by 14

Machine Learning Reveals Synovial Fibroblast Genes Associated with Pain Affect Sensory Nerve Growth in Rheumatoid ArthritisPreprint

Bai, Z., Bartelo, N., Aslam, M., Hale, C. R., Blachère, N. E., Parveen, S., Spolaore, E., DiCarlo, E. F., Gravallese, E. M., Smith, M. H., et al. (2023) · medRxiv · doi:10.1101/2023.08.17.23294232 · Cited by 13

Spatial transcriptomics reveals immune-stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis

Inamo, J., Fierkens, R., Clay, M. R., Jonsson, A. H., Lin, C., Hayes, K., Rogers, N. D., Leach, H., & Yomogida, K. (2025) · JCI Insight · doi:10.1172/jci.insight.198074 · Cited by 15

Macrophage-centred crosstalk with infiltrating immune cells in rheumatoid arthritis and its regulation by mesenchymal stem cells

Zheng, S., Wang, H., Mu, J., Liu, X., Jin, X., Li, Z., Jiang, J., & Yang, M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07346-w · Cited by 12

Macrophages: Redefining extracellular matrix architecture through phenotypic switches as therapeutic targets

Dai, B., ZHENG, L., Cheung, J. C., Yufeng, L. O. N. G., Liu, J., Wen, C., Qin, L., & Cheng, D. O. N. G. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124063 · Cited by 15

Single-cell computational machine learning approaches to immune-mediated inflammatory disease: New tools uncover novel fibroblast and macrophage interactions driving pathogenesis

Fritz, D., Inamo, J., & Zhang, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1076700 · Cited by 12

Restoring Balance: Immune Tolerance in Rheumatoid Arthritis

Kaur, J., Cairns, E., & Barra, L. (2023) · The Journal of Rheumatology · doi:10.3899/jrheum.220881 · Cited by 13

DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8

Swarnkar, G., Semenkovich, N. P., Arra, M., Mims, D. K., Naqvi, S. K., Peterson, T. R., Mbalaviele, G., Wu, C., & Abu‐Amer, Y. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2310264121 · Cited by 14

Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis

Alivernini, S., Cañete, J. D., Bacardit, J., & Kurowska-Stolarska, M. (2024) · Nature Medicine · doi:10.1038/s41591-024-02818-w · Cited by 12

ARID5B is a negative modulator of IL-6 production in rheumatoid arthritis synovial fibroblasts

Tagawa, Y., Saito, T., Iwai, H., Sato, M., Noda, S., Yamamoto, A., Ota, M., Endo, K., Koga, H., Takahara, Y., et al. (2024) · Immunological Medicine · doi:10.1080/25785826.2024.2346956 · Cited by 12

Ganlu formula ethyl acetate extract (GLEE) blocked the development of experimental arthritis by inhibiting NLRP3 activation and reducing M1 type macrophage polarization

Zhang, S., Hou, B., Xu, A., Wen, Y., Zhu, X., Cai, W., Han, Z., Chen, J. W., Nhamdriel, T., Mi, M., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118377 · Cited by 12

Biological clock perspective in rheumatoid arthritis

Liu, Q., & Zhang, Y. (2024) · Inflammation · doi:10.1007/s10753-024-02120-4 · Cited by 12

NK cell subsets define sustained remission in rheumatoid arthritis

Coyle, C., Ma, M. H. Y., Abraham, Y., Mahony, C. B., Steel, K. J. A., Simpson, C., Guerra, N., Croft, A. P., Rapecki, S., Cope, A. P., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.182390 · Cited by 12

Multifunctional manganese-based nanogels catalyze immune energy metabolism to promote bone repair

Huang, Z., Jiang, X., Zhang, L., Wang, W., Li, Z., Huang, Y., Xu, Y., Zhou, L., Wu, J., Tang, J., et al. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.112005 · Cited by 13

Perivascular RELMα-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis

Schonfeldova, B., Chibwana, M. G., Gentek, R., Zec, K., & Udalova, I. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1567661 · Cited by 14

Inflammation across tissues: can shared cell biology help design smarter trials?

Hosack, T., Thomas, T. R., Ravindran, R. P., Uhlig, H. H., Travis, S. P. L., & Buckley, C. D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01007-2 · Cited by 12

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synoviumPreprint

Dunlap, G. S., Wagner, A., Meednu, N., Zhang, F., Jonsson, A. H., Wei, K., Sakaue, S., Nathan, A., Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Bykerk, V. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.18.533282 · Cited by 12

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid ArthritisPreprint

Weinand, K., Sakaue, S., Nathan, A., Jonsson, A., Zhang, F., Watts, G., Zhu, Z., Rao, D. A., Anolik, J., Brenner, M., et al. (2023) · bioRxiv · doi:10.1101/2023.04.07.536026 · Cited by 23

Bench to Bedside: Modelling Inflammatory Arthritis

Chidomere, C. I., Wahid, M., Kemble, S., Chadwick, C., Thomas, R., Hardy, R., McGettrick, H. M., & Naylor, A. J. (2022) · Discovery Immunology · doi:10.1093/discim/kyac010 · Cited by 11

Horizon scan: State-of-the-art therapeutics for psoriatic arthritis

Hutton, J., Mease, P. J., & Jadon, D. R. (2022) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2022.101809 · Cited by 11

Osteoimmunology research in rheumatoid arthritis: From single-cell omics approach

Hu, N., Wang, J., Ju, B., Li, Y., Fan, P., Jin, X., Kang, X., & Wu, S. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002678 · Cited by 11

Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start

Ciurea, A., Distler, O., Kwok, K. K., Jo, H., Wang, L., Killeen, T., Ospelt, C., & Frank‐Bertoncelj, M. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03144-1 · Cited by 11

Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and scoping review

Ward, M. M., Madanchi, N., Yazdanyar, A. R., Shah, N. R., & Constantinescu, F. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03199-0 · Cited by 11

Immune checkpoints in rheumatoid arthritis: progress and promise

Small, A., Lowe, K., & Wechalekar, M. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1285554 · Cited by 13

Intensive training programme for ultrasound-guided minimally invasive synovial tissue biopsy on knees and wrists in different phases of inflammation

Coletto, L. A., Marino, V., Rizzo, C., Goulas, N., Rubortone, P., Verardi, L., Gaggiano, E., Bruno, D., D’Antonio, A., Gessi, M., et al. (2024) · RMD Open · doi:10.1136/rmdopen-2023-003705 · Cited by 11

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel

Bisconti, F., Vilardo, B., Corallo, G., Scalera, F., Gigli, G., Chiocchetti, A., Polini, A., & Gervaso, F. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400166 · Cited by 12

Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis

Ke, L., He, Q., Jing, Q. U., Wang, X., Li, K., Gong, X., Li, L., Yu, Q., Yu, H., Yu, H., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.09.031 · Cited by 11

LncRNA-MEG3/miR-93-5p/SMAD7 axis mediates proliferative and inflammatory phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis

Liu, Y., Wang, J., Zhou, T.-S., Fang, L., Li, J., & Xia, Q. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139390 · Cited by 11

Residual pain and fatigue are affected by disease perception in rheumatoid arthritis in sustained clinical and ultrasound remission

Perniola, S., Bruno, D., Mario, C. D., Campobasso, D., Calabretta, M., Gessi, M., Petricca, L., Tolusso, B., Alivernini, S., & Gremese, E. (2025) · Clinical Rheumatology · doi:10.1007/s10067-025-07331-0 · Cited by 13

CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis

Li, Z., Jiang, J., Cai, K., Qiao, Y., Zhang, X., Wang, L., Kang, Y., Wu, X., Zhao, B., Wang, X., et al. (2025) · Bone Research · doi:10.1038/s41413-025-00400-9 · Cited by 11

Advances in Regenerative Therapies for Inflammatory Arthritis: Exploring the Potential of Mesenchymal Stem Cells and Extracellular Vesicles

Klyucherev, T. O., Peshkova, M., Yurkanova, M. D., Kosheleva, N. V., Svistunov, A. А., Liang, X., & Timashev, P. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125766 · Cited by 12

Lipidomic Profiling in Synovial Tissue

Coras, R., Murillo‐Saich, J., Singh, A. G., Kavanaugh, A., & Gumá, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.857135 · Cited by 13

Targeting the tissue-complosome for curbing inflammatory disease

Dutta, K., Friščić, J., & Hoffmann, M. H. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101644 · Cited by 13

COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging association, therapeutic options, and challengesPreprint

Kandimalla, R. J. L., Dewanjee, S., Kalra, R. S., Valupadas, C., Vallamkondu, J., Kolli, V., Reddy, P. A., & Reddy, P. H. (2021) · doi:10.31219/osf.io/pzehv · Cited by 11

Epigenetic modifications of immune cells in rheumatoid arthritis

Cai, X. T., & Yao, Y. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2533432 · Cited by 10

Macrophages and osteoclasts: similarity and divergence between bone phagocytes

Halper, J., Dolfi, B., Ivanov, S., Madel, M., & Blin‐Wakkach, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1683872 · Cited by 12

Detecting and exploiting the circadian clock in rheumatoid arthritis

Wilantri, S., Graßhoff, H., Lange, T., Gaber, T., Besedovsky, L., & Buttgereit, F. (2023) · Acta Physiologica · doi:10.1111/apha.14028 · Cited by 11

Patterns and determinants of response to novel therapies in juvenile and adult-onset polyarthritis

Triaille, C., Quartier, P., Somer, L. D., Durez, P., Lauwerys, B. R., Verschueren, P., Taylor, P. C., & Wouters, C. H. (2023) · Rheumatology · doi:10.1093/rheumatology/kead490 · Cited by 10

HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS

Binder, M. D., Nwoke, E. C., Morwitch, E., Dwyer, C., Li, V., Xavier, A., Lea, R. A., Lechner‐Scott, J., Taylor, B. V., Ponsonby, A., et al. (2023) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200190 · Cited by 11

Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets

Cheng, L., & Rong, X. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12387 · Cited by 10

Anti-infammatory and antioxidant activities of acteoside isolated from Acanthus ilicifolius var. xiamenensis

Zhang, Y., Shen, J., Ma, X., Yao, M., Zhang, Y., & Cao, D. (2022) · Applied Biological Chemistry · doi:10.1186/s13765-022-00695-w · Cited by 10

Biomimetic and inflammation-targeted nanoparticles for rheumatoid arthritis therapy via M1-macrophages apoptosis and polarization

Hao, X., Gai, W., Zhang, Y., Zhou, W., & Feng, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112806 · Cited by 11

Synovial macrophage populations linked to RA remission

McHugh, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0481-6 · Cited by 10

Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL

Chatzidionysiou, K., Cîrciumaru, A., Réthi, B., Joshua, V., Engström, M., Hensvold, A. H., af Klint, E., & Catrina, A. I. (2021) · RMD Open · doi:10.1136/rmdopen-2021-001662 · Cited by 10

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study

Rayner, F., Anderson, A. E., Baker, K. F., Buckley, C. D., Dyke, B., Fenton, S. A. M., Filer, A. D., Goodyear, C. S., Hilkens, C. M. U., Hiu, S. K. W., et al. (2021) · BMC Rheumatology · doi:10.1186/s41927-021-00194-3 · Cited by 10

Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis

Menarim, B. C., Ali, H. E., Loux, S. C., Scoggin, K. E. S., Kalbfleisch, T., MacLeod, J. N., & Dahlgren, L. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734322 · Cited by 10

GTS-21 alleviates murine collagen-induced arthritis through inhibition of peripheral monocyte trafficking into the synovium

Bai, X., Zhou, B., Wu, S., Zhang, X., Zuo, X., & Li, T. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110676 · Cited by 10

Computational approaches in rheumatic diseases – Deciphering complex spatio-temporal cell interactions

Hegarty, C., Neto, N. G. B., Cahill, P. A., & Floudas, A. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.08.005 · Cited by 9

Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission

Hu, X., Zhang, Z., Long, L., Gu, M., Chen, W., Pan, B., Wu, X., Wang, C., Li, C., Zheng, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1307748 · Cited by 11

A biomimetic, triggered‐release micelle formulation of methotrexate and celastrol controls collagen‐induced arthritis in mice

Ren, H., Wu, Z., Li, J., Zhang, N., Nah, C. Y., Li, J., Zhang, J., Lovell, J. F., Zhang, L., & Zhang, Y. (2024) · BMEMat · doi:10.1002/bmm2.12104 · Cited by 9

Unraveling immune cell heterogeneity in autoimmune arthritis: insights from single-cell RNA sequencing

Nakajima, S., Tsuchiya, H., & Fujio, K. (2024) · Immunological Medicine · doi:10.1080/25785826.2024.2388343 · Cited by 11

Single-cell technology for drug discovery and development

Zhang, A., Zou, J., Xi, Y., Gao, L., Deng, F., Liu, Y., Gao, P., Tong, H. H. Y., Tan, L., Zou, X., et al. (2024) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2024.1459962 · Cited by 9

PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment

Yao, Y., Cai, X. T., Zhang, M., Zhang, X., Ren, F., Zheng, Y., Fei, W., Zhao, M., & Zheng, C. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02939-y · Cited by 9

Melanocortin therapies to resolve fibroblast-mediated diseases

Khodeneva, N., Sugimoto, M. A., Davan-Wetton, C. S. A., & Montero‐Melendez, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084394 · Cited by 10

Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis

Umemoto, A., Kuwada, T., Murata, K., Shiokawa, M., Ota, S., Murotani, Y., Itamoto, A., Nishitani, K., Yoshitomi, H., Fujii, T., et al. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03007-9 · Cited by 9

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

Knights, A. J., Farrell, E. C., Ellis, O. M., Song, M. J., Appleton, C. T., & Maerz, T. (2025) · eLife · doi:10.7554/elife.93283.2 · Cited by 10

Translational immunology: Applying fundamental discoveries to human health and autoimmune diseases

Buckner, J. H. (2023) · European Journal of Immunology · doi:10.1002/eji.202250197 · Cited by 11

Exploring the molecular mechanisms and shared potential drugs between rheumatoid arthritis and arthrofibrosis based on large language model and synovial microenvironment analysis

Wei, Z., Chen, X. D., Sun, Y., Zhang, Y., Dong, R., Wang, X., & Chen, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-69080-5 · Cited by 8

Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis

Fang, X., Chen, Y., Ding, H., Huang, C., Hu, H., Zhang, C., Lin, Y., Wang, Q., Hu, X., Lin, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202409251 · Cited by 8

NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium

Zhu, X., Xu, A., Cai, W.-W., Han, Z., Zhang, S., Hou, B., Wen, Y., Cao, X., Li, H., Du, Y., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03286-1 · Cited by 8

The ontogeny of synovial tissue macrophages

Hutton, J., Sun, W., & Hasegawa, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1603473 · Cited by 10

Research progress on mesenchymal stem cell‑derived exosomes in the treatment of osteoporosis induced by knee osteoarthritis (Review)

Xue, H., Shen, X.-L., Wang, Z., Bi, H., Xu, H., Wu, J., Cui, R., & Liu, M.-W. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5601 · Cited by 11

Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes

Wang, W., Wang, Z., Ling, A., Zhang, C., Lv, M., Huang, L., & Niu, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1613679 · Cited by 8

Platelet-derived exosomes in situ reprogramming macrophages for rheumatoid arthritis treatment

Yu, D. H., Wang, D., Yu, Y., Xu, Y., Tang, W., Guo, Y., & Deng, A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02473-9 · Cited by 8

Sinomenine ameliorates fibroblast-like synoviocytes dysfunction by promoting phosphorylation and nuclear translocation of CRMP2

Yu, J., Wang, S., Chen, S., Zheng, M.-J., Yuan, C.-R., Lai, W.-D., Wen, J., You, W., Liu, P., Khanna, R., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117704 · Cited by 8

Transcriptomic Insights into Different Stimulation Intensity of Electroacupuncture in Treating COPD in Rat Models

Liu, L., Tang, Z., Zeng, Q., Qi, W., Zhou, Z., Chen, D., Cai, D., Chen, Y., Sun, S., Gong, S., et al. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s458580 · Cited by 8

Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1

Zhu, L., Li, Z., Dong, X., Wu, H., Cheng, Y., Xia, S., Bao, X., Xu, Y., & Cao, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01571-4 · Cited by 8

Rheumatology in the era of precision medicine: synovial tissue molecular patterns and treatment response in rheumatoid arthritis

Lakhanpal, A., Smith, M. H., & Donlin, L. T. (2020) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000767 · Cited by 7

Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis

Manferdini, C., Saleh, Y., Dolzani, P., Gabusi, E., Trucco, D., Filardo, G., & Lisignoli, G. (2020) · Biology · doi:10.3390/biology9120459 · Cited by 8

Deep topic modeling of spatial transcriptomics in the rheumatoid arthritis synovium identifies distinct classes of ectopic lymphoid structuresPreprint

Periyakoil, P. K., Smith, M. H., Kshirsagar, M., Ramirez, D. C., DiCarlo, E. F., Goodman, S. M., Rudensky, A. Y., Donlin, L. T., & Leslie, C. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.08.631928 · Cited by 8

Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophagesPreprint

Sokhi, U. K., Yuan, R., Mishra, B., Chinenov, Y. V., Singaraju, A., Chan, K. K., Bass, A. R., Bell, R. D., Donlin, L. T., & Ivashkiv, L. B. (2025) · eLife · doi:10.7554/elife.104367 · Cited by 8

Impact of synovial biopsy procedures and disease-specific aspects on synovial tissue outcome: a systematic literature review informing the EULAR points to consider for the minimal reporting requirements in synovial tissue research in rheumatology

Najm, A., Costantino, F., Wéill, C., Filer, A. D., & D’Agostino, M. A. (2022) · RMD Open · doi:10.1136/rmdopen-2021-002116 · Cited by 7

Two Broad Categories Overlapping With Rheumatoid Arthritis Observed in Synovial Biopsies from Patients With Juvenile Idiopathic Arthritis

Triaille, C., Tilman, G., Baert, C. A., Sokolova, T., Loriot, A. E., Nzeusseu‐Toukap, A., de Bellefon, L. M., Galant, C., Boulanger, C., Fonseca, J. E., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42922 · Cited by 7

Integration of single-cell and bulk RNA sequencing revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis patients

Mao, X., Shi, M., Zhang, B., Fu, R., Cai, M., Yu, S., Lin, K., Zhang, C., Li, D., Chen, G., et al. (2024) · Immunologic Research · doi:10.1007/s12026-024-09513-5 · Cited by 7

Wuwei Ganlu and Myricetin alleviate rheumatoid arthritis by inhibiting M1 macrophage polarization through modulation of SHBG/SREBP1-mediated lipid metabolism

Wen, Y., Wang, Y., Zhuang, Y., Xu, G., Zhang, Y., Zhang, S., Xu, A., Chen, X., Li, K., Cai, W., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157167 · Cited by 7

Histological synovitis and radiographic damage in knee osteoarthritis: insights from a comprehensive analysis of ultrasound-guided synovial biopsies in 161 patients

Rubortone, P., Lorenzis, E. D., Leone, F., Tolusso, B., Bruno, D., Gessi, M., D’Agostino, M. A., Alivernini, S., & Lizzio, M. M. (2025) · RMD Open · doi:10.1136/rmdopen-2025-006011 · Cited by 7

A 2D inflammatory co-culture model for investigating synovial fibroblast and macrophage interactions in rheumatoid arthritis

Thangadurai, M., Sethuraman, S., & Subramanian, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-16007-3 · Cited by 9

New Insights into the Structural Profiling of Polyphenol Aggregates from Pu-erh Tea and Their Anti-Inflammatory Activity via the TLR4/MyD88/NF-κB Signaling Pathway and Gut Microbiota

Wu, Y.-L., Liu, Y., Shahidin, Liu, Z., Sun, X., Wang, Y., Wang, X., Sheng, J., & Zi, C. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c03760 · Cited by 7

Macrophage Membrane‐Coated Carbon Nanozymes for Targeted Drug Delivery and NIR‐Responsive Synergistic Therapy in Rheumatoid Arthritis

Li, Y., Cong, L., Zhang, W., Zhang, R., Gao, Y., Zheng, S., Li, D., Zhang, Z., Zhang, L., Yang, M., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503316 · Cited by 7

3D Bioprinted Human Synovium‐Cartilage Models Mimic Rheumatoid Arthritis Microenvironment and Recapitulate In Vivo Therapeutic Responses

Zhou, H., Zhang, Z., Mu, Y., Ma, L., Xu, H., Liu, B., & Wang, D. (2025) · Advanced Materials · doi:10.1002/adma.202513952 · Cited by 7

MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E2

Bermejo-Álvarez, I., Vázquez‐Carballo, C., Irigaray-Moreno, A., Quevedo-Romero, I., Mediero, A., Herrero‐Beaumont, G., & Largo, R. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04877-3 · Cited by 7

Integrative Single‐Cell RNA Sequencing and Spatial Transcriptomics Uncover Distinct Fibroblast–Macrophage Crosstalk in Human Hip Synovium Between Patients With Femoroacetabular Impingement and Osteoarthritis

Kulzhanova, G., Klee, A., Botros, M., Hansen, V. L., Reuter, J. E., Tashbib, E. T., Fadial, E., Ricciardi, B. F., Giordano, B. D., & Wu, C. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70033 · Cited by 12

Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis.

Saeki, N., & Imai, Y. (2023) · PubMed · doi:10.14670/hh-18-628 · Cited by 8

Synovial biopsies for molecular definition of rheumatoid arthritis and treatment response phenotyping: where can we improve?

Iaquinta, F. S., Rivellese, F., & Pitzalis, C. (2023) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2023.2284774 · Cited by 7

Macrophages in Bone and Synovial Inflammation in Rheumatoid Arthritis

Jalalvand, M., Khanmohammadi, S., Akhtari, M., Farhadi, E., Jamshidi, A., & Mahmoudi, M. (2023) · Journal of Cellular Immunology · doi:10.33696/immunology.5.184 · Cited by 9

CELL MEMBRANE COATED POLYMERIC NANOCARRIERS: A NOVEL DRUG DELIVERY APPROACH FOR THE TARGETED THERAPY OF RHEUMATOID ARTHRITIS

Iqba, T., Altaf, S., Salma, U., 4, M. F., 5, M. N. K., Farooq, S., 7, M. A., & Tasleem, M. (2024) · Agrobiological Records · doi:10.47278/journal.abr/2024.003 · Cited by 12

Increased interleukin-26 in the peripheral joints of patients with axial spondyloarthritis and psoriatic arthritis, co-localizing with CD68-positive synoviocytes

Hammitzsch, A., Ossadnik, A., Bachmann, Q., Merwald-Fraenk, H., Lorenz, G., Witt, M., Wiesent, F., Mühlhofer, H., Simone, D., Bowness, P., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1355824 · Cited by 7

Fibroblast-Like Synovial Cell Subsets in Rheumatoid Arthritis

Lomholt, S., Nielsen, M. A., Aspari, M., Jørgensen, P. L., Croft, A. P., Buckley, C. D., & Kragstrup, T. W. (2021) · Biochemistry · doi:10.5772/intechopen.99240 · Cited by 7

Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis

Bohaud, C., Contreras-López, R. A., Cruz, J. D. L., Terraza‐Aguirre, C., Wei, M., Djouad, F., & Jørgensen, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.718938 · Cited by 8

Consensus transcriptional states describe human mononuclear phagocyte diversity in the lung across health and diseasePreprint

Peters, J. M., Blainey, P. C., & Bryson, B. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.06.240424 · Cited by 9

CD206+ Trem2+ macrophage accumulation in the murine knee joint after injury is associated with protection against post-traumatic osteoarthritis in MRL/MpJ mice

McCool, J. L., Sebastian, A., Hum, N. R., Wilson, S. P., Davalos, O. A., Murugesh, D. K., Amiri, B., Morfin, C., Christiansen, B., & Loots, G. G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0312587 · Cited by 6

Single-cell RNA sequencing in autoimmune diseases: New insights and challenges

Huang, J., Hu, Y., Wang, S., Liu, Y., Sun, X., Wang, X., & Yu, H. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108807 · Cited by 7

Augmentation of PRDX1–DOK3 interaction alleviates rheumatoid arthritis progression by suppressing plasma cell differentiation

Dang, W., Wang, X., Li, H., Xu, Y., Li, X., Huang, S., Tao, H., Li, X., Yang, Y., Xuan, L., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.06.006 · Cited by 6

Causal Link and Shared Biomarkers Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis

Pan, X., Jiang, C., Chen, J., Sun, T., Wang, X., & Chen, J. (2025) · Med Research · doi:10.1002/mdr2.70021 · Cited by 6

Fibroblast activation protein-α drives rheumatoid arthritis inflammation through the AKT/mTOR signaling pathway and its therapeutic effect by Wangbi granules

Wang, Z., Dong, Q., Zhang, L., Wang, X., Jiao, Y., Geng, Q., Cai, W., Zhang, Q., Xiao, C., Tao, Q., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157179 · Cited by 6

Synovial MS4A4A correlates with inflammation and counteracts response to corticosteroids in arthritis

Boutet, M., Mattiola, I., Silva-Gomes, R., Nerviani, A., Sironi, M., Ghirardi, G. M., Troilo, A., Gianoli, S., Rivellese, F., Çubuk, C., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2504529122 · Cited by 7

Synovial matrix turnover controls immune cell spatial patterning in inflammation resolution

Richard, J.-B., Hoyle, A., Bower, M. A., Wu, S., Worthington, L. A., Davidson, S., Varyova, Z., Morrell, C., Pohin, M., Schonfeldova, B., et al. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00149-7 · Cited by 7

Synovial CXCL3+FOSL2+ Macrophages Mediate Inflammation via FOSL2/AP-1 in Rheumatoid Arthritis: A Single-Cell Transcriptome Analysis

Wu, Y., Yang, J., Chen, M., Chen, X., & Cao, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199718 · Cited by 6

Synovial macrophage populations linked to RA remission

McHugh, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0481-6 · Cited by 10

Distinct tissue macrophage subsets regulate inflammation and provide a novel cellular and molecular mechanism for disease remission in rheumatoid arthritis

Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Mario, C. D., Bui, L., Perniola, S., et al. (2020) · Nature Medicine

03.13 Synovial tissue of ra patients in remission contains a unique population of regulatory macrophages

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D., Sante, G. D., Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B., & Kurowska‐Stolarska, M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-211049.13 · Cited by 3

OP0208 Synovial tissue of ra patients in remission contains a unique population of regulatory macrophages

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. D., Sante, G. D., Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B., & Kurowska‐Stolarska, M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-eular.5910 · Cited by 1

Synovial tissue macrophages: friend or foe?

Kurowska‐Stolarska, M., & Alivernini, S. (2017) · RMD Open · doi:10.1136/rmdopen-2017-000527 · Cited by 140