Cited by 777Rheumatoid Arthritis Research and TherapiesImmune cells in cancerAutoimmune and Inflammatory Disorders Research

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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

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Alivernini, Stefano, MacDonald, Lucy, Elmesmari, Aziza, Finlay, Samuel, Tolusso, Barbara, Gigante, Maria Rita, Petricca, Luca, Di Mario, Clara, Bui, Laura, Perniola, Simone, Attar, Moustafa, Gessi, Marco, Fedele, Anna Laura, Chilaka, Sabarinadh, Somma, Domenico, Sansom, Stephen N., Filer, Andrew, McSharry, Charles, Millar, Neal L., Kirschner, Kristina, Nerviani, Alessandra, Lewis, Myles J., Pitzalis, Costantino, Clark, Andrew R., Ferraccioli, Gianfranco, Udalova, Irina, Buckley, Christopher D., Gremese, Elisa, McInnes, Iain B., Otto, Thomas D., Kurowska-Stolarska, Mariola·2020·Nature Medicine

DOI 10.1038/s41591-020-0939-8

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Abstract

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phenotypic changes in patients with early/active RA, treatment-refractory/active RA and RA in sustained remission. Each clinical state was characterized by different frequencies of nine discrete phenotypic clusters within four distinct STM subpopulations with diverse homeostatic, regulatory and inflammatory functions. This cellular atlas, combined with deep-phenotypic, spatial and functional analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulations (MerTK pos TREM2 high and MerTK pos LYVE1 pos) with unique remission transcriptomic signatures enriched in negative regulators of inflammation. These STMs were potent producers of inflammation-resolving lipid mediators and induced the repair response of synovial fibroblasts in vitro. A low proportion of MerTK pos STMs in remission was associated with increased risk of disease flare after treatment cessation. Therapeutic modulation of MerTK pos STM subpopulations could therefore be a potential treatment strategy for RA.

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Additional file 16 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 19 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 35 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 3 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 9 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 11 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 22 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 17 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 36 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
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Additional file 7 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691637
Additional file 34 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691718
Additional file 23 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691685
Additional file 28 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691700
Additional file 33 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691715
Additional file 29 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691703
Additional file 31 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691709
Additional file 6 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691634
Additional file 27 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691697
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Additional file 10 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691646
Additional file 18 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691670
Additional file 37 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691727
Additional file 12 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691652
Additional file 5 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752246
Additional file 1 of Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model
Kenney, H. M., Wu, C.-L., Loiselle, A. E., Xing, L., Ritchlin, C. T., & Schwarz, E. M. (2022) · Figshare · doi:10.6084/m9.figshare.19321217
Additional file 5 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691631
Additional file 1 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25389502
Additional file 1 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26341944
Additional file 1 of Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis
Huynh, N. C.-N., Ling, R., Komagamine, M., Tianshu, S., Tsukasaki, M., Matsuda, K., Okamoto, K., Asano, T., Muro, R., Pluemsakunthai, W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755144
Additional file 2 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25389926
Additional file 24 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691688
Additional file 7 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752252
Additional file 14 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691658
Additional file 8 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752255
Additional file 15 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691661
Additional file 2 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26341989
Additional file 9 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752258
Additional file 26 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691694
Additional file 13 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691655
Additional file 25 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691691
Additional file 1 of Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1
Zhu, L.-W., Li, Z., Dong, X., Wu, H., Cheng, Y., Xia, S., Bao, X., Xu, Y., & Cao, R. (2024) · Figshare · doi:10.6084/m9.figshare.25834107
Additional file 39 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691736
Additional file 4 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691625
Additional file 21 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691679
Additional file 8 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691640
Additional file 20 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691676
Additional file 38 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691733
Additional file 1 of Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling
Liu, H., Chen, Y., Huang, Y., Wei, L., Ran, J., Li, Q., Tian, Y., Luo, Z., Yang, L., Liu, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25661754
Additional file 30 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691706
Additional file 32 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Sánchez-Fernández, S. Á., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691712
Additional file 6 of The regulatory effect of TiO2 nanotubes loaded with graphene oxide on macrophage polarization in an inflammatory environment
Cao, X., Luo, B., Mu, Y., Wang, C., Lu, R., Yao, Y., & Chen, S. (2024) · Figshare · doi:10.6084/m9.figshare.26752249
Additional file 40 of Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, A., López-Lasanta, M., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Fernandez, S. S., Sanmartí, R., Fernández‐Nebro, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26691739
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Authors: Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., Attar, M., Gessi, M., Fedele, A. L., Chilaka, S., Somma, D., Sansom, S. N., Filer, A., McSharry, C., Millar, N. L., Kirschner, K., Nerviani, A., Lewis, M. J., Pitzalis, C., Clark, A. R., Ferraccioli, G., Udalova, I., Buckley, C. D., Gremese, E., McInnes, I. B., Otto, T. D., & Kurowska-Stolarska, M.
Affiliations: Università Cattolica del Sacro Cuore (IT)
Arthritis UK (GB)
Agostino Gemelli University Polyclinic (IT)
University of Oxford (GB)
University of Glasgow (GB)
University Hospitals Birmingham NHS Foundation Trust (GB)
Queen Mary University of London (GB)
Corresponding author: Alivernini, Stefano
ORCID: Alivernini, Stefano
MacDonald, Lucy
Elmesmari, Aziza
Tolusso, Barbara
Gigante, Maria Rita
Petricca, Luca
Perniola, Simone
Attar, Moustafa
Gessi, Marco
Fedele, Anna Laura
Chilaka, Sabarinadh
Somma, Domenico
Sansom, Stephen N.
Filer, Andrew
McSharry, Charles
Millar, Neal L.
Kirschner, Kristina
Nerviani, Alessandra
Lewis, Myles J.
Pitzalis, Costantino
Clark, Andrew R.
Ferraccioli, Gianfranco
Udalova, Irina
Buckley, Christopher D.
Gremese, Elisa
McInnes, Iain B.
Otto, Thomas D.
Kurowska-Stolarska, Mariola
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2020-06-29
Volume: 26
Issue: 8
Pages: 1295-1306
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-020-0939-8
OpenAlex: W3037615636
Cited by: 740
References: 65
Citations by year: 2026: 143 · 2025: 161 · 2024: 145 · 2023: 106 · 2022: 90 · 2021: 80 · 2020: 14
FWCI: 54.63
Type: journal article
Language: en
Open access: green
eprints.gla.ac.uk
Licence: cc-by-sa
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
Funders: European Hematology Association (TRTH172)
Kennedy Trust for Rheumatology Research (KENN161704, KENN192004)
Versus Arthritis (21890, 22253, 22272, 21802)
Medical Research Council (MR/S025308/1)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: rheumatoid arthritis, synovial macrophages, macrophage subsets, inflammation, clinical remission, disease flares, tissue repair, macrophage heterogeneity
MeSH terms: Mannose Receptor, Arthritis, Rheumatoid, Biopsy, Humans, Inflammation, Joints, Macrophages, Receptors, Cell Surface, Receptors, Immunologic, Synovial Fluid, Synovial Membrane, Cell Lineage, Lectins, C-Type, Mannose-Binding Lectins

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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

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