Cited by 777Rheumatoid Arthritis Research and TherapiesImmune cells in cancerAutoimmune and Inflammatory Disorders Research

The DOI matches its Crossref record; 60 of the 65 references it cites were found in a registry or an index.

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Open access

Alivernini, Stefano, MacDonald, Lucy, Elmesmari, Aziza, Finlay, Samuel, Tolusso, Barbara, Gigante, Maria Rita, Petricca, Luca, Di Mario, Clara, Bui, Laura, Perniola, Simone, Attar, Moustafa, Gessi, Marco, Fedele, Anna Laura, Chilaka, Sabarinadh, Somma, Domenico, Sansom, Stephen N., Filer, Andrew, McSharry, Charles, Millar, Neal L., Kirschner, Kristina, Nerviani, Alessandra, Lewis, Myles J., Pitzalis, Costantino, Clark, Andrew R., Ferraccioli, Gianfranco, Udalova, Irina, Buckley, Christopher D., Gremese, Elisa, McInnes, Iain B., Otto, Thomas D., Kurowska-Stolarska, Mariola·2020·Nature Medicine

DOI 10.1038/s41591-020-0939-8

Open this paper in CoChat — free account Open PDF

Abstract

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phenotypic changes in patients with early/active RA, treatment-refractory/active RA and RA in sustained remission. Each clinical state was characterized by different frequencies of nine discrete phenotypic clusters within four distinct STM subpopulations with diverse homeostatic, regulatory and inflammatory functions. This cellular atlas, combined with deep-phenotypic, spatial and functional analyses of synovial biopsy fluorescent activated cell sorted STMs, revealed two STM subpopulations (MerTK pos TREM2 high and MerTK pos LYVE1 pos) with unique remission transcriptomic signatures enriched in negative regulators of inflammation. These STMs were potent producers of inflammation-resolving lipid mediators and induced the repair response of synovial fibroblasts in vitro. A low proportion of MerTK pos STMs in remission was associated with increased risk of disease flare after treatment cessation. Therapeutic modulation of MerTK pos STM subpopulations could therefore be a potential treatment strategy for RA.

Integrity signals

Registry

Crossref · 10.1038/s41591-020-0939-8

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Self-citation
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159
Rheumatoid arthritis
Smolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,534
Self-citation
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
Tissue-resident macrophages
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
S100A8/A9 in Inflammation
Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372
Self-citation

Show all 65 references

Research works printed but not linked: 1

Firestein, G. S., Gabriel, S. E., McInnes, I. B. & O’Dell, J. R. Kelley and Firestein’s Textbook of Rheumatology 2nd edn (Elsevier, 2016).

Sorted by citations

Items 701–777 of 777

Defective macrophage plasticity exacerbates progression of inflammation in patients with rheumatoid arthritis
Kulakova, K. A., Doulaptsi-Teeuwen, D., Sanaei, R., McCarthy, E. M., Durcan, L., Hughes, C., Kirby, C., Freeley, M., & Floudas, A. (2026) · Frontiers in Immunology · doi:10.21203/rs.3.rs-9096264/v1
MYSM1 expression in monocytes is negatively correlated to disease activity in Rheumatoid Arthritis, which may be related to the inhibitory effect on inflammatory aging
Huang, R., Quan, S., Zeng, J., Shi, J., Zhang, J., Chen, E., Liao, P., & Li, X. Y. (2026) · Clinical Rheumatology · doi:10.1007/s10067-026-08090-2
lmmunopathologie de la synoviale : intérêt diagnostic, pronostic et nouvelles cibles thérapeutiques
Najm, A. (2020) · theses.fr (ABES) · doi:10.70675/28853ef8z63d7z4b6dz8945zeb1966569db9
Etude de l’influence du TGF-β sur les sous-populations de fibroblastes associés au cancer et leur implication pronostique dans les cancers du pancréas
Vienot, A. (2021) · theses.fr (ABES) · doi:10.70675/25d883b4z5eadz4f1bz93f0zcfa886c08e78
Barrière intestinale, translocation de composés bactériens et développement de l'arthrite inflammatoire : étude du lien mécanistique
Poline, J. (2022) · theses.fr (ABES) · doi:10.70675/3bf35673z4a77z4947zb0a0z527a68ad6881
Computational modeling of the cellular interplay in rheumatoid arthritis. Deciphering the role of resident and immune cells in the arthritic joint
Zerrouk, N. (2023) · theses.fr (ABES) · doi:10.70675/ba5bbd99zc999z4e8ez8936z8135f6cfb751
Integrative analysis of single-cell and bulk RNA sequencing data using machine learning identifies PTGDS as a key subsynovial fibroblast gene in osteoarthritis
Wang, W., Niu, C., Zhao, C., Xu, Q., Guo, L., Liu, J., & Zeng, P. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-026-10789-0
Etude du "Reverse Signaling" du TNF transmembranaire : médiateur de la résolution de l'inflammation et outil de prédiction de la réponse clinique aux biothérapies anti-TNF dans la polyarthrite rhumatoïde
Diallo, K. (2020) · theses.fr (ABES) · doi:10.70675/132cc287z8173z44f0z9290zed00679f84d9
Expression of MS4A4A on synovial infiltrating macrophages is a hallmark of rheumatoid arthritis and reflects disease severity
Asakura, H., Matsueda, Y., Ikeda, K., Kyoda, S., Shishido, E., Shindo, R., Ino, K., Hasegawa, Y., Tanaka, T., Wada, T., et al. (2026) · Immunological Medicine · doi:10.1080/25785826.2026.2647497
Capsaicin alleviates rheumatoid arthritis by regulating macrophage M1 polarization through HIF-1α-mediated effects on mitochondrial autophagy and glycolysis
Wu, Z., Long, Y., Huang, F., Yang, Z., Wu, Y., Gan, Y., Chen, X., & Xie, G. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107290
PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease
Wahid, M., Kemble, S., Abudu, O., Saviano, A., Mahony, C. B., Lewis, J. W., Nicholson, T. A., Schettino, A., Marigliano, N., Frost, K., et al. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70108
Self-citation
An APOC1 + inflammatory CAF-like state drives a senescent, treatment-resistant niche in rheumatoid arthritisPreprint
Yoshihara, R., Nakajima, S., Yamazato, R., Yoshida, T., Takazawa, I., Omata, Y., Wang, T.-W., Ishigaki, K., Itamiya, T., Ota, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.17.718831
Single-cell atlas reveals age-related cellular shifts underlying fibrosis in murine synoviumPreprint
Bortolotti, O., Marinèche, L., Abasi-Ali, B., Séverac, D., Leccia, F., Duperray, C., Brugioti, L., Colinge, J., Bertrand‐Gaday, C., Sebti, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.17.719179
Angelica sinensis polysaccharides modulate iron metabolism and macrophage polarization to alleviate rheumatoid arthritis
Zhan, Y., Zhang, H., Guo, T., Qin, H., Huang, L., Wu, N., Wang, J., Xu, M., Wang, J., Li, M., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152182
Scalable synovial fibroblast sources enable reproducible basal synovial organoid formation: an in vitro platform study
Lomholt, S., Øllgaard, A. M. B. H., Madsen, A. A., Nielsen, M. A., & Kragstrup, T. W. (2026) · Rheumatology International · doi:10.1007/s00296-026-06112-5
The vicious cycle from inflammation to pyroptosis: the core role of macrophage polarization imbalance in the pathogenesis of knee osteoarthritis
Du, X., Li, F., Deng, Y., He, Y., Song, C., & Peng, L. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11970-0
Asiaticoside alleviates mesothelial cell senescence and peritoneal fibrosis by targeting macrophage-mesothelial communication in single-cell peritoneal landscape
You, Y., Wang, F., Zhou, Z., Chen, X., Yu, M., Meng, X., Jia, J., Shan, Y., & Sheng, M. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158339
Identification of an immediate-early gene-activated fibroblast state in frozen shoulder capsular fibrosis
Ren, Z., Lian, J., Wang, R., Niu, W., Zhou, X., Huo, Y., Lin, H., Jiang, D., & Yang, C. (2026) · iScience · doi:10.1016/j.isci.2026.116183
Reciprocal Regulation of GLI1 and GLI3 Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis
Sato, M., Saito, T., Komiya, Y., Noda, S., Tagawa, Y., Yamamoto, A., Iwai, H., Endo, K., Koga, H., Takahara, Y., et al. (2026) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.70690
Osteoclast-regulatory biomaterials: Direct cellular intervention and indirect microenvironment modulation
Ji, J., 王俏镟, & Gao, C. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124371
TEAD4 integrates IFN-γ and TGF-β signaling to drive pathogenic synovial fibroblast programs in difficult-to-treat rheumatoid arthritisPreprint
Saito, T., Sato, M., Horie, K., Nakahara, T., Da, R., Li, S., Yamamoto, A., Noda, S., Hosoya, T., Sugimoto, K., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9652440/v1
Melatonin alleviates rheumatoid arthritis via elimination of damaged mitochondria
Wang, B., Wu, Y., Li, G., Che, Z., Sun, Q., Wang, C., Gao, Y., Li, L., & Cai, M. (2026) · Autophagy · doi:10.1080/15548627.2026.2689419
Resolution Biology in Soft Tissue Joint Disease
Dakin, S. G. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_346
Arthritis susceptibility begins before birth
Ramming, A. (2026) · Nature Immunology · doi:10.1038/s41590-026-02570-y
Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritisPreprint
Geiß, C., Calvo-Cebrián, C., Houtman, M., Ezen, E., Apostolopoulou, K., Iperi, C., Toitou, M., Khmelevskaya, A. A., Lugar, M., Cauvet, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.30.733140
HLA class I-naturally presented synovial tissue peptides are recognized by CD8+ T lymphocytes from rheumatoid arthritis patients
Catalán, D., Schneider, D. I., Pesce, B., Jaime, M., Toro, L., Varela-Villarroel, C., Montano-Bruno, D., Soto, L., Bozán, F., Cuéllar‐Gutiérrez, M. C., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1843318
β‐Cyclodextrin inclusion enhances the pro‐resolving effects of the annexin A1 mimetic Ac2–26 in a mouse model of antigen‐induced arthritis
Félix, F. B., Maravilha, A. P. S. D. C., Beltrami, V. A., Resende, L. C., Santos, A. L. D. C., Vago, J. P., Queiroz‐Junior, C. M., Galvão, I., Guimarães, P. P. G., Costa, V. V., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70555
AdipoRon ameliorates synovial inflammatory lesions and joint destruction in experimental arthritis by downregulating KRT7
Jiang, C., Zhang, W., Ren, H., Dai, M., Wang, J., Chen, H., Hu, W., Ding, J., Cheng, Y., Fang, Y., et al. (2026) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2026.107604
The alkaloid-rich extract of Piper sintenense Hatusima alleviates gouty inflammatory response via Nrf2-mediated antioxidant induction
Yao, Z., Su, Y., Huang, Y., Hu, C., Pan, K., Zhang, J., Zhao, G., Wang, L., & Yin, Z. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02302-6
When and how chronicity develops in rheumatoid arthritis: towards a temporal and tissue-integrated perspective
Çevirgel, A., & Mil, A. H. M. V. D. H. (2026) · The Lancet Rheumatology · doi:10.1016/s2665-9913(26)00107-4
LCK gene contributes to T cell activation and osteoclast-mediated bone loss in rheumatoid arthritis
Cai, X., Li, C., Zhang, Y., Jia, D., & Xu, Y. (2026) · European journal of medical research · doi:10.1186/s40001-026-04875-y
Biomarkers of treatment response in rheumatoid arthritis: from conventional markers to tissue immunophenotype
Batashkov, N. A., Gerasimova, E. V., Gerasimova, D. A., Svetlichnyy, D. V., Petryakina, E. S., Tychinin, D. I., Yudin, S. M., Yudin, V. S., Keskinov, A. A., Bogdanov, V. P., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1880487
Monocytes on the move: from pulmonary checkpoint to tissue fate
Porter, J. C. (2026) · Thorax · doi:10.1136/thorax-2026-225542
Predicting the risk of bone erosion in rheumatoid arthritis using a SHAP-based interpretable machine learning model
Yan, L., Zheng, Y., Lin, M., Ye, X., & Chen, S. (2026) · Clinical Rheumatology · doi:10.1007/s10067-026-08289-3
Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation
Sánchez-Corrales, Y. E., Xenakis, T. A., Moreno-Villena, J. J., Forrest, L., Sebire, N. J., Rosser, E. C., Wedderburn, L. R., Castellano, S., & Hillman, S. L. (2026) · Science Advances · doi:10.1126/sciadv.aed8964 · Cited by 1
Plant-derived extracellular vesicles deliver spermidine to reprogram macrophage metabolism and ameliorate rheumatoid arthritis
Wang, X., He, J., Hong, Y., Zeng, X., Li, M., Cao, S., Liang, R., Zhou, G., & Wang, Q. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04836-x
Extracellular vesicle-mediated immune crosstalk in rheumatoid arthritis synovium: mechanistic insights and translational challenges
Luo, F., Yuan, X., Zhou, H., Wang, Q., Chen, C., Ling, Y., Zheng, J., Yao, X., & Ma, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1891984
From psoriatic plaque to synovium: decoding the skin–joint axis in psoriatic arthritis
Raimondo, M. G., Gandolfo, S., Gensler, L. S., Thomas, R., Schett, G. A., Ramming, A., & Ciccia, F. (2026) · Nature Reviews Rheumatology · doi:10.1038/s41584-026-01412-3
Inflammation-driven neoplastic-like progression in tenosynovial giant cell tumor: The cellular crosstalk between synovial macrophages and fibroblast-like synoviocytes
Lin, Z., Li, X., Liu, Q., Yuan, Y., Zheng, H., & Luo, W. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102386
A genetic regulatory map of human synovium and fat pad across the osteoarthritis spectrumPreprint
Uchida, Y., Fujii, Y., Swahn, H., Gómez‐Luque, I., Ueda, M. T., Chiba, T., Matsushima, T., Nakamichi, R., Takahashi, K., Olmer, M., et al. (2026) · medRxiv · doi:10.64898/2026.07.27.26358831
CX3CR1 And MHCII Define Distinct Synovial Macrophage Populations With Conserved Inflammatory Response Across Mouse Models Of Rheumatoid ArthritisPreprint
Wang, Y., Chen, S.-Y., Homan, P., Montgomery, A. B., Maciuch, J., Dowling, S. D., Dominguez, S. T., Gadhvi, G. T., Therron, T., Eckman, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.30.741914
Self-citation
Psoriasis as a spatial immune ecosystem: insights from single-cell and spatial transcriptomics
Cheng, W., Luo, T., Zhou, X., & Jing, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1915876
The Multifaceted Roles of Macrophages in Rheumatoid Arthritis: From Cytokine Networks to the Discovery of Novel Subsets
Yi, X., Liu, Y., Fan, Y., & Zhang, Z. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167137
Molecular mechanisms of biologic and targeted synthetic antirheumatic drugs in rheumatoid arthritis
Li, L., Chen, X., Wang, S., Li, Z., & Xie, X. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.07.006
Multi-level transcriptional control of specific macrophage responses
Drakaki, A., Huisman, J. M. A., & Hoeksema, M. A. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00898-7
Synovial lining macrophages form during early postnatal life via fetal-derived CX3CR1+ cells and AQP1+ intermediates
Magalhaes, M. S., Malengier‐Devlies, B., Seuzaret, G., Ahlback, A., Becker, S., Patatsos, K., Drakoulis, G., Karjalainen, J., Ruedl, C., Voehringer, D., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117698 · Cited by 2
Self-citation
Integration of synovial pathotypes and serum proteomic modules as determinants of disease progression and therapeutic response in early rheumatoid arthritis
Corrales, S., Osuna-Soto, J., Cid-Chaves, A., Ortega-Castro, R., Ladehesa-Pineda, L., Merlo-Ruiz, C., Vilchez, D. R., Barbarroja, N., Leiva‐Cepas, F., Pérez‐Sánchez, C., et al. (2026) · RMD Open · doi:10.1136/rmdopen-2026-007196
Lymphatic vessels invade bone in disease but are absent in health and regeneration
Meng, X., Liu, K., Tang, M., Weng, W., Zhang, Z., Huang, X., He, Z., Han, X., Sun, R., Shen, R., et al. (2026) · Cell · doi:10.1016/j.cell.2026.05.039
Immune-mediated rheumatoid arthritis: from single-cell genomics to new therapies
Ivashkiv, L. B. (2026) · Nature Immunology · doi:10.1038/s41590-026-02639-8
Pharmacokinetics and Tissue Distribution in Rats After Oral Administration of Tibetan Medicine Wuwei Leze Powder
Wang, P., Wang, P., Wu, Y., Wu, S., Xu, H., Yang, W., Tu, Y., & Liu, C. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71653
Single-cell transcriptomics reveals that tenocyte-derived MIF contributes to tendon injury pathogenesis
Kot, C. H., Xu, X., Hong, P., Liang, X., Chen, G., & Ma, Z. (2026) · iScience · doi:10.1016/j.isci.2026.117411
Synovial short-lived plasma cells mediate adalimumab resistance in rheumatoid arthritis via MIF–CD74 axis-driven, partially TNF-α-independent inflammation
Li, J., Jiang, H., Wu, D., Xiong, Z., Peng, Y., Zhao, J., Liu, P., & Wu, R. (2026) · Journal of Autoimmunity · doi:10.1016/j.jaut.2026.103622
SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4
Zack, S. R., Satoeya, N., HERNÁNDEZ, V. A. S., Deen, S., Nijim, W., Zanotti, B., Volin, M. V., Burgos, A. C., Karam, J. A., Xia, Y., et al. (2026) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2026.07.025
Macrophages in fibrin-rich lining niche shape the rheumatoid pannus
Kurowska‐Stolarska, M., & Alivernini, S. (2026) · Nature Reviews Rheumatology · doi:10.1038/s41584-026-01428-9
Self-citation
Failed resolution as a mechanistic basis of difficult-to-treat rheumatoid arthritis: stromal–myeloid crosstalk in the synovium and emerging resolution-restoring therapies
Wei, W., & Xu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1935792
Uncovering combination therapies for immune-mediated inflammatory diseases through systems biology analysis on longitudinal patient data
Martínez-Mateu, S. H., Guillén, Y., Angelats, E., López-Lasanta, M. A., Madonna, S., Jiménez-Gracia, L., Rodríguez-Nunez, I., Álvarez‐Errico, D., Aterido, A., Tortosa, R., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.103026
Advances in traditional Chinese medicine for modulating macrophage polarization in the treatment of rheumatoid arthritis
Wang, W., Ma, J., Zhang, X., Mei, H., Wang, L., Yu, J., Xu, S., & Huang, C. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1702947
ApoE deficiency in mice exacerbates antigen-induced arthritis, alters HDL anti-oxidant capacity and promotes macrophage activation which are reversed by simvastatin treatment
Kakale, A., Lazaridou, D., Axiotis, I., Tzardi, M., & Kardassis, D. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159771
Integrated serum proteomics and autoantibody analyses reveal a biomarker signature predictive of flare during biologic tapering in rheumatoid arthritis
Blanco, F. J., Quaranta, P., Domínguez-Guerrero, P., Calamia, V., Fernández‐Puente, P., Paz-González, R., Balboa-Barreiro, V., Noriega-Cobo, D. M., Galindo, L., Acasuso, B., et al. (2026) · RMD Open · doi:10.1136/rmdopen-2026-007198
Barrier-Guided Local Nanopharmaceutics for Cartilage and Osteochondral Regeneration: From Effective Tissue Exposure to Cell-State Control and Translational Quality Attributes
Shen, T., 徐, 寧., Cai, Z., Guo, W., & Jin, J. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101206
Resolution of inflammation: A novel therapeutic paradigm for rheumatoid arthritis and its comorbidities
Yazdi, R. F., Tan, S. I., Bu, W., FRANCO, B. B., Ng, A. J. K., Peh, H. Y., & Chen, J. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.109655
RNA therapeutics in rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis: a compartment-aware translational framework
Afandizada, Y., Memmedov, H., Orujov, M., Eyvazova, S., & Amikishiyev, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1950465
Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy
张佳宇, Xing, S., Zhang, S., Hao, Y., Qu, X., Bao, W., Hao, M., Sun, H., Dong, M., Zhang, H., et al. (2026) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.70079
Advances in the roles of synovial macrophage subsets in the pathogenesis of rheumatoid arthritis
Zhiping, W. E. I., Yajun, L. I. U., & Shulong, Y. A. N. G. (2026) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2025-0916
Macrophage lipid metabolism and inflammasome activation in rheumatoid arthritis: emerging mechanisms and therapeutic implications
Hao, H., Hongyu, Z., Dong, P., Fan, X., Liu, J., Wu, H., Jia, L., Li, C., Ao, L., & Dong, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1902920
Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis
Nguyen, T.-H., Nguyen, T.-D., Hoang, O.-T., Can, T.-T. T., Nguyen, M.-H. T., Tran, M.-H., Chu, H.-C., & Nguyen, D.-V. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09211-0
Integrated Transcriptomic and Single-Cell Analysis Reveals Shared Macrophage-Associated Inflammatory Signatures in MASLD/NAFLD and Rheumatoid Arthritis
Yu, W., Nie, Q., Wu, Y., Lan, X., Liu, J., Xu, D., & Guan, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209150
Spatial multiomics identifies rheumatoid arthritis synovial niches and de-novo laminar histological patterns of fibroblasts subtypes
Sisó, S., Iyer, A., Raghuram, V., Chaudhary, N., Knight, H., Wang, F., Filip, I., Duggan, L., Wang, X., Naughton, K. A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1883263
Embracing macrophage complexity for research and translation
Ginhoux, F., Mulder, K., Arcila-Barrera, S., & Amit, I. (2026) · Immunity · doi:10.1016/j.immuni.2026.09.015
Joint disease in systemic lupus erythematosus: clinical manifestations, immunopathology, and treatment
Ong, M., Tariq, F., Mahto, A., & Wincup, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1959167
Single-Cell Transcriptomic Analysis Reveals Distinct Pathogenic Subtypes in Hepatocyte- and Cholangiocyte-Directed Autoimmune Liver Injury
Zhao, P., Zhao, L., Zhang, H., Pu, X., Qian, J., Zhao, Y., You, Z., & Ma, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209323
Cell DiffErential Expression by Pooling (CellDEEP) highlights issues in differential gene expression in scRNA-seq
Cheng, Y., Kettlewell, T., Laidlaw, R. F., Hardy, O. M., McCluskey, A., Otto, T. D., & Somma, D. (2026) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqag128
Self-citation
Nanomaterial-based therapeutic strategies for systemic autoimmune rheumatic diseases: from molecular mechanisms to preclinical translation
Guo, H., Xiang, W., Zeng, L., Xiao, W., & Sun, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1981246
Safety, tissue adequacy, and diagnostic contribution of ultrasound-guided synovial biopsy: a retrospective multicenter observational study in a heterogeneous rheumatology cohort
Apaydın, H., Deniz, R., Çelik, G., Erdoğan, M., Kapaklı, G. E. T., Uner, H., Erdoğan, N. Y., Cesmecioglu, E., Türköz, H. K., Beş, C., et al. (2026) · Rheumatology International · doi:10.1007/s00296-026-06340-9
From flare control to recurrence prevention: immune mechanisms and phase-specific therapeutic targets in gouty arthritis
Zhai, X., Wang, T., Xie, M., 蒯乐, Huang, Y., Luo, Y., Song, J., Ru, Y., Ding, X., Zhang, Y., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117603
Molecular underpinnings of rheumatic diseases and emerging therapeutic concepts
Krönke, G., Schett, G. A., & Latz, E. (2026) · Nature · doi:10.1038/s41586-026-10966-x
C/EBPδ in autoimmunity: Linking inflammation and tissue protection
Hu, Y., Chen, J., Liu, Y., Li, C., Wu, B., & Ding, L. (2026) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2026.100412

Authors: Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., Attar, M., Gessi, M., Fedele, A. L., Chilaka, S., Somma, D., Sansom, S. N., Filer, A., McSharry, C., Millar, N. L., Kirschner, K., Nerviani, A., Lewis, M. J., Pitzalis, C., Clark, A. R., Ferraccioli, G., Udalova, I., Buckley, C. D., Gremese, E., McInnes, I. B., Otto, T. D., & Kurowska-Stolarska, M.
Affiliations: Università Cattolica del Sacro Cuore (IT)
Arthritis UK (GB)
Agostino Gemelli University Polyclinic (IT)
University of Oxford (GB)
University of Glasgow (GB)
University Hospitals Birmingham NHS Foundation Trust (GB)
Queen Mary University of London (GB)
Corresponding author: Alivernini, Stefano
ORCID: Alivernini, Stefano
MacDonald, Lucy
Elmesmari, Aziza
Tolusso, Barbara
Gigante, Maria Rita
Petricca, Luca
Perniola, Simone
Attar, Moustafa
Gessi, Marco
Fedele, Anna Laura
Chilaka, Sabarinadh
Somma, Domenico
Sansom, Stephen N.
Filer, Andrew
McSharry, Charles
Millar, Neal L.
Kirschner, Kristina
Nerviani, Alessandra
Lewis, Myles J.
Pitzalis, Costantino
Clark, Andrew R.
Ferraccioli, Gianfranco
Udalova, Irina
Buckley, Christopher D.
Gremese, Elisa
McInnes, Iain B.
Otto, Thomas D.
Kurowska-Stolarska, Mariola
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2020-06-29
Volume: 26
Issue: 8
Pages: 1295-1306
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-020-0939-8
OpenAlex: W3037615636
Cited by: 740
References: 65
Citations by year: 2026: 143 · 2025: 161 · 2024: 145 · 2023: 106 · 2022: 90 · 2021: 80 · 2020: 14
FWCI: 54.63
Type: journal article
Language: en
Open access: green
eprints.gla.ac.uk
Licence: cc-by-sa
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
Funders: European Hematology Association (TRTH172)
Kennedy Trust for Rheumatology Research (KENN161704, KENN192004)
Versus Arthritis (21890, 22253, 22272, 21802)
Medical Research Council (MR/S025308/1)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: rheumatoid arthritis, synovial macrophages, macrophage subsets, inflammation, clinical remission, disease flares, tissue repair, macrophage heterogeneity
MeSH terms: Mannose Receptor, Arthritis, Rheumatoid, Biopsy, Humans, Inflammation, Joints, Macrophages, Receptors, Cell Surface, Receptors, Immunologic, Synovial Fluid, Synovial Membrane, Cell Lineage, Lectins, C-Type, Mannose-Binding Lectins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks