Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Comprehensive Integration of Single-Cell Data

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2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

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Rheumatoid arthritis

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Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

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Tissue-resident macrophages

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S100A8/A9 in Inflammation

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Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372

Mechano-activation of synovial fibroblasts and macrophages during OA progression in the dynamically stiffening synovial microenvironmentPreprint

Kim, S. Y., Farrell, E. C., Burt, K. G., Kwok, B., Liang, Q., Knights, A. J., Sharp, K. L., Nguyen, V., Murphy, L. A., Hu, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.16.706240 · Cited by 3

Targeting macrophages in liver fibrosis

González del Barrio, L., Ipsen, D. H., Pfister, D. R., Hancz, D., & Scott, C. L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1835489 · Cited by 3

The joint accumulation model of arthritis

Nigrovic, P. A. (2025) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2025.152685 · Cited by 2

Engineering CCR2/IFN-γ overexpression in enucleated mesenchymal stem cells enhances therapy for rheumatoid arthritis

Sui, Y., Pu, Z., Yang, N., Luo, Y., Sa, Y., Qi, Q., Tan, L., Yan, Y., & Si, W. (2025) · Communications Biology · doi:10.1038/s42003-025-09248-5 · Cited by 2

Proinflammatory CD20+CD3+ T cells as a potential driver of macrophage reprogramming in rheumatoid arthritis

Jiang, S., Xue, J., Jia, H., Chu, M., Ma, Y., Zhang, H., Li, W., Li, C., Wang, Y., Li, H., et al. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103515 · Cited by 2

Immune cell-derived cytokines synergistically interact to drive synovial fibroblast invasive function and metabolic capacity

Tynan, O., Gilmore, A., Brugman, A. A., Floudas, A., Smith, C. M., Anton, D., Wade, S. C., Orr, C. K., Veale, D. J., & Fearon, U. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103519 · Cited by 2

Understanding the Inflammatory Aspect of Osteoarthritis: Lessons from Immune Checkpoint Inhibitors

Portnoy, D. M., Paiola, M., Tymm, C. C., WINCHESTER, R. J., Mor, A., & Gartshteyn, Y. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15020658 · Cited by 3

TLR3 and GLUL orchestrate inflammatory and homeostatic imbalance in osteoarthritis

Wang, J., Xu, S., Chen, B., Peng, P., Wang, K., & Qin, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1650375 · Cited by 2

Integrative multi-omics analysis reveals CXCL10-driven inflammation and TREM2 + macrophage-plasma cell survival niche as hallmarks of late-stage rheumatoid arthritis

Li, J., Liu, M., Peng, Y., & Wu, R. (2026) · Arthritis Research & Therapy · doi:10.1186/s13075-026-03764-3 · Cited by 2

Naringin nanoparticles alleviate RA-ILD pulmonary fibrosis by targeting 14-3-3ζ to inhibit LYVE1+ macrophages TGF-β1 secretion

Li, X., Wang, J., Zhang, X., Wang, X., Sun, C., Zhao, N., Liu, Z., Schiöth, H. B., Wang, H., & Zhang, Y. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102982 · Cited by 2

Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response

Ríos, I., Schiaffino, M. T., López-Navarro, B., Triguero‐Martínez, A., Lin, M., Torres‐Torresano, M., Struys, E. A., Álvarez, S., Román, M., Abad‐Santos, F., et al. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06162-9 · Cited by 2

Mitochondrial dysregulation in rheumatoid arthritis: From pathogenic mechanisms to therapeutic innovations

Wang, A., Ma, T., Yu, J., Hu, Y., & Di, X. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116622 · Cited by 2

Diagnostic, prognostic and therapeutic biomarkers in rheumatoid arthritis

Szekanecz, Z., Gunkl-Tóth, L., Szamosi, S., van der Woude, D., McInnes, I. B., & Nagy, G. (2026) · Nature Reviews Rheumatology · doi:10.1038/s41584-026-01391-5 · Cited by 2

Macrophage Metabolic Reprogramming in Rheumatoid Arthritis: Pathogenic Mechanisms and Therapeutic Implications

Chen, L., Leng, S., Liu, X., Zhang, J., Zhao, F., Hu, Z., Cai, X., & Lin, Y. (2026) · Cells · doi:10.3390/cells15131166 · Cited by 2

Cellular crosstalk and signaling networks in the rheumatoid arthritis synovial microenvironment

Feng, M., Chen, H. H., Liao, L., Huang, D., Shen, J., Xiao, L., Lu, Q., & Xie, P. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08482-7 · Cited by 2

CD19 CAR T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a phase 1 trial

Albach, F. N., Rehm, M. C., Hütter‐Krönke, M. L., Le, T. H., Giezen, J. M., Torğutalp, M., Sattler, A., Minopoulou, I., Biesen, R., Wiebe, E., et al. (2026) · Nature Medicine · doi:10.1038/s41591-026-04603-3 · Cited by 2

Influence of Staphylococcus epidermidis on Collagen Crimp Patterns of Soft Tissue Allograft

Blunt, K. M., Bentkowski, B. N., Milliron, E. M., Cavendish, P. A., Qin, C. D., Magnussen, R. A., Stoodley, P., & Flanigan, D. C. (2023) · The American Journal of Sports Medicine · doi:10.1177/03635465231181649 · Cited by 2

Electroacupuncture attenuates bone erosion and promotes macrophage polarization in a mouse model of collagen-induced arthritis

Dong, S., Zhou, Y., Wang, X.-C., Du, Z.-H., & Tian-shen, Y. (2025) · Acupuncture in Medicine · doi:10.1177/09645284251331991 · Cited by 2

The distinct transcriptomic signature of the resolution phase fibroblast-like synoviocytes supports endothelial cell dysfunction

Gautam, S., Whittaker, J. E., Vekariya, R., Ramírez-Pérez, S., Gangishetti, U., Drissi, H., & Bhattaram, P. (2025) · Communications Biology · doi:10.1038/s42003-025-08250-1 · Cited by 3

Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis

Floudas, A., Gorman, Á., Neto, N. G. B., Monaghan, M. G., Elliott, Z., Fearon, U., & Marzaioli, V. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.830998 · Cited by 3

A multiparametric risk table for loss of clinical remission status in patients with rheumatoid arthritis: a STARTER study post-hoc analysis

Perniola, S., Alivernini, S., Gremese, E., Landolfi, G., Carrara, G., Iagnocco, A., & Scirè, C. A. (2024) · Lara D. Veeken · doi:10.1093/rheumatology/keae094 · Cited by 2

Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosisPreprint

Ng, M., Borst, R., Gacaferi, H., Davidson, S., Machado, C. C., Reekie, I. R., Attar, M., Windell, D., Kurowska‐Stolarska, M., MacDonald, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.16.522218 · Cited by 2

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesisPreprint

Gopee, N. H., Huang, N., Olabi, B., Admane, C., Botting, R. A., Foster, A. R., Torabi, F., Winheim, E., Sumanaweera, D., Goh, I., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.12.556307 · Cited by 2

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent processPreprint

Pinto, M. M., Malengier‐Devlies, B., Seuzaret, G., Ahlback, A., Becker, S., Patatsos, K., Drakoulis, G., Karjalainen, J., Ruedl, C., Voehringer, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.21.655269 · Cited by 2

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synoviumPreprint

Khmelevskaya, A. A., Apostolopoulou, K., Cebrian, C. C., Ezen, E., Toitou, M., Laphanuwat, P., Mirrahimi, M., Geiß, C., Lugar, M., Kakale, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.17.688477 · Cited by 3

Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clustersPreprint

Bell, R. D., Huang, M., Yuan, R., Wingert, C. K., Mishra, B., Seren, S., Singh, T., MacLauchlan, S., Gravallese, E. M., Singh, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.24.690174 · Cited by 2

Fibroblasts sense spatial proximity via an EGFR–CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritisPreprint

Presti, S., Anufrieva, K. S., Gao, C., Prell, S. A., Bhamidipati, K., Khedgikar, V., BLAZAR, P. E., Lange, J. K., Jones, M. H., Brenner, M. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.10.693501 · Cited by 2

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

MacDonald, L., Apostolopoulou, K., Hardy, O. M., Toitou, M., Kania, G., Błyszczuk, P., Micheroli, R., Otto, T. D., Kurowska‐Stolarska, M., & Ospelt, C. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70238 · Cited by 1

Effects of Bone Marrow-derived Mesenchymal Stem Cells-loaded Self-assembling Peptide Scaffold on Synovial Volume and Cartilage Thickness on Rabbit Model of Rheumatoid Arthritis

Sha, R., & Li, J. Z. (2025) · The Journal of Animal and Plant Sciences · doi:10.36899/japs.2025.4.0078 · Cited by 1

The basic and research progress of joint barrier dysfunction in joint diseases

Peng, R. Y., Peng, Y., Zou, Y., Li, Z., Zha, Z., & Zhang, H. (2025) · Guidelines and Standards of Chinese Medicine · doi:10.1097/gscm.0000000000000067 · Cited by 2

Challenges and Opportunities in Psoriatic Disease: An Integrated View of the Future

Chinchay, L., Song, K., Stark, J. L., Ward, N. L., & McInnes, I. B. (2025) · The Journal of Rheumatology · doi:10.3899/jrheum.2025-0264 · Cited by 1

Reduced mortality but elevated venous thromboembolism risk following knee and hip arthroplasty in patients with rheumatoid arthritis: A general population-based cohort study

Deng, X., Lu, N., Xie, D., Li, H., & Wang, H.-C. (2025) · PLoS ONE · doi:10.1371/journal.pone.0335453 · Cited by 1

Engineered cell therapies for autoimmune diseases: evaluating CAR-T and CAR-M progress and prospects

Zheng, M., Chen, J., & Yang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1658867 · Cited by 1

Modulating synovial macrophage responses to nociceptive signals attenuates inflammation in rheumatoid arthritis

Lin, L., Yang, C., Lin, Y., Yuan, X., Huang, J., Cai, Y., Zhang, C., Li, H., Zhang, C., Lin, H., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.11.028 · Cited by 2

IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis

Liu, H., Wu, C., Li, G., Peng, X., Zhang, Z., Su, Z., Lin, J., Wang, X., Shen, H., Wu, Y., et al. (2025) · Arthritis Research & Therapy · doi:10.1186/s13075-025-03708-3 · Cited by 2

Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling

Shi, G., Liu, X., Wei, Y., Gao, R., Gao, X., Zhou, Y., Chen, C., Yang, J., Wang, W., Sun, L., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.11.031 · Cited by 1

Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes

Alluri, A. A., Pawar, A. R., Khetan, S. P., Singhal, R., Suvarna, S. S., Adsure, M. R., & Swathi, N. L. (2025) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2025-0060 · Cited by 1

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Spoelstra, L. R., Semmekrot, F., Araújo‐Gomes, N., Wijnperlé, D., Helsen, M. M. A., van den Bosch, M. H. J., Segerink, L. I., Gac, S. L., & Karperien, M. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202504857 · Cited by 1

Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis

Nicorescu, I., Thomson, A., Merces, G., Harrison, J., Millar, B., Pratt, A. G., Anderson, A. E., Diboll, J., Rankin, K. S., Somma, D., et al. (2026) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2026.01.004 · Cited by 1

Rheumatoid arthritis: revisiting pathogenesis for prevention, stratification, and repair

Coutant, F., & Miossec, P. (2026) · Current Opinion in Immunology · doi:10.1016/j.coi.2026.102735 · Cited by 1

Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models

He, Y., Ye, K., Zhang, Y., Chen, Z., Sun, H., Cui, G., Ghanad, P., Mao, Z., Huang, Y., Ren, Z., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69540-8 · Cited by 2

Sex-associated transcriptional changes to synovial macrophages in the aging joint

Dapas, M., DeJong, E. N., Wang, Y., Mills, C., Dowling, S. D., Mayer, M., Therron, T., Hamilton, S., Cuda, C. M., Bowdish, D. M. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1724385 · Cited by 2

Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages

Satoeya, N., Zack, S. R., Zoubi, O. A., Umar, S., Burgos, A. C., Abdulrab, S., Zanotti, B., Volin, M. V., Karam, J. A. Q., Xia, Y., et al. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01395-x · Cited by 1

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Sheridan, K. J., Dorris, E., Pimenta, M. I., Falkov, J., Fisher, M., Pledger, S., Devey, H., Muthana, M., Shields, D. C., Mains, R. E., et al. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70123 · Cited by 1

Single-cell omics reveals arg-1 as a key regulator of age-dependent macrophage-mediated cartilage repair

Chu, J., Wen, Z., Wu, W., & Wu, S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0344693 · Cited by 1

Insights into the pathogenesis of rheumatic and immune diseases from single-cell omics

Wan, W., Zhang, S., Jiang, Y., & Zhao, D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1768719 · Cited by 1

Ultrasound-Guided Synovial Biopsy Can Be Effectively and Safely Performed in Different Clinical Settings Favouring a Widespread Application of Precision Medicine in Rheumatoid Arthritis: A Post-hoc Analysis of Three Clinical Trials

Congia, M., Marini, S., Nerviani, A., Rivellese, F., Thorborn, G., Hands, R., Angioni, M. M., Chessa, E., Floris, A., Mascia, P., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15062233 · Cited by 1

Gut microbiome differences by serostatus in rheumatoid arthritis: a systematic review

Nurgaziyev, M., Kozhakhmetov, S., Issilbayeva, A., Jarmukhanov, Z., Nurgaziyeva, A., Sergazy, S. D., Kuantkhan, M., Chulenbayeva, L., & Kushugulova, A. R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1722255 · Cited by 1

Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBP+ myeloid cells

Wang, L., Qi, H., Zhang, Y., 魏国招, Pan, Z., Li, X., Ma, F., Zhang, H., Yang, R., Li, X., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08075-4 · Cited by 1

PANoptosis fuels the fire of arthritis

Nagakannan, P., & Kanneganti, T. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.017 · Cited by 1

Collagen hybridizing peptide imaging and delivery of therapeutic antibody in rheumatoid arthritis models

Mo, X., Huang, Y., Chen, H., Huang, J., Huang, K., Zhao, S., Wang, X., 张奎渤, & Li, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-72038-y · Cited by 1

How Selective are Nanomaterials to Treat Osteoarthritis

Zhang, Y., Cheng, X., Tian, J., Liu, J., Teng, Y., Chen, J., Wu, Z., Ding, H., & Zhang, Z. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s601362 · Cited by 1

Synovial biopsy and tissue sampling in the management of RA

Bruno, D., Tolusso, B., Gremese, E., & Pitzalis, C. (2026) · Lara D. Veeken · doi:10.1093/rheumatology/keag241 · Cited by 1

Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis

Wang, Y., Dowling, S. D., Maciuch, J., Rodriguez, V., Mayer, M., Mian, K., Therron, T., Makinde, H. M., Cuda, C. M., Winter, D. R., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag077 · Cited by 1

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

Wang, L., Ge, J., Wang, Z., Fang, Y., Jia, Y., Zhang, R., & Qin, Y. (2026) · MedComm · doi:10.1002/mco2.70764 · Cited by 1

Synovial Telocytes Are Characterized by Efhd1, Dpp4 , and Pi16 Expression, Show High Responsiveness to Osmotic Stress, and Exhibit Fibroblast Plasticity Potential

Peng, Y. H., Kobryn, A., Xing, L., Korman, B. D., Ritchlin, C. T., & Schwarz, E. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70241 · Cited by 1

HIF-1α in macrophage polarization: roles in immunometabolism and autoimmune diseases

Li, D., Pan, X., He, Z., Cui, J., Zhu, R., & Guo, D. (2026) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiag082 · Cited by 1

Single-cell and spatial transcriptomics analysis of osteoarthritis: pathway regulation, cell interaction networks, and therapeutic translation

Yang, D., Lü, J., Liu, Q., Gong, G. N., Chen, J., Song, Z., Ye, Z., Wang, S., Xiao, Y., & Wang, G. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08603-2 · Cited by 1

Macrophages and the Tissue Repair Circuit: Homeostasis, Autoimmune Diseases, and Resolution-Based Therapeutic Strategies

Mosallanejad, K., Hubeau, C., Sterman, A. S., & Tan, Y. (2026) · Cells · doi:10.3390/cells15151412 · Cited by 1

B. burgdorferi infection alters synovial macrophage responses in a human ex vivo model of Lyme Arthritis

Mulford, K. E., Johnson, R. M., Oleson, E. S., Dennis, J. L., Butler, K. L., Draayer, T., Elkins, J. M., Petersen, C. A., & Cyndari, K. I. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1819452 · Cited by 1

KETO[18F]FDG -VAP-P1: In vivo studies of a potential PET radiotracer for diagnosis of inflammation

Almeida, F. A. D. F., Schirmer, B. G. D. A., Silva, J. D. O., Bispo, A. C. D. A., Mendes, B. M., Ferreira, A. V., Silva, J. B., & Mamede, M. H. (2022) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2022.110547 · Cited by 1

Are the origins of adult arthritis seeded during embryonic development?

Hackland, A., & Croft, A. P. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00911-x · Cited by 1

Identification the immune related marker genes and transcription-factor network in ruptured cerebral aneurysms using bioinformatics analysis and machine-learning strategies

Zhao, X., Fu, J., Lei, C., Wang, Z., & Jing, Z. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.105611 · Cited by 1

Structural Features and Physiological Associations of Human 14-3-3ζ Pseudogenes

Lughmani, H. Y., Patel, H., & Chakravarti, R. (2024) · Genes · doi:10.3390/genes15040399 · Cited by 1

Перспективы применения системы CRISPR/Cas9 с позиции клинической фармакологии A.S. Kolbin Y.M. Gomon The authors review the data on the use of the CRISPR/Cas9 system in clinical pharmacology. The discovery of the CRISPR/Cas9 system and the first clinical application, structure and mechanism of action, delivery platforms, and ethical aspects of genome editing are described. Issues of pharmacokinetics, pharmacodynamics, dosing and safety are considered. Examples of the ex vivo and in vivo use of CRISPR/Cas9 in clinical trials are provided. The indicators that distinguish CRISPR therapy from previous classes of drugs are highlighted. 06 25 2024 05 26 2024 7 15. 10.32756/0869-5490-2024-2-7-15. https://clinpharm-journal.ru/articles/2024-2/perspektivy-primeneniya-sistemy-crispr-cas9-s-pozitsii-klinicheskoj-farmakologii/ <!-- ============== --> Is it possible to cure rheumatoid arthritis by studying factors that impede recovery?

Muravyov, Y. V. (2024) · Clinical pharmacology and therapy · doi:10.32756/0869-5490-2024-2-23-26

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Jiang, K., He, Q., Wang, C., Yang, W., Zhou, C., Li, J., Li, J., Cui, Y., Shi, J., Wei, Z., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12112526 · Cited by 1

Exploring perinatal mesenchymal stromal cells as a potential therapeutic strategy for rheumatoid arthritis

Alivernini, S., Masserdotti, A., Magatti, M., Cargnoni, A., Papait, A., Silini, A. R., Romoli, J., Ficai, S., Mario, C. D., Gremese, E., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41438 · Cited by 4

Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression

Chen, Y., Zhang, Z., Yao, Y., Zhou, X., Ling, Y., Mao, L., & Gu, Z. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47010038 · Cited by 1

Fibroblast and myeloid cells with high mitochondrial RNA content represent biologically significant populations within the OA synovium

Tran, W., Blackler, G., Luo, R., Appleton, C. T., & Grol, M. W. (2025) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2025.10.002 · Cited by 2

COVID-19 and Rheumatoid Arthritis share myeloid pathogenic and resolving pathwaysPreprint

MacDonald, L., Otto, T. D., Elmesmari, A., Tolusso, B., Somma, D., McSharry, C. P., Gremese, E., McInnes, I. B., Alivernini, S., & Kurowska‐Stolarska, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.26.221572 · Cited by 2

Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expressionPreprint

Meednu, N., Rangel‐Moreno, J., Zhang, F., Escalera-Rivera, K., Corsiero, E., Prediletto, E., DiCarlo, E. F., Goodman, S. M., Donlin, L. T., Raychaudhuri, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.14.443150 · Cited by 1

Seven chain adaptive immune receptor repertoire analysis in rheumatoid arthritis: association to disease and clinically relevant phenotypesPreprint

Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Fernández, S., Sanmartí, R., Fernández‐Nebro, A., et al. (2021) · medRxiv · doi:10.1101/2021.11.26.21266347 · Cited by 1

Perivascular RELM⍺-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritisPreprint

Schonfeldova, B., Chibwana, M. G., Gentek, R., Zec, K., & Udalova, I. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.11.637672 · Cited by 1

Cellular composition of tissue-resident monocyte-lineage cells reveal functional heterogeneity during inflammatory arthritisPreprint

Wang, Y., Dowling, S. D., Maciuch, J., Rodriguez, V., Mayer, M., Mian, K., Therron, T., Makinde, H. M., Cuda, C. M., Winter, D. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.13.659432 · Cited by 1

Spatially resolved fetal and maternal cell contributions to severe PreeclampsiaPreprint

Sánchez-Corrales, Y. E., Xenakis, T., Moreno-Villena, J. J., Forrest, L., Sebire, N. J., Rosser, E. C., Wedderburn, L. R., Castellano, S., & Hillman, S. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.18.665528 · Cited by 1

Subcellular spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritisPreprint

Inamo, J., Fierkens, R., Clay, M. R., Jonsson, A. H., Lin, C., Hayes, K., Rogers, N., Leach, H., & Yomogida, K. (2025) · medRxiv · doi:10.1101/2025.08.05.25332835 · Cited by 1

Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the jointsPreprint

Raimondo, M. G., Mohammadian, H., Angeli, M. R., Alivernini, S., Fedorchenko, V., Huang, K., Demmler, R., Rhein, P., Xu, C., Li, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.14.665302 · Cited by 1

Synovial lining–expressed mechanosensor PIEZO1 drives inflammation-permissive macrophage phenotypes and joint inflammationPreprint

Simakou, T., Doohan, M., Huesa, C., Woolcock, K., Somma, D., Nyasulu, W. H., Prakash, S., Boyle, K. A., Yang, L., Zhang, B. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.12.699005 · Cited by 1

Practical Use of Advanced AI Frameworks on Real-Life Scientific Problems: Three Case StudiesPreprint

Gulluoglu, H. S. A., Baby, J., Bagul, K. M., Basangari, B. R., Bathini, S. A., Chalamalla, N. K. R., Dcunha, J., Gupta, O., Huang, L., Jiang, X., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.23.734132 · Cited by 2

Exosome-mediated immune modulation in rheumatoid arthritis and its role in synovial inflammation and autoimmune amplification

Kalidass, B., Murugesan, K., Shanmugam, A., Kaveri, P. K., & Lakshmanan, D. K. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105129

Tissue-resident, extravascular CD64 - Ly6C - population forms a critical barrier for inflammation in the synoviumPreprint

Montgomery, A. B., Chen, S. Y., Gadhvi, G. T., Mayr, M. G., Cuda, C. M., Dominguez, S. T., Makinde, H. M., Misharin, A. V., Gurra, M. G., Akbarpour, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.25.432850

Can we treat inflammation by managing misbehaving monocytes?

Milling, S. W. F. (2021) · Immunology · doi:10.1111/imm.13334

Protektive Makrophagen

Knab, K., Chambers, D., & Krönke, G. (2021) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-021-01112-1

PERSONALITY PROFILE AND TENDINOPATHIES IN SOCCER PLAYERS

Vago, P., Casolo, F., & Gatti, M. (2013)

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistencePreprint

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Lawson, H., Coelho, P., Murphy, F. A., Griffith, D. M., Zhang, A., Sánchez-García, M. A., Reyes, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.11.483935

Macrophage differentiation

Timperi, E., & Ramos, R. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821385-8.00005-6

Seven Chain Adaptive Immune Receptor Repertoire Analysis in Rheumatoid Arthritis: Association to Disease and Clinically Relevant PhenotypesPreprint

Aterido, A., Lasanta, M. L., Blanco, F. J., Juan-Mas, A., García-Vivar, M. L., Erra, A., Pérez-García, C., Fernández, S., Sanmartí, R., Fernández‐Nebro, A., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3992679

Ablation of PDIA3 attenuates rheumatoid arthritis by restraining Th1 and Th17 polarization programPreprint

Wang, C., Wang, F., Yang, C., Luo, J., Rong, S.-J., Zhou, H., Lu, W.-Y., Chen, Q.-J., Wang, T., Song, D.-N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2136951/v1

Rémission prolongée en l'absence d'un traitement de fond dans la polyarthrite rhumatoïde – concepts et évolution vers la pratique

Verstappen, M., & Mil, A. H. M. V. D. H. (2022) · Revue du Rhumatisme · doi:10.1016/j.rhum.2022.11.003

Macrophages et inflammation articulaire : quoi de neuf dans l’arthrose ?

Gaigeard, N., Blanchard, F., Vinatier, C. S., Goff, B. L., Guicheux, J., & Boutet, M. (2023) · Revue du Rhumatisme · doi:10.1016/j.rhum.2022.12.015

Immunopharmacology sessions at the 19th World Congress of Basic & Clinical Pharmacology 2023

Peh, H. Y., Gurgone, D., & Maffia, P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106911

Resident Synovial Macrophages in Synovial Fluid: Implications for Immunoregulation in Infectious and Inflammatory ArthritisPreprint

Cyndari, K. I., Scorza, B. M., Zacharias, Z. R., Strand, L., Mahachi, K. G., Oviedo, J. M., Gibbs, L. C., Pessôa-Pereira, D., Ausdal, G., Hendricks, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.29.560183

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencingPreprint

Binvignat, M., Miao, B., Wibrand, C., Yang, M., Rychkov, D., Flynn, E., Nititham, J., Tamaki, W., Khan, U., Carvidi, A. B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.05.560352

Correlation Analysis between Serum LYVE1 and Rheumatoid Arthritis

李, 骁. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.142343

Reply

Wood, M. K., Won, T., & Čiháková, D. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42855

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modificationPreprint

Haag, S. M., Xie, S., Eidenschenk, C., Fortin, J., Callow, M. G., Costa, M., Lun, A. T. L., Cox, C., Wu, S. Z., Pradhan, R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.12.589122

Levels of sCD163 in women rheumatoid arthritis: Relationship with cardiovascular risk markers

Zaragoza-García, Ó., Briceño, O., Villafán-Bernal, J. R., Gutiérrez-Pérez, I. A., Rojas-Delgado, H. U., Alonso-Silverio, G. A., Alarcón-Paredes, A., Navarro‐Zarza, J. E., Morales-Martínez, C., Rodríguez-García, R., et al. (2024) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2024.04.002

PFS alleviates bone destruction in collagen-induced arthritis mice associated with macrophage polarizationPreprint

Sun, G., Bao, C., Sun, X., & Liu, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.12.598735

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid ArthritisPreprint

MacDonald, L., Elmesmari, A., Somma, D., Frew, J., Mario, C. D., Madhu, R., Paoletti, A., Simakou, T., Hardy, O. M., Tolusso, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.17.600758

Synovial macrophage populations linked to RA remission

McHugh, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0481-6 · Cited by 10

Distinct tissue macrophage subsets regulate inflammation and provide a novel cellular and molecular mechanism for disease remission in rheumatoid arthritis

Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Mario, C. D., Bui, L., Perniola, S., et al. (2020) · Nature Medicine

03.13 Synovial tissue of ra patients in remission contains a unique population of regulatory macrophages

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D., Sante, G. D., Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B., & Kurowska‐Stolarska, M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-211049.13 · Cited by 3

OP0208 Synovial tissue of ra patients in remission contains a unique population of regulatory macrophages

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. D., Sante, G. D., Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B., & Kurowska‐Stolarska, M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-eular.5910 · Cited by 1

Synovial tissue macrophages: friend or foe?

Kurowska‐Stolarska, M., & Alivernini, S. (2017) · RMD Open · doi:10.1136/rmdopen-2017-000527 · Cited by 140