A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq
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The mouse has been widely used as a model organism for studying human diseases and for evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity that may be reflected by tissue-specific gene-expression profiles. Here we construct a comprehensive mouse transcriptomic BodyMap across 17 tissues of six-weeks old C57BL/6JJcl mice using RNA-seq. We find different expression patterns between protein-coding and non-coding genes. Liver expressed the least complex transcriptomes, that is, the smallest number of genes detected in liver across all 17 tissues, whereas testis and ovary harbor more complex transcriptomes than other tissues. We report a comprehensive list of tissue-specific genes across 17 tissues, along with a list of 4,781 housekeeping genes in mouse. In addition, we propose a list of 27 consistently and highly expressed genes that can be used as reference controls in expression-profiling analysis. Our study provides a unique resource of mouse gene-expression profiles, which is helpful for further biomedical research.
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The kidney and submandibular gland had higher expression of endogenous acidic β-gal.
“we found that the kidney and submandibular gland had higher expression of endogenous acidic β-gal”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [51]
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- Authors
- Li, B., Qing, T., Zhu, J., Wen, Z., Yu, Y., Fukumura, R., Zheng, Y., Gondo, Y., & Shi, L.
- Affiliations
- Fudan University (CN)
- Sichuan University (CN)
- RIKEN BioResource Research Center (JP)
- Corresponding author
- Zheng, Yuanting
- Gondo, Yoichi
- Shi, Leming
- Venue
- Scientific Reports
- Published
- 2017-06-23
- Volume
- 7
- Issue
- 1
- Pages
- 4200-4200
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5482823
- OpenAlex
- W2644618666
- Cited by
- 184
- References
- 49
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 18 · 2023: 25 · 2022: 22 · 2021: 22 · 2020: 37 · 2019: 22 · 2018: 6 · 2017: 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (111 Project, B13016, 31671368, 31471239, 31601085, 31471239, 31671368)
- Higher Education Discipline Innovation Project (B13016)
- Japan Society for the Promotion of Science (16H06279, 17H00789, 25241016)
- National Key Research and Development Program of China (2016YFC0901704)
- National Supercomputing Center, Korea Institute of Science and Technology Information
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- mouse transcriptome, tissue-specific gene expression, C57BL/6J mice, tissue-specific genes, housekeeping genes, non-coding RNA, liver transcriptome, tissue expression profiling
- MeSH terms
- Animals, Female, Male, Mice, Inbred C57BL, Organ Specificity, Sequence Analysis, RNA, Genes, Essential, Gene Expression Profiling, Transcriptome
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