Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

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New evidence for refinement of anesthetic choice in procedures preceding the forced swimming test and the elevated plus-maze

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Rapid‐acting antidepressants and the regulation of TrkB neurotrophic signalling—Insights from ketamine, nitrous oxide, seizures and anaesthesia

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A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction

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Synthetic surprise as the foundation of the psychedelic experience

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Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons

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Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

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Ketamine alleviates fear memory and spatial cognition deficits in a PTSD rat model via the BDNF signaling pathway of the hippocampus and amygdala

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Effects of the Antidepressant Fluoxetine on the Somatostatin Interneurons in the Basolateral Amygdala

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Perineuronal Nets in the Dorsomedial Striatum Contribute to Behavioral Dysfunction in Mouse Models of Excessive Repetitive Behavior

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Influence of MRI Examinations on Animal Welfare and Study Results

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Linking Hypothermia and Altered Metabolism with TrkB Activation

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A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine

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Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: Importance of burst suppression pattern

Theilmann, W., Alitalo, O., Yorke, I., & Rantamäki, T. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.018 · Cited by 11 · see citing works

HCN channels: New targets for the design of an antidepressant with rapid effects

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Efficacy of chronic ultrasound neurostimulation on behaviors and distributed brain metabolism in depressive-like micePreprint

Legrand, M., Galineau, L., Novell, A., Planchez, B., Brizard, B., Leman, S., Tauber, C., Escoffre, J., Lefèvre, A., Gosset, P., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/813006 · Cited by 11 · see citing works

Antidepressant effects of dexmedetomidine compared with ECT in patients with treatment-resistant depression.

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Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice

Alitalo, O., Kohtala, S., Rosenholm, M., Saarreharju, R., González-Hernández, G., Sarparanta, M. P., Rozov, S. V., & Rantamäki, T. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110172 · Cited by 10 · see citing works

In silico repositioning of approved drugs against Schistosoma mansoni energy metabolism targets

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Sevoflurane augmentation in treatment-resistant depression: a clinical case study

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Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model

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Lack of antidepressant effects of burst-suppressing isoflurane anesthesia in adult male Wistar outbred rats subjected to chronic mild stress

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Effects of the presence and absence of amino acids on translation, signaling, and long‐term depression in hippocampal slices from Fmr1 knockout mice

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Sevoflurane exerts antidepressant-like effects via the BDNF-TrkB pathway

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Propofol for treatment resistant depression: A randomized controlled trialPreprint

Tadler, S. C., Jones, K. G., Lybbert, C., Huang, J. C., Jawish, R., Solzbacher, D., Kendrick, E., Pierson, M. D., Weischedel, K., Rana, N., et al. (2023) · medRxiv · doi:10.1101/2023.09.12.23294678 · Cited by 7 · see citing works

A synopsis of multitarget therapeutic effects of anesthetics on depression

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Effect of ischemic lesions in medial prefrontal cortex and nucleus accumbens on affective behavior in rats

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Learned Helplessness in Rodents

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Combination of Shengmai San and Radix puerariae ameliorates depression‐like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression

Ahmed, A., Zeng, G., Azhar, M., Wang, F., Wang, J., Fan, B., Liu, X., Jiang, D., & Wang, Q. (2023) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12333 · Cited by 6 · see citing works

Digital autoradiography for efficient functional imaging without anesthesia in experimental animals: Reversing phencyclidine-induced functional alterations using clozapine

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Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress

Hennessy, L. A., Seewoo, B. J., Jaeschke-Angi, L., Mackie, L. A., Figliomeni, A., Arena-Foster, Y., Etherington, S. J., Dunlop, S. A., Croarkin, P. E., & Rodger, J. (2022) · Neuroimage Reports · doi:10.1016/j.ynirp.2022.100104 · Cited by 5 · see citing works

Pimavanserin treatment increases plasma brain-derived neurotrophic factor levels in rats

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Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats

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CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice

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Confirmation of Decreased Rates of Cerebral Protein SynthesisIn Vivoin a Mouse Model of Tuberous Sclerosis Complex

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Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinctionPreprint

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The neural substrates of different depression symptoms: Animal and human studies

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Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25‐6981, increases glutamate neurotransmission and induces antidepressant‐like effects

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Isoflurane Rescue Schizophrenia-Related Deficits through Parvalbumin-Positive Neurons in the Dentate Gyrus

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Short or moderate-time exposure to the inhalational anesthetics isoflurane and sevoflurane does not alter the marble-burying behavior in mice

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Ketamine alleviates fear memory and spatial cognition deficits in PTSD rat model via BDNF signaling pathway of hippocampus and amygdalaPreprint

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Beyond surgery: Repurposing anesthetics for treatment of central nervous system disorders

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Inhaled gases for treatment-resistant major depression

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Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook

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Optimized ultrasound neurostimulation of ventromedial prefrontal cortex reverses depression behaviours and normalizes brain metabolism

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