Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986

NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis

Zhou, G., Soufan, O., Ewald, J., Hancock, R. E. W., Basu, N., & Xia, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz240 · Cited by 1,915

The underappreciated role of muscle in health and disease

Wolfe, R. R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.475 · Cited by 1,629

Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes

Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.010 · Cited by 1,531

Fasting: molecular mechanisms and clinical applications

Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145

Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges

Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data

Xia, J., Gill, E. E., & Hancock, R. E. W. (2015) · Nature Protocols · doi:10.1038/nprot.2015.052 · Cited by 954

Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Wilkinson, M. J., Manoogian, E. N. C., Zadourian, A., Lo, H., Fakhouri, S., Shoghi, A., Wang, X., Fleischer, J. G., Navlakha, S., Panda, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.004 · Cited by 927

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549

Molecular mechanisms of dietary restriction promoting health and longevity

Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Acosta-Rodríguez, V., Rijo-Ferreira, F., Izumo, M., Xu, P., Wight-Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 390

Dietary restriction impacts health and lifespan of genetically diverse mice

Francesco, A. D., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L. L., Garland, G., Donato, H., Vincent, M. J., Schott, W., et al. (2024) · Nature · doi:10.1038/s41586-024-08026-3 · Cited by 204

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., Wright, K. M., et al. (2023) · doi:10.1101/2023.11.28.568901 · Cited by 194

Dietary regulation in health and disease

Wu, Q., Gao, Z., Yu, X., & Wang, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01104-w · Cited by 190

Lipid metabolism around the body clocks

Petrenko, V., Sinturel, F., Riezman, H., & Dibner, C. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101235 · Cited by 171

Developing dietary interventions as therapy for cancer

Taylor, S. R., Falcone, J. N., Cantley, L. C., & Goncalves, M. D. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00485-y · Cited by 166

Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial

Teong, X. T., Liu, K., Vincent, A. D., Bensalem, J., Liu, B., Hattersley, K. J., Zhao, L., Feinle‐Bisset, C., Sargeant, T. J., Wittert, G., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02287-7 · Cited by 147

Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals

Deota, S., Lin, T. C., Chaix, A., Williams, A. E., Le, H. D., Calligaro, H., Ramasamy, R., Huang, L., & Panda, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.006 · Cited by 142

The obesity-breast cancer link: a multidisciplinary perspective

Devericks, E. N., Carson, M. S., McCullough, L. E., Coleman, M. F., & Hursting, S. D. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10043-5 · Cited by 117

When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging

Mihaylova, M. M., Chaix, A., Delibegović, M., Ramsey, J. J., Bass, J. T., Melkani, G. C., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.008 · Cited by 94

The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF

Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.012 · Cited by 74

Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism

Trautman, M. E., Richardson, N. E., & Lamming, D. W. (2022) · Aging Cell · doi:10.1111/acel.13626 · Cited by 68

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Suchacki, K. J., Thomas, B. J., Ikushima, Y. M., Chen, K.-C., Fyfe, C., Tavares, A., Sulston, R. J., Lovdel, A., Woodward, H. J., Han, X., et al. (2023) · eLife · doi:10.7554/elife.88080 · Cited by 75

Dietary strategies with anti-aging potential: Dietary patterns and supplements

Duan, H., Pan, J., Guo, M., Li, J., Yu, L., & Fan, L. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111501 · Cited by 72

Adipose tissue aging is regulated by an altered immune system

Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62

Traditional and Medical Applications of Fasting

Visioli, F., Mucignat‐Caretta, C., Anile, F., & Panaite, S.-A. (2022) · Nutrients · doi:10.3390/nu14030433 · Cited by 63

Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review

Surugiu, R., Iancu, M. A., Vintilescu, Ş. B., Stepan, M. D., Burdusel, D., Genunche-Dumitrescu, A. V., Dogaru, C.-A., & Dumitra, G. G. (2024) · Nutrients · doi:10.3390/nu16172878 · Cited by 72

Current Trends in Anti-Aging Strategies

Rosén, R., & Yarmush, M. L. (2023) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-120122-123054 · Cited by 54

Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment

Rajeev, V., Fann, D. Y., Dinh, Q. N., Kim, H. A., Silva, T. M. D., Jo, D., Drummond, G. R., Sobey, C. G., Lai, M. K. P., Chen, C., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.75188 · Cited by 49

Adipose tissue macrophages: implications for obesity-associated cancer

Li, B., Sun, S., Li, J.-J., Yuan, J.-P., Sun, S., & Wu, Q. (2023) · Military Medical Research · doi:10.1186/s40779-022-00437-5 · Cited by 53

An integrative approach to dietary balance across the life course

Raubenheimer, D., Senior, A. M., Mirth, C. K., Cui, Z., Hou, R., Couteur, D. G. L., Solon‐Biet, S. M., Léopold, P., & Simpson, S. J. (2022) · iScience · doi:10.1016/j.isci.2022.104315 · Cited by 50

Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules

Kazmirczak, F., Hartweck, L. M., Vogel, N. T., Mendelson, J. B., Park, A. K., Raveendran, R. M., O‐Uchi, J., Jhun, B. S., Prisco, S. Z., & Prins, K. W. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.12.001 · Cited by 43

Does diet influence aging? Evidence from animal studies

Couteur, D. G. L., Raubenheimer, D., Solon‐Biet, S. M., de Cabo, R., & Simpson, S. J. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13530 · Cited by 47

Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity

Ripa, R., Ballhysa, E., Steiner, J. D., Laboy, R., Annibal, A., Hochhard, N., Latza, C., Dolfi, L., Calabrese, C., Meyer, A. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00521-y · Cited by 44

Dietary and metabolic effects on intestinal stem cells in health and disease

Shay, J. E. S., & Yilmaz, Ö. H. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00980-7 · Cited by 43

The cyclic metabolic switching theory of intermittent fasting

Mattson, M. P. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01254-5 · Cited by 46

Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice

dos Santos, C., Cambraia, A., Shrestha, S., Cutler, M., Cottam, M. A., Perkins, G. A., Lev‐Ram, V., Roy, B., Acree, C., Keun-young Kim, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53127-2 · Cited by 51

The Catabolic—Anabolic Cycling Hormesis Model of Health and Resilience

Calabrese, E. J., & Mattson, M. P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102588 · Cited by 38

Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice

Duregon, E., Fernández, M. E., Romero, J. M., Germanio, C. D., Cabassa, M., Voloshchuk, R. S., Ehrlich-Mora, M. R., Moats, J. M., Wong, S., Bosompra, O., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.05.003 · Cited by 36

Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks

Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., van Rosmalen, L., Izumo, M., Park, N., Joseph, C., Hepler, C., Thorne, A. K., Stubblefield, J. J., Bass, J. T., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114523 · Cited by 35

Fecal microbiota transplantation, a tool to transfer healthy longevity

Novelle, M. G., Naranjo-Martínez, B., Lopez-Canovas, J. L., & Díaz‐Ruiz, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102585 · Cited by 35

Circadian mechanisms in adipose tissue bioenergetics and plasticityPreprint

Hepler, C., & Bass, J. T. (2023) · Genes & Development · doi:10.1101/gad.350759.123 · Cited by 34

Boosting mitochondrial health to counteract neurodegeneration

Burtscher, J., Romani, M., Bernardo, G., Popa, T., Ziviani, E., Hummel, F. C., Sorrentino, V., & Millet, G. P. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102289 · Cited by 36

Circadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding

Roth, J. R., Varshney, S., de Moraes, R. C. M., & Melkani, G. C. (2023) · Obesity · doi:10.1002/oby.23664 · Cited by 34

Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions

Cote, A. L., Munger, C. J., & Ringel, A. E. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115234 · Cited by 29

Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming

Liu, Y., Dong, Y. W., Jiang, Y., Han, S., Liu, X., Xu, X., Zhu, A., Zhao, Z., Gao, Y., Zou, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.014 · Cited by 26

Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression

Liu, X., Jin, Z., Summers, S., Derous, D., Li, M., Li, B., Li, L., & Speakman, J. R. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110835 · Cited by 28

Amino acid restriction, aging, and longevity: an update

Austad, S. N., Smith, J. R., & Hoffman, J. M. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1393216 · Cited by 28

Intermittent fasting-induced biomolecular modifications in rat tissues detected by ATR-FTIR spectroscopy and machine learning algorithms

Ceylani, T., Teker, H. T., Samgane, G., & Gurbanov, R. (2022) · Analytical Biochemistry · doi:10.1016/j.ab.2022.114825 · Cited by 25

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

Dhillon, R. S., Qin, Y., van Ginkel, P. R., Fu, V. X., Vann, J. M., Lawton, A. J., Green, C. L., Manchado-Gobatto, F. D. B., Gobatto, C. A., Lamming, D. W., et al. (2022) · Aging Cell · doi:10.1111/acel.13721 · Cited by 25

Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

Hedges, C. P., Shetty, B., Broome, S. C., MacRae, C. L., Koutsifeli, P., Buckels, E. J., Macindoe, C., Boix, J., Tsiloulis, T., Matthews, B. G., et al. (2023) · Nature Aging · doi:10.1038/s43587-022-00349-y · Cited by 22

Chowing down: diet considerations in rodent models of metabolic disease

Klatt, K. C., Bass, K. N., Speakman, J. R., & Hall, K. D. (2023) · Life Metabolism · doi:10.1093/lifemeta/load013 · Cited by 21

Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals

Gille, B., Galuska, C. E., Fuchs, B., & Peleg, S. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.773795 · Cited by 23

Tuning up an aged clock: Circadian clock regulation in metabolism and aging

Sato, S., Solanas, G., Sassone‐Corsi, P., & Benitah, S. A. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.11.003 · Cited by 21

The road ahead of dietary restriction on anti-aging: focusing on personalized nutrition

Duan, H., Li, J., Yu, L., & Fan, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2110034 · Cited by 20

Can Fasting Curb the Metabolic Syndrome Epidemic?

Vrdoljak, J., Kumrić, M., Vilović, M., Martinović, D., Rogošić, V., Borovac, J. A., Kurir, T. T., & Božić, J. (2022) · Nutrients · doi:10.3390/nu14030456 · Cited by 20

Future foods, dietary factors and healthspan

Li, K., Wang, C., Wang, Y., Fu, L., & Zhang, N. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.12.001 · Cited by 20

Effects and possible mechanisms of intermittent fasting on health and disease: a narrative review

Li, Z., Huang, L., Luo, Y., Yu, B., & Tian, G. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad026 · Cited by 21

Caloric restriction exacerbates renal post-ischemic injury and fibrosis by modulating mTORC1 signaling and autophagy

Shi, L., Zha, H., Zhao, J., An, H., Huang, H., Xia, Y., Yan, Z., Song, Z., & Zhu, J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103500 · Cited by 18

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

Babygirija, R., Han, J. H., Sonsalla, M. M., Matoska, R., Calubag, M. F., Green, C. L., Tobon, A., Yeh, C., Vertein, D., Schlorf, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62416-3 · Cited by 16

Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice

Dai, X.-C., Zhang, Y., Huang, Y., Wu, X., Fang, Y., Gao, Y., & Wang, F. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11758 · Cited by 16

A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting

Shao, Y., Fu, Z., Wang, Y., Yang, Z., Lin, Y., Li, S., Cheng, C., Wei, M., Liu, Z., Xu, G., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01552-y · Cited by 17

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova, M. N., Savova, M. S., Mihaylova, L. V., & Georgiev, M. I. (2024) · Food Frontiers · doi:10.1002/fft2.350 · Cited by 17

Anti-Tumor Effect and Mechanism Study of Caloric Restriction, Achieved by Time-Restricted Feeding, in Mice

Lu, W., Wang, J., Wang, C., Wang, H., Gao, W., Ye, S., & Shen, R. (2024) · Cancer Control · doi:10.1177/10732748241302957 · Cited by 16

Dietary restriction in aging and longevity

Schmauck‐Medina, T., Lautrup, S., Francesco, A. D., Mitchell, S. J., Clemmensen, C., Partridge, L., Roth, G. S., Anderson, R. M., Mattison, J. A., de Cabo, R., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01091-5 · Cited by 18

Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism

Landsberger, T., Amit, I., & Alon, U. S. (2023) · GeroScience · doi:10.1007/s11357-023-00915-1 · Cited by 16

Pharmacological interventions in human aging

Petr, M. A., Matiyevskaya, F., Osborne, B., Berglind, M., Reves, S., Zhang, B., Ezra, M. B., Carmona-Marin, L. M., Syadzha, M. F., Mediavilla, M. C., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102213 · Cited by 19

Does early time-restricted eating reduce body weight and preserve fat-free mass in adults? A systematic review and meta-analysis of randomized controlled trials

He, M., Li, B., Li, M., & Gao, S. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.102952 · Cited by 20

Intermittent Fasting–Improved Glucose Homeostasis Is Not Entirely Dependent on Caloric Restriction in db/db Male Mice

Zheng, D., Hong, X., He, X., Lin, J., Fan, S., Wu, J., Liang, Z., Chen, S., Yan, L., Ren, M., et al. (2024) · Diabetes · doi:10.2337/db23-0157 · Cited by 16

Ketone body metabolism declines with age in mice in a sex-dependent mannerPreprint

Eap, B., Nomura, M., Panda, O., Garcia, T. Y., King, C. D., Rose, J., Leone, T. C., Kelly, D. P., Schilling, B., & Newman, J. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.05.511032 · Cited by 18

A high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Hu, F., Yu, L., Tu, X., Huang, R., Yan, X., Wang, L., Wei, X., Wei, X., & Wu, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-61046-z · Cited by 15

Effects of dietary restriction on cognitive function: a systematic review and meta-analysis

Lü, W., Yu, T., & Kuang, W. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2068876 · Cited by 16

Association of the dietary inflammatory index with phenotypic age in the United States adults

Sun, M., Fang, J., Gao, W., He, Y., Ma, Y., & Jin, L. (2023) · Epidemiology and Health · doi:10.4178/epih.e2023051 · Cited by 15

Unraveling the Health Benefits and Mechanisms of Time-Restricted Feeding: Beyond Caloric Restriction

Wang, R., Liao, Y., Deng, Y., & Rong, S. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae074 · Cited by 15

Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

Pak, H. H., Grossberg, A. N., Sanderfoot, R. R., Babygirija, R., Green, C. L., Koller, M., Dzieciątkowska, M., Paredes, D., & Lamming, D. W. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114663 · Cited by 13

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies

Nunkoo, V. S., Cristian, A., Jurcău, A., Diaconu, R. G., & Jurcău, M. C. (2024) · Biomedicines · doi:10.3390/biomedicines12112540 · Cited by 15

Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease

Sonsalla, M. M., & Lamming, D. W. (2023) · GeroScience · doi:10.1007/s11357-023-00782-w · Cited by 17

Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases

Liu, J., Yu, H., & Xu, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13071727 · Cited by 14

Dietary regulation of intestinal stem cells in health and disease

Fan, H., Wu, J., Yang, K., Xiong, C., Xiong, S., Wu, X., Fang, Z., Zhu, J., & Huang, J. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2262780 · Cited by 13

Metabolic dysregulation of trained immunity in immune aging and the impact of dietary patterns

Grigorescu, A., Riza, A., Streață, I., & Netea, M. G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00153.2025 · Cited by 15

Obesity and lifespan, a complex tango

Díaz‐Ruiz, A., Price, N. L., Ferrucci, L., & de Cabo, R. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adh1175 · Cited by 12

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease

Sonsalla, M. M., Babygirija, R., Johnson, M., Cai, Y. S., Cole, M., Yeh, C., Grunow, I., Liu, Y., Vertein, D., Calubag, M. F., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01337-3 · Cited by 14

The Geometric Framework for Nutrition and Its Application to Rodent Models

Senior, A. M., Raubenheimer, D., Couteur, D. G. L., & Simpson, S. J. (2024) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-111523-102327 · Cited by 12

Aging and Lifestyle Modifications for Preventing Aging‐Related Diseases

Li, Q., Zhang, H., Xiao, N., Liang, G., Lin, Y., Yang, X. Y., Yang, J., Qian, Z., Fu, Y., Zhang, C., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402797rr · Cited by 16

Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes

Ouellette, A. R., Hadad, N., Deighan, A. G., Robinson, L. L., O’Connell, K. M. S., Freund, A., Churchill, G. A., & Kaczorowski, C. C. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.07.004 · Cited by 12

Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification

Das, S. K., Silver, R. E., Senior, A., Gilhooly, C. H., Bhapkar, M., & Le Couteur, D. (2023) · Aging Cell · doi:10.1111/acel.14018 · Cited by 11

A detective story of intermittent fasting effect on immunity

Ma, R. (2024) · Immunology · doi:10.1111/imm.13829 · Cited by 14

Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice

Litichevskiy, L., Considine, M., Gill, J., Shandar, V., Cox, T. O., Descamps, H. C., Wright, K. M., Amses, K. R., Dohnalová, L., Liou, M. J., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-01963-3 · Cited by 16

Evolution, mechanism and limits of dietary restriction induced health benefits & longevity

Becker, F. R., Behrends, M., & Rudolph, K. L. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102725 · Cited by 12

Anti-aging strategies and ex vivo organ rejuvenation

Haoui, M., Reddy, P., & Belmonte, J. C. I. (2026) · Cell stem cell · doi:10.1016/j.stem.2025.12.011 · Cited by 11

Biology of Stress Responses in Aging

Calubag, M. F., Ademi, I., Yeh, C., Babygirija, R., Bhoopat, A. M., Kasza, I., Sonsalla, M. M., Green, C. L., Pak, H. H., & Lamming, D. W. (2023) · doi:10.59368/agingbio.20230002 · Cited by 10

Triiodothyronine (T3) promotes browning of white adipose through inhibition of the PI3K/AKT signalling pathway

Huang, L., Guo, Z., Huang, M.-J., Zeng, X., & Huang, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-71591-0 · Cited by 10

Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis

Korenfeld, N., Charni‐Natan, M., Bruse, J., Goldberg, D. T., Marciano-Anaki, D., Rotaro, D., Gorbonos, T., Radushkevitz-Frishman, T., Polizzi, A., Nasereddin, A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1161 · Cited by 9

The cold truth: torpor as a confound in studies of caloric restriction

Wheatley, W. S. R., Marshall, C. J., Taddei, L., Hitrec, T., Pickering, A. E., & Ambler, M. T. (2025) · Journal of Comparative Physiology B · doi:10.1007/s00360-025-01616-1 · Cited by 13

The shades of grey in adipose tissue reprogramming

Qi, Y., & Hui, X. H. (2022) · Bioscience Reports · doi:10.1042/bsr20212358 · Cited by 9

Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice

Emiliano, A. B., Lopatinsky, N. R., Kraljević, M., Higuchi, S., He, Y., Haeusler, R. A., & Schwartz, G. J. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00017.2022 · Cited by 9

Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

Liu, Z., Zhang, J., Jiang, F., Liu, C., Shao, Y., & Le, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70392 · Cited by 8

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice

van Galen, I., Birkisdóttir, M. B., Ozinga, R. A., Brandt, R. M. C., Barnhoorn, S., Imholz, S., van Oostrom, C. T., van der Marel, R. W. G. N., Smit, K., Rijksen, Y., et al. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00064-3 · Cited by 10

Circadian clock and its effect on aging and lifespan

Verma, A. K., Singh, S., & Rizvi, S. I. (2025) · Biogerontology · doi:10.1007/s10522-025-10281-4 · Cited by 8

Tissue‐Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched‐Chain Amino Acids

Calubag, M. F., Ademi, I., Grunow, I., Breuer, L., Babygirija, R., Lialios, P., Le, S. M., Minton, D. M., Sonsalla, M. M., Illiano, J., et al. (2025) · Aging Cell · doi:10.1111/acel.70176 · Cited by 9

Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction

Ebeigbe, O. P., Mezhnina, V., Astaf’ev, A. A., Velingkaar, N., Kodger, J. V., Poe, A., Fritz, J., Williams, K. Z., Trokhimenko, E., Rom, J.-M. B., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116141 · Cited by 7

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

Calubag, M. F., Ademi, I., Green, C. L., Manchanayake, D. N. H., Jayarathne, H. S. M., Marshall, R. N., Le, S. M., Lialios, P., Breuer, L. E., Yakar, S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01169-0 · Cited by 9

Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention

Yanai, H., Park, B., Koh, H., Jang, H. J., Vaughan, K. L., Tanaka-Yano, M., Aon, M. A., Blanton, M. B., Messaoudi, I., Díaz‐Ruiz, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45359-z · Cited by 10

Autophagy-inducing nutritional interventions in experimental and clinical oncology

Hofer, S. J., Kroemer, G., & Kepp, O. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.08.003 · Cited by 8

Intervening on Calorie Intake or Eating Timing in Older Adults: Lessons Learned in the Healthy Aging and Late-Life Outcomes Randomized Controlled Pilot Trial

Fanning, J. T., Rejeski, W. J., Nicklas, B. J., Kritchevsky, S. B., Miller, M. E., Houston, D. K., Walkup, M. P., Kennedy, K., Stowe, C. L., Ford, S. A., et al. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s520273 · Cited by 8

The Rhesus Macaque as an Animal Model for Human Nutrition: An Ecological-Evolutionary Perspective

Cui, Z., Dong, Y., Sholl, J., Lu, J., & Raubenheimer, D. (2024) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-111523-102354 · Cited by 8

Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy

Sato, M., Torigoe, D., Kinoshita, Y., Cyuman, M., Toda, C., Satô, M., Ikeda, K., Kadomatsu, T., Horiguchi, H., Morinaga, J., et al. (2025) · npj Aging · doi:10.1038/s41514-024-00191-z · Cited by 7

When a Calorie Is Not a Calorie: Metabolic and Molecular Effects of Intermittent Fasting in Humans; Exploratory Outcomes of a Randomized Clinical Trial

Fontana, L., Tosti, V., Barve, R. A., Bertozzi, B., Veronese, N., Spelta, F., Cava, E., Mattson, M. P., Piccio, L. M., Early, D. S., et al. (2023) · doi:10.59368/agingbio.20230013 · Cited by 7

Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice

Duregon, E., Fernández, M. E., Romero, J. M., Germanio, C. D., Cabassa, M., Voloshchuk, R. S., Ehrlich-Mora, M. R., Moats, J. M., Wong, S., Bosompra, O., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.05.003 · Cited by 36

More evidence of the benefits of fasting

Starling, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00594-y

PROLONGED DAILY FASTING TIMES ARE BEST WHEN COMBINED WITH CALORIE RESTRICTION FOR HEALTH AND SURVIVAL

de Cabo, R. (2023) · Innovation in Aging · doi:10.1093/geroni/igad104.0456

Exploring the effect of diet composition in calorie restriction interventions

Morris, A. W. J. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0103-4

Anticipatory metabolic reprogramming distinguishes caloric restriction from fasting-refeeding cyclesPreprint

Velingkaar, N., Astaf’ev, A. A., Prabahar, A., Trokhimenko, E., Rom, J.-M. B., Asi, G. J., Jiang, P., & Kondratov, R. V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.15.711957