Cited by 448AI in cancer detectionRadiomics and Machine Learning in Medical ImagingArtificial Intelligence in Healthcare and Education

Artificial intelligence in histopathology: enhancing cancer research and clinical oncology

Shmatko, Artem, Ghaffari Laleh, Narmin, Gerstung, Moritz, Kather, Jakob Nikolas·2022·Nature Cancer

Abstract

Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative information from digital histopathology images. AI is expected to reduce workload for human experts, improve the objectivity and consistency of pathology reports, and have a clinical impact by extracting hidden information from routinely available data. Here, we describe how AI can be used to predict cancer outcome, treatment response, genetic alterations and gene expression from digitized histopathology slides. We summarize the underlying technologies and emerging approaches, noting limitations, including the need for data sharing and standards. Finally, we discuss the broader implications of AI in cancer research and oncology.

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Crossref · 10.1038/s43018-022-00436-4

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Authors
Shmatko, A., Ghaffari Laleh, N., Gerstung, M., & Kather, J. N.
Affiliations
  • European Bioinformatics Institute (GB)
  • University of Leeds (GB)
Corresponding author
  • Gerstung, Moritz
  • Kather, Jakob Nikolas
Venue
Nature Cancer
Published
2022-09-22
Volume
3
Issue
9
Pages
1026-1038
ISSN
2662-1347 (ISSN-L)
OpenAlex
W4296693015
Cited by
446
References
147
Citations by year
2026: 98 · 2025: 121 · 2024: 121 · 2023: 95 · 2022: 10 · 2020: 1
FWCI
6.07
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Funders
  • Deutsche Krebshilfe (Kather)
  • Bundesministerium für Gesundheit (DEEP LIVER)
Topics
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
Keywords
artificial intelligence, digital histopathology, cancer diagnosis, cancer prognosis, cancer classification, treatment response prediction, genetic alterations, gene expression, data sharing, data standards
MeSH terms
Artificial Intelligence, Humans, Medical Oncology, Neoplasms, Research

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