Cited by 2,238Antioxidant Activity and Oxidative StressRedox biology and oxidative stressFree Radicals and Antioxidants

The DOI matches its Crossref record; 385 of the 385 references it cites were found in a registry or an index.

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

Open access

Halliwell, Barry, Whiteman, Matthew·2004·British Journal of Pharmacology

DOI 10.1038/sj.bjp.0705776PMC PMC1574951

Open this paper in CoChat — free account

Abstract

Free radicals and other reactive species (RS) are thought to play an important role in many human diseases. Establishing their precise role requires the ability to measure them and the oxidative damage that they cause. This article first reviews what is meant by the terms free radical, RS, antioxidant, oxidative damage and oxidative stress. It then critically examines methods used to trap RS, including spin trapping and aromatic hydroxylation, with a particular emphasis on those methods applicable to human studies. Methods used to measure oxidative damage to DNA, lipids and proteins and methods used to detect RS in cell culture, especially the various fluorescent "probes" of RS, are also critically reviewed. The emphasis throughout is on the caution that is needed in applying these methods in view of possible errors and artifacts in interpreting the results.

Integrity signals

Registry

Crossref · 10.1038/sj.bjp.0705776

Cites

385 of 385 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Self-citation
GLUTATHIONE
Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,694
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
LeBel, C. P., Ischiropoulos, H., & Bondy, S. C. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00026a012 · Cited by 2,694
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417 · cited 2×
“…caused by the RS. British Journal of Pharmacology vol 142 (2) Ascorbic acid (vitamin C) reacts with a wide range of free radicals and other RS (Buettner, 1993; Halliwell, 1999c) and one of its oxidation products, semidehydroascorbate radical, can easily be detected by ESR (Buettner &…”
BackgroundMethod
Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
Self-citation

Flagged first, then by citations

Show all 385 references

Research works printed but not linked: 2

10.1042/bj3450453 · DOI
10.1172/JCI0215021 · DOI

Sorted by citations

Items 901–1,000 of 1,000

Effects of Cornus and Its Mixture with Oregano and Thyme Essential Oils on Dairy Sheep Performance and Milk, Yoghurt and Cheese Quality under Heat Stress
Kalaitsidis, K., Sidiropoulou, E., Tsiftsoglou, O. S., Mourtzinos, I., Moschakis, T., Basdagianni, Z., Vasilopoulos, S., Chatzigavriel, S., Lazari, D. M., & Giannenas, Ι. (2021) · Animals · doi:10.3390/ani11041063 · Cited by 31
17β-Estradiol and steady-state concentrations of H2O2: antiapoptotic effect in endometrial cells from patients with endometriosis
Andrade, S. S., Azevedo, A. D. C., Guerra, I. M., Paredes‐Gamero, E. J., Gonçalves, G., Bonetti, T. C., Albertoni, G., Schor, E., Barreto, J. A., Oliva, M. L. V., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.034 · Cited by 30
Are we over oxidized? Oxidative stress, cardio-vascular disease, and the future of intervention studies with antioxidants
Dusting, G. J., & Triggle, C. R. (2005) · Vascular Health and Risk Management · doi:10.2147/vhrm.1.2.93.64080 · Cited by 30
Protein carbonylation in human endothelial cells exposed to cigarette smoke extract
Gornati, R., Colombo, G., Clerici, M., Rossi, F., Gagliano, N., Riva, C., Colombo, R., Dalle‐Donne, I., Bernardini, G., & Milzani, A. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.023 · Cited by 29
Liver-homing of purified glucose oxidase: A novel in vivo model of physiological hepatic oxidative stress (H2O2)
Rost, D., Welker, A., Welker, J., Millonig, G., Berger, I., Autschbach, F., Schuppan, D., & Mueller, S. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.09.025 · Cited by 29
Health benefits of isoflavones in functional foods? Proteomic and metabonomic advances
Wong, M. C. Y., Emery, P. W., Preedy, V. R., & Wiseman, H. (2008) · Inflammopharmacology · doi:10.1007/s10787-008-8023-x · Cited by 30
Multi‐organ injuries caused by lipopolysaccharide‐induced periodontal inflammation in rats: role of melatonin
Gülle, K., Akpolat, M., Kurçer, Z., Cengiz, M. İ., Baba, F., & Acikgoz, S. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12156 · Cited by 30
Characterization of a novel antioxidative peptide from the sand eel Hypoptychus dybowskii
Lee, W.-S., Jeon, J.-K., & Byun, H. (2011) · Process Biochemistry · doi:10.1016/j.procbio.2011.02.001 · Cited by 30
Each to their own: skeletal muscles of different function use different biochemical strategies during aestivation at high temperature
Young, K. M., Cramp, R. L., & Franklin, C. E. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.072827 · Cited by 31
Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism
Fletcher, M. E., Boshier, P. R., Wakabayashi, K., Keun, H. C., Smolenski, R. T., Kirkham, P., Adcock, I. M., Barton, P. J. R., Takata, M., & Marczin, N. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00220.2014 · Cited by 31
Protective Effect of the Hexanic Extract of Eryngium carlinae Inflorescences In Vitro, in Yeast, and in Streptozotocin-Induced Diabetic Male Rats
Peña‐Montes, D. J., Huerta‐Cervantes, M., Ríos‐Silva, M., Trujillo, X., Huerta, M., Noriega‐Cisneros, R., Salgado‐Garciglia, R., & Saavedra‐Molina, A. (2019) · Antioxidants · doi:10.3390/antiox8030073 · Cited by 30
Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019
Bartel, C., Egger, A., Jakupec, M. A., Heffeter, P., Galanski, M. S., Berger, W., & Keppler, B. K. (2011) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-011-0809-4 · Cited by 29
Antioxidant and hepatoprotective effects of Oxalis corniculata against carbon tetrachloride (CCl4) induced injuries in rat
Khan, M. R. (2012) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.370 · Cited by 29
Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress
Wages, P. A., Cheng, W., Gibbs-Flournoy, E. A., & Samet, J. M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.05.017 · Cited by 29
The effect of d-galactose induced oxidative stress on in vitro redox homeostasis in rat plasma and erythrocytes
de Lima, D. D., Hennrich, S. B., Magro, D. D. D., Aurélio, J. G. M., Serpa, A. P., Waltrich-Augusto, T., & Pereira, N. R. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.011 · Cited by 29
Learning and memory impairment of mice caused by gaseous formaldehyde
Li, F., Qin, Y., Gong, S., Zhang, H., & Ding, S. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109318 · Cited by 29
Splenic Gene Expression Signatures in Slow-Growing Chickens Stimulated in Ovo with Galactooligosaccharides and Challenged with Heat
Pietrzak, E., Dunisławska, A., Siwek, M. Z., Zampiga, M., Sirri, F., Meluzzi, A., Tavaniello, S., Maiorano, G., & Sławińska, A. (2020) · Animals · doi:10.3390/ani10030474 · Cited by 31
Plant Extracts and Isolated Compounds Reduce Parameters of Oxidative Stress Induced by Heavy Metals: An up-to-Date Review on Animal Studies
Mirkov, I. I., Stojković, D. S., Aleksandrov, A. P., Ivanov, M., Kostić, M., Glamočlija, J., & Sokóvić, M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200407163408 · Cited by 29
Quantification of superoxide radical production in thylakoid membrane using cyclic hydroxylamines
Kozuleva, M. A., Klenina, I. B., Mysin, I. E., Kirilyuk, I. A., Opanasenko, V. K., Proskuryakov, I. I., & Ivanov, B. N. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.016 · Cited by 29
Bioactives in Commonly Consumed Cereal Grains: Implications for Oxidative Stress and Inflammation
Lee, Y.-M., Han, S., Song, B. C., & Yeum, K. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3394 · Cited by 30
Assessment of oxidative stress and antioxidant property using electron spin resonance (ESR) spectroscopy
Lee, M. (2012) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.12-58 · Cited by 29
Neuroprotective effect of resveratrol on arsenic trioxide–induced oxidative stress in feline brain
Cheng, Y., Xue, J., Jiang, H., Wang, M.-J., Gao, L., Ma, D., & Zhang, Z. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113506235 · Cited by 29
The Effect of an Atmospheric Pressure, DC Nonthermal Plasma Microjet on Tooth Root Canal, Dentinal Tubules Infection and Reinfection Prevention
Wang, R., Zhou, H., Sun, P., Wu, H., Pan, J., Zhu, W., Zhang, J., & Fang, J. (2011) · Plasma Medicine · doi:10.1615/plasmamed.2011003259 · Cited by 29
In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds
Nunes, G. B. L., Policarpo, P., Costa, L. M., da Silva, T., Militão, G. C. G., Câmara, C. A., Barbosa‐Filho, J. M., Gutierrez, S. J. C., Islam, M. T., & de Freitas, R. M. (2014) · Molecules · doi:10.3390/molecules19044595 · Cited by 29
Light, lipids and photoreceptor survival: live or let die?
German, O. L., Agnolazza, D. L., Politi, L. E., & Rotstein, N. P. (2015) · Photochemical & Photobiological Sciences · doi:10.1039/c5pp00194c · Cited by 31
Antioxidants and Polyphenols: Concentrations and Relation to Male Infertility and Treatment Success
Silberstein, T., Har‐Vardi, I., Harlev, A., Friger, M. D., Hamou, B., Barac, T., Levitas, E., & Saphier, O. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9140925 · Cited by 30
Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain
Ignácio, Z. M., Réus, G. Z., Abelaira, H. M., de Moura, A. B., de Souza, T. G., Matos, D., Goldim, M. P. D. S., Mathias, K., Garbossa, L., Petronilho, F. C., et al. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0028-y · Cited by 29
Effects of co-exposure to atrazine and ethanol on the oxidative damage of kidney and liver in Wistar rats
Abarikwu, S. O., Duru, Q. C., Njoku, R.-C. C., Amadi, B. A., Tamunoibuomie, A., & Keboh, E. (2017) · Renal Failure · doi:10.1080/0886022x.2017.1351373 · Cited by 29
Proteomic strategies to unravel age-related redox signalling defects in skeletal muscle
Cobley, J. N., Sakellariou, G. K., Husi, H., & McDonagh, B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.012 · Cited by 32
Environmental Toxicity of Nanomaterials
(2018) · CRC Press eBooks · doi:10.1201/9781351252966 · Cited by 29
Noninvasive Markers of Oxidative DNA Stress, RNA Degradation and Protein Degradation Are Differentially Correlated With Resting Metabolic Rate and Energy Intake in Children and Adolescents
Topp, H., Fusch, G., Schöch, G., & Fusch, C. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e31817cfca6 · Cited by 29
Measurement of oxidative stress parameters using liquid chromatography–tandem mass spectroscopy (LC–MS/MS)
Winnik, W., & Kitchin, K. T. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.05.003 · Cited by 29
Simple Phenotypic Sensor for Visibly Tracking H2O2 Fluctuation to Detect Plant Health Status
Yin, Y., Wang, G., Liu, Y., Wang, X., Gao, W., Zhang, S., & You, C. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02170 · Cited by 28
Cellular evaluation of superoxide dismutase mimics as catalytic drugs: Challenges and opportunities
Schanne, G., Demignot, S., Policar, C., & Delsuc, N. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215906 · Cited by 28
Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria
Mello, M. D. S., Ribas, G. S., Wayhs, C. A. Y., Hammerschmidt, T. G., Guerreiro, G., Faverzani, J. L., Sitta, Â., Coelho, D. D. M., Wajner, M., & Vargas, C. R. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2322-x · Cited by 28
Carrageenans effect on neutrophils alone and in combination with LPS in vitro
Sokolova, E. V., Karetin, Y. A., Давыдова, В. Н., Byankina, A. O., Kalitnik, A. A., Николаевна, Б. Л., & Yermak, I. M. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35693 · Cited by 28
In vitro membrane stabilizing, thrombolytic and antioxidant potentials of Drynaria quercifolia L., a remedial plant of the Garo tribal people of Bangladesh
Chaity, F. R., Khatun, M., & Rahman, M. S. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1170-5 · Cited by 28
Antioxidant enzyme activity in responses to environmentally induced oxidative stress in the 5th instar nymphs of Aiolopus thalassinus (Orthoptera: Acrididae)
Yousef, H. A., Abdelfattah, E. A., & Augustyniak, M. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3756-6 · Cited by 32
Antioxidants as Renoprotective Agents for Ischemia during Partial Nephrectomy
Buys‐Gonçalves, G. F., Abreu, L. D. A. D. S., Gregório, B. M., Sampaio, F. J. B., Pereira-Sampaio, M. A., & de Souza, D. B. (2019) · BioMed Research International · doi:10.1155/2019/8575398 · Cited by 28
Biomarkers of Oxidative Stress for Neonatal Lung Disease
Ferrante, G., Carota, G., Volti, G. L., & Giuffrè, M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.618867 · Cited by 28
Cutaneous oxidative stress
Polefka, T. G., Meyer, T. A., Agin, P. P., & Bianchini, R. J. (2012) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2011.00596.x · Cited by 28
Role of Catalase and Superoxide Dismutase Activities on Oxidative Stress in the Brain of a Phenylketonuria Animal Model and the Effect of Lipoic Acid
Moraes, T. B., Jacques, C. E. D., Rosa, A. P., Dalazen, G. R., Terra, M., Coelho, J. G., & Dutra‐Filho, C. S. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9892-5 · Cited by 28
Effect of Priming in Subpopulations of Peripheral Neutrophils From Patients with Chronic Periodontitis
Fredriksson, M. I. (2012) · Journal of Periodontology · doi:10.1902/jop.2012.110584 · Cited by 28
Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children
Abdel‐Salam, O. M. E., Youness, E. R., Mohammed, N. A., & Abuelhamd, W. A. (2015) · Open Journal of Molecular and Integrative Physiology · doi:10.4236/ojmip.2015.51002 · Cited by 28
Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells
Abrantes, A. M., Serra, M. E. S., Gonçalves, A. C., Rio, J., Oliveiros, B., Laranjo, M., Gonsalves, A. M. D. R., Sarmento‐Ribeiro, A. B., & Botelho, M. F. (2009) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2009.11.001 · Cited by 28
Rooibos (Aspalathus linearis) and its Major Flavonoids — Potential Against Oxidative Stress-Induced Conditions
Ajuwon, O. R., Marnewick, J. L., & Davids, L. M. (2015) · InTech eBooks · doi:10.5772/61614 · Cited by 31
Oxidative stress and therapeutic opportunities: focus on the Ewing’s sarcoma family of tumors
Smith, D. G., Magwere, T., & Burchill, S. A. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.224 · Cited by 29
Inhibition of peroxide-induced radical generation by plant polyphenols in C6 astroglioma cells
Rüweler, M., Anker, A., Gülden, M., Maser, E., & Seibert, H. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.02.019 · Cited by 28
Induction of Apoptosis in Renal Cell Carcinoma by Reactive Oxygen Species: Involvement of Extracellular Signal-Regulated Kinase 1/2, p38δ/γ, Cyclooxygenase-2 Down-Regulation, and Translocation of Apoptosis-Inducing Factor
Ambrose, M. J., Ryan, A. E., O’Sullivan, G. C., Dunne, C. P., & Barry, Ó. P. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.020875 · Cited by 28
Flavonols Induced by 5-Aminolevulinic Acid Are Involved in Regulation of Stomatal Opening in Apple Leaves
Liu, L., XIONG, L., An, Y., ZHENG, J., & Wang, L. (2016) · Horticultural Plant Journal · doi:10.1016/j.hpj.2017.02.002 · Cited by 27
Response of Microcystis aeruginosa BCCUSP 232 to barley (Hordeum vulgare L.) straw degradation extract and fractions
Mecina, G. F., Dokkedal, A. L., Saldanha, L. L., Chia, M. A., Araújo, M. K. C., Bittencourt‐Oliveira, M. D. C., & da Silva, R. M. G. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.05.156 · Cited by 27
Protective effect of metformin on toxicity of butyric acid and arsenic in isolated liver mitochondria and langerhans islets in male mice: an in vitro study.
Ahangarpour, A., Zeidooni, L., Rezaei, M., Alboghobeish, S., Samimi, A., & Oroojan, A. A. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.9567 · Cited by 27
Effects of Dietary Strategies on Exercise-Induced Oxidative Stress: A Narrative Review of Human Studies
Zeng, Z., Centner, C., Gollhofer, A., & König, D. (2021) · Antioxidants · doi:10.3390/antiox10040542 · Cited by 31
The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer
Acevedo-León, D., Monzó-Beltrán, L., Gómez‐Abril, S. Á., Estañ-Capell, N., Lillo, N. C., Pérez-Ebri, M. L., Escandón-Álvarez, J., Alonso‐Iglesias, E., Santaolaria-Ayora, M. L., Carbonell-Moncho, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126183 · Cited by 27
Neonatal hyperglycemia induces oxidative stress in the rat brain: the role of pentose phosphate pathway enzymes and NADPH oxidase
Rosa, A. P., Jacques, C. E. D., de Souza, L. O., Bitencourt, F., Mazzola, P. N., Coelho, J. G., Mescka, C. P., & Dutra‐Filho, C. S. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2346-x · Cited by 27
Peroxidação lipídica e obesidade: Métodos para aferição do estresse oxidativo em obesos
França, B. K., Alves, M. R. M., Souto, F. M. S., Tiziane, L., Boaventura, R. F., Guimarães, A., & Alves, A. S. (2013) · GE Portuguese Journal of Gastroenterology · doi:10.1016/j.jpg.2013.04.002 · Cited by 32
The abilities of selenium dioxide and selenite ion to coordinate DNA-bound metal ions and decrease oxidative DNA damage
Hart, W. E., Marczak, S. P., Kneller, A. R., French, R. A., & Morris, D. L. (2013) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2013.03.016 · Cited by 28
Effects of Ovariohysterectomy on Oxidative Stress Markers in Female Dogs
Szczubiał, M., Kankofer, M., Bochniarz, M., & Dąbrowski, R. (2015) · Reproduction in Domestic Animals · doi:10.1111/rda.12501 · Cited by 27
Peripheral Blood Lymphocytes: A Model for Monitoring Physiological Adaptation to High Altitude
Mariggiò, M. A., Falone, S., Morabito, C., Guarnieri, S., Mirabilio, A., Pilla, R., Bucciarelli, T., Verratti, V., & Amicarelli, F. (2010) · High Altitude Medicine & Biology · doi:10.1089/ham.2009.1097 · Cited by 27
A class of imidazolium salts is anti-oxidative and anti-fibrotic in hepatic stellate cells
Zhang, C., Ding, Z., Suhaimi, N.-A. M., Kng, Y. L., Zhang, Y., & Zhuo, L. (2009) · Free Radical Research · doi:10.1080/10715760903137002 · Cited by 27
Exercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption
Youssef, H. A., Groussard, C., Pincemail, J., Moussa, E., Jacob, C. O., Lemoine, S., Zind, M., Jo, D., Cillard, J., Delamarche, P., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.49 · Cited by 27
Fructose-induced stress signaling in the liver involves methylglyoxal
Wei, Y., Wang, D., Moran, G., Estrada, A. L., & Pagliassotti, M. J. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-32 · Cited by 27
A simple and cost effective method for the quantification of 8‐hydroxy‐2′‐deoxyguanosine from urine using liquid chromatography tandem mass spectrometry
Crow, B. S., Bishop, M., Kovalcik, K. D., Norton, D., George, J., & Bralley, J. A. (2007) · Biomedical Chromatography · doi:10.1002/bmc.946 · Cited by 27
Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure
Luo, X., Chen, M., Duan, Y., Duan, W., Zhang, H., He, Y., Yin, C., Sun, G., & Sun, X. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.005 · Cited by 27
Gas chromatography-mass spectrometry analysis and in vitro antioxidant potential of ajwain seed (Trachyspermum ammi L.) essential oil and its extracts
Dhaiwal, K., Chahal, K. K., Kataria, D., & Kumar, A. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12364 · Cited by 27
The use of quetiapine in the treatment of major depressive disorder: Evidence from clinical and experimental studies
Ignácio, Z. M., Calixto, A. V., da Silva, R. H., Quevedo, J., & Réus, G. Z. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.12.012 · Cited by 27
An ESIPT based naphthalimide chemosensor for visualizing endogenous ONOO − in living cells
Fu, Y., Nie, H., Zhang, R., Xin, F., Tian, Y., Jing, J., & Zhang, X. (2018) · RSC Advances · doi:10.1039/c7ra11774d · Cited by 27
Impairment of spatial working memory and oxidative stress induced by repeated crack cocaine inhalation in rats
Lipaus, I. F. S., Gomes, E. F., Martins, C. W., Martins-Silva, C., Pires, R. G. W., Malgarin, F., Schuck, P. F., Nakamura-Palacios, E. M., & Rodrigues, L. C. D. M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.020 · Cited by 28
Enzymatic antioxidants but not baseline glucocorticoids mediate the reproduction–survival trade-off in a wild bird
Casagrande, S., & Hau, M. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.2141 · Cited by 27
The protective effect exerted by dietary borax on toxicity metabolism in rainbow trout (Oncorhynchus mykiss) tissues
Alak, G., Parlak, V., Yeltekin, A. Ç., Uçar, A., Çomaklı, S., Topal, A., Atamanalp, M., Özkaraca, M., & Türkez, H. (2018) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2018.10.005 · Cited by 27
A ratiometric fluorescent probe for the detection of endogenous hydroxyl radicals in living cells
Wu, B., Yang, J., Zhang, J., Li, Z., Li, H., & Yang, X. (2018) · Talanta · doi:10.1016/j.talanta.2018.12.065 · Cited by 27
Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS
Recinella, L., Chiavaroli, A., Orlando, G., Menghini, L., Ferrante, C., Mannelli, L. D. C., Ghelardini, C., Brunetti, L., & Leone, S. (2019) · Molecules · doi:10.3390/molecules24163002 · Cited by 27
Sulfite facilitates LDL lipid oxidation by transition metal ions: A pro‐oxidant in wine?
Laggner, H., Hermann, M., Sturm, B., Gmeiner, B. M. K., & Kapiotis, S. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.045 · Cited by 26
Relationship between intracellular Ca2+ and ROS during fluoride‐induced injury in SH‐SY5Y cells
Xu, Z., Xu, B., Xia, T., He, W., Gao, P., Guo, L., Wang, Z., Niu, Q., & Wang, A. (2011) · Environmental Toxicology · doi:10.1002/tox.20721 · Cited by 28
Zero effect of multiple dosage of olive leaf supplements on urinary biomarkers of oxidative stress in healthy humans
Kendall, M., Batterham, M. J., Obied, H. K., Prenzler, P. D., Ryan, D., & Robards, K. (2008) · Nutrition · doi:10.1016/j.nut.2008.08.008 · Cited by 28
Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress—Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?
Masuda, D., Nakanishi, I., Ohkubo, K., Ito, H., Matsumoto, K., Ichikawa, H., Chatatikun, M., Klangbud, W. K., Kotepui, M., Imai, M., et al. (2024) · Biomolecules · doi:10.3390/biom14010128 · Cited by 27
Reactive oxygen species formation is not enhanced by exposure to UMTS 1950 MHz radiation and co‐exposure to ferrous ions in Jurkat cells
Brescia, F., Sarti, M., Massa, R., Calabrese, M. L., Sannino, A., & Scarfı̀, M. R. (2009) · Bioelectromagnetics · doi:10.1002/bem.20502 · Cited by 26
Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation
Bavis, R. W., Wenninger, J. M., Miller, B. M., Dmitrieff, E. F., Olson, E. B., Mitchell, G. S., & Bisgard, G. E. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.10.013 · Cited by 26
Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats
Noworyta, K., Kamińska, K., Kreiner, G., Rogóż, Z., & Gołembiowska, K. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9654-0 · Cited by 27
Nucleolar GTP-Binding Protein 1-2 (NOG1-2) Interacts with Jasmonate-ZIMDomain Protein 9 (JAZ9) to Regulate Stomatal Aperture during Plant Immunity
Lee, S., Rojas, C. M., Oh, S., Kang, M., Choudhury, S. R., Lee, H., Allen, R. D., Pandey, S., & Mysore, K. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071922 · Cited by 27
A lysosome-targeted ratiometric fluorescent probe with a large blue shift for monitoring hypochlorous acid in living cells and zebrafish
Hou, P., Chen, S., Liang, G., Li, H., & Zhang, H. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117866 · Cited by 26
Antioxidative enzyme activities in the Rhodeinae sinensis Gunther and Macrobrachium nipponense and multi-endpoint assessment under tonalide exposure
Li, W., Wang, S., Li, J., Wang, X., Cui, L. R., Chen, J., & Liu, Z. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110751 · Cited by 26
Intracellular antioxidant activity and intestinal absorption of amaranth peptides released using simulated gastrointestinal digestion with Caco-2 TC7 cells
Filleria, S. F. G., & Tironi, V. A. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101086 · Cited by 26
Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product
Zheng, R., Heck, D. E., Mishin, V. M., Black, A. T., Shakarjian, M. P., Kong, A. T., Laskin, D. L., & Laskin, J. D. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.01.001 · Cited by 26
The effects of dietary thiamin on oxidative damage and antioxidant defence of juvenile fish
Li, X., Huang, H., Hu, K., Liu, Y., Jiang, W., Jiang, J., Li, S., Feng, L., & Zhou, X. (2013) · Fish Physiology and Biochemistry · doi:10.1007/s10695-013-9875-6 · Cited by 25
Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals
Suddek, G. M. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1402-1 · Cited by 26
Individual responses to chemotherapy-induced oxidative stress
Il’yasova, D., Kennedy, K. M., Spasojević, I., Wang, F. M., Tolun, A. A., Baše, K., Young, S. P., Marcom, P. K., Marks, J. R., Millington, D. S., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1158-7 · Cited by 26
Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor
Shim, S., Kim, S., Kwon, Y., & Kwon, J. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.11.042 · Cited by 26
Development of a pair of differential H/D isotope-coded derivatization reagents d0/d3-4-(1-methyl-1H-phenanthro[9,10-d]imidazol-2-yl)phenlamine and its application for determination of aldehydes in selected aquatic products by liquid chromatography–tandem mass spectrometry
Sun, Z., Wang, X., Cai, Y., Fu, J., & You, J. (2013) · Talanta · doi:10.1016/j.talanta.2013.11.064 · Cited by 26
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase
Portugal‐Cohen, M., & Kohen, R. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.05.006 · Cited by 26
Hepatitis B Virus Alters the Antioxidant System in Transgenic Mice and Sensitizes Hepatocytes to Fas Signaling
Wang, Q., Na, B., Ou, J. J., Pulliam, L., & Yen, T. S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036818 · Cited by 26
Redox Proteomics Changes in the Fungal Pathogen Trichosporon asahii on Arsenic Exposure: Identification of Protein Responses to Metal-Induced Oxidative Stress in an Environmentally-Sampled Isolate
Ilyas, S., Rehman, A., Varela, A. C., & Sheehan, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102340 · Cited by 26
Comparison of UVA-induced ROS and sunscreen nanoparticle-generated ROS in human immune cells
Shen, C., Turney, T. W., Piva, T., Feltis, B. N., & Wright, P. F. A. (2014) · Photochemical and Photobiological Sciences · doi:10.1039/c3pp50428j · Cited by 25
Mutant mouse models of oxidative stress
Pouyet, L., & Carrier, A. (2009) · Transgenic Research · doi:10.1007/s11248-009-9308-6 · Cited by 27
Mechanosensory Neuron Aging: Differential Trajectories with Lifespan-Extending Alaskan Berry and Fungal Treatments in Caenorhabditis elegans
Scerbak, C., Vayndorf, E. M., Hernández, A., McGill, C. M., & Taylor, B. E. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00173 · Cited by 27
Evaluation of the Protective Effects of Sarains on H2O2-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Neuroblastoma Cells
Alvariño, R., Alonso, E., Tribalat, M., Gegunde, S., Thomas, O., & Botana, L. M. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9748-3 · Cited by 28
UV-B radiation on lemons enhances antifungal activity of flavedo extracts against Penicillium digitatum
Ruiz, V. E., Cerioni, L., Zampini, I. C., Cuello, S., Isla, M. I., Hilal, M., & Rapisarda, V. A. (2017) · LWT · doi:10.1016/j.lwt.2017.07.002 · Cited by 26
Role of Antioxidant Phytochemicals in Prevention, Formation and Treatment of Cancer
Koçyiğit, A., Güler, E. M., & Dikilitaş, M. (2018) · InTech eBooks · doi:10.5772/intechopen.72217 · Cited by 28
Important Role of Sarcoplasmic Reticulum Ca 2+ Release via Ryanodine Receptor-2 Channel in Hypoxia-Induced Rieske Iron–Sulfur Protein-Mediated Mitochondrial Reactive Oxygen Species Generation in Pulmonary Artery Smooth Muscle Cells
Yang, Z., Song, T., Truong, L., Reyes-García, J., Wang, L., Zheng, Y., & Wang, Y.-X. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7652 · Cited by 27
Aspirin Eugenol Ester Reduces H2O2-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis
Huang, M., Yang, Y., Liu, X.-W., Qin, Z., & Li, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8098135 · Cited by 26

Authors: Halliwell, B., & Whiteman, M.
Affiliations: National University of Singapore (SG)
ORCID: Halliwell, Barry
Whiteman, Matthew
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2004-05
Volume: 142
Issue: 2
Pages: 231-255
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/sj.bjp.0705776
PMC: PMC1574951
OpenAlex: W1977913875
Cited by: 2,238
References: 385
Citations by year: 2026: 47 · 2025: 51 · 2024: 77 · 2023: 78 · 2022: 92 · 2021: 103 · 2020: 127 · 2019: 106 · 2018: 110 · 2017: 113 · 2016: 123 · 2015: 129 · 2014: 134 · 2013: 141 · 2012: 134
FWCI: 6.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1734 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: reactive species, free radicals, oxidative stress, oxidative damage, antioxidants, spin trapping, aromatic hydroxylation, fluorescent probes, DNA damage, lipid peroxidation, protein oxidation, in vivo measurement, cell culture, measurement artifacts
MeSH terms: Animals, Electron Spin Resonance Spectroscopy, Humans, Predictive Value of Tests, Spectrometry, Fluorescence, Reactive Oxygen Species, Oxidative Stress, Cell Culture Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks