Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay

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Free radicals in biology and medicine

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Biochemistry and molecular cell biology of diabetic complications

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Free Radicals in Biology and Medicine

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GLUTATHIONE

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Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

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Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

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Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy

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Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats

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Screening for antioxidants in complex matrices using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.

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Redox modification of proteins as essential mediators of CNS autophagy and mitophagy

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Antioxidant and Anti-Inflammatory Effects of Peanut Skin Extracts

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The effects of moderately oxidised dietary oil with or without vitamin E supplementation on performance, nutrient digestibility, some blood traits, lipid peroxidation and antioxidant defence of male broilers

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Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study

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Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F2α in human urine using liquid chromatography–tandem mass spectrometry

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Determination of low urinary 8-hydroxy-2`-deoxyguanosine excretion with capillary electrophoresis and molecularly imprinted monolith solid phase microextraction

Zhang, S., Song, X., Zhang, W., Luo, N., & Cai, L. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.02.025 · Cited by 36

Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study

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Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders

Andreazza, A. C. (2012) · Molecular BioSystems · doi:10.1039/c2mb25118c · Cited by 36

Phytochemical constituents and radical scavenging properties of Borago officinalis and Malva sylvestris

Mohajer, S., Taha, R. M., Ramli, R., & Mohajer, M. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.09.045 · Cited by 36

Evaluation of oxidative stress biomarkers in Aiolopus thalassinus (Orthoptera: Acrididae) collected from areas polluted by the fertilizer industry

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Effects of two aerobic exercise training protocols on parameters of oxidative stress in the blood and liver of obese rats

de Lima, D. D., Ulbricht, A. S. S. F., Werlang-Coelho, C., Magro, D. D. D., Joaquim, V. H. A., Salamaia, E. M., de Quevedo, S. R., & Desordi, L. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0584-2 · Cited by 36

Neuroprotective Effect of Epalrestat on Hydrogen Peroxide-Induced Neurodegeneration in SH-SY5Y Cellular Model

Lingappa, S., Shivakumar, M. S., Manivasagam, T., Somasundaram, S. T., & Seedevi, P. (2021) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2101.01002 · Cited by 37

Zinc antagonizes common carp (Cyprinus carpio) intestinal arsenic poisoning through PI3K/AKT/mTOR signaling cascade and MAPK pathway

Guo, M., Wang, Y., Zhao, H., Wang, D., Yin, K., Liu, Y., Li, B., & Xing, M. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105986 · Cited by 36

Effect of nonylphenol on response of physiology and photosynthesis-related gene transcription of Chlorella vulgaris

Qian, H., Pan, X., Shi, S., Yu, S., Jiang, H., Lin, Z., & Fu, Z. (2011) · Environmental Monitoring and Assessment · doi:10.1007/s10661-010-1858-9 · Cited by 36

Vitamin C and E Suppress Mitogen-Stimulated Peripheral Blood Mononuclear Cells in vitro

Winkler, C., Schroecksnadel, K., Schennach, H., & Fuchs, D. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000096438 · Cited by 36

Inorganic nanoparticles enhance the production of reactive oxygen species (ROS) during the autoxidation of l-3,4-dihydroxyphenylalanine (l-dopa)

Luna‐Velasco, A., Field, J. A., Cobo-Curiel, A., & Sierra‐Álvarez, R. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.06.053 · Cited by 37

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells

Bandarra, S., Fernandes, A. S., dos Reis, I. M., Guerreiro, P. S., Pingarilho, M., Churchwell, M. I., Gil, O. M., Batinic-Haberle, I., Goncalves, S., Rueff, J., et al. (2013) · Mutagenesis · doi:10.1093/mutage/get052 · Cited by 36

Merokok dan Oksidasi DNA

Fitria, F., Triandhini, R. I. N. K. R., Mangimbulude, J. C., & Karwur, F. F. (2013) · Sains Medika Jurnal Kedokteran dan Kesehatan · doi:10.30659/sainsmed.v5i2.352 · Cited by 36

Oxidants, Antioxidants and Oxidative Stress

Ďuračková, Z., & Gvozdjáková, A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6714-3_2 · Cited by 35

Genomodifier capacity assay: a non-cell test using dsDNA molecules to evaluate the genotoxic/genoprotective properties of chemical compounds

Cadoná, F. C., Mânica-Cattani, M. F., Machado, A. K., Oliveira, R. M., Flôres, E. R. D. S., Assmann, C. E., Algarve, T. D., & da Cruz, I. B. M. (2014) · Analytical Methods · doi:10.1039/c4ay01709a · Cited by 35

Spatial and seasonal heterogeneity of atmospheric particles induced reactive oxygen species in urban areas and the role of water-soluble metals

Gali, N. K., Yang, F., Jiang, S. Y., Chan, K. L., Sun, L., Ho, K., & Ning, Z. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.01.001 · Cited by 35

Dietary flavonoid intake, total antioxidant capacity and lipid oxidative damage: A cross-sectional study of Iranian women

Alipour, B., Rashidkhani, B., & Edalati, S. (2015) · Nutrition · doi:10.1016/j.nut.2015.11.011 · Cited by 35

Hyperglycemia induced structural and functional changes in human serum albumin of diabetic patients: a physico-chemical study

Neelofar, K., Arif, Z., Alam, K., & Ahmad, J. (2016) · Molecular BioSystems · doi:10.1039/c6mb00324a · Cited by 35

ROS-induced oxidative stress is closely related to pollen deterioration following cryopreservation

Jia, M. X., Shi, Y., Di, W., Jiang, X. R., Xu, J., & Liu, Y. (2017) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-017-9844-3 · Cited by 35

Non-Thermal Plasma Application in Tumor-Bearing Mice Induces Increase of Serum HMGB1

Troitskaya, O. S., Патракова, Е. А., Biryukov, M., Varlamov, M., Гугин, П. П., Milakhina, E. V., Richter, V. A., Schweigert, I. V., Zakrevsky, D. E., & Koval, O. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145128 · Cited by 36

Protective role of arzanol against lipid peroxidation in biological systems

Rosa, A., Pollastro, F., Atzeri, A., Appendino, G., Melis, M., Deiana, M., Incani, A., Loru, D., & Dessì, M. (2010) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2010.09.009 · Cited by 35

Development of an AND Logic‐Gate‐Type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy

Takashima, I., Kawagoe, R., Hamachi, I., & Ojida, A. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201405686 · Cited by 35

Physicochemical and antioxidant properties of kiwifruit as a function of cultivar and fruit harvested month

Pal, R. S., Kumar, V. A., Arora, S., Sharma, A. K., Kumar, V., & Agrawal, S. (2015) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-8913201500371 · Cited by 34

Evaluation of oxidative status in acetaminophen treated rat hepatocytes in culture

Roušar, T., Kučera, O., Křiváková, P., Lotková, H., Kanďár, R., Mužáková, V., & Červinková, Z. (2009) · Physiological Research · doi:10.33549/physiolres.931437 · Cited by 34

The carotenoid beta-carotene enhances facial color, attractiveness and perceived health, but not actual health, in humans

Foo, Y. Z., Rhodes, G., & Simmons, L. W. (2016) · Behavioral Ecology · doi:10.1093/beheco/arw188 · Cited by 34

The hematological and biochemical changes in rats exposed to britholite mineral

Şaşmaz, A., Ozkan, S., Gürsu, M. F., & Sasmaz, M. (2017) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2017.07.060 · Cited by 34

Waterlogging tolerance rendered by oxylipin-mediated metabolic reprogramming in Arabidopsis

Savchenko, T., Rolletschek, H., Heinzel, N., Tikhonov, K. G., & Dehesh, K. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz110 · Cited by 34

Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

Simičić, D., Cudalbu, C., & Pierzchała, K. (2022) · Analytical Biochemistry · doi:10.1016/j.ab.2022.114795 · Cited by 38

Hypoxanthine induces oxidative stress in kidney of rats: protective effect of vitamins E plus C and allopurinol

Rodrigues, A. F., Roecker, R., Junges, G. M., de Lima, D. D., da Cruz, J. G. P., Wyse, Â. T. D. S., & Magro, D. D. D. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3029 · Cited by 34

The L-type Ca2+ Channel as a Potential Mediator of Pathology During Alterations in Cellular Redox State

Hool, L. C. (2009) · Heart Lung and Circulation · doi:10.1016/j.hlc.2008.11.004 · Cited by 35

Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer

Dillioğlugil, M. Ö., MEKİK, H., Müezzínoğlu, B., Özkan, T. A., Demir, C. G., & Dillioğlugil, Ö. (2012) · International Urology and Nephrology · doi:10.1007/s11255-012-0221-1 · Cited by 34

Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats

Green, M. L., Freel, R. W., & Hatch, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00735.x · Cited by 34

Effects of Oral Supplementation With Plant Superoxide Dismutase Extract on Selected Redox Parameters and an Inflammatory Marker in a 2,000-m Rowing-Ergometer Test

Skarpańska-Stejnborn, A., Pilaczyńska-Szczȩśniak, Ł., Basta, P., Deskur-Śmielecka, E., Woitas-Ślubowska, D., & Adach, Z. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.2.124 · Cited by 34

Flow Cytometric Analysis of the Oxidative Status in Human Peripheral Blood Mononuclear Cells of Workers Exposed to Welding Fumes

Plessis, D., Laubscher, P., Jooste, J., du Plessis, J., Franken, A., van Aarde, N., & Eloff, F. C. (2010) · Journal of Occupational and Environmental Hygiene · doi:10.1080/15459621003724108 · Cited by 34

Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model

Selby-Pham, S. N. B., Cottrell, J. J., Dunshea, F. R., Ng, K., Bennett, L. E., & Howell, K. S. (2017) · Nutrients · doi:10.3390/nu9070758 · Cited by 33

Reactive oxygen species (ROS) and aging: Do we need them — can we measure them — should we block them?

Simm, A., & Brömme, H. (2005) · Signal Transduction · doi:10.1002/sita.200400053 · Cited by 34

The Extraction and High Antiproliferative Effect of Anthocyanin from Gardenblue Blueberry

Zhao, F., Wang, J., Wang, W., Lyu, L., Wu, W., & Li, W. (2023) · Molecules · doi:10.3390/molecules28062850 · Cited by 33

The effect of graphene and graphene oxide induced reactive oxygen species on polycaprolactone scaffolds for bone cancer applications

Hou, Y., Wang, W., & Bártolo, P. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100886 · Cited by 33

Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line

Tedesco, I., Russo, M., Bilotto, S., Spagnuolo, C., Scognamiglio, A., Palumbo, R., Nappo, A., Iacomino, G., Luigi Moio, B., & Russo, G. L. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.078 · Cited by 33

Febuxostat for Hyperuricemia in Patients with Advanced Chronic Kidney Disease

Akimoto, T., Morishita, Y., Ito, C., Iimura, O., Tsunematsu, S., Watanabe, Y., Kusano, E., & Nagata, D. (2014) · Drug Target Insights · doi:10.4137/dti.s16524 · Cited by 35

Active recovery training does not affect the antioxidant response to soccer games in elite female players

Andersson, H., Karlsen, A. S., Blomhoff, R., Raastad, T., & Kadi, F. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002394 · Cited by 33

Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging

Balke, J., Volz, P., Neumann, F., Brodwolf, R., Wolf, A. M., Pischon, H., Radbruch, M., Mundhenk, L., Gruber, A. D., Ma, N., et al. (2018) · Small · doi:10.1002/smll.201800310 · Cited by 33

Quantification and characterization of radical production in human, animal and 3D skin models during sun irradiation measured by EPR spectroscopy

Albrecht, S., Elpelt, A., Kasim, C., Reble, C., Mundhenk, L., Pischon, H., Hedtrich, S., Witzel, C., Lademann, J. M., Zastrow, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.022 · Cited by 33

β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway – An in-vitro and in-silico study

Ramachandhiran, D., Sankaranarayanan, C., Murali, R., Babukumar, S., & Vinothkumar, V. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1669057 · Cited by 34

The role of metal ion binding in the antioxidant mechanisms of reduced and oxidized glutathione in metal-mediated oxidative DNA damage

Eteshola, E. O. U., Haupt, D. A., Koos, S. I., Siemer, L. A., & Morris, D. L. (2019) · Metallomics · doi:10.1039/c9mt00231f · Cited by 34

Theoretical Study of Radical Inactivation, LOX Inhibition, and Iron Chelation: The Role of Ferulic Acid in Skin Protection against UVA Induced Oxidative Stress

Amić, A., Marković, J. M. D., Marković, Z., Milenković, D., Milanović, Ž., Antonijević, M. R., Cagardová, D., & Rodrı́guez-Guerra, J. (2021) · Antioxidants · doi:10.3390/antiox10081303 · Cited by 33

Anti-inflammatory effect of Kaba Sura Kudineer (AYUSH approved COVID-19 drug)-A Siddha poly-herbal formulation against lipopolysaccharide induced inflammatory response in RAW-264.7 macrophages cells

Jose, S. P., Ratheesh, M., Sheethal, S., Rajan, S., Saji, S., Narayanan, V., & Sukumaran, S. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114738 · Cited by 33

Occupational exposure to chemicals and oxidative toxic stress

Soleimani, E., Heidarimoghadam, R., & Ranjbar, A. (2015) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-015-0216-2 · Cited by 33

DCFH2 interactions with hydroxyl radicals and other oxidants – Influence of organic solvents

Brömme, H., Zühlke, L., Silber, R., & Simm, A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.01.010 · Cited by 33

Protective potential of methanol extract of Digera muricata on acrylamide induced hepatotoxicity in rats

Muhammad, R. K., Muhammad, A., Saeed, N., & Maria, S. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.771 · Cited by 33

Biomarkers of oxidative stress in amniotic fluid and complications in pregnancy

Bogavac, M. A., Lakić, N., Simin, N. Đ., Nikolic, A., Sudji, J., & Božin, B. N. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.560625 · Cited by 33

Folic acid and its photoproducts, 6-formylpterin and pterin-6-carboxylic acid, as generators of reactive oxygen species in skin cells during UVA exposure

Juzeniene, A., Grigalavicius, M., Ma, L. W., & Juraleviciute, M. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.01.001 · Cited by 33

The cardiac L‐type calcium channel alpha subunit is a target for direct redox modification during oxidative stress—the role of cysteine residues in the alpha interacting domain

Muralidharan, P., Szappanos, H. C., Ingley, E., & Hool, L. C. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12750 · Cited by 33

Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth

Bizerea, T. O., Pitulice, L., Bizerea-Spiridon, O., & Moga, T. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137276 · Cited by 34

Subclinical Vascular Endothelial Dysfunctions and Myocardial Changes With Type 1 Diabetes Mellitus in Children and Adolescents

Eltayeb, A. A., Ahmad, F., Sayed, D. M., & Osama, A. (2014) · Pediatric Cardiology · doi:10.1007/s00246-014-0883-9 · Cited by 32

Characterization of oxidative stress in blood from diabetic vs. hypercholesterolaemic patients, using a novel synthesized marker

Szuchman-Sapir, A. J., Aviram, M., Musa, R., Khatib, S., & Vaya, J. (2008) · Biomarkers · doi:10.1080/13547500701614556 · Cited by 32

Evidence of association between aerosol properties and in-vitro cellular oxidative response to PM1, oxidative potential of PM2.5, a biomarker of RNA oxidation, and its dependency on combustion sources

Costabile, F., Gualtieri, M., Canepari, S., Tranfo, G., Consales, C., Grollino, M. G., Paci, E., Petralia, E., Pigini, D., & Simonetti, G. (2019) · Atmospheric Environment · doi:10.1016/j.atmosenv.2019.06.023 · Cited by 32

Association between periodontitis and fibrotic progression of non‐alcoholic fatty liver among Japanese adults

Kuroe, K., Furuta, M., Takeuchi, K., Takeshita, T., Suma, S., Shinagawa, T., Shimazaki, Y., & Yamashita, Y. (2020) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13415 · Cited by 33

Enzymatic responses in the head and midgut of Africanized Apis mellifera contaminated with a sublethal concentration of thiamethoxam

Décio, P., Miotelo, L., Pereira, F. D. C., Roat, T. C., Marin‐Morales, M. A., & Malaspina, O. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112581 · Cited by 32

Capacidad atrapadora de radicales oxígeno (ORAC) y fenoles totales de frutas y hortalizas de Colombia

Zapata, S., Piedrahita, A. M., & Rojano, B. A. (2014) · Perspectivas en Nutrición Humana · doi:10.17533/udea.penh.20310 · Cited by 32

Production of hydroxyl radicals from Fe-containing fine particles in Guangzhou, China

Ma, S., Ren, K., Liu, X., Chen, L., Li, M., Li, X., Yang, J., Huang, B., Zheng, M., & Xu, Z. (2015) · Atmospheric Environment · doi:10.1016/j.atmosenv.2015.10.057 · Cited by 32

Effects of Cyclodextrin Type on Vitamin C, Antioxidant Activity, and Sensory Attributes of a Mandarin Juice Enriched with Pomegranate and Goji Berries

Navarro, P., Nicolas, T. S., Gabaldón, J. A., Mercader‐Ros, M. T., Calín‐Sánchez, Á., Carbonell-Barrachina, Á. A., & Perez-Lopez, A. J. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02176.x · Cited by 32

The role of the PCM in reducing oxidative stress induced by radical initiated photoencapsulation of chondrocytes in poly(ethylene glycol) hydrogels

Farnsworth, N. L., Bensard, C., & Bryant, S. J. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.06.015 · Cited by 32

Inhibition of acrylamide genotoxicity in human liver-derived HepG2 cells by the antioxidant hydroxytyrosol

Zhang, X., Jiang, L., Geng, C., Yoshimura, H., & Zhong, L. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.08.002 · Cited by 32

Responsiveness of entomopathogenic fungi to menadione-induced oxidative stress

Azevedo, R. F. F., Souza, R. K. F., Braga, G. Ú. L., & Rangel, D. E. N. (2014) · Fungal Biology · doi:10.1016/j.funbio.2014.09.003 · Cited by 32

The effect of levamisole and levamisole+vitamin C on oxidative damage in rats naturally infected with Syphacia muris

İnce, S., Kozan, E., Küçükkurt, İ., & Bacak, E. (2010) · Experimental Parasitology · doi:10.1016/j.exppara.2009.12.017 · Cited by 32

Protective Role of Malvidin-3-Glucoside on Peroxynitrite-Induced Damage in Endothelial Cells by Counteracting Reactive Species Formation and Apoptotic Mitochondrial Pathway

Paixão, J., Dinis, T. C. P., & Almeida, L. M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428538 · Cited by 33

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

Abdel-Halim, K. Y. (2013) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp2013.3434 · Cited by 32

Naringin Mitigates Cardiac Hypertrophy by Reducing Oxidative Stress and Inactivating c-Jun Nuclear Kinase-1 Protein in Type I Diabetes

Adebiyi, O. A., Adebiyi, O. O., & Owira, P. M. O. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000325 · Cited by 32

Immunological Techniques to Assess Protein Thiol Redox State: Opportunities, Challenges and Solutions

Cobley, J. N., & Husi, H. (2020) · Antioxidants · doi:10.3390/antiox9040315 · Cited by 33

Oxidative Stress in Muscle Diseases: Current and Future Therapy

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