Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay

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Free radicals in biology and medicine

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Free Radicals in Biology and Medicine

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Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

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Effects of Pomegranate Juice Supplementation on Oxidative Stress Biomarkers Following Weightlifting Exercise

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Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

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Antioxidant and anti-inflammatory activities of Arbutus unedo aqueous extract

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Heavy metals generate reactive oxygen species in terrestrial and aquatic ciliated protozoa

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Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity

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Antioxidant and Free Radical Scavenging Activities of Some Fruits

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Medicinal plants and antioxidants: What do we learn from cell culture and Caenorhabditis elegans studies?

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Evidences that maternal swimming exercise improves antioxidant defenses and induces mitochondrial biogenesis in the brain of young Wistar rats

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Mitochondrial Hyperpolarization in Pulmonary Vascular Remodeling. Mitochondrial Uncoupling Protein Deficiency as Disease Model

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Carbamate Derivatives of Indolines as Cholinesterase Inhibitors and Antioxidants for the Treatment of Alzheimer’s Disease

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Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

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Advanced oxidation protein products (AOPP): novel uremic toxins, or components of the non-enzymatic antioxidant system of the plasma proteome?

Selmeci, L. (2011) · Free Radical Research · doi:10.3109/10715762.2011.602074 · Cited by 76

Investigation of oxidative stress parameters in treated phenylketonuric patients

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Ovothiol Isolated from Sea Urchin Oocytes Induces Autophagy in the Hep-G2 Cell Line

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Neuroprotective Effect of CNB-001, a Novel Pyrazole Derivative of Curcumin on Biochemical and Apoptotic Markers Against Rotenone-Induced SK-N-SH Cellular Model of Parkinson’s Disease

Jayaraj, R. L., Tamilselvam, K., Manivasagam, T., & Elangovan, N. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0075-8 · Cited by 76

Predominant role of obesity/insulin resistance in oxidative stress development

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Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress

Farías, J. G., Herrera, E. A., Carrasco‐Pozo, C., Sotomayor‐Zárate, R., Cruz, G., Morales, P., & Castillo, R. L. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.006 · Cited by 77

Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal

Romano, A., Serviddio, G., Calcagnini, S., Villani, R., Giudetti, A. M., Cassano, T., & Gaetani, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.046 · Cited by 79

Transcriptional Profiling of Aflatoxin B1-Induced Oxidative Stress and Inflammatory Response in Macrophages

Ma, J., Liu, Y., Guo, Y., Ma, Q., Ji, C., & Zhao, L. (2021) · Toxins · doi:10.3390/toxins13060401 · Cited by 85

α-Mangostin: A Dietary Antioxidant Derived from the Pericarp of Garcinia mangostana L. Inhibits Pancreatic Tumor Growth in Xenograft Mouse Model

Hafeez, B. B., Mustafa, A., Fischer, J. W., Singh, A. K., Zhong, W., Shekhani, M. O., Meske, L. M., Havighurst, T. C., Kim, K., & Verma, A. K. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5212 · Cited by 77

Chromatin Remodeling, DNA Damage Repair and Aging

Liu, B., Yip, R. K. H., & Zhou, Z. (2012) · Current Genomics · doi:10.2174/138920212803251373 · Cited by 81

Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients

Rana, S. V., Sharma, S. K., Kaur, J., Prasad, K. K., Sinha, S. K., Kochhar, R. K., Malik, A., & Morya, R. K. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.01.007 · Cited by 74

Principles and Practice of Photoprotection

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Quantification of Basal and Stimulated ROS Levels as Predictors of Islet Potency and Function

Armann, B., Hansona, M., Hatch, E. W., Steffen, A., & Fernandez, L. A. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01577.x · Cited by 75

A fluorometer‐based method for monitoring oxidation of redox‐sensitive GFP (roGFP) during development and extended dark stress

Rosenwasser, S., Rot, I., Meyer, A. J., Feldman, L. J., Jiang, K., & Friedman, H. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01334.x · Cited by 73

Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species

Tetz, L. M., Kamau, P. W., Cheng, A. A., Meeker, J. D., & Loch-Caruso, R. K. (2013) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2013.01.195 · Cited by 74

A single 30 min treadmill exercise session is suitable for ‘proof-of concept studies’ in adult mdx mice: A comparison of the early consequences of two different treadmill protocols

Radley‐Crabb, H. G., Terrill, J. R., Shavlakadze, T., Tonkin, J. N., Arthur, P. G., & Grounds, M. D. (2011) · Neuromuscular Disorders · doi:10.1016/j.nmd.2011.07.008 · Cited by 74

Effect of resveratrol on growth performance, rectal temperature and serum parameters of yellow‐feather broilers under heat stress

He, S., Li, S., Arowolo, M. A., Yu, Q., Chen, F., Hu, R., & He, J. (2019) · Animal Science Journal · doi:10.1111/asj.13161 · Cited by 74

Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis

Salomone, F., Galvano, F., Marino, A., Paternostro, C., Tibullo, D., Bucchieri, F., Mangiameli, A., Parola, M., Bugianesi, E., & Volti, G. L. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.11.010 · Cited by 73

Chlorpyrifos pesticide promotes oxidative stress and increases inflammatory states in BV-2 microglial cells: A role in neuroinflammation

Weis, G. C. C., Assmann, C. E., Mostardeiro, V. B., Alves, A. D. O., da Rosa, J. R., Pillat, M. M., de Andrade, C. M., Schetinger, M. R. C., Morsch, V. M., da Cruz, I. B. M., et al. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130417 · Cited by 74

Influence of dietary zinc on lipid peroxidation, protein oxidation and antioxidant defence of juvenile Jian carp (Cyprinus carpio var. Jian)

Feng, L., Tan, L., LIU, Y., Jiang, J., Jiang, W., Hu, K., LI, S.-H., & Zhou, X. (2011) · Aquaculture Nutrition · doi:10.1111/j.1365-2095.2011.00858.x · Cited by 72

Copper-catalyzed Protein Oxidation and Its Modulation by Carbon Dioxide

Ramírez, D. C., Gomez-Mejiba, S., & Mason, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504241200 · Cited by 73

Trolox and Ascorbic Acid Reduce Direct and Indirect Oxidative Stress in the IPEC-J2 Cells, an In Vitro Model for the Porcine Gastrointestinal Tract

Vergauwen, H., Tambuyzer, B. R., Jennes, K., Degroote, J., Wang, W., SMET, S. D., Michiels, J., & Ginneken, C. J. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120485 · Cited by 73

In Vitro Antioxidant Activities of Sulfated Derivatives of Polysaccharides Extracted from Auricularia auricular

Zhang, H., Wang, Z., Yang, L., Yang, X. H., Wang, X., & Zhang, Z. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12053288 · Cited by 73

The seasonal changes in innate immunity of the common carp (Cyprinus carpio)

Buchtíková, S., Šimková, A. V., Rohlenová, K., Flajšhans, M., Lojek, A., Lilius, E., & Hyršl, P. (2011) · Aquaculture · doi:10.1016/j.aquaculture.2011.05.013 · Cited by 73

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells

Pollard, J. M., Reboucas, J. S., Durazo, A., Kos, I., Fike, F. M., Panni, M. K., Gralla, E. B., Valentine, J. S., Batinic̈‐Haberle, I., & Gatti, R. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.018 · Cited by 72

An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure

Braakhuis, H., Murphy, F. A., Ma‐Hock, L., Dekkers, S., Keller, J. G., Oomen, A. G., & Stone, V. (2021) · Applied In Vitro Toxicology · doi:10.1089/aivt.2021.0009 · Cited by 74

Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high‐cholesterol diet

Tomofuji, T., Azuma, T., Kusano, H., Sanbe, T., Ekuni, D., Tamaki, N., Yamamoto, T., & Watanabe, T. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.041 · Cited by 72

Development of reversible fluorescence probes based on redox oxoammonium cation for hypobromous acid detection in living cells

Yu, F., Song, P., Li, P., Wang, B., & Han, K. (2012) · Chemical Communications · doi:10.1039/c2cc33264g · Cited by 72

Principles for integrating reactive species into in vivo biological processes: Examples from exercise physiology

Margaritelis, N. V., Cobley, J. N., Paschalis, V., Veskoukis, A. S., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.12.011 · Cited by 74

Effects of in ovo injection of sulfur-containing amino acids on heat shock protein 70, corticosterone hormone, antioxidant indices, and lipid profile of newly hatched broiler chicks exposed to heat stress during incubation

Elnesr, S. S., Elwan, H. A. M., Xu, Q., Xie, C., Dong, X., & Zou, X. (2019) · Poultry Science · doi:10.3382/ps/pey609 · Cited by 72

Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus

Sun, X., Li, J., Zhao, H., Wang, Y., Liu, J., Shao, Y., Xue, Y., & Xing, M. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.10.006 · Cited by 71

Protective Effect of Bergapten against Human Erythrocyte Hemolysis and Protein Denaturation In Vitro

Aidoo, D. B., Konja, D., Henneh, I. T., & Ekor, M. (2021) · International Journal of Inflammation · doi:10.1155/2021/1279359 · Cited by 71

Effect of short-term cold stress on oxidative damage and transcript accumulation of defense-related genes in chickpea seedlings

Kazemi-Shahandashti, S.-S., Maali-Amiri, R., Zeinali, H., Khazaei, M., Talei, A., & Ramezanpour, S. S. (2014) · Journal of Plant Physiology · doi:10.1016/j.jplph.2014.03.020 · Cited by 71

Spectrophotometric assays for measuring redox biomarkers in blood

Veskoukis, A. S., Kyparos, A., Paschalis, V., & Nikolaidis, M. G. (2016) · Biomarkers · doi:10.3109/1354750x.2015.1126648 · Cited by 71

Rapid preparation of human urine and plasma samples for analysis of F2-isoprostanes by gas chromatography-mass spectrometry

Lee, J. C., Jenner, A. M., & Halliwell, B. B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.015 · Cited by 71

Mangiferin from Salacia chinensis Prevents Oxidative Stress and Protects Pancreatic β -Cells in Streptozotocin-Induced Diabetic Rats

Sellamuthu, P. S., Arulselvan, P., Muniappan, B. P., Fakurazi, S., & Kandasamy, M. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2480 · Cited by 70

Histological changes, lipid metabolism, and oxidative and endoplasmic reticulum stress in the liver of laying hens exposed to cadmium concentrations

Zhu, M., Li, H. Y., Bai, L. H., Wang, L., & Zou, X. (2020) · Poultry Science · doi:10.1016/j.psj.2019.12.073 · Cited by 72

Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never!

Cobley, J. N., Moult, P. R., Burniston, J. G., Morton, J. P., & Close, G. L. (2014) · Biogerontology · doi:10.1007/s10522-014-9546-8 · Cited by 74

Oxidative damage in dengue fever

Seet, R. C. S., Lee, J. C., Lim, E. C. H., Quek, A. M. L., Yeo, L. L. L., Huang, S.-H., & Halliwell, B. B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.035 · Cited by 70

Characterization of redox state of two human prostate carcinoma cell lines with different degrees of aggressiveness

Chaiswing, L., Bourdeau-Heller, J. M., Zhong, W., & Oberley, T. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.031 · Cited by 70

Mitochondrial ROS-PKCε signaling axis is uniquely involved in hypoxic increase in [Ca2+]i in pulmonary artery smooth muscle cells

Rathore, R., Zheng, Y., Li, X., Wang, Q., Liu, Q., Ginnan, R. G., Singer, H. A., Ho, Y., & Wang, Y.-X. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.116 · Cited by 70

Postdistillation waste material of thyme (Thymus vulgaris L., Lamiaceae) as a potential source of biologically active compounds

Gavarić, N., Kladar, N., Mišan, A. Č., Nikolić, A., Samojlik, I., Mimica–Dukić, N., & Božin, B. N. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.05.070 · Cited by 70

Antioxidant, anti-inflammatory and immunomodulatory effects of spirulina in exercise and sport: A systematic review

Calella, P., Cerullo, G., Di Dio, M., Liguori, F., Di Onofrio, V., Gallè, F., & Liguori, G. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1048258 · Cited by 69

Increase in oxidative stress levels following welding fume inhalation: a controlled human exposure study

Graczyk, H., Lewinski, N. A., Zhao, J., Sauvain, J., Suárez, G., Wild, P. P., Danuser, B., & Riediker, M. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0143-7 · Cited by 70

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Cintra, L. T. Â., Estrela, C., Azuma, M. M., Queiroz, Í. O. D. A., Kawai, T., & Gomes‐Filho, J. E. (2018) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2018.vol32.0068 · Cited by 69

Interaction between cadmium (Cd), selenium (Se) and oxidative stress biomarkers in healthy mothers and its impact on birth anthropometric measures

Al‐Saleh, I., Al-Rouqi, R., Obsum, C. A., Shinwari, N., Mashhour, A., Billedo, G., Al-Sarraj, Y. A., & Rabbah, A. (2014) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2014.08.001 · Cited by 72

Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl

Kellett, A., Howe, O. L., O’Connor, M. J., McCann, M., Creaven, B. S., McClean, S., Kia, A. F.-A., Casey, A., & Devereux, M. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.034 · Cited by 68

Pentaquinone based probe for nanomolar detection of zinc ions: Chemosensing ensemble as an antioxidant

Bhalla, V., Roopa, & Kumar, M. (2012) · Dalton Transactions · doi:10.1039/c2dt31341c · Cited by 70

Approaches to study yeast cell aging and death

Mirisola, M. G., Braun, R. J., & Petranović, D. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12112 · Cited by 72

Metal uptake, oxidative stress and histopathological alterations in gills and hepatopancreas of Callinectes amnicola exposed to industrial effluent

Jerome, F. C., Hassan, A. A., Omoniyi-Esan, G. O., Odujoko, O. O., & Chukwuka, A. V. (2017) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.01.032 · Cited by 71

Sialic acid deficiency is associated with oxidative stress leading to muscle atrophy and weakness in GNE myopathy

Cho, A., Christine, M., Malicdan, V., Miyakawa, M., Nonaka, I., Nishino, I., & Noguchi, S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx192 · Cited by 73

Abscisic acid increases hydrogen peroxide in mitochondria to facilitate stomatal closure

Postiglione, A. E., & Muday, G. K. (2022) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiac601 · Cited by 66

The protective effects of guaraná extract (Paullinia cupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside

Bittencourt, L. D. S., Machado, D. C., Machado, M. M., Santos, G., Algarve, T. D., Marinowic, D. R., Ribeiro, E. E., Soares, F. A. A., Barbisan, F., Athayde, M. L., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.11.041 · Cited by 68

Reversible and selective luminescent determination of ClO − /H 2 S redox cycle in vitro and in vivo based on a ruthenium trisbipyridyl probe

Liu, F., Gao, Y., Wang, J., & Sun, S. (2014) · The Analyst · doi:10.1039/c4an00331d · Cited by 68

The role of oxidative stress in acrolein-induced DNA damage in HepG2 cells

Li, L., Jiang, L., Geng, C., Cao, J., & Zhong, L. (2008) · Free Radical Research · doi:10.1080/10715760802008114 · Cited by 68

The Nitric Oxide Prodrug JS-K Is Effective against Non–Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen Species

Maciag, A. E., Chakrapani, H., Saavedra, J. E., Morris, N. L., Holland, R. J., Kosak, K. M., Shami, P. J., Anderson, L. M., & Keefer, L. K. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.174904 · Cited by 68

A novel profluorescent nitroxide as a sensitive probe for the cellular redox environment

Morrow, B. J., Keddie, D. J., Gueven, N., Lavin, M. F., & Bottle, S. E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.019 · Cited by 68

Potential of novel Lactobacillus helveticus strains and their cell wall bound proteases to release physiologically active peptides from milk proteins

Elfahri, K., Donkor, O. N., & Vasiljevic, T. (2014) · International Dairy Journal · doi:10.1016/j.idairyj.2014.03.010 · Cited by 67

Inactivation of Candida Biofilms by Non-Thermal Plasma and Its Enhancement for Fungistatic Effect of Antifungal Drugs

Sun, Y., Yu, S., Sun, P., Wu, H., Zhu, W., Liu, W., Zhang, J., Fang, J., & Li, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040629 · Cited by 68

Cytotoxicity of InP/ZnS Quantum Dots With Different Surface Functional Groups Toward Two Lung-Derived Cell Lines

Chen, T., Li, L., Xu, G., Wang, X., Wang, J., Chen, Y., Jiang, W., Yang, Z., & Lin, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00763 · Cited by 68

Integrated study of the role of Phragmites australis in azo-dye treatment in a constructed wetland: From pilot to molecular scale

Davies, L. C., Cabrita, G. J. M., Ferreira, R., Carias, C. C., Novais, J. M., & Martins-Dias, S. (2009) · Ecological Engineering · doi:10.1016/j.ecoleng.2008.08.001 · Cited by 67

Color alteration, hydrogen peroxide diffusion, and cytotoxicity caused by in-office bleaching protocols

de Almeida, L. C. A. G., Soares, D. G., Gallinari, M. D. O., Costa, C. A. D. S., dos Santos, P. H., & Briso, A. L. F. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1285-3 · Cited by 67

Blueberry anthocyanins extract inhibits acrylamide-induced diverse toxicity in mice by preventing oxidative stress and cytochrome P450 2E1 activation

Zhao, M., Wang, P., Zhu, Y., Liu, X., Hu, X., & Chen, F. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.035 · Cited by 67

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

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