Cited by 131Cannabis and Cannabinoid ResearchPrenatal Substance Exposure EffectsAnesthesia and Neurotoxicity Research

Cannabis and the developing brain: Insights from behavior

Trezza, Viviana, Cuomo, Vincenzo, Vanderschuren, Louk J.M.J.·2008·European Journal of Pharmacology

Abstract

The isolation and identification, in 1964, of delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, opened the door to a whole new field of medical research. The exploration of the therapeutic potential of THC and other natural and synthetic cannabinoid compounds was paralleled by the discovery of the endocannabinoid system, comprising cannabinoid receptors and their endogenous ligands, which offered exciting new insights into brain function. Besides its well-known involvement in specific brain functions, such as control of movement, memory and emotions, the endocannabinoid system plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation. For this reason, changes in its activity during stages of high neuronal plasticity, such as the perinatal and the adolescent period, can have long-lasting neurobehavioral consequences. Here, we summarize human and animal studies examining the behavioral and neurobiological effects of in utero and adolescent exposure to cannabis. Since cannabis preparations are widely used and abused by young people, including pregnant women, understanding how cannabinoid compounds affect the developing brain, leading to neurobehavioral alterations or neuropsychiatric disorders later in life, is a serious health issue. In addition, since the endocannabinoid system is emerging as a novel therapeutic target for the treatment of several neuropsychiatric diseases, a detailed investigation of possible adverse effects of cannabinoid compounds on the central nervous system (CNS) of immature individuals is warranted.

Integrity signals

Registry

Crossref · 10.1016/j.ejphar.2008.01.058

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163 of 163 references verified0 citation errors · 0 not checkable

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  • There is some evidence from animal models that adolescence could be a critical period for development of the endocannabinoid system.

    “There is some evidence from animal models that adolescence could be a critical period for development of the endocannabinoid system (33,34).”

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Authors
Trezza, V., Cuomo, V., & Vanderschuren, L. J. M. J.
Affiliations
  • University Medical Center Utrecht (NL)
  • Sapienza University of Rome (IT)
Corresponding author
Trezza, Viviana
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2008-05
Volume
585
Issue
2-3
Pages
441-452
ISSN
0014-2999 (ISSN-L)
OpenAlex
W1978267551
Cited by
131
References
165
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 12 · 2013: 7 · 2012: 10
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Iris (Roma Tre University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords
cannabis, delta-9-tetrahydrocannabinol, endocannabinoid system, cannabinoid receptors, brain development, prenatal cannabis exposure, adolescent cannabis exposure, neurobehavioral effects, neuropsychiatric disorders, neuroplasticity, cannabinoid therapeutics
MeSH terms
Adolescent, Animals, Behavior, Behavior, Animal, Brain, Cannabis, Female, Humans, Synaptic Transmission, Neuronal Plasticity, Pregnancy, Cannabinoid Receptor Modulators

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