Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease
Abstract
We previously demonstrated that black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. To investigate potential mechanisms of this effect, we examined plasma catechins and systemic markers of oxidation, inflammation, and antioxidant protection from 66 subjects enrolled in that study. We collected samples at baseline, 2 h after 450 ml of black tea (acute), after 4 weeks of 900 ml of black tea per day (chronic), and after acute and chronic consumption of water. Total catechins increased 33% after acute tea (P < 0.05) and 29% after chronic tea (P < 0.05). Of individual catechins, plasma epicatechin gallate (ECG) concentration significantly increased with acute tea consumption, and plasma epicatechin (EC) increased with chronic tea consumption. Tea consumption did not improve plasma antioxidant capacity and did not reduce urinary 8-hydroxy-2'-deoxyguanosine, or urinary 8-isoprostane levels. Changes in catechin levels did not correlate with changes in endothelial function, plasma markers of oxidative stress, or C-reactive protein. In contrast, endothelial function at baseline correlated with dietary flavonoid intake (beta = 0.32, P = 0.02) and with baseline plasma EC concentration after adjusting for confounding variables (beta = 0.39, P = 0.03). These findings suggest that the benefits of black tea consumption on endothelial function may not be attributable to tea catechins or a systemic antioxidant or anti-inflammatory effect. Chronic dietary flavonoid status appears to relate to endothelial function, possibly suggesting that other flavonoids or polyphenolic components of tea favorably influence vascular health and risk for cardiovascular disease.
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BMI and other obesity measures such as waist circumference are positively related to circulating concentrations of CRP and other inflammatory markers.
“However, there is a positive relationship between BMI and other measures of obesity such as waist circumference and circulating concentrations of CRP and other inflammatory markers (7) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [7]
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336 · see citing works
Hertog, M. G. L. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430040053006 · Cited by 2,225 · see citing works
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854 · see citing works
Self-citationOxygen-radical absorbance capacity assay for antioxidants
Cao, G., Alessio, H. M., & Cutler, R. G. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90027-r · Cited by 1,612 · see citing works
Flavonoid intake and coronary mortality in Finland: a cohort study
Knekt, P., Jarvinen, R., Reunanen, A., & Maatela, J. (1996) · BMJ · doi:10.1136/bmj.312.7029.478 · Cited by 1,268 · see citing works
Overview of Dietary Flavonoids: Nomenclature, Occurrence and Intake
Beecher, G. R. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3248s · Cited by 909 · see citing works
Lee, M., Maliakal, P. P., Chen, L., Meng, X., Bondoc, F. Y., Prabhu, S., Lambert, G. H., Mohr, S. N., & Yang, C. S. (2002) · PubMed · Cited by 716 · see citing works
Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M., Scoditti, E., Storelli, C., Visioli, F., Distante, A., & De Caterina, R. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000062884.69432.a0 · Cited by 640 · see citing works
Stein, J. H., Keevil, J. G., Wiebe, D. A., Aeschlimann, S. E., & Folts, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.10.1050 · Cited by 573 · see citing works
Duffy, S. J., Keaney, J. F., HOLBROOK, M. M., Gokce, N., Swerdloff, P. L., Frei, B. B., & Vita, J. A. (2001) · Circulation · doi:10.1161/01.cir.104.2.151 · Cited by 552 · see citing works
Self-citationLin, Y., & Lin, J. (1997) · PubMed · Cited by 539 · see citing works
Total Phenol, Catechin, and Caffeine Contents of Teas Commonly Consumed in the United Kingdom
Khokhar, S., & Magnusdottir, S. G. M. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010153l · Cited by 533 · see citing works
Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study
Hertog, M. G. L., Sweetnam, P. M., FEHILY, A. M., Elwood, P. C., & Kromhout, D. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1489 · Cited by 511 · see citing works
Antioxidant Effects of Tea: Evidence from Human Clinical Trials
Rietveld, A. G., & Wiseman, S. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3285s · Cited by 501 · see citing works
Self-citationAnalysis of plasma and urinary tea polyphenols in human subjects.
Lee, M. J., Wang, Z., Li, H., Chen, L., Sun, Y., Gobbo, S., Balentine, D. A., & Yang, C. S. (1995) · PubMed · Cited by 493 · see citing works
Mechanisms of Cancer Prevention by Tea Constituents
Lambert, J. D., & Yang, C. S. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3262s · Cited by 489 · see citing works
Engler, M. B., Engler, M. M., Chen, C. Y., Malloy, M. J., Browne, A., Chiu, E. Y., Kwak, H., Milbury, P. E., Paul, S. M., Blumberg, J. B., et al. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719361 · Cited by 465 · see citing works
Lin, Y., & Lin, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.3.465 · Cited by 463 · see citing works
Characteristics and Occurrence of Phenolic Phytochemicals
King, A. J. G., & YOUNG, G. (1999) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(99)00051-6 · Cited by 428 · see citing works
Vascular effects of cocoa rich in flavan-3-ols
Heiss, C. (2003) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.290.8.1030 · Cited by 425 · see citing works
Antioxidant Vitamin Supplements and Cardiovascular Disease
Kris‐Etherton, P. M., Lichtenstein, A. H., Howard, B. V., Steinberg, D. H., & Witztum, J. L. (2004) · Circulation · doi:10.1161/01.cir.0000137822.39831.f1 · Cited by 408 · see citing works
Yang, F., de Villiers, W. J. S., McClain, C. J., & Varilek, G. W. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2334 · Cited by 389 · see citing works
Arts, I. C. W., Hollman, P. C. H., Feskens, E. J. M., Bueno-de-Mesquita, H. B., & Kromhout, D. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.2.227 · Cited by 346 · see citing works
Lorenz, M., Weßler, S., Follmann, E., Michaelis, W., Düsterhöft, T., Baumann, G., Stangl, K., & Stangl, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309114200 · Cited by 334 · see citing works
Effects of Cocoa Extracts on Endothelium-Dependent Relaxation
Karim, M., Hallam, K. M., & Kappagoda, C. T. (2000) · Journal of Nutrition · doi:10.1093/jn/130.8.2105s · Cited by 263 · see citing works
Catechins Are Bioavailable in Men and Women Drinking Black Tea throughout the Day
Warden, B. A., Smith, L. S., Beecher, G. R., Balentine, D. A., & Clevidence, B. A. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1731 · Cited by 238 · see citing works
Self-citationLudwig, A., Lorenz, M., Grimbo, N., Steinle, F., Meiners, S., Bartsch, C., Stangl, K., Baumann, G., & Stangl, V. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.099 · Cited by 198 · see citing works
Hakim, I. A., Harris, R. B., Brown, S., Chow, H. ‐. S., Wiseman, S. A., Agarwal, S., & Talbot, W. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3303s · Cited by 188 · see citing works
Self-citationYang, C. S., Lee, M.-J., & Chen, L. (1999) · PubMed · Cited by 181 · see citing works
Regular ingestion of black tea improves brachial artery vasodilator function
Hodgson, J. M., Puddey, I. B., Burke, V., Watts, G. F., & Beilin, L. J. (2002) · Clinical Science · doi:10.1042/cs20010120 · Cited by 170 · see citing works
A flavonoid‐rich diet increases nitric oxide production in rat aorta
Benito, S., Lopez, D., Sáiz, M. P., Buxaderas, S., Sánchez, J., Puig‐Parellada, P., & Mitjavila, M. T. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704534 · Cited by 164 · see citing works
Aldini, G., Carini, M., Piccoli, A., Rossoni, G., & Facino, R. M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00697-0 · Cited by 160 · see citing works
Plasma concentrations of individual tea catechins after a single oral dose in humans
van Amelsvoort, J. M. M., Hof, K. H. V. H., Mathot, J. N. J. J., MULDER, T. P. J., Wiersma, A., & Tijburg, L. B. M. (2001) · Xenobiotica · doi:10.1080/00498250110079149 · Cited by 155 · see citing works
Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols
Anter, E., Thomas, S. R., Schulz, E., Shapira, O. M., Vita, J. A., & Keaney, J. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405547200 · Cited by 142 · see citing works
Self-citationChou, E. J., Keevil, J. G., Aeschlimann, S. E., Wiebe, D. A., Folts, J. D., & Stein, J. H. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01738-6 · Cited by 129 · see citing works
Acute effects of ingestion of black and green tea on lipoprotein oxidation
Hodgson, J. M., Puddey, I. B., Croft, K. D., Burke, V., Mori, T. A., Caccetta, R., & Beilin, L. J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1103 · Cited by 121 · see citing works
Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein
Yoshida, H., Ishikawa, T., Hosoai, H., Suzukawa, M., Ayaori, M., Hisada, T., Sawada, S., Yonemura, A., Higashi, K., Ito, T., et al. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00256-7 · Cited by 120 · see citing works
Duffy, S. J., Gokce, N., HOLBROOK, M. M., Hunter, L. M., Biegelsen, E. S., Huang, A., Keaney, J. F., & Vita, J. A. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h528 · Cited by 118 · see citing works
Self-citationde Maat, M., Pijl, H., Kluft, C., & Princen, H. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601084 · Cited by 101 · see citing works
Huang, Y. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00034-3 · Cited by 91 · see citing works
Tea Consumption and Cardiovascular Disease: Effects on Endothelial Function
Vita, J. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3293s · Cited by 89 · see citing works
Self-citationBrown, C. A., Bolton-Smith, C., Woodward, M., & Tunstall‐Pedoe, H. (1993) · Journal of Epidemiology & Community Health · doi:10.1136/jech.47.3.171 · Cited by 80 · see citing works
Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans
Hodgson, J., Puddey, I., Mori, T., Burke, V, Baker, R., & Beilin, L. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601231 · Cited by 76 · see citing works
Schröeder, P., Klotz, L., & Sies, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01132-x · Cited by 66 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Antioxidant and prooxidant properties of flavonoids
Procházková, D., Boušová, I., & Wilhelmová, N. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.01.018 · Cited by 1,572 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081 · see citing works
Studies on free radicals, antioxidants, and co-factors.
Rahman, K. (2007) · PubMed Central · Cited by 981 · see citing works
Herbal Medicine: Biomolecular and Clinical Aspects
Iff, B., & Wachtel-Galor, S. (2011) · Cited by 923 · see citing works
Low-grade inflammation, diet composition and health: current research evidence and its translation
Minihane, A. M., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M. F., Vauzour, D., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002093 · Cited by 919 · see citing works
Flavonoids as anti-inflammatory agents
Serafini, M., Peluso, I., & Raguzzini, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000162x · Cited by 826 · see citing works
LOTITO, S. B., & Frei, B. B. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.033 · Cited by 771 · see citing works
Self-citationRetractedNutritional, Dietary and Postprandial Oxidative Stress
Sies, H., Stahl, W., & Sevanian, A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.969 · Cited by 608 · see citing works
Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 608 · see citing works
Inflammatory Disease Processes and Interactions with Nutrition
Calder, P. C., Albers, R., Antoine, J., Blum, S., Bourdet‐Sicard, R., Ferns, G. A., Folkerts, G., Friedmann, P. S., Frost, G. S., Guarner, F., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509377867 · Cited by 570 · see citing works
Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C.-P., & Sinaiko, A. R. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.11.036 · Cited by 496 · see citing works
Vascular Endothelial Function and Hypertension: Insights and Directions
Dharmashankar, K., & Widlansky, M. E. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0150-2 · Cited by 426 · see citing works
Self-citationHollman, P. C. H., Cassidy, A., Comte, B., Heinonen, M., Richelle, M., Richling, E., Serafini, M., Scalbert, A., Sies, H., & Vidry, S. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.131490 · Cited by 406 · see citing works
Fruit polyphenols, immunity and inflammation
González-Gallego, J., García-Mediavilla, M. V., Sánchez-Campos, S., & Tuñón, M. J. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003910 · Cited by 387 · see citing works
Potenza, M. A., Marasciulo, F. L., Tarquinio, M., Tiravanti, E., Colantuono, G., Federici, A., Kim, J., Quon, M. J., & Montagnani, M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00698.2006 · Cited by 380 · see citing works
Loke, W. M., Hodgson, J. M., Proudfoot, J. M., McKinley, A. J., Puddey, I. B., & Croft, K. D. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1018 · Cited by 372 · see citing works
Antioxidant Activity of Phenolic Compounds: FromIn VitroResults toIn VivoEvidence
Fernández‐Pachón, M., Villaño, D., Troncoso, A. M., & García-Parrilla, M. C. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701761845 · Cited by 365 · see citing works
Loke, W. M., Proudfoot, J. M., Hodgson, J. M., McKinley, A. J., Hime, N. J., Magat, M., Stocker, R., & Croft, K. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.199687 · Cited by 284 · see citing works
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277 · see citing works
Chun, O. K., Chung, S.-J., Claycombe, K. J., & Song, W. O. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.4.753 · Cited by 263 · see citing works
Potì, F., Santi, D., Spaggiari, G., Zimetti, F., & Zanotti, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020351 · Cited by 256 · see citing works
Molecular targets of tea polyphenols in the cardiovascular system
Stangl, V., Dreger, H., Stangl, K., & Lorenz, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.022 · Cited by 240 · see citing works
Peluso, I., & Serafini, M. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13649 · Cited by 240 · see citing works
Kim, J., Formoso, G., Li, Y., Potenza, M. A., Marasciulo, F. L., Montagnani, M., & Quon, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609725200 · Cited by 236 · see citing works
Acute EGCG Supplementation Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease
Widlansky, M. E., Hamburg, N. M., Anter, E., HOLBROOK, M. M., Kahn, D. F., Elliott, J. G., Keaney, J. F., & Vita, J. A. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719590 · Cited by 217 · see citing works
Self-citationGreen tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
Basu, A., Du, M., Sanchez, K., Leyva, M. J., Betts, N. M., Blevins, S., Wu, M., Aston, C. E., & Lyons, T. J. (2011) · Nutrition · doi:10.1016/j.nut.2010.01.015 · Cited by 194 · see citing works
Tea and cardiovascular disease
Deka, A., & Vita, J. A. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.03.009 · Cited by 184 · see citing works
Self-citationGómez‐Guzmán, M., Jiménez, R., Sánchez, M., Zarzuelo-Romero, M. J., Galindo, P., Quintela, A. M., López-Sepúlveda, R., Romero, M., Tamargo, J. L., Vargas, F., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.015 · Cited by 179 · see citing works
Overview of polyphenols and their properties
Belščak‐Cvitanović, A., Durgo, K., Huđek, A., Bačun‐Družina, V., & Komes, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813572-3.00001-4 · Cited by 179 · see citing works
The impact of oolong and black tea polyphenols on human health
Zhang, H., Qi, R., & Mine, Y. (2019) · Food Bioscience · doi:10.1016/j.fbio.2019.03.009 · Cited by 171 · see citing works
Marnewick, J. L., Rautenbach, F., Venter, I., Neethling, H., Blackhurst, D., Wolmarans, P., & Macharia, M. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.061 · Cited by 170 · see citing works
Rangel-Huerta, Ó. D., Pastor‐Villaescusa, B., Aguilera, C. M., & Gil, Á. (2015) · Nutrients · doi:10.3390/nu7075177 · Cited by 167 · see citing works
A Thought on the Biological Activities of Black Tea
Sharma, V., & Rao, L. J. M. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802068066 · Cited by 165 · see citing works
Henning, S. M., Niu, Y., Liu, Y., Lee, N. H., Hara, Y., Thames, G., Minutti, R. R., Carpenter, C. L., Wang, H., & Heber, D. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.003 · Cited by 155 · see citing works
da Silva-Maia, J. K., Cazarin, C. B. B., Colomeu, T. C., Batista, Â. G., Meletti, L. M. M., Paschoal, J. A. R., Bogusz, S., Furlan, M. F., Reyes, F. G. R., Augusto, F., et al. (2013) · Food Research International · doi:10.1016/j.foodres.2012.12.043 · Cited by 145 · see citing works
Can EGCG Reduce Abdominal Fat in Obese Subjects?
Hill, A. M., Coates, A. M., Buckley, J. D., Ross, R., Thielecke, F., & Howe, P. R. C. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719628 · Cited by 139 · see citing works
Vauzour, D. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6473 · Cited by 136 · see citing works
The acute effect of green tea consumption on endothelial function in healthy individuals
Alexopoulos, N. A., Vlachopoulos, C. V., Aznaouridis, K. A., Baou, K., Vasiliadou, C., Pietri, P., Xaplanteris, P., Stefanadi, E., & Stefanadis, C. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f4832f · Cited by 131 · see citing works
Milenković, D., Deval, C., Dubray, C., Mazur, A., & Morand, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026669 · Cited by 125 · see citing works
Steptoe, A., Gibson, E. L., Vuononvirta, R., Hamer, M., Wardle, J., Rycroft, J. A., Martin, J. F., & Erusalimsky, J. D. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.054 · Cited by 116 · see citing works
Flanagan, E. C., Müller, M. M., Hornberger, M., & Vauzour, D. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0226-1 · Cited by 115 · see citing works
Iglesias‐Aguirre, C. E., Cortés‐Martín, A., Ávila‐Gálvez, M. Á., Giménez‐Bastida, J. A., Selma, M. V., González‐Sarrías, A., & Espı́n, J. C. (2021) · Food & Function · doi:10.1039/d1fo02033a · Cited by 117 · see citing works
Plant Food Supplements with Anti-Inflammatory Properties: A Systematic Review (II)
Lorenzo, C. D., Dell’Agli, M., Badea, M., Dima, L., Colombo, E., Sangiovanni, E., Restani, P., & Bosisio, E. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.691916 · Cited by 111 · see citing works
Effect of Flavonoids on Human Health: Old Subjects but New Challenges
Lee, E.-R., Kang, G., & Cho, S. (2007) · Recent Patents on Biotechnology · doi:10.2174/187220807780809445 · Cited by 103 · see citing works
O’Grady, M. N., Maher, M., TROY, D. J., MOLONEY, A. P., & Kerry, J. P. (2006) · Meat Science · doi:10.1016/j.meatsci.2005.11.008 · Cited by 100 · see citing works
van Duynhoven, J., Vaughan, E. E., van Dorsten, F. A., Roldán, M. V. G., de Vos, R. C. H., Vervoort, J. J. M., van der Hooft, J. J. J., Roger, L. C., Draijer, R., & Jacobs, D. M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058263 · Cited by 100 · see citing works
Surma, S., Sahebkar, A., & Banach, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106596 · Cited by 99 · see citing works
Black tea: Phytochemicals, cancer chemoprevention, and clinical studies
Singh, B. N., Prateeksha, Rawat, A. K. S., Bhagat, R. M., & Singh, B. R. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.994700 · Cited by 99 · see citing works
Black Tea Polyphenols: A Mechanistic Treatise
Butt, M. S., Imran, A., Sharif, M. K., Ahmad, R. S., Xiao, H., Imran, M., & Rsool, H. A. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.623198 · Cited by 91 · see citing works
Effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials
Liu, G., Mi, X.-N., Zheng, X.-X., Xu, Y.-L., Lu, J., & Huang, X.-H. (2014) · British Journal of Nutrition · doi:10.1017/s0007114514001731 · Cited by 85 · see citing works
Drug Treatment of Hypertension: Focus on Vascular Health
Cameron, A. C., Lang, N. N., & Touyz, R. M. (2016) · Drugs · doi:10.1007/s40265-016-0642-8 · Cited by 83 · see citing works
van Duynhoven, J., van der Hooft, J. J. J., van Dorsten, F. A., Peters, S., Foltz, M., Roldán, M. V. G., Vervoort, J. J. M., de Vos, R. C. H., & Jacobs, D. M. (2014) · Journal of Proteome Research · doi:10.1021/pr5001253 · Cited by 82 · see citing works
De Bacquer, D., Clays, E., Delanghe, J., & De Backer, G. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.028 · Cited by 78 · see citing works
Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review
Luvián‐Morales, J., Varela-Castillo, F. O., Flores-Cisneros, L. A., Cetina, L., & Castro-Eguiluz, D. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1875189 · Cited by 81 · see citing works
Anti-inflammatory Effects of Plant-based Foods and of their Constituents
Watzl, B. (2008) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.78.6.293 · Cited by 76 · see citing works
Industrial Application and Health Prospective of Fig (Ficus carica) By-Products
Rasool, I. F. U., Aziz, A., Khalid, W., Koraqi, H., Siddiqui, S. A., AL-Farga, A. M., Lai, W., & Ali, A. (2023) · Molecules · doi:10.3390/molecules28030960 · Cited by 74 · see citing works
Lettieri‐Barbato, D., Tomei, F., Sancini, A., Morabito, G., & Serafini, M. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000263 · Cited by 73 · see citing works
Bahorun, T., Luximon‐Ramma, A., Gunness, T. K., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A., & Aruoma, O. I. (2009) · Toxicology · doi:10.1016/j.tox.2009.11.024 · Cited by 72 · see citing works
Ni, H., Chen, F., Jiang, Z., Cai, M. Y., Yuan, Y., Xiao, A., & Cai, H. N. (2014) · LWT · doi:10.1016/j.lwt.2014.09.010 · Cited by 71 · see citing works
Epicatechin: Endothelial Function and Blood Pressure
Jiménez, R., Duarte, J., & Pérez‐Vizcaíno, F. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205370q · Cited by 66 · see citing works
Hamer, M. (2007) · Nutrition Research · doi:10.1016/j.nutres.2007.05.008 · Cited by 64 · see citing works
Modulation of human neutrophils' oxidative burst by flavonoids
Ribeiro, D., Freitas, M., Tomé, S. M., Silva, A. M. S., Porto, G., & Fernandes, E. G. R. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.06.019 · Cited by 61 · see citing works
Cutler, R. G., PLUMMER, J., Chowdhury, K., & Heward, C. B. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1323.031 · Cited by 59 · see citing works
Cornelis, M. C., & van Dam, R. M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa212 · Cited by 58 · see citing works
Bioactive compounds with effects on inflammation markers in humans
Rosa, F. T., Zulet, M. Á., Marchini, J. S., & Martínez, J. A. (2012) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.649250 · Cited by 59 · see citing works
Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function
Shenouda, S. M., & Vita, J. A. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719625 · Cited by 58 · see citing works
Self-citationThe effects of tea extracts on proinflammatory signaling
Pajonk, F., Riedisser, A., Henke, M., McBride, W. H., & Fiebich, B. L. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-28 · Cited by 58 · see citing works
Vauzour, D., Martinsen, A., & Layé, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.004 · Cited by 57 · see citing works
Redox Activity of Flavonoids: Impact on Human Health, Therapeutics, and Chemical Safety
Sarkar, C. K., Chaudhary, P., Jamaddar, S., Janmeda, P., Mondal, M., Mubarak, M. S., & Islam, M. T. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00348 · Cited by 58 · see citing works
Plant Food Supplements with Anti-Inflammatory Properties: A Systematic Review (I)
Dell’Agli, M., Lorenzo, C. D., Badea, M., Sangiovanni, E., Dima, L., Bosisio, E., & Restani, P. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.682123 · Cited by 53 · see citing works
Analgesic and anti‐inflammatory activities of epicatechin gallate from Bauhinia hookeri
Al‐Sayed, E., & Abdel‐Daim, M. M. (2018) · Drug Development Research · doi:10.1002/ddr.21430 · Cited by 52 · see citing works
Assad, M., Ashaolu, T. J., Khalifa, I., Baky, M. H., & Farag, M. A. (2023) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03701-5 · Cited by 52 · see citing works
Anti-Inflammatory Effects of Flavonoids in Common Neurological Disorders Associated with Aging
Martínez‐Coria, H., Arrieta‐Cruz, I., Juárez, R. G., & López-Valdés, H. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054297 · Cited by 51 · see citing works
Çelik, F., & Topçu, F. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.04.006 · Cited by 49 · see citing works
Serafini, M., Rio, D. D., N’dri, Y. D., Bettuzzi, S., & Peluso, I. (2011) · Oxidative stress and disease · doi:10.1201/b10787-13 · Cited by 48 · see citing works
Kazemi, S., yaghooblou, F., Siassi, F., Foroushani, A. R., Ghavipour, M., Koohdani, F., & Sotoudeh, G. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8414 · Cited by 48 · see citing works
Serafini, M., Miglio, C., Peluso, I., & Petrosino, T. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611796235125 · Cited by 47 · see citing works
Trace metals and flavonoids in different types of tea
Pękal, A., Biesaga, M., & Pyrzyńska, K. (2013) · Food Science and Biotechnology · doi:10.1007/s10068-013-0165-y · Cited by 45 · see citing works
Sureda, A., Tejada, S., Bibiloni, M. D. M., Tur, J. A., & Pons, A. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140813123843 · Cited by 45 · see citing works
A 6-month randomized pilot study of black tea and cardiovascular risk factors
Mukamal, K. J., MacDermott, K., Vinson, J. A., Oyama, N., Manning, W. J., & Mittleman, M. A. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.07.008 · Cited by 44 · see citing works
Floegel, A., Chung, S., von Ruesten, A., Yang, M., Chung, C., Song, W. O., Koo, S. I., Pischon, T., & Chun, O. K. (2011) · Public Health Nutrition · doi:10.1017/s1368980011000395 · Cited by 44 · see citing works
CH 6 Dietary Flavonoids and Health — Broadening the Perspective
Andersen, O. M., & Markham, K. R. (2005) · CRC Press eBooks · doi:10.1201/9781420039443-10 · Cited by 43 · see citing works
Hamer, M., & Steptoe, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061741 · Cited by 43 · see citing works
Acute Effect of Black and Green Tea on Aortic Stiffness and Wave Reflections
Vlachopoulos, C., Alexopoulos, N., Dima, I., Aznaouridis, K., Andreadou, I., & Stefanadis, C. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719535 · Cited by 49 · see citing works
Microbial and host cells acquire enhanced oxidant-scavenging abilities by binding polyphenols
Ginsburg, I., Kohen, R., & Koren, E. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.11.009 · Cited by 42 · see citing works
Ma, J., Wang, Y., Li, J., Zhang, J., Wei, Y., Yan, Y., Wang, H., Yue, P., Xiong, Z., Wang, R., et al. (2024) · LWT · doi:10.1016/j.lwt.2024.116019 · Cited by 39 · see citing works
In vivoeffects ofAspalathus linearis(rooibos) on male rat reproductive functions
Opuwari, C. S., & Monsees, T. K. (2013) · Andrologia · doi:10.1111/and.12158 · Cited by 39 · see citing works
Shalaby, E. A., Mahmoud, G. I., & Shanab, S. M. M. (2016) · Frontiers in Life Science · doi:10.1080/21553769.2016.1233909 · Cited by 39 · see citing works
Dietary Flavonoids and Health — Broadening the Perspective
Clifford, M. N., & Brown, J. E. (2005) · CRC Press eBooks · doi:10.1201/9781420039443.ch6 · Cited by 39 · see citing works
Zhu, C., Tai, L.-L., Wan, X., Li, D., Zhao, Y.-Q., & Xu, Y. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2017.1377736 · Cited by 38 · see citing works
Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids
González‐Gallego, J., García‐Mediavilla, M. V., Sánchez‐Campos, S., & Tuñón, M. J. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00032-3 · Cited by 38 · see citing works
Tea in cardiovascular health and disease: a critical appraisal of the evidence
Lange, K. W. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.12.034 · Cited by 37 · see citing works
Alipour, B., Rashidkhani, B., & Edalati, S. (2015) · Nutrition · doi:10.1016/j.nut.2015.11.011 · Cited by 35 · see citing works
Ruxton, C. H. S. (2008) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2008.00691.x · Cited by 34 · see citing works
Asoudeh, F., Dashti, F., Jayedi, A., Hemmati, A., Fadel, A., & Mohammadi, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.822557 · Cited by 33 · see citing works
Ziyatdinova, G. K., Kozlova, E., & Budnikov, H. C. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.09.075 · Cited by 33 · see citing works
Evidence for circulatory benefits of resveratrol in humans
Wong, R. H. X., Coates, A. M., Buckley, J. D., & Howe, P. R. C. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12155 · Cited by 31 · see citing works
Widlansky, M. E., Puppala, V. K., Suboc, T. M. B., Malik, M. A., Branum, A., Signorelli, K., Wang, J., Ying, R., Tanner, M. J., & Tyagi, S. (2017) · Vascular Medicine · doi:10.1177/1358863x16681486 · Cited by 30 · see citing works
Self-citationHypoxia induced cognitive impairment modulating activity of Cyperus rotundus
Kandikattu, H. K., Deep, S. N., Razack, S., Amruta, N., Prasad, D. N., & Khanum, F. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.035 · Cited by 29 · see citing works
- Authors
- Widlansky, M. E., Duffy, S. J., Hamburg, N. M., Gokce, N., Warden, B. A., Wiseman, S., Keaney, J. F., Frei, B., & Vita, J. A.
- Affiliations
- Boston University (US)
- Unilever Research and Development Vlaardingen (NL)
- Oregon State University (US)
- Corresponding author
- Vita, Joseph A.
- ORCID
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 38
- Issue
- 4
- Pages
- 499-506
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2057732608
- Cited by
- 162
- References
- 48
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 11 · 2013: 19 · 2012: 8
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL060886, HL 060886, T32HL007224, K23HL004425)
- National Center for Research Resources (M01RR000533)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- black tea consumption, tea catechins, epicatechin, epicatechin gallate, endothelial function, coronary artery disease, oxidative stress, inflammation, antioxidant capacity, urinary 8-hydroxy-2'-deoxyguanosine, C-reactive protein, dietary flavonoids, cardiovascular risk
- MeSH terms
- Catechin, Coronary Artery Disease, Female, Humans, Inflammation, Male, Phytotherapy, Middle Aged, Oxidation-Reduction, Plant Extracts, Tea, Oxidative Stress, Endothelial Cells
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