Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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The DNA damage response: putting checkpoints in perspective

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

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The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

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Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

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Requirement of the MRN complex for ATM activation by DNA damage

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The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

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Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

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The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase

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Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

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hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

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Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

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The Many Interfaces of Mre11

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DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

Mirzoeva, O. K., & Petrini, J. H. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.281-288.2001 · Cited by 387 · see citing works

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Zhu, J., Petersen, S., Tessarollo, L., & Nussenzweig, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00019-7 · Cited by 374 · see citing works

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

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The cellular response to DNA double-strand breaks: defining the sensors and mediators

Petrini, J. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00170-3 · Cited by 339 · see citing works

ATM: Genome stability, neuronal development, and cancer cross paths

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The MRN complex: coordinating and mediating the response to broken chromosomes

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Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

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Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

Yamaguchi‐Iwai, Y., Sonoda, E., Sasaki, M. S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y. M., Yagi, T., Takata, M., Price, C., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6619 · Cited by 282 · see citing works

DNA Structure-specific Nuclease Activities in theSaccharomyces cerevisiae Rad50·Mre11 Complex

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Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

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Specific Recruitment of Human Cohesin to Laser-induced DNA Damage

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Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication

Costanzo, V., Robertson, K., Bibikova, M., Kim, E., Grieco, D., Gottesman, M., Carroll, D., & Gautier, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00294-5 · Cited by 239 · see citing works

The Mre11 complex and ATM: collaborating to navigate S phase

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Trading Places on DNA—A Three-Point Switch Underlies Primer Handoff from Primase to the Replicative DNA Polymerase

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Initial Steps of Ferulic Acid Polymerization by Lignin Peroxidase

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53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

Mochan, T. A., Venere, M., DiTullio, R. A., & Halazonetis, T. D. (2003) · PubMed · Cited by 192 · see citing works

DNA replication-dependent nuclear dynamics of the Mre11 complex.

Mirzoeva, O. K., & Petrini, J. H. J. (2003) · PubMed · Cited by 188 · see citing works

Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage

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Vanillins--a novel family of DNA-PK inhibitors

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Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice

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The architecture of the human Rad54–DNA complex provides evidence for protein translocation along DNA

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The Pathogenesis of Ataxia-Telangiectasia

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Regulation of Mre11/Rad50 by Nbs1

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TPEN, a Zn2+/Fe2+ chelator with low affinity for Ca2+, inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro

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Conserved genetic programs in insect and mammalian brain development

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Checking on DNA damage in S phase

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

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The ATM-mediated DNA-damage response: taking shape

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Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break

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The emerging role of nuclear architecture in DNA repair and genome maintenance

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Mechanisms of ATM Activation

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ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

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A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

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ATR and ATM regulate the timing of DNA replication origin firing

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Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Shiotani, B., & Zou, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.024 · Cited by 353 · see citing works

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

Lavin, M. F. (2007) · Oncogene · doi:10.1038/sj.onc.1210880 · Cited by 301 · see citing works

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 283 · see citing works

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

Kim, J. S., Krasieva, T. B., Kurumizaka, H., Chen, D. J., Taylor, A. M. R., & Yokomori, K. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411083 · Cited by 248 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

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Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

Spycher, C., Miller, E. S., Townsend, K., Pavic, L., Morrice, N. A., Janščák, P., Stewart, G. S., & Stucki, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709008 · Cited by 246 · see citing works

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 233 · see citing works

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

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Cellular Responses to DNA Damage: One Signal, Multiple Choices

Su, T. T. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090428 · Cited by 227 · see citing works

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

Trenz, K., Smith, E., Smith, S. J., & Costanzo, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601045 · Cited by 219 · see citing works

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

Helt, C. E., Cliby, W. A., Keng, P. C., Bambara, R. A., & O'Reilly, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410873200 · Cited by 216 · see citing works

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

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ATM-Dependent Phosphorylation of ATF2 Is Required for the DNA Damage Response

Bhoumik, A., Takahashi, S., Breitweiser, W., Shiloh, Y., Jones, N., & Ronai, Z. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.04.015 · Cited by 169 · see citing works

MRE11/RAD50/NBS1: complex activities

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Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans

García‐Muse, T., & Boulton, S. J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600896 · Cited by 161 · see citing works

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.

Shao, L., Fujii, H., Colmegna, I., Oishi, H., Goronzy, J. J., & Weyand, C. M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082251 · Cited by 159 · see citing works

The role of the DNA damage response in neuronal development, organization and maintenance

Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 135 · see citing works

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

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Mre11–Rad50–Nbs1‐dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

Jazayeri, A. R., Balestrini, A., Garner, E., Haber, J. E., & Costanzo, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.128 · Cited by 131 · see citing works

Early events in the mammalian response to DNA double-strand breaks

Riches, L. C., Lynch, A. M., & Gooderham, N. J. (2008) · Mutagenesis · doi:10.1093/mutage/gen039 · Cited by 122 · see citing works

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

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Rad50 Adenylate Kinase Activity Regulates DNA Tethering by Mre11/Rad50 Complexes

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Choreography of recombination proteins during the DNA damage response

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ATM protein kinase: the linchpin of cellular defenses to stress

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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

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Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

Lee, J., Mand, M. R., Deshpande, R. A., Kinoshita, E., Yang, S.-H., Wyman, C., & Paull, T. T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.460378 · Cited by 111 · see citing works

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

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Srs2 and Sgs1 DNA Helicases Associate with Mre11 in Different Subcomplexes following Checkpoint Activation and CDK1-Mediated Srs2 Phosphorylation

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Mutations in Mre11 Phosphoesterase Motif I That Impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 Complex Stability in Addition to Nuclease Activity

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POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps

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The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensorPreprint

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Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

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The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage

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The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks

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Brca2, Rad51 and Mre11: Performing balancing acts on replication forks

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Disruption of Mechanisms That Prevent Rereplication Triggers a DNA Damage Response

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The Mre11-Rad50-Nbs1 Complex Mediates Activation of TopBP1 by ATM

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DNA Structure and Integrity Checkpoints during the Cell Cycle and Their Role in Drug Targeting and Sensitivity of Tumor Cells to Anticancer Treatment

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MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

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Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11

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MCL-1 localizes to sites of DNA damage and regulates DNA damage response

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A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint

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An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

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A Mutant Allele ofMRE11Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner

Wen, Q., Scorah, J., Phear, G. A., Rodgers, G. R., Rodgers, S., & Meuth, M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0975 · Cited by 61 · see citing works

Localization of checkpoint and repair proteins in eukaryotes

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Ataxia‐telangiectasia: Mild neurological presentation despite null ATM mutation and severe cellular phenotype

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PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

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Guiding ATM to Broken DNA

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Studying the DNA damage response using in vitro model systems

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Dynamic structures of Bacillus subtilis RecN–DNA complexes

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Rad50 Zinc Hook Is Important for the Mre11 Complex to Bind Chromosomal DNA Double-stranded Breaks and Initiate Various DNA Damage Responses

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The Fanconi Anemia Protein FANCM Is Controlled by FANCD2 and the ATR/ATM Pathways

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Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses

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DNA damage induces nucleoid compaction via the Mre11‐Rad50 complex in the archaeon H aloferax volcanii

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DNA damage-induced signalling in ataxia-telangiectasia and related syndromes

Lavin, M. F., & Kozlov, S. (2007) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2007.04.032 · Cited by 38 · see citing works

DNA Replication Stress-induced Phosphorylation of Cyclic AMP Response Element-binding Protein Mediated by ATM

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Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase

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Structural Studies of DNA End Detection and Resection in Homologous RecombinationPreprint

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Sen1p Contributes to Genomic Integrity by Regulating Expression of Ribonucleotide Reductase 1 (RNR1) in Saccharomyces cerevisiae

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The DNA damage response during an unperturbed S-phase

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Ploidy Dictates Repair Pathway Choice under DNA Replication Stress

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In Situ Analysis of DNA Damage Response and Repair Using Laser Microirradiation

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Mammalian DNA Damage Response Pathway

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The MRN-CtIP Pathway Is Required for Metaphase Chromosome Alignment

Rozier, L., Guo, Y., Peterson, S., Sato, M., Baer, R. J., Gautier, J., & Mao, Y. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.023 · Cited by 19 · see citing works

Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair

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Cellular responses to DNA damage: Current state of the field and review of the 52nd Benzon Symposium

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Xenopus laevis as Model System to Study DNA Damage Response and Replication Fork Stability

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NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication

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Study of Cell Cycle Checkpoints Using Xenopus Cell-Free Extracts

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DNA damage responses in murine Pre-B cells with genetic deficiencies in damage response genes

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Rad50 connects by hook or by crook

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Responding to chromosomal breakage during M-phase: insights from a cell-free system

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ATM , ATR and Mre11 complex genes in hereditary susceptibility to breast cancer

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The DNA Damage Response of Filamentous Fungi: Novel Features Associated with a Multicellular Lifestyle

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DNA Damage Response in Xenopus laevis Cell-Free Extracts

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A Regulatory Role for ATM in Suppression of Mre11-Dependent DNA Degradation and Microhomology-Mediated End Joining

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Cyclin A/CDK2 regulates multiple G2 phase pathways

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The Cell Biology of Rad54: Implications for homologous recombination

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SiDNA and Other Tools for the Indirect Induction of DNA Damage Responses

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Development of Defined Biological Models for Complex Radiation-Induced DNA Lesions Using Homing Endonucleases and Transposon Technology: Feasibility and Initial Characterization

Saha, J. (2011) · DuEPublico (University of Duisburg-Essen)

Structural Characterization of the DNA Repair Protein Complex SbcC-SbcD of Thermotoga maritima

Bemeleit, D. (2008) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.8072

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Part-time cop nabs deviant DNA

Abraham, R. T. (2005) · Nature Medicine · doi:10.1038/nm0305-257

Characterization of MRE11 Mutants Provides Insight into Human Genetic Disease, Cancer, and Clinical Intervention.

Regal, J. A. (2015) · Deep Blue (University of Michigan)

Effects of HSV-1 infection on disparate cell signaling pathways

Gregory, D. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/frbp-wa82

Aspects Of Eukaryotic Dna Replication, Repair And Recombination

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Epigenetic mechanisms in dna replication

Loureiro, R. (2016) · Dialnet (Universidad de la Rioja)

Overview of the DNA Damage Checkpoint

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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

Schiller, C., Lammens, K., Guerini, I., Coordes, B., Feldmann, H. M., Schlauderer, F., Möckel, C., Schele, A., Sträßer, K., Jackson, S. P., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2323 · Cited by 115 · see citing works

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Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

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Advances in Structure and Function of MRN Complex

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The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks

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