Anti‐obesity effects of long‐chain omega‐3 polyunsaturated fatty acids
Abstract
Summary: Animal studies suggest that increased consumption of the long‐chain omega‐3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, can protect against the development of obesity in animals exposed to an obesogenic diet and reduce body fat when already obese. There is also evidence that increased intakes of these fatty acids can reduce body fat in humans, but human studies are relatively few and have generally been conducted over short time periods with small sample sizes, making it difficult to draw definitive conclusions. Reported reductions in body fat may result from appetite‐suppressing effects, adipocyte apoptosis and changes of gene expression in skeletal muscle, heart, liver, intestine and adipose tissues that suppress fat deposition and increase fat oxidation and energy expenditure. We conclude that increased intakes of long‐chain omega‐3 fatty acids may improve body composition, but longer‐term human studies are needed to confirm efficacy and determine whether increasing omega‐3 intakes might be an effective strategy to combat obesity.
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The anti-obesity effects of eicosapentaenoic acid and docosahexaenoic acid have been shown in previous studies.
“The anti-obesity effects of eicosapentaenoic acid and docosahexaenoic acid have been shown in previous studies [89, 90].”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [89]
Omega-3 fatty acids are rich in ALA, which may increase resting energy expenditure by upregulating uncoupling protein 3 mRNA and peroxisomal acyl-CoA oxidase expression.
“Additionally, ω-3 fatty acids are rich in ALA, which may increase resting energy expenditure by upregulating uncoupling protein 3 mRNA and peroxisomal acyl-CoA oxidase expression.38”
Cites
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works
Intake of Fish and Omega-3 Fatty Acids and Risk of Stroke in Women
Iso, H. (2001) · JAMA · doi:10.1001/jama.285.3.304 · Cited by 478 · see citing works
Reddy, J. K., & Mannaerts, G. P. (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002015 · Cited by 418 · see citing works
Flachs, P., Horakova, O., Brauner, P., Rossmeisl, M., Pecina, P., Franssen-van Hal, N., Ruzickova, J., Sponarova, J., Drahota, Z., Vlcek, C., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1944-7 · Cited by 388 · see citing works
Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults
Couet, C., Delarue, J., Ritz, P., Antoine, J.-M., & Lamisse, F. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800451 · Cited by 344 · see citing works
Fish Consumption and Risk of Stroke in Men
He, K. (2002) · JAMA · doi:10.1001/jama.288.24.3130 · Cited by 340 · see citing works
Ruzickova, J., Rossmeisl, M., Prazak, T., Flachs, P., Sponarova, J., Vecka, M., TVRZICKÁ, E., Bryhn, M., & Kopecký, J. (2004) · Lipids · doi:10.1007/s11745-004-1345-9 · Cited by 327 · see citing works
Mascaró, C., Acosta, E., Ortiz, J. A., Marrero, P. F., Hegardt, F. G., & Haro, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8560 · Cited by 318 · see citing works
Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1670 · Cited by 316 · see citing works
Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 306 · see citing works
Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content
Þórsdóttir, I., Tómasson, H., Gunnarsdóttir, I., Gisladottir, E. U., Kiely, M. E., Parra, M. D., Bandarra, N. M., Schaafsma, G., & Martínez, J. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803643 · Cited by 261 · see citing works
Hill, A. M., Buckley, J. D., Murphy, K. J., & Howe, P. R. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1267 · Cited by 237 · see citing works
Self-citationHelland, I. B., Smith, L., Blomén, B., Saarem, K., Saugstad, O. D., & Drevon, C. A. (2008) · PEDIATRICS · doi:10.1542/peds.2007-2762 · Cited by 232 · see citing works
Pérez‐Matute, P., Pérez-Echarri, N., Martínez, J. A., Martí, A., & Moreno-Aliaga, M. J. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507207627 · Cited by 227 · see citing works
Krebs, J. D., Browning, L. M., McLean, N., Rothwell, J. L., Mishra, G. D., Moore, C. S., & Jebb, S. A. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803309 · Cited by 221 · see citing works
Baillie, R., TAKADA, R., Nakamura, M., & Clarke, S. D. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(99)80011-8 · Cited by 195 · see citing works
Belzung, F., Raclot, T., & Groscolas, R. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.6.r1111 · Cited by 193 · see citing works
Takahashi, Y., & Ide, T. (2000) · British Journal of Nutrition · doi:10.1017/s0007114500001409 · Cited by 175 · see citing works
Buckley, J. D., Thomson, R. L., Coates, A. M., Howe, P. R. C., DeNichilo, M. O., & Rowney, M. K. (2010) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2008.06.007 · Cited by 164 · see citing works
Self-citationParra, D., Ramel, A., Bandarra, N., Kiely, M., Martinez, J., & Thorsdottir, I. (2008) · Appetite · doi:10.1016/j.appet.2008.06.003 · Cited by 155 · see citing works
Power, G. W., & Newsholme, E. A. (1997) · Journal of Nutrition · doi:10.1093/jn/127.11.2142 · Cited by 152 · see citing works
Kunešová, M., Braunerová, R., Hlavatý, P., TVRZICKÁ, E., Staňková, B., Škrha, J., Hilgertová, J., Hill, M., Kopecký, J., Wagenknecht, M., et al. (2006) · Physiological Research · doi:10.33549/physiolres.930770 · Cited by 152 · see citing works
Huang, X., Xin, X., McLennan, P. L., & Storlien, L. H. (2003) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00312.x · Cited by 151 · see citing works
Dietary fish oils limit adipose tissue hypertrophy in rats
Parrish, C. C., Pathy, D. A., & Ángel, A. (1990) · Metabolism · doi:10.1016/0026-0495(90)90038-e · Cited by 135 · see citing works
Brown, A. J., Pang, E., & Roberts, D. C. K. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.4.668 · Cited by 121 · see citing works
Mori, T., Kondo, H., Hase, T., Tokimitsu, I., & Murase, T. (2007) · Journal of Nutrition · doi:10.1093/jn/137.12.2629 · Cited by 113 · see citing works
Bergmann, R. L., Bergmann, K. E., Haschke‐Becher, E., Richter, R., Dudenhausen, J. W., Barclay, D., & Haschke, F. (2007) · Journal of Perinatal Medicine · doi:10.1515/jpm.2007.085 · Cited by 101 · see citing works
Groh‐Wargo, S. L., Jacobs, J. R., Auestad, N., O’Connor, D. L., Moore, J. J., & Lerner, E. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000156509.29310.55 · Cited by 91 · see citing works
Maternal Fish Oil Supplementation in Lactation and Growth during the First 2.5 Years of Life
Lauritzen, L., Hoppe, C., Straarup, E. M., & Michaelsen, K. F. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000169978.92437.58 · Cited by 89 · see citing works
Hainault, I., CARLOTTI, M., Hajduch, É., Guichard, C., & Lavau, M. M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35696.x · Cited by 89 · see citing works
DHA-rich fish oil lowers heart rate during submaximal exercise in elite Australian Rules footballers
Buckley, J. D., Burgess, S. A., Murphy, K. J., & Howe, P. R. C. (2008) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2008.01.011 · Cited by 88 · see citing works
Self-citationFontani, G., Corradeschi, F., Felici, A., Alfatti, F., Bugarini, R., Fiaschi, A. I., Cerretani, D., Montorfano, G., Rizzo, A. M., & Berra, B. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01540.x · Cited by 81 · see citing works
Diaphragmatic fatigue assessed by 31P-magnetic resonance spectroscopy in vivo
Nichols, D. G., Buck, J. R., Eleff, S. M., Shungu, D. C., Robotham, J. L., Koehler, R. C., & Traystman, R. J. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.5.c1111 · Cited by 63 · see citing works
Combined effects of aerobic exercise and omega-3 fatty acids in hyperlipidemic persons
Warner, J. G., ULLRICH, I. H., Albrink, M. J., & YEATER, R. A. (1989) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198910000-00003 · Cited by 53 · see citing works
Effect of fish oil supplementation and exercise on serum lipids and aerobic fitness.
BRILLA, L. R., & Landerholm, T. E. (1990) · PubMed · Cited by 50 · see citing works
Effect of glucose infusion on muscle malonyl-CoA during exercise
Elayan, I., & Winder, W. W. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.4.1495 · Cited by 42 · see citing works
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An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
Simopoulos, A. P. (2016) · Nutrients · doi:10.3390/nu8030128 · Cited by 1,673 · see citing works
Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960 · see citing works
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
Marine Bioactive Compounds and Their Health Benefits: A Review
Hamed, I., Özogul, F., Özogul, Y., & Regenstein, J. M. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12136 · Cited by 444 · see citing works
Long-Chain Omega-3 Polyunsaturated Fatty Acids May Be Beneficial for Reducing Obesity—A Review
Buckley, J. D., & Howe, P. R. C. (2010) · Nutrients · doi:10.3390/nu2121212 · Cited by 229 · see citing works
Self-citationObesity and metabolic syndrome: Potential benefit from specific nutritional components
Abete, I., Goyenechea, E., Zulet, M. Á., & Martínez, J. A. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.05.001 · Cited by 215 · see citing works
Peripheral Mechanisms in Appetite Regulation
Camilleri, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.09.016 · Cited by 215 · see citing works
López‐Vicario, C., Alcaraz‐Quiles, J., García‐Alonso, V., Rius, B., Hwang, S. H., Titos, E., Lopategi, A., Hammock, B. D., Arroyo, V., & Clària, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422590112 · Cited by 213 · see citing works
White, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185 · see citing works
Akinkuolie, A. O., Ngwa, J. S., Meigs, J. B., & Djoussé, L. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.08.013 · Cited by 167 · see citing works
Zhuang, P., Li, H., Jia, W. P., Shou, Q., Zhu, Y., Mao, L., Wang, W., Wu, F. L., Chen, X., Wan, X., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01126-6 · Cited by 168 · see citing works
Food Ingredients as Anti-Obesity Agents: A Review
Trigueros, L., Peña, S., Ugidos, A. V., Sayas‐Barberá, E., Pérez‐Álvarez, J. Á., & Sendra, E. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.574215 · Cited by 146 · see citing works
Making Weight in Combat Sports
Langan‐Evans, C., Close, G. L., & Morton, J. P. (2011) · Strength and conditioning journal · doi:10.1519/ssc.0b013e318231bb64 · Cited by 123 · see citing works
Albert, B. B., Derraik, J. G. B., Brennan, C. M., Biggs, J. B., Smith, G. C., Garg, M. L., Cameron-Smith, D., Hofman, P. L., & Cutfield, W. S. (2014) · Scientific Reports · doi:10.1038/srep06697 · Cited by 105 · see citing works
Role of ω3 Longchain Polyunsaturated Fatty Acids in Reducing Cardio- Metabolic Risk Factors
Abeywardena, M. Y., & Patten, G. S. (2011) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153011796429817 · Cited by 104 · see citing works
Robertson, R. C., Mateo, M. R. G., O’Grady, M. N., Guihéneuf, F., Stengel, D. B., Ross, R. P., Fitzgerald, G. F., Kerry, J. P., & Stanton, C. (2016) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2016.03.017 · Cited by 99 · see citing works
Zhang, Y. Y., Liu, W., Zhao, T. Y., & Tian, H. M. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-016-0755-5 · Cited by 101 · see citing works
Shen, W., Wang, C., Xia, L., Fan, C., Dong, H., Deckelbaum, R. J., & Qi, K. (2014) · Scientific Reports · doi:10.1038/srep05282 · Cited by 98 · see citing works
Soil health and nutrient density: preliminary comparison of regenerative and conventional farming
Montgomery, D. R., Biklé, A., Archuleta, R., Brown, P., & Jordan, J. (2022) · PeerJ · doi:10.7717/peerj.12848 · Cited by 97 · see citing works
Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism
Caesar, R., Nygrén, H., Orešič, M., & Bäckhed, F. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m065847 · Cited by 93 · see citing works
Zhuang, P., Zhang, Y., Shou, Q., Li, H., Zhu, Y., He, L., Chen, J., & Jiao, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900946 · Cited by 90 · see citing works
DeFina, L. F., Marcoux, L. G., Devers, S. M., Cleaver, J. P., & Willis, B. L. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002741 · Cited by 89 · see citing works
The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function
Todorčević, M., & Hodson, L. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm5010003 · Cited by 87 · see citing works
Du, S., Jin, J., Fang, W., & Su, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142652 · Cited by 85 · see citing works
Koek, M. M., van der Kloet, F. M., Kleemann, R., Kooistra, T., Verheij, E. R., & Hankemeier, T. (2010) · Metabolomics · doi:10.1007/s11306-010-0219-6 · Cited by 84 · see citing works
Liu, S., Du, M., Tu, Y., You, W., Chen, W., Liu, G., Li, J., Wang, Y., Lu, Z., Wang, T., et al. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.09.003 · Cited by 83 · see citing works
Kim, E., Bae, J.-S., Hahm, K. B., & Cha, J.-Y. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.029 · Cited by 77 · see citing works
Lemas, D. J., Wiener, H. W., O’Brien, D. M., Hopkins, S. E., Stanhope, K. L., Havel, P. J., Allison, D. B., Fernández, J. R., Tiwari, H. K., & Boyer, B. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p018952 · Cited by 76 · see citing works
Omega-3 polyunsaturated fatty acids
Hull, M. A. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.08.001 · Cited by 73 · see citing works
Mohammadi‐Sartang, M., Mazloom, Z., Raeisi‐Dehkordi, H., Barati‐Boldaji, R., Bellissimo, N., & de Zepetnek, J. O. T. (2017) · Obesity Reviews · doi:10.1111/obr.12550 · Cited by 71 · see citing works
Munro, I., & Garg, M. L. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511006817 · Cited by 66 · see citing works
Crochemore, I. C. C., Souza, A. F. P., de Souza, A. C. F., & Rosado, E. L. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612444535 · Cited by 66 · see citing works
Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology
Khadge, S., Sharp, J. G., Thiele, G. M., McGuire, T. R., Klassen, L. W., Duryee, M. J., Britton, H. C., Dafferner, A. J., Beck, J., Black, P. N., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.09.017 · Cited by 66 · see citing works
Mechanisms of Abnormal Lipid Metabolism in the Pathogenesis of Disease
Xu, L., Yang, Q., & Zhou, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158465 · Cited by 71 · see citing works
A New Insight to Bone Turnover: Role of ω‐3 Polyunsaturated Fatty Acids
Kajarabille, N., Díaz‐Castro, J., Hijano, S., López‐Frías, M., López‐Aliaga, I., & Ochoa, J. J. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/589641 · Cited by 65 · see citing works
Munro, I., & Garg, M. L. (2011) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2011.11.001 · Cited by 65 · see citing works
Host-microbial interactions in the metabolism of different dietary fats
Chadaideh, K. S., & Carmody, R. N. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.011 · Cited by 63 · see citing works
Plasma stearoyl‐CoA desaturase indices: Association with lifestyle, diet, and body composition
Vinknes, K. J., Elshorbagy, A. K., Nurk, E., Drevon, C. A., Gjesdal, C. G., Tell, G. S., Nygard, O. K., Vollset, S. E., & Refsum, H. (2013) · Obesity · doi:10.1002/oby.20011 · Cited by 64 · see citing works
The microbiome-adipose tissue axis in systemic metabolism
Lundgren, P., & Thaiss, C. A. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2019 · Cited by 60 · see citing works
Khalili, L., Valdés‐Ramos, R., & Harbige, L. S. (2021) · Metabolites · doi:10.3390/metabo11110742 · Cited by 59 · see citing works
Yum, H.-W., Na, H., & Surh, Y. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.08.004 · Cited by 58 · see citing works
Vidakovic, A. J., Jaddoe, V. W. V., Gishti, O., Felix, J. F., Williams, M. A., Albert Hofman, D., Demmelmair, H., Koletzko, B. V., Tiemeier, H. W., & Gaillard, R. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0106-6 · Cited by 54 · see citing works
Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
Khan, S. A., Ali, A., Khan, S. A., Zahran, S. A., Damanhouri, G. A., Azhar, E. I., & Qadri, I. (2014) · Mediators of Inflammation · doi:10.1155/2014/502749 · Cited by 52 · see citing works
White, P. J., Mitchell, P. L., Schwab, M. G., Trottier, J., Kang, J., Barbier, O., & Marette, A. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.017 · Cited by 51 · see citing works
Fish oil supplementation for two generations increases insulin sensitivity in rats
Hirabara, S. M., Folador, A., Fiamoncini, J., Lambertucci, R. H., Rodrigues, C., Rocha, M. S., Aikawa, J., Yamazaki, R. K., Martins, A. R., Rodrigues, A. C., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.014 · Cited by 51 · see citing works
Sun, F., Huang, Y., Chen, H., Huang, J., Zhang, L., Wei, S., Liu, F., Chen, D., & Huang, W. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161521 · Cited by 51 · see citing works
Fan, C., Liu, X., Shen, W., Deckelbaum, R. J., & Qi, K. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-31 · Cited by 48 · see citing works
Food Components with Anti-Obesity Effect
Kim, K., & Park, Y. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133656 · Cited by 47 · see citing works
Neuman, J. C., Schaid, M. D., Brill, A. L., Fenske, R. J., Kibbe, C. R., Fontaine, D. A., Sdao, S. M., Brar, H. K., Connors, K. M., Wienkes, H. N., et al. (2017) · Diabetes · doi:10.2337/db16-1362 · Cited by 46 · see citing works
Hsueh, T., Baum, J., & Huang, Y. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00015 · Cited by 48 · see citing works
Tsurutani, Y., Inoue, K., Sugisawa, C., Saito, J., Omura, M., & Nishikawa, T. (2018) · Internal Medicine · doi:10.2169/internalmedicine.0816-18 · Cited by 47 · see citing works
The Effects of Omega 3 and Omega 6 Fatty Acids on Glucose Metabolism: An Updated Review
Egalini, F., Guardamagna, O., Gaggero, G., Varaldo, E., Giannone, B., Beccuti, G., Benso, A. S., & Broglio, F. (2023) · Nutrients · doi:10.3390/nu15122672 · Cited by 46 · see citing works
Khadge, S., Thiele, G. M., Sharp, J. G., McGuire, T. R., Klassen, L. W., Black, P. N., Dirusso, C., Cook, L. M., & Talmadge, J. E. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9941-7 · Cited by 45 · see citing works
Musazadeh, V., Dehghan, P., & Khoshbaten, M. (2021) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002297 · Cited by 45 · see citing works
COX inhibitors: a patent review (2011 – 2014)
Consalvi, S., Biava, M., & Poce, G. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1090973 · Cited by 44 · see citing works
Zarantoniello, M., Randazzo, B., Secci, G., Notarstefano, V., Giorgini, E., Lock, E., Parisi, G., & Olivotto, I. (2021) · Journal of Insects as Food and Feed · doi:10.3920/jiff2020.0135 · Cited by 44 · see citing works
Oliveira, T. E., Castro, É., Belchior, T., Andrade, M. L., Chaves‐Filho, A. B., Peixoto, Á. S., Moreno, M. F., Ortiz‐Silva, M., Moreira, R. J., Inague, A., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800813 · Cited by 41 · see citing works
Harden, C. J., Dible, V. A., Russell, J., Garaiová, I., Plummer, S. F., Barker, M. E., & Corfe, B. M. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.10.004 · Cited by 41 · see citing works
Relationship between Erythrocyte Omega-3 Content and Obesity Is Gender Dependent
Howe, P. R. C., Buckley, J. D., Murphy, K. J., Pettman, T. L., Milte, C. M., & Coates, A. M. (2014) · Nutrients · doi:10.3390/nu6051850 · Cited by 40 · see citing works
Self-citationYang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00619-3 · Cited by 40 · see citing works
Senanayake, V. K., Pu, S., Jenkins, D. A., Lamarche, B., Kris‐Etherton, P. M., West, S. G., Fleming, J. A., Liu, X., McCrea, C. E., & Jones, P. J. H. (2014) · Trials · doi:10.1186/1745-6215-15-136 · Cited by 39 · see citing works
Voortman, T., van den Hooven, E. H., Braun, K. V. E., van den Broek, M., Bramer, W. M., Chowdhurry, R., & Franco, O. H. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.05.001 · Cited by 40 · see citing works
Greasing the wheels of managing overweight and obesity with omega-3 fatty acids
Golub, N. I., Geba, D.-A., Mousa, S. A., Williams, G. C., & Block, R. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.016 · Cited by 37 · see citing works
Meyer, B. J., & Kolanu, N. (2011) · Nutrition · doi:10.1016/j.nut.2011.01.004 · Cited by 37 · see citing works
Of 'junk food' and 'brain food': how parental diet influences offspring neurobiology and behaviour
Bodden, C., Hannan, A. J., & Reichelt, A. C. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.04.001 · Cited by 36 · see citing works
Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models
Zheng, H., Tang, H., Liu, M., He, M., Lai, P., Dong, H., Lin, J., Jia, C., Zhong, M., Dai, Y., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0378-t · Cited by 36 · see citing works
Go, R., Hwang, K., Geon-Tae, P., Lee, H.-M., Lee, G.-A., Kim, C., Jeon, S., Seo, J., Hong, W.-K., & Choi, K. (2016) · Journal of Biomedical Research · doi:10.7555/jbr.30.2016k0004 · Cited by 35 · see citing works
Kaikkonen, J., Jula, A., Viikari, J. S. A., Juonala, M., Hutri‐Kähönen, N., Kähönen, M. A. P., Lehtimäki, T. J., & Raitakari, O. T. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa409 · Cited by 36 · see citing works
Choi, W. H., Gwon, S. Y., Ahn, J., Jung, C. H., & Ha, T. Y. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.04.006 · Cited by 35 · see citing works
Song, M., Wang, J., Lee, Y., Lee, J. H., Kwon, K.-S., Bae, E. J., & Park, B. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600014 · Cited by 35 · see citing works
Worsch, S., Heikenwalder, M., Hauner, H., & Bader, B. L. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0291-x · Cited by 34 · see citing works
Marzuca-Nassr, G. N., Vitzel, K. F., de Sousa, L. G. O., Murata, G. M., Crisma, A. R., Rodrigues, C., Abreu, P., Torres, R. P., Mancini-Filho, J., Hirabara, S. M., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12958 · Cited by 33 · see citing works
Omega-3 fatty acids and changes in LBM: alone or in synergy for better muscle health?
McDonald, C. J., Bauer, J. D., & Capra, S. M. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0304 · Cited by 33 · see citing works
Nuernberg, K., Breier, B. H., Jayasinghe, S. N., Bergmann, H., Thompson, N. M., Nuernberg, G., Dannenberger, D., Schneider, F., Renne, U., Langhammer, M., et al. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-56 · Cited by 32 · see citing works
Iannelli, A., Martini, F., Schneck, A. S., Ghavami, B., Baudin, G., Anty, R., & Gugenheim, J. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0942-y · Cited by 31 · see citing works
Wu, Z., Jianjie, Q., & Liyong, P. (2012) · Journal of Biomedical Research · doi:10.7555/jbr.26.20120058 · Cited by 30 · see citing works
Andersen, M. K., Jørsboe, E., Sandholt, C. H., Grarup, N., Jørgensen, M. E., Færgeman, N. J., Bjerregaard, P., Pedersen, O. B., Moltke, I., Hansen, T. F., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006119 · Cited by 30 · see citing works
Sunagawa, Y., Katayama, A., Funamoto, M., Shimizu, K., Shimizu, S., Sari, N., Katanasaka, Y., Miyazaki, Y., Hosomi, R., Hasegawa, K., et al. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109031 · Cited by 30 · see citing works
Voortman, T., Tielemans, M. J., Stroobant, W., Schoufour, J. D., Jong, J. C. K., Graaff, J. S., van den Hooven, E. H., Tiemeier, H. W., Jaddoe, V. W. V., & Franco, O. H. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.04.006 · Cited by 31 · see citing works
Lopez-Dominguez, J. A., Khraiwesh, H. M., González-Reyes, J. A., López‐Lluch, G., Navas, P., Ramsey, J. J., de Cabo, R., Burón, M. I., & Villalba, J. M. (2012) · AGE · doi:10.1007/s11357-012-9492-9 · Cited by 28 · see citing works
Haimeur, A., Mimouni, V., Ulmann, L., Martineau, A., Messaouri, H., Pineau‐Vincent, F., Tremblin, G., & Meskini, N. (2016) · Lipids · doi:10.1007/s11745-016-4177-2 · Cited by 28 · see citing works
Kumar, S. P. S., Shen, M., Spicer, E. G., Goudjo-Ako, A. J., Stumph, J. D., Zhang, J., & Shi, H. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej13-0455 · Cited by 26 · see citing works
Fish consumption and subsequent change in body weight in European women and men
Jakobsen, M. U., Dethlefsen, C., Due, K. M., May, A. M., Romaguera, D., Vergnaud, A., Norat, T., Sørensen, T. I. A., Halkjær, J., Tjønneland, A. M., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001079 · Cited by 26 · see citing works
N-3 Polyunsaturated Fatty Acids, Body Fat and Inflammation
Lund, A.-S. Q., Hasselbalch, A. L., Gamborg, M., Skogstrand, K., HOUGAARD, D. M., Heitmann, B. L., Kyvik, K. O., Sørensen, T. I. A., & Jess, T. (2013) · Obesity Facts · doi:10.1159/000354663 · Cited by 26 · see citing works
Impact of health and lifestyle food supplements on periodontal tissues and health
Spahr, A., & Divnic‐Resnik, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12455 · Cited by 27 · see citing works
Ivanova, Z., Bjørndal, B., Григорова, Н., Rusenov, A. G., Vachkova, Е., Berge, K., Burri, L., Berge, R. K., Stanilova, S. A., Milanova, A., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0782-0 · Cited by 25 · see citing works
Lou, D.-J., Zhu, Q.-Q., Si, X.-W., Guan, L.-L., You, Q.-Y., Yu, Z., Zhang, A., & Li, D. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.04.008 · Cited by 24 · see citing works
Microalgal Oil fromSchizochytriumsp. Prevents HFD-Induced Abdominal Fat Accumulation in Mice
Yu, J., Ma, Y., Sun, J. L., Ran, L., Li, Y., Wang, N., Yu, T., Gao, W., Jia, W., Jiang, R., et al. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1302366 · Cited by 25 · see citing works
Anti‐obesity potentiality of Tapra fish ( Opisthopterus tardoore ) oil
Pradhan, S., Panchali, T., Paul, B., Khatun, A., Jarapala, S. R., Mondal, K. C., Ghosh, K., & Chakrabarti, S. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13448 · Cited by 23 · see citing works
Wiese, D. M., Lashner, B. A., Lerner, E., DeMichele, S. J., & Seidner, D. L. (2011) · Nutrition in Clinical Practice · doi:10.1177/0884533611413778 · Cited by 22 · see citing works
Başyi̇ğit, B., Sağlam, H., Köroğlu, K., & Karaaslan, M. (2020) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.14692 · Cited by 22 · see citing works
LipiD-QuanT: a novel method to quantify lipid accumulation in live cells
Varinli, H., Osmond-McLeod, M. J., Molloy, P. L., & Vallotton, P. (2015) · Journal of Lipid Research · doi:10.1194/jlr.d059758 · Cited by 21 · see citing works
Seeds from ancient food crops with the potential for antiobesity promotion
Hernández‐Pérez, T., Valverde, M. E., & Paredes‐López, O. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1877107 · Cited by 21 · see citing works
Song, N., Na, H., Baek, J., & Surh, Y. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.030 · Cited by 20 · see citing works
Fish consumption does not prevent increase in waist circumference in European women and men
Jakobsen, M. U., Due, K. M., Dethlefsen, C., Halkjær, J., Holst, C., Forouhi, N. G., Tjønneland, A. M., Boeing, H., Buijsse, B., Palli, D., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006039 · Cited by 20 · see citing works
Myrie, S. B., & Jones, P. J. H. (2011) · Elsevier eBooks · doi:10.1533/9780857092557.2.234 · Cited by 19 · see citing works
Phitak, T., Boonmaleerat, K., Pothacharoen, P., Pruksakorn, D., & Kongtawelert, P. (2017) · Connective Tissue Research · doi:10.1080/03008207.2017.1385605 · Cited by 19 · see citing works
Adipose Tissue Fatty Acid Patterns and Changes in Anthropometry: A Cohort Study
Dahm, C. C., Gorst‐Rasmussen, A., Jakobsen, M. U., Schmidt, E. B., Tjønneland, A. M., Sørensen, T. I. A., & Overvad, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022587 · Cited by 18 · see citing works
Hastert, T. A., Otto, M. C. D. O., Lê‐Scherban, F., Steffen, B. T., Steffen, L. M., Tsai, M. Y., Jacobs, D. R., & Baylín, A. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.282 · Cited by 17 · see citing works
Moradi, S., Alivand, M., Khajebishak, Y., Jafarabadi, M. A., Alipour, M., Chilibeck, P. D., & Alipour, B. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00266-4 · Cited by 17 · see citing works
- Authors
- Buckley, J. D., & Howe, P. R. C.
- Affiliations
- University of South Australia (AU)
- Corresponding author
- Buckley, J. D.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2009-10-28
- Volume
- 10
- Issue
- 6
- Pages
- 648-659
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W2018489015
- Cited by
- 213
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 20 · 2020: 19 · 2019: 9 · 2018: 12 · 2017: 16 · 2016: 18 · 2015: 15 · 2014: 25 · 2013: 9 · 2012: 10
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- omega-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, obesity, anti-obesity, obesogenic diet, fat loss, appetite suppression, adipocyte apoptosis, fat oxidation, energy expenditure, gene expression, body composition
- MeSH terms
- Adipose Tissue, Animals, Body Composition, Diet, Reducing, Disease Models, Animal, Energy Metabolism, Humans, Obesity, Fatty Acids, Omega-3, Apoptosis, Evidence-Based Medicine
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