The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Abstract
Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.
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In the citing paper
“Improvements in repetitive behaviors in adults with autism following oxytocin infusion have been demonstrated [169] as well as positive effects on social behaviors and cognition [170].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [169]
In the citing paper
“The neuromodulator oxytocin (OT) has been shown to improve social deficits in both ASD and other disorders accompanied by social deficits (Guastella et al., 2010, 2010; Hollander et al., 2002, 2007; Yatawara et al., 2015; Young and Barrett, 2015).”
From Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys (2016) · cites this paper as Hollander et al., 2002
In the citing paper
“reduce repetitive behaviors (Hollander et al., 2003)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Hollander et al., 2003
In the citing paper
“This study demonstrated that administration of OT led to a decrease in a core ASD symptom, RRB.”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Hollander et al., 2003
In the citing paper
“Overall, these observed effects on repetitive behaviors are in line with previous trials with adult men with ASD showing beneficial effects of OT on repetitive behaviors after 4 h of intravenous OT administration [4] and after 6 weeks of daily administrations [8, 10].”
From Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up (2020) · cites this paper as [4]
In the citing paper
“In this view, it appears that beneficial effects of OT treatment on repetitive behaviors were mostly demonstrated in studies that adopted assessments based on self-reports (current study, [4, 8]), whereas no beneficial effects were evident in studies adopting informant-based reports of repetitive behavior [9–14].”
From Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up (2020) · cites this paper as [4]
In the citing paper
“There is both animal (Popik et al., 1992) and human (Hollander et al., 2007(Hollander et al., , 2003) ) research to suggest systemic OT can influence social behavior and cognition”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Hollander et al., 2003
In the citing paper
“oxytocin , relative to placebo, reduces repetitive stereotypic behaviors [172]”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [172]
Citations
Cites
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1×
“For males, vasopressin has been shown to evoke partner preference and aggression after mating (Winslow et al, 1993).”
BackgroundOxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404
Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments
de Wied, D. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90165-x · Cited by 359
Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
de Wied, D., Diamant, M., & Fodor, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1009 · Cited by 327
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The social, genetic and environmental aspects
Castle, D. J., & Abel, K. M. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781107045132.002 · Cited by 1
Psychopharmacology of Autism Spectrum Disorder
Ozdemir, S., Keary, C. J., Joshi, G., Ceranoglu, A. T., & McDougle, C. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-46295-6_25 · Cited by 1
Kumkum, M., Marzan, L. W., Akter, S., Biswas, S. C., Chowdhury, M. A., & Hossain, M. A. (2020) · Asian Journal of Medical and Biological Research · doi:10.3329/ajmbr.v6i2.48048 · Cited by 1
Tsai, L. Y. (2008) · Elsevier eBooks · doi:10.1016/b978-012373606-2.50015-2 · Cited by 1
Psychiatric and physical comorbidity in adults with autism spectrum disorder
O’Rourke, L. (2016) · doi:10.25419/rcsi.10817558 · Cited by 1
Genetic Basis of Psychotic Illnesses: A Comprehensive Overview
Aziz, M. A., Akter, T., Barek, M. A., & Islam, M. S. (2021) · Springer eBooks · doi:10.1007/978-981-16-4558-7_9 · Cited by 1
A neurobehavioural analysis of social behaviour and learning in fish and mammals
Lindeijer, C. M. (2008) · Utrecht University Repository (Utrecht University) · Cited by 1
Berlin, H. A., & Hollander, E. (2008) · doi:10.3109/9780849382666-20 · Cited by 1
Self-citationDisorders of the Autonomic Nervous System
Axelrod, F. B. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0435-8.00087-1 · Cited by 1
Relação entre rede social, Inteligência geral, inteligência social e hormonas em humanos
Pestana, J. A. M. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1
Choleris, E., Pfaff, D. W., & Kavaliers, M. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.021 · Cited by 1
Raza, S. (2015) · Open ULeth Scholarship (OPUS) (University of Lethbridge) · Cited by 1
Ingenhoven, T., & Rinne, T. (2007) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6404-6_18 · Cited by 1
Audunsdottir, K., Quintana, D. S., Westlye, L. T., Kang, H., Sartorius, A. M., Glaser, B. D., Andreassen, O. A., Nærland, T., Havdahl, A., Bøen, R., et al. (2023) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/8msku · Cited by 1
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Schöner, J. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Actions of appetite regulating peptides on supraoptic nucleus (SON) oxytocin neurones
Velmurugan, S. (2009) · ERA · Cited by 1
Effects of central neuropeptides on social preference and social recognition in male rats
Lukas, M. (2011) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.22540
A Missense Mutation in CD38 Associated with Autism Spectrum Disorder in Three Pedigrees
Higashida, H., Munesue, T., Yokoyama, S., Hashii, M., Koizumi, K., & Matsushim, A. (2011) · InTech eBooks · doi:10.5772/17774
Serafini, G., Lindqvist, D., Brundin, L., Dwivedi, Y., Girardi, P., & Amore, M. (2014) · Wiley eBooks · doi:10.1002/9783527684403.ch15
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Aday, M. (2011) · Figshare
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Espino, C. C., & Vale-Martı́nez, A. (2015) · Revista de Neurología · doi:10.33588/rn.6109.2015219
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Milutinović‐Smiljanić, S. (2013) · doi:10.2298/bg20130620milutinovicsmiljanic
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Gibbard, C. R. (2016) · UCL Discovery (University College London)
A Reevaluation of the State of Autism Treatment
London, E. (2009) · CRC Press eBooks · doi:10.1201/9781420068870-c19
Developmental disorders in girls
Knight, B., Carpenter, P. K., & Rai, D. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781107045132.007
Johnson, M. E., & Rausch, J. L. (2008) · Medical psychiatry · doi:10.3109/9780849383649.012
Future Directions in Psychopharmacology of Autism Spectrum Disorder
Mankad, D., & Anagnostou, E. A. (2014) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814602167_0019
Self-other distinction based on motor and tactile processes in the autism spectrum
Deschrijver, E. (2016) · Ghent University Academic Bibliography (Ghent University)
Ghajar, K. (2016) · MacSphere (McMaster University) · doi:10.71548/24365
What Have Proteomic Studies Taught Us About Novel Drug Targets in Autism?
Guest, P. C., & Martins‐de‐Souza, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-52479-5_3
Lefèvre, A. (2016) · theses.fr (ABES) · doi:10.70675/137893f0z4808z4aa8z9008z05c2a19b5144
Search for Susceptibility Genes in Autism Spectrum Disorders
Ylisaukko‐oja, T. (2005) · Työväentutkimus Vuosikirja
Pharmacologic Management of Comorbid Post-Traumatic Stress Disorder and Addictions
Shorter, D. I., Hsieh, J. J., & Kosten, T. R. (2017) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.150405
Rapid Estrogenic Mediation of Oxytocin in The Regulation of Social Recognition in Female Mice
Paletta, P. (2018) · The Atrium (University of Guelph)
Oxytocin receptor agonists and their clinical application
Tsirkin, V. I., Трухина, С. И., Trukhin, A. N., Khlybova, S., & Anisimov, K. Y. (2018) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush201818421
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Hovey, D. (2018) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Neuroendocrine studies in patients with affective disorders
Bendix, M. (2019) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Partridge, M. (2007)
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Chetcuti, S., Sammut, E., Sammut, M., & Calleja‐Agius, J. (2019) · doi:10.24946/ijpls.20.18.00.00.040605
Sassano, M. F. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/wwr3-7m34
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Charles, É. (2020) · theses.fr (ABES) · doi:10.70675/3da592d6z8881z4ef0z89f0z36a5b3f117fb
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Zian, Z., & Bouhoudan, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-37681-9_7
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Cardaillac, C., Rua, C., Simon, E. G., & El‐Hage, W. (2017) · Sages-Femmes · doi:10.1016/j.sagf.2017.04.005
DeMayo, M. M. (2020) · The Sydney eScholarship Repository (The University of Sydney)
Iwashita, M., & Yoshizawa, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.20.258640
Neurodevelopmental Aspects of Suicide
Chatzittofis, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-68932-2_1
Natural and Synthetic Oxytocin—Structurally Same but Differ in Effects—A Pilot StudyPreprint
Wszołek, K., Chmaj-Wierzchowska, K., Pięt, M., Tarka, A., & Wilczak, M. (2021) · Research Square · doi:10.21203/rs.3.rs-345886/v1
Was erklärbar ist: Ätiologie und Entwicklungspsychopathologie
Remschmidt, H., & Theisen, F. (2011) · Springer eBooks · doi:10.1007/978-3-540-36273-9_3
棟居, 俊. (2011) · Institutional Repositories DataBase (IRDB) · doi:10.11249/jsbpjjpp.22.1_35
The connection between oxytocin and autism, explained
Hess, P. (2022) · The Transmitter · doi:10.53053/nlau3623
Current awareness in human psychopharmacology
(2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.461
Sinzig, J., & Resch, F. (2011) · Springer eBooks · doi:10.1007/978-3-642-19846-5_30
(2016) · Duke University Press eBooks · doi:10.1215/9780822374213-009
(2013) · CRC Press eBooks · doi:10.1201/b15462-35
Ocytocine pour le traitement du trouble du spectre de l’autisme chez les enfants
Griffiths, J. L., Mishaal, R. A., Nabetani, M., & Goldman, R. D. (2022) · Canadian Family Physician · doi:10.46747/cfp.6802106
Was erklärbar ist: Ätiologie und Entwicklungspsychopathologie
Sinzig, J. (2011) · Springer eBooks · doi:10.1007/978-3-642-13071-7_3
Romanos, M., Wewetzer, C., & Schmeck, K. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1501-5_22
Faculty Opinions recommendation of Crystal structure of the human oxytocin receptor.
Freidinger, R. M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738337689.793579103
Herpertz, S. C. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_85
Was erklärbar ist: Ätiologie und Entwicklungspsychopathologie
Remschmidt, H., & Kamp‐Becker, I. (2006) · Springer eBooks · doi:10.1007/978-3-540-35072-9_3
Hollander, E., Kaplan, A., & Pallanti, S. (2010) · Springer eBooks · doi:10.1007/978-88-470-1538-8_13
Self-citationMoberg, K. U. (2015) · Springer eBooks · doi:10.1007/978-3-662-47359-7_11
Bibliography: Personality Disorders
(2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.2.214
Approches moléculaires et thérapeutiques des interactions entre l’ocytocine et son récepteur
Hibert, M. (2022) · Biologie Aujourd hui · doi:10.1051/jbio/2022013
Arakawa, H., & Higuchi, Y. (2023) · Springer eBooks · doi:10.1007/978-3-031-42383-3_6
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Samandra, R., Rosa, M. G. P., & Mansouri, F. A. (2025) · American Journal of Primatology · doi:10.1002/ajp.23717
Parsa, M., Mansouri, M., & Pouretemad, H. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111419
Perspectives d’avenir dans l’évaluation et le traitement des troubles du spectre de l’autisme
Smith, I. C., Pugliese, C. E., Corbett, B. A., & White, S. W. (2020) · Elsevier eBooks · doi:10.1016/b978-2-294-76574-2.00015-3
Патофизиология послеродовых аффективных расстройств: классификация, современные представления
Викторовна, К. Е., & Бикбов, И. З. (2025) · Russian Biomedical Research · doi:10.56871/rbr.2025.67.63.006
Oxytocin and Vasopressin in Autism and Genetic Syndromes
Levin‐Decanini, T., Francis, S. M., Sagar, A., Liu, W., Carter, C. S., & Jacob, S. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_14
Cooper, M. G. (2012) · D-Scholarship@Pitt (University of Pittsburgh)
På vilket sätt är oxytocin intressant för behandling av autism
Andersson, M. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
IDENTIFYING NOVEL PSYCHOLOGICAL AND PHARMACOLOGICAL TREATMENT TARGETS IN ANOREXIA NERVOSA
Whitfeld, A. (2019) · UNSWorks (University of New South Wales, Sydney, Australia) · doi:10.26190/unsworks/31294
Baker, E. J. (2023) · eScholarship (California Digital Library)
Lishaugen, H. T. S. (2017) · NORA - Norwegian Open Research Archives
Sexton, C. (2022) · The Atrium (University of Guelph)
Oprea, O. G., Lungu, P. F., Chelaru, I. A., Balmuș, I.-M., Jijie, R., Plavan, G. I., Nicoară, M., Ciobica, A., Gheban, D., & Chiriac, S. A. (2026) · Pharmaceuticals · doi:10.3390/ph19020343
Etudes des variations structurales chromosomiques dans l'autisme et la déficience mentale
Marouillat, S. (2011) · theses.fr (ABES) · doi:10.70675/61c503abz73b9z4e2eza417z1c6d98894a3b
Nuchadee, M.-L. (2014) · theses.fr (ABES) · doi:10.70675/6e429c3fzcbccz4801zbe2czc51c606f76ba
Royer, J. (2021) · theses.fr (ABES) · doi:10.70675/9561320dz3197z4755zbb24zf51613d38d02
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
BindingDB (2014) · UC San Diego · doi:10.7270/q20r9qvh
Metadata
- Authors
- Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Hollander, Eric
- ORCID
- Hollander, Eric
- Venue
- Neuropsychopharmacology
- Published
- 2003-01
- Volume
- 28
- Issue
- 1
- Pages
- 193-198
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2036441276
- Cited by
- 689
- References
- 60
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 15 · 2023: 15 · 2022: 23 · 2021: 22 · 2020: 27 · 2019: 15 · 2018: 29 · 2017: 33 · 2016: 47 · 2015: 49 · 2014: 49 · 2013: 51 · 2012: 44
- FWCI
- 29.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Center for Research Resources (5 M01RR00071, M01RR000071)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, repetitive behavior, autism spectrum disorder, Asperger syndrome, autistic adults, oxytocin infusion, vasopressin, social behavior, self-harm, need to know, ordering behavior
- MeSH terms
- Adult, Autistic Disorder, Blood Pressure, Body Temperature, Double-Blind Method, Female, Humans, Infusions, Intravenous, Male, Oxytocin, Psychiatric Status Rating Scales, Pulse, Treatment Outcome, Asperger Syndrome
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