The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Abstract
Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Improvements in repetitive behaviors in adults with autism following oxytocin infusion have been demonstrated [169] as well as positive effects on social behaviors and cognition [170].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [169]
In the citing paper
“The neuromodulator oxytocin (OT) has been shown to improve social deficits in both ASD and other disorders accompanied by social deficits (Guastella et al., 2010, 2010; Hollander et al., 2002, 2007; Yatawara et al., 2015; Young and Barrett, 2015).”
From Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys (2016) · cites this paper as Hollander et al., 2002
In the citing paper
“reduce repetitive behaviors (Hollander et al., 2003)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Hollander et al., 2003
In the citing paper
“This study demonstrated that administration of OT led to a decrease in a core ASD symptom, RRB.”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Hollander et al., 2003
In the citing paper
“Overall, these observed effects on repetitive behaviors are in line with previous trials with adult men with ASD showing beneficial effects of OT on repetitive behaviors after 4 h of intravenous OT administration [4] and after 6 weeks of daily administrations [8, 10].”
From Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up (2020) · cites this paper as [4]
In the citing paper
“In this view, it appears that beneficial effects of OT treatment on repetitive behaviors were mostly demonstrated in studies that adopted assessments based on self-reports (current study, [4, 8]), whereas no beneficial effects were evident in studies adopting informant-based reports of repetitive behavior [9–14].”
From Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up (2020) · cites this paper as [4]
In the citing paper
“There is both animal (Popik et al., 1992) and human (Hollander et al., 2007(Hollander et al., , 2003) ) research to suggest systemic OT can influence social behavior and cognition”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Hollander et al., 2003
In the citing paper
“oxytocin , relative to placebo, reduces repetitive stereotypic behaviors [172]”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [172]
Citations
Cites
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1×
“For males, vasopressin has been shown to evoke partner preference and aggression after mating (Winslow et al, 1993).”
BackgroundOxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404
Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments
de Wied, D. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90165-x · Cited by 359
Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
de Wied, D., Diamant, M., & Fodor, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1009 · Cited by 327
Cited by
Sorted by citations
Items 701–704 of 704
POWERS, J. H., Thom, R. P., & McDougle, C. J. (2026) · Wiley eBooks · doi:10.1002/9781394389933.ch24
Psicofarmacologia e terapia elettroconvulsivante
Citrome, L. (2014) · Springer eBooks · doi:10.1007/978-88-470-1738-2_15
The Relationship of Oxytocin and Reelin in the Brain
Pappas, G. D., & Carter, C. S. (2008) · Springer eBooks · doi:10.1007/978-0-387-76761-1_14
Metadata
- Authors
- Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Hollander, Eric
- ORCID
- Hollander, Eric
- Venue
- Neuropsychopharmacology
- Published
- 2003-01
- Volume
- 28
- Issue
- 1
- Pages
- 193-198
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2036441276
- Cited by
- 689
- References
- 60
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 15 · 2023: 15 · 2022: 23 · 2021: 22 · 2020: 27 · 2019: 15 · 2018: 29 · 2017: 33 · 2016: 47 · 2015: 49 · 2014: 49 · 2013: 51 · 2012: 44
- FWCI
- 29.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Center for Research Resources (5 M01RR00071, M01RR000071)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, repetitive behavior, autism spectrum disorder, Asperger syndrome, autistic adults, oxytocin infusion, vasopressin, social behavior, self-harm, need to know, ordering behavior
- MeSH terms
- Adult, Autistic Disorder, Blood Pressure, Body Temperature, Double-Blind Method, Female, Humans, Infusions, Intravenous, Male, Oxytocin, Psychiatric Status Rating Scales, Pulse, Treatment Outcome, Asperger Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
