Cited by 104Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

Impoverished Rearing Environment Alters Metabotropic Glutamate Receptor Expression and Function in the Prefrontal Cortex

Melendez, Roberto I, Lee Gregory, Mary, Bardo, Michael T, Kalivas, Peter W·2004·Neuropsychopharmacology

Abstract

Rearing rats in impoverished (IC) and enriched (EC) environmental conditions alters synaptic plasticity and cognitive processes. Metabotropic glutamate receptors (mGluRs) are known to play a key role in synaptic and behavioral plasticity. In the present study, the effect of rearing conditions on the expression of mGluR proteins in the prefrontal cortex (PFC) was assessed by immunoblotting. A significant difference in the content of prefrontal mGluR1 and mGluR5 (ie group I) and mGluR2/3 (ie group II) was observed between IC and EC rats. To functionally characterize this difference, in vivo microdialysis was used to verify differences in mGluR regulation of extracellular glutamate in the PFC. The results indicate that the capacity of group I and II mGluRs to elevate extracellular glutamate levels was significantly blunted in the PFC of IC rats compared to either EC subjects, or rats reared in normal environmental conditions (ie NIH standards). Group II mGluR receptors regulate performance in a forced T-maze spatial memory task that involves the PFC, and IC rats demonstrated deficits in this task relative to EC rats. These data suggest that reduced mGluR transmission in the PFC produced by impoverished, relative to enriched, rearing environments may contribute to cognitive deficits.

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Crossref · 10.1038/sj.npp.1300507

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Authors
Melendez, R. I., Lee Gregory, M., Bardo, M. T., & Kalivas, P. W.
Affiliations
  • University of Kentucky (US)
  • Medical University of South Carolina (US)
Corresponding author
Kalivas, Peter W
Venue
Neuropsychopharmacology
Published
2004-06-09
Volume
29
Issue
11
Pages
1980-1987
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2332377175
Cited by
104
References
40
Citations by year
2025: 2 · 2024: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 4 · 2012: 6
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f30mh070194-02)
  • National Institute of Mental Health (R01MH040817, MH070194, MH-40817)
  • National Institute on Drug Abuse (DA07288)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
environmental enrichment, metabotropic glutamate receptors, prefrontal cortex, mGluR1, mGluR5, mGluR2/3, extracellular glutamate, synaptic plasticity, spatial memory, cognitive impairment
MeSH terms
Animals, Environment, Gene Expression Regulation, Male, Social Isolation, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Metabotropic Glutamate, Rats

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