Cited by 111Stress Responses and CortisolNeuroscience and Neuropharmacology ResearchNeuroendocrine regulation and behavior

Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats

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Hermes, Gretchen, Li, Nanxin, Duman, Catharine, Duman, Ronald·2011·Physiology & Behavior

Abstract

Early life stressors in rodents, including maternal separation and social isolation, have been shown to disrupt brain development and profoundly affect a wide-range of behaviors in adult animals. In this study, we focus on the development of female Sprague-Dawley rats in the presence and absence of conspecifics during the critical period of social play. Similar studies in male rodents have shown that this form of social deprivation results in dysregulated dopaminergic and serotonergic functions in the brain with core features of neuropsychiatric disorders including anxiety disorder and schizophrenia. Here we examined the behavioral and biochemical effects of post-weaning social isolation in female rats. Our findings demonstrated that isolation rearing produced marked deficits in social interaction behaviors and increased anxiety in open-field and novelty-suppressed feeding tests. The expression of synaptic-associated proteins PSD95 and synapsin I as well as glutamate receptors subunits GluR1 and NR1 in the prefrontal cortex (PFC) were significantly reduced in isolation-reared female rats. Current findings provide evidence that in female rats, post-weaning environmental disruption can result in profound dysregulation of synapse-related proteins and behavior.

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Authors
Hermes, G., Li, N., Duman, C., & Duman, R.
Affiliations
Yale University (US)
Corresponding author
Hermes, Gretchen
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2011-08
Volume
104
Issue
2
Pages
354-359
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2065919724
Cited by
111
References
43
Citations by year
2026: 7 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 2 · 2017: 11 · 2016: 7 · 2015: 10 · 2014: 3 · 2013: 14 · 2012: 5
FWCI
3.05
Type
journal article
Language
en
Open access
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (5T32 MH-19961, T32MH019961, R25MH071584)
  • National Institute on Drug Abuse (K24DA017899)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
post-weaning social isolation, early life stress, female rats, prefrontal cortex, PSD-95, synapsin I, GluR1, NR1, glutamate receptors, anxiety, social interaction deficits, social play, synaptic dysfunction, sex differences
MeSH terms
Disks Large Homolog 4 Protein, Age Factors, Animals, Animals, Newborn, Behavioral Symptoms, Body Weight, Estriol, Estrus, Exploratory Behavior, Female, Food Deprivation, Membrane Proteins, Pregnancy, Social Isolation, Receptors, N-Methyl-D-Aspartate, Synapsins, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, AMPA, Gene Expression Regulation, Developmental, Intracellular Signaling Peptides and Proteins, Rats

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