The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Open accessAbstract
Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“DBS targeting the NAc was shown to exert antidepressant, anxiolytic, and hedonic effects, notably in treatment-resistant depression (Bewernick et al. 2010; Giacobbe et al. 2009; Schlaepfer et al. 2008).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Schlaepfer et al. 2008
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“deep brain stimulation applied via electrodes situated in the accumbens area/ventral internal capsule improves depressive symptoms in treatmentrefractory depression (Malone et al, 2009;Schlaepfer et al, 2008).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Schlaepfer et al, 2008
The cited source says what the claim attributes to it.
In the citing paper
“and that deep brain stimulation applied via electrodes situated in the accumbens area/ventral internal capsule reportedly improves depressive symptoms in treatment-refractory depression (Schlaepfer et al. 2008).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Schlaepfer et al. 2008
In the citing paper
“Treatments with enhanced spatial specificity such as deep brain stimulation (DBS) or transcranial magnetic stimulation (TMS), aimed to restore region-specific hypoactivity, show great promise in alleviating treatment-resistant depression in even the most severe cases (2–10).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [8]
In the citing paper
“High frequency DBS of the NAc, among other regions, shows great promise in alleviating treatment-resistant depression, though its mechanism is still unclear (5, 8, 10).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [8]
In the citing paper
“patients responding to DBS of the NAc, a region more associated with reward and positive affect, report acutely improved motivation for pleasurable activities [99].”
From Deep brain stimulation for depression. (2022) · cites this paper as [99]
In the citing paper
“interaction with world targets can also be seen in people who suddenly have their mesolimbic dopamine systems artificially activated for the first time, such as by a newly-implanted brain stimulation electrode.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Schlaepfer et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease
Deuschl, G., Schade‐Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschlander, A. B., Dillmann, U., Eisner, W. E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060281 · Cited by 3,018
Self-citationBlood, A. J., & Zatorre, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191355898 · Cited by 2,814
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,000
Wang, Q., Wang, Y., Tian, Y., Li, Y., Han, J., Tai, F., & Jia, R. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114687 · Cited by 10
Network analysis of central symptoms in Chinese young adults with subthreshold depression
Jiang, X., Wang, X., Yu, L., He, J., Wu, S., Zhou, Y., Zhang, M., Yao, L., Yan, J., Zheng, Y., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03307-5 · Cited by 10
Anticipating possible policy uses of addiction neuroscience research
Hall, W., & Carter, A. (2013) · Drugs Education Prevention and Policy · doi:10.3109/09687637.2013.779426 · Cited by 10
Principles and Practice of Electroconvulsive Therapy
(2019) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379422 · Cited by 10
Ablative Procedures for Depression
Coenen, V. A., & Honey, C. R. (2009) · Springer eBooks · doi:10.1007/978-3-540-69960-6_175 · Cited by 10
Acute Depression and Suicidal Attempt Following Lowering the Frequency of Deep Brain Stimulation
Mahgoub, N. A., & Kotbi, N. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.4.468 · Cited by 10
Restoration of positive mood states in major depression as a potential drug development target
Lane, R. M. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114532857 · Cited by 9
Deep Brain Stimulation (DBS) : Current and Emerging Applications
Rezai, A. R., & Sharma, M. (2014) · Japanese Journal of Neurosurgery · doi:10.7887/jcns.23.648 · Cited by 9
Neural Foundations of Major Depression
Hamilton, J. P., Furman, D. J., & Gotlib, I. H. (2011) · Frontiers in neuroscience · doi:10.1201/b11232-4 · Cited by 9
Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms
Kee, M. Z. L., Teh, A. L., Clappison, A. S., Pokhvisneva, I., MacIssac, J. L., Lin, D. T. S., Ramadori, K. E., Broekman, B. F. P., Chen, H., Daniel, M. L., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104860 · Cited by 9
Yuan, Z., Lin, X., Li, P., Gao, Y., Yuan, K., Yan, W., Zhang, Y., Liu, L., Zhu, X.-M., Zhang, Y.-J., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1090369 · Cited by 9
Borairi, S., & Dougherty, D. D. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.581888 · Cited by 9
Glannon, W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00079 · Cited by 9
Unilateral accumbal dopamine depletion affects decision-making in a side-specific manner
Cunha, A. M., Teixeira, F. G., Guimarães, M. R., Esteves, M., Pereira-Mendes, J., Soares, A. R., Almeida, A., Sousa, N., Salgado, A. J., & Leite‐Almeida, H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113221 · Cited by 9
Yang, B. P., Tam, F., Davidson, B., Wei, P., Hamani, C., Lipsman, N., Chen, C., & Graham, S. J. (2020) · Medical Physics · doi:10.1002/mp.14214 · Cited by 9
Kuhlmann, S., Walter, H., & Schlaepfer, T. E. (2012) · Der Nervenarzt · doi:10.1007/s00115-012-3654-y · Cited by 9
Self-citationMechanisms of Action of Deep Brain Stimulation
Lee, K. H., Mosier, E. M., & Blaha, C. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805353-9.00017-6 · Cited by 9
Deep Brain Stimulation Reveals Emotional Impact Processing in Ventromedial Prefrontal Cortex
GJEDDE, A. H., & Geday, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008120 · Cited by 9
Kita, A., Ishida, T., Kita, N., Tabata, M., Tamaki, A., Uenishi, S., Yasuda, K., Takahashi, S., Matsuura, H., Yamada, S., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03480-7 · Cited by 8
Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation
Johnson, S. B., Rocks, D., Chalençon, L., Johnson, K., Hassan, U., Arefin, A., Akgül, G., Donatelle, A., Asher, H., Elbau, I., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.030 · Cited by 8
The Targets of Deep Brain Stimulation in the Treatment of Treatment‐Resistant Depression: A Review
Dong, J., Dai, M., Guo, Z., Xu, T., Li, F., & Li, J. (2025) · Brain and Behavior · doi:10.1002/brb3.70505 · Cited by 8
Prins, N. W., Geng, S., Pohlmeyer, E. A., Mahmoudi, B., & Sanchez, J. C. (2013) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2013.6610733 · Cited by 8
A step-wise approach to deep brain stimulation in mice
Halpern, C. H., Attiah, M. A., Tekriwal, A., & Baltuch, G. H. (2014) · Acta Neurochirurgica · doi:10.1007/s00701-014-2062-4 · Cited by 8
Deep Brain Stimulation in the Treatment of Obsessive-Compulsive Disorder
Blomstedt, P. C., Sjöberg, R. L., Hansson, M., Bodlund, O., & Hariz, M. I. (2015) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.130216 · Cited by 8
Deep Brain Stimulation for Depression
Bergfeld, I. O., & Figee, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-36346-8_18 · Cited by 8
Panksepp, J., & Wright, J. S. (2012) · Neuropsychoanalysis · doi:10.1080/15294145.2012.10773690 · Cited by 8
Halgren, A. S., Siegel, Z., Golden, R., & Bazhenov, M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1784-21.2023 · Cited by 8
Sobstyl, M. R., Prokopienko, M., & Pietras, T. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1100609 · Cited by 8
Schlaepfer, T. E., & Kayser, S. (2010) · Der Nervenarzt · doi:10.1007/s00115-010-2941-8 · Cited by 8
Self-citationBorderline personality disorder - a dysregulation of the endogenous opioid system?
Bandelow, B., Schmahl, C. G., Falkai, P., & Wedekind, D. (2011) · European Psychiatry · doi:10.1016/s0924-9338(11)72713-4 · Cited by 8
Neurobiological predictors for clinical trajectories in fully remitted depressed patients
Blank, T. S., Meyer, B. M., Rabl, U., Schögl, P., Wieser, M., & Pezawas, L. (2020) · Depression and Anxiety · doi:10.1002/da.23108 · Cited by 8
Langenecker, S. A., Schreiner, M. W., Thomas, L. R., Bessette, K. L., DelDonno, S. R., Jenkins, L. M., Easter, R. E., Stange, J. P., Pocius, S. L., Dillahunt, A. K., et al. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.06.014 · Cited by 8
Stimulation cérébrale profonde, maladie de Parkinson et complications neuropsychiatriques
Jaafari, N., Giré, P., & Houéto, J. (2009) · La Presse Médicale · doi:10.1016/j.lpm.2008.11.019 · Cited by 8
Kehinde, F., Oduyeye, O., & Mohammed, R. (2019) · Substance Abuse and Rehabilitation · doi:10.2147/sar.s202996 · Cited by 8
Kringelbach, M. L., Owen, S. L., & Aziz, T. Z. (2007) · Future Neurology · doi:10.2217/14796708.2.6.633 · Cited by 8
Amiri, S., Arbabi, M., Rahimi, M., Parvaresh, M., & Mirbagheri, M. M. (2023) · Brain Communications · doi:10.1093/braincomms/fcad256 · Cited by 7
Rotstein, N. M., Cohen, Z. D., Welborn, A., Zbozinek, T. D., Akre, S., Jones, K. G., Null, K. E., Pontanares, J., Sanchez, K. L., Flanagan, D. C., et al. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1478534 · Cited by 7
Ye, Y., Tian, Y., Liu, H., Liu, J., Zhou, C., Xu, C., Zhou, T., Nie, Y., Wu, Y. C., Qin, L., et al. (2025) · Exploration · doi:10.1002/exp.70040 · Cited by 7
The neuroevolutionary sources of mind
Panksepp, J. (2015) · Advances in consciousness research · doi:10.1075/aicr.92.09pan · Cited by 7
Vega-Zelaya, L., & Pastor, J. (2023) · Brain Sciences · doi:10.3390/brainsci13060943 · Cited by 7
Fitzgerald, P. B., Hoy, K. E., Richardson, K. E., Gainsford, K., Segrave, R. A., Herring, S. E., Daskalakis, Z. J., & Bittar, R. G. (2024) · Brain Sciences · doi:10.3390/brainsci14050499 · Cited by 7
Graph Theory and Modeling of Network Topology in Clinical Neurosurgery
Mithani, K., Suresh, H., & Ibrahim, G. M. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-64892-2_7 · Cited by 7
Medical Management and Indications for Surgery in Depression
Giacobbe, P., & Kennedy, S. H. (2009) · Springer eBooks · doi:10.1007/978-3-540-69960-6_174 · Cited by 7
Role of serotonergic system on modulation of depressogenic-like effects of silymarine.
Yaghmaei, P., Oryan, S., Mohammadi, K., & Solati, J. (2012) · Europe PMC (PubMed Central) · Cited by 7
Advanced research on deep brain stimulation in treating mental disorders (Review)
Wang, D., Liu, X., Zhou, B., Kuang, W., & Guo, T. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5366 · Cited by 7
Depression Onset in Long-term Adolescent Cannabinoid Use: A Neurobiological Review
Forrester, S. Y., & Jahan, N. (2020) · Cureus · doi:10.7759/cureus.7759 · Cited by 7
Modern neurosurgical techniques for psychiatric disorders
Salles, A. D., Lucena, L., Paranhos, T., Ferragut, M. A., de Oliveira‐Souza, R., & Gorgulho, A. A. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.025 · Cited by 7
Lévêque, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-01144-8_2 · Cited by 7
Electroencephalographic Changes Following Direct Current Deep Brain Stimulation of Auditory Cortex
Rojas, J. O. D., Saunders, J. A., Luminais, C., Hamilton, R. H., & Siegel, S. J. (2012) · Neurosurgery · doi:10.1227/neu.0b013e31827b93c0 · Cited by 7
Neuroimaging and the Pathophysiology and Treatment of Depression: Recent Advances and Future Needs
Cannon, D. M. (2010) · Modern trends in psychiatry · doi:10.1159/000319510 · Cited by 7
Ye, K., Cao, Y., Wu, Y., Ning, C., Wang, D., Guo, H., Wang, Y., Zhang, Y., Qiu, X., Li, N., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03669-w · Cited by 6
Hoyer, C., Sartorius, A., Lecourtier, L., Kiening, K. L., Meyer‐Lindenberg, A., & Gass, P. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.07.014 · Cited by 6
Closing the Loop on Deep Brain Stimulation for Treatment-Resistant Depression
Widge, A. S., Malone, D. A., & Dougherty, D. D. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.16302 · Cited by 6
Substance and Behavioral Addictions Assessment Instruments
Grigsby, T. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.012 · Cited by 6
An In-vitro Study of Electrodes Impedance in Deep Brain Stimulation
Ali, H. A. M., Abdullah, S. S., & Faraj, M. K. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1829/1/012019 · Cited by 6
Accrombessi, G., Galineau, L., Tauber, C., Sérrière, S., Moyer, E., Brizard, B., Guisquet, A. L., Surget, A., & Belzung, C. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02119-1 · Cited by 6
Contemporary Role of Stereotactic Radiosurgery for Psychiatric Disorders
Sadashiva, N., Tripathi, M., & Salles, A. D. (2023) · Neurology India · doi:10.4103/0028-3886.373648 · Cited by 6
Deep Brain Stimulation (DBS) in Treatment-Resistant Depression (TRD): Hope and Concern
Asir, B., Boscutti, A., Fenoy, A. J., & Quevedo, J. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-97-4402-2_9 · Cited by 6
Guridi, J., & Aldave, G. N. J. (2011) · Neurocirugía · doi:10.1016/s1130-1473(11)70001-x · Cited by 6
Apathy in melancholic depression and abnormal neural activity within the reward-related circuit
Jiang, Y. B., Zhang, T., Zhang, M., Xie, X., Tian, Y., Wang, K., & Bai, T. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114379 · Cited by 6
Liu, X., & Read, S. J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1349576 · Cited by 6
Deep Brain Stimulation in Schizophrenia
Kuhn, J., Bodatsch, M., Sturm, V., Lenartz, D., Klosterkötter, J., Uhlhaas, P. J., Winter, C., & Gruendler, T. O. J. (2014) · Activitas Nervosa Superior · doi:10.1007/bf03379611 · Cited by 6
Self-citationKale, R. P., Kouzani, A. Z., Berk, J., Walder, K. R., Berk, M., & Tye, S. J. (2016) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2016.7591071 · Cited by 6
Richieri, R. M., Borius, P.-Y., Cermolacce, M., Millet, B., Lançon, C., & Régis, J. M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.009 · Cited by 6
Ding, Y., Ou, Y., Yan, H., Liu, F., Li, H., Li, P., Xie, G., Cui, X., & Guo, W. (2023) · Biomedicines · doi:10.3390/biomedicines11123138 · Cited by 5
A circuit-based framework for depression: Reshaping the pathological attractor
Yuan, Z., Quan, J., Cui, Y., & Luo, M. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.009 · Cited by 5
Okuda, Y., Li, D., Maruyama, Y., Sonobe, H., Mano, T., Tainaka, K., Shinohara, R., & Furuyashiki, T. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02034-7 · Cited by 5
Translating progress in depression research to the clinic: one step at a time on a very long road
Drevets, W. C. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00299.x · Cited by 5
Gaming Disorder and Its Treatment
Griffiths, M. D., Kuss, D. J., & Pontes, H. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.029 · Cited by 6
Deep-Brain Stimulation for Neurologic and Psychiatric Disorders
Wichmann, T., & DeLong, M. R. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00039-1 · Cited by 5
Synofzik, M. (2014) · Springer eBooks · doi:10.1007/978-94-007-4707-4_32 · Cited by 5
Imaging Functional Systems in Depression
Young, C. B., Mueller, B. W., & Tendolkar, I. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802456-0.00008-x · Cited by 5
The Neuropsychiatric Spectrum of Motivational Disorders
Epstein, J., & Silbersweig, D. (2016) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.140401 · Cited by 5
Ahn, S., Jo, S., Jun, S. B., Lee, H. W., & Lee, S. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000786 · Cited by 5
Anhedonia in depressive disorders
Siwek, M. (2017) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2017.0026 · Cited by 5
Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics
Beauchaine, T. P., Klein, D. N., Knapton, E., & Zisner, A. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00005-6 · Cited by 5
Schläpfer, T. E., Meyer‐Lindenberg, A., Synofzik, M., Visser-Vandewalle, V. E. R. M., Voges, J., & Coenen, V. A. (2021) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2021.0017 · Cited by 5
High impedance analysis in recordings of deep brain stimulation surgery
Ali, H. A. M., Abdullah, S. S., & Faraj, M. K. (2021) · Interdisciplinary Neurosurgery · doi:10.1016/j.inat.2021.101115 · Cited by 5
White matter predicts tDCS antidepressant effects in a sham-controlled clinical trial study
Zanao, T. A., Luethi, M. S., Goerigk, S. A., Suen, P. J. C., Díaz, A. P., Soares, J. C., & Brunoni, A. R. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01504-7 · Cited by 5
Neurotransmitter Release During Deep Brain Stimulation
Abulseoud, O. A., Knight, E. J., & Lee, K. H. (2012) · Springer eBooks · doi:10.1007/978-3-642-30991-5_18 · Cited by 5
Research Advances in Geriatric Depression
Alexopoulos, G. S., & Kelly, R. E. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.107 · Cited by 5
The value of clinical and translational neuroscience approaches to psychiatric illness
Hur, J., Tillman, R. M., Fox, A. S., & Shackman, A. J. (2019) · Behavioral and Brain Sciences · doi:10.1017/s0140525x18001036 · Cited by 5
Role of the Endocannabinoid System in the Neurobiology of Suicide
Vinod, K. (2012) · Frontiers in neuroscience · doi:10.1201/b12215-6 · Cited by 4
What do we know about astrocytes and the antidepressant effects of DBS?
Campos, A. C. P., Pagano, R. L., Lipsman, N., & Hamani, C. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114501 · Cited by 4
Anhedonia as a Core Symptom of Depression and a Construct for Biological Research
Al‐Soleiti, M., Voort, J. L. V., & Singh, B. (2025) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20240050 · Cited by 4
Neuroimaging of pleasantness and unpleasantness induced by thermal stimuli
Banožić, A. (2021) · Temperature · doi:10.1080/23328940.2021.1959288 · Cited by 4
(2013) · Palgrave Macmillan eBooks · doi:10.1057/9781137367839.0004 · Cited by 4
Chahuan, S., Grover, S., & Singh, S. (2022) · Drug and Chemical Toxicology · doi:10.1080/01480545.2022.2105862 · Cited by 4
Yan, H., Chu, Z., Shen, Z., Yuan, L., Wu, Y., Lu, Y., Jiang, H., & Xu, X. (2024) · Neuroreport · doi:10.1097/wnr.0000000000002097 · Cited by 4
Biomarkers: The Key to Enhancing Deep Brain Stimulation Treatment for Psychiatric Conditions
Castro, G. J. B., Casitas, V., Macho, C. M., Pohlen, A. M., Álvarez-Salas, A., Pablos, E. B., Alén, J. F., & Torres, C. V. (2024) · Brain Sciences · doi:10.3390/brainsci14111065 · Cited by 4
Yampolsky, C., & Bendersky, D. (2014) · Surgical Neurology International · doi:10.4103/2152-7806.137936 · Cited by 4
Deep Brain Stimulation for Psychiatric Disorders
Lipsman, N., & Lozano, A. M. (2014) · Springer eBooks · doi:10.1007/978-3-319-08476-3_13 · Cited by 4
Elektrokrampftherapie und neue Hirnstimulationsmethoden
Walter, H., Schläpfer, T. E., & Kayser, S. (2010) · Nervenheilkunde · doi:10.1055/s-0038-1628725 · Cited by 4
Schlaepfer, T. E., & Kayser, S. (2012) · Der Nervenarzt · doi:10.1007/s00115-011-3428-y · Cited by 4
Self-citationElectrophysiological Signatures of Reward Processing in Anhedonia
Mallorquí, A., Padrão, G., & Rodríguez‐Fornells, A. (2014) · Springer eBooks · doi:10.1007/978-94-017-8591-4_11 · Cited by 4
Nucleus accumbens stereotactic surgery: Achieving accuracy through area M
Mavridis, I. N. (2013) · World Journal of Neurology · doi:10.5316/wjn.v3.i2.7 · Cited by 4
Anhedonia as a Crucial Factor of Depression: Assessment, Neurobiological Underpinnings and Treatment
Chow, T. K., Kennedy, S. H., & Rizvi, S. J. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_7 · Cited by 4
Prevention and Treatment of Sex Addiction
Reid, R. C., Grubbs, J. B., & Kraus, S. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.025 · Cited by 4
Contemporary methods of non-drug therapy for depression
Tumova, M. A., Муслимова, Л. М., Stanovaya, V. V., Abdyrakhmanova, A. K., & Ivanov, M. V. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202112105291 · Cited by 4
Glannon, W. (2021) · doi:10.1093/oso/9780198813910.001.0001 · Cited by 4
Metadata
- Authors
- Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V.
- Affiliations
- Johns Hopkins University (US)
- University Hospital Bonn (DE)
- University Hospital Cologne (DE)
- Corresponding author
- Schlaepfer, Thomas E
- Venue
- Neuropsychopharmacology
- Published
- 2007-04-11
- Volume
- 33
- Issue
- 2
- Pages
- 368-377
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2141467587
- Cited by
- 1,027
- References
- 61
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 36 · 2023: 42 · 2022: 36 · 2021: 54 · 2020: 81 · 2019: 52 · 2018: 54 · 2017: 45 · 2016: 51 · 2015: 73 · 2014: 75 · 2013: 66 · 2012: 78
- FWCI
- 41.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- deep brain stimulation, nucleus accumbens, anhedonia, reward system dysfunction, brain metabolism, FDG-PET, fronto-striatal network, treatment-resistant depression
- MeSH terms
- Depressive Disorder, Double-Blind Method, Humans, Philosophy, Reward, Time Factors, Deep Brain Stimulation, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
