The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Open accessAbstract
Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“DBS targeting the NAc was shown to exert antidepressant, anxiolytic, and hedonic effects, notably in treatment-resistant depression (Bewernick et al. 2010; Giacobbe et al. 2009; Schlaepfer et al. 2008).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Schlaepfer et al. 2008
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“deep brain stimulation applied via electrodes situated in the accumbens area/ventral internal capsule improves depressive symptoms in treatmentrefractory depression (Malone et al, 2009;Schlaepfer et al, 2008).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Schlaepfer et al, 2008
The cited source says what the claim attributes to it.
In the citing paper
“and that deep brain stimulation applied via electrodes situated in the accumbens area/ventral internal capsule reportedly improves depressive symptoms in treatment-refractory depression (Schlaepfer et al. 2008).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Schlaepfer et al. 2008
In the citing paper
“Treatments with enhanced spatial specificity such as deep brain stimulation (DBS) or transcranial magnetic stimulation (TMS), aimed to restore region-specific hypoactivity, show great promise in alleviating treatment-resistant depression in even the most severe cases (2–10).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [8]
In the citing paper
“High frequency DBS of the NAc, among other regions, shows great promise in alleviating treatment-resistant depression, though its mechanism is still unclear (5, 8, 10).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [8]
In the citing paper
“patients responding to DBS of the NAc, a region more associated with reward and positive affect, report acutely improved motivation for pleasurable activities [99].”
From Deep brain stimulation for depression. (2022) · cites this paper as [99]
In the citing paper
“interaction with world targets can also be seen in people who suddenly have their mesolimbic dopamine systems artificially activated for the first time, such as by a newly-implanted brain stimulation electrode.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Schlaepfer et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease
Deuschl, G., Schade‐Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschlander, A. B., Dillmann, U., Eisner, W. E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060281 · Cited by 3,018
Self-citationBlood, A. J., & Zatorre, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191355898 · Cited by 2,814
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585
Cited by
Sorted by citations
Items 501–600 of 1,000
Sequeira‐Cordero, A., Mora-Gallegos, A., Cuenca-Berger, P., & Trías, J. F. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.046 · Cited by 20
Silk, E., Diwan, M., Rabelo, T. K., Katzman, H., Campos, A. C. P., Gouveia, F. V., Giacobbe, P., Lipsman, N., & Hamani, C. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06259-6 · Cited by 20
Lai, Y., Dai, L., Wang, T., Zhang, Y., Zhao, Y., Wang, F., Liu, Q., Zhan, S., Li, D., Jin, H., et al. (2022) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-329702 · Cited by 20
Williams, N. (2014) · World Journal of Radiology · doi:10.4329/wjr.v6.i10.756 · Cited by 20
Deep brain stimulation for treatment-resistant depression: a safe and effective option
Torre, D. L., Torre, A. D., Chirchiglia, D., Volpentesta, G., Guzzi, G., & Lavano, A. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1749049 · Cited by 20
PAIN AND PSYCHO-AFFECTIVE DISORDERS
Broggi, G. (2008) · Neurosurgery · doi:10.1227/01.neu.0000317337.51936.43 · Cited by 20
Enhanced subgenual cingulate response to altruistic decisions in remitted major depressive disorder
Pulcu, E., Zahn, R., Moll, J., Trotter, P. D., Thomas, E. J., Juhász, G., Deakin, J. F. W., Anderson, I. M., Sahakian, B. J., & Elliott, R. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.04.010 · Cited by 20
What Is Deep Brain Stimulation?
Montgomery, E. B. (2014) · Oxford University Press eBooks · doi:10.1093/med/9780199338825.003.0001 · Cited by 20
Zhou, H., Zhu, J., Jia, J., Xiang, W., Peng, H., Zhang, Y., Liu, B., Mu, Y., & Lu, Y. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100492 · Cited by 19
Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application
Nangunoori, R., Tomycz, N. D., Oh, M. Y., & Whiting, D. M. (2015) · Neural Plasticity · doi:10.1155/2016/7971460 · Cited by 19
Cho, S., Hachmann, J. T., Balzekas, I., In, M., Andres‐Beck, L. G., Lee, K. H., Min, H.-K. P., & Jo, H. J. (2019) · Brain and Behavior · doi:10.1002/brb3.1431 · Cited by 19
Transient Dose-dependent Effects of Ketamine on Neural Oscillatory Activity in Wistar-Kyoto Rats
Manduca, J. D., Thériault, R.-K., Williams, O. O. F., Rasmussen, D. J., & Perreault, M. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.012 · Cited by 19
Brain stimulation therapies for neuropsychiatric disease
Holtzheimer, P. E., Kosel, M., & Schlaepfer, T. E. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00041-3 · Cited by 19
Self-citationGeller, W. N., Liu, K., & Warren, S. L. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111349 · Cited by 18
Zhang, S., He, J., Wang, Y., Zhong, G., Zhao, Y., Li, S.-Y., Xiao, X., Zheng-yi, Y., Zhao, B., Wang, L., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12121730 · Cited by 18
Altinay, M. I., Estemalik, E., & Malone, D. A. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12517 · Cited by 18
Baioui, A., Pilgramm, J., Kagerer, S., Walter, B., Vaitl, D., & Stark, R. M. (2013) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2013.04.006 · Cited by 18
p11 and Gene Therapy for Severe Psychiatric Disorders: A Practical Goal?
Chen, G., Twyman, R. E., & Manji, H. K. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001754 · Cited by 18
Beeker, T., Schlaepfer, T. E., & Coenen, V. A. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00011 · Cited by 18
Self-citationWeise, L. M., Schneider, G., Kupsch, A. R., Haumesser, J. K., & Hoffmann, K. (2010) · Acta Neurochirurgica · doi:10.1007/s00701-010-0738-y · Cited by 18
Kuhn, J., & Huff, W. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.80 · Cited by 18
Schlaepfer, T. E., & Bewernick, B. H. (2014) · Brain Topography · doi:10.1007/s10548-013-0315-9 · Cited by 17
Self-citationConner, C. R., Quevedo, J., Soares, J. C., & Fenoy, A. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01726-0 · Cited by 17
Cognitive effects of focal neuromodulation in neurological and psychiatric disorders
Wiseman, M., Sewell, I. J., Nestor, S. M., Giacobbe, P., Hamani, C., Lipsman, N., & Rabin, J. S. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00291-3 · Cited by 18
Patrick, E. E., Fleeting, C. R., Patel, D. R., Casauay, J. T., Patel, A., Shepherd, H., & Wong, J. K. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1333183 · Cited by 17
Deep brain stimulation for depression: Scientific issues and future directions
Mosley, P. E., Marsh, R., & Carter, A. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415599845 · Cited by 17
Bloomfield-Clagett, B., Greenstein, D. K., Kush, J. M., Musci, R. J., Zarate, C. A., & Ballard, E. D. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.01.027 · Cited by 17
Neurochemical mechanisms of deep brain stimulation for depression in animal models
Campos, A. C. P., Pople, C. B., Silk, E., Surendrakumar, S., Rabelo, T. K., Meng, Y., Gouveia, F. V., Lipsman, N., Giacobbe, P., & Hamani, C. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.12.003 · Cited by 17
Mavridis, I. N., Boviatsis, E. I., & Anagnostopoulou, S. (2011) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-011-0804-z · Cited by 17
Britt, J. P., McDevitt, R. A., & Reed, S. J. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s45896 · Cited by 17
A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
Salviati, M., Bersani, F. S., Valeriani, G., Minichino, A., Panico, R., Romano, G. F., Mazzei, F., Testugini, V., ALTISSIMI, G., & Cianfrone, G. (2014) · Neural Plasticity · doi:10.1155/2014/817852 · Cited by 17
Guérin, B., Iacono, M. I., Davids, M., Dougherty, D. D., Angelone, L. M., & Wald, L. L. (2019) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aafce8 · Cited by 17
Modeling the symptoms of psychopathology: A pluralistic approach
Clack, S., & Ward, T. J. (2020) · New Ideas in Psychology · doi:10.1016/j.newideapsych.2020.100799 · Cited by 17
A Miniature Low-Power Multi-Biomarker-Based Brain Sensor for Closed-Loop DBS
Parastarfeizabadi, M., & Kouzani, A. Z. (2017) · IEEE Sensors Journal · doi:10.1109/jsen.2017.2686642 · Cited by 17
Sharma, M., Zibly, Z., Deogaonkar, M. S., & Rezai, A. R. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_38 · Cited by 16
Letzen, J. E., Seminowicz, D. A., Campbell, C. M., & Finan, P. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.011 · Cited by 16
Multi‐dimensional predictions of psychotic symptoms via machine learning
Taylor, J. A., Larsen, K. M., & Garrido, M. I. (2020) · Human Brain Mapping · doi:10.1002/hbm.25181 · Cited by 16
Vila-Merkle, H., González-Martínez, A., Campos-Jiménez, R., Martínez‐Ricós, J., Teruel‐Martí, V., Blasco‐Serra, A., Lloret, A., Celada, P., & Cervera‐Ferri, A. (2021) · Biomedicines · doi:10.3390/biomedicines9070783 · Cited by 16
Circuit-Targeted Neuromodulation for Anhedonia
Siddiqi, S., Haddad, N. R., & Fox, M. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_350 · Cited by 16
Brain Stimulation Techniques for the Treatment of Depression and Other Psychiatric Disorders
Fitzgerald, P. B. (2008) · Australasian Psychiatry · doi:10.1080/10398560701874291 · Cited by 16
Tohyama, S., Walker, M. R., Sammartino, F., Krishna, V., & Hodaie, M. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13107 · Cited by 16
Tobar, I. D. B., Fernández, P., Sáez, J. C., & Dagnino‐Subiabre, A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24902 · Cited by 16
Sachdev, P. S., & Chen, X. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32831c8475 · Cited by 16
Dumitriu, D., Collins, K., Alterman, R. L., & Mathew, S. J. (2008) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20044 · Cited by 16
Psychosurgery, Deep Brain Stimulation, and the Re-writing of History
Hariz, M. I. (2008) · Neurosurgery · doi:10.1227/01.neu.0000325681.70894.91 · Cited by 16
Song, N., Du, J., Gao, Y., & Yang, S. (2020) · Translational Neuroscience · doi:10.1515/tnsci-2020-0146 · Cited by 15
Atrophy of bilateral nucleus accumbens in melancholic depression
Chu, Z., Yuan, L., He, M., Cheng, Y., Lu, Y., Xu, X., & Shen, Z. (2023) · Neuroreport · doi:10.1097/wnr.0000000000001915 · Cited by 15
Neurosurgical Treatments of Depression
Temel, Y., & Lim, L. W. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_222 · Cited by 15
Deep Brain Stimulation for Treatment-Resistant Depression
Kaur, N., Chou, T., Corse, A. K., Arulpragasam, A. R., Deckersbach, T., & Evans, K. C. (2013) · Psychiatric Annals · doi:10.3928/00485713-20130806-04 · Cited by 15
“Extimate” Technologies and Techno-Cultural Discontent
Zwart, H. A. E. (2017) · Techné Research in Philosophy and Technology · doi:10.5840/techne20174560 · Cited by 15
Casquero‐Veiga, M., García‐García, D., Pascau, J., Desco, M., & Soto‐Montenegro, M. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204740 · Cited by 15
Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension
Ems, R., Garg, A., Ostergard, T. A., & Miller, J. P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00093 · Cited by 15
Vallée, M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3593-3 · Cited by 15
Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders
Ruan, H., Tong, G., Jin, M., Koch, K., & Wang, Z. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.06.009 · Cited by 14
Che, Q., Xi, C., Sun, Y., Zhao, X., Wang, L. A., Wu, K., Mao, J., Huang, X., Wang, K., Tian, Y., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115463 · Cited by 15
Neuroethics of Deep Brain Stimulation for Mental Disorders: Brain Stimulation Reward in Humans
Oshima, H., & Katayama, Y. (2010) · Neurologia medico-chirurgica · doi:10.2176/nmc.50.845 · Cited by 14
The Laterality of Age-Related Hearing Loss and Depression
Chern, A., Irace, A. L., & Golub, J. S. (2022) · Otology & Neurotology · doi:10.1097/mao.0000000000003531 · Cited by 14
Cognitive and emotional processing associated with the Season of Birth and dopamine D4 receptor gene
Roussos, P., Giakoumaki, S. G., & Bitsios, P. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.09.021 · Cited by 14
Beyond Blind Optimism and Unfounded Fears: Deep Brain Stimulation for Treatment Resistant Depression
Johansson, V. M., Garwicz, M., Kanje, M., Röcklinsberg, H., Schouenborg, J., Tingström, A., & Görman, U. (2011) · Neuroethics · doi:10.1007/s12152-011-9112-x · Cited by 14
Radman, T., & Lisanby, S. H. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1304898 · Cited by 14
Georgiev, D., Akram, H., & Jahanshahi, M. (2021) · Psychoradiology · doi:10.1093/psyrad/kkab012 · Cited by 14
Deep Brain Stimulation for Parkinson’s Disease—A Narrative Review
Wójcik, R., Dębska, A., Zaczkowski, K., Szmyd, B. M., Podstawka, M., Bobeff, E. J., Piotrowski, M., Ratajczyk, P., Jaskólski, D. J., & Wiśniewski, K. (2025) · Biomedicines · doi:10.3390/biomedicines13102430 · Cited by 13
Patel, E., Ramaiah, P., Mamaril‐Davis, J., Bauer, I. L., Koujah, D., Seideman, T. A., Kelbert, J., Nosova, K., & Bina, R. W. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.251 · Cited by 13
Sharma, P., & Pienaar, I. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.026 · Cited by 13
Advancing deep brain stimulation for obsessive–compulsive disorder
Burdick, A. P., & Foote, K. D. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.20 · Cited by 13
Papp, M., Gruca, P., Litwa, E., Łasoń, M., & Willner, P. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110715 · Cited by 13
Increased brain nucleus accumbens functional connectivity in melancholic depression
Chen, Z., Ou, Y., Liu, F., Li, H., Li, P., Xie, G., Cui, X., & Guo, W. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109798 · Cited by 13
Ou, Y., Su, Q., Liu, F., Ding, Y., Chen, J., Zhang, Z., Zhao, J., & Guo, W. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00585 · Cited by 13
Appetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12
Liu, F., Huang, S., Guo, D., Li, X., & Han, Y. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122222 · Cited by 12
Liang, Y. L., Yang, Y., Huang, R., Ning, J., Bao, X., Yan, Z., Chen, H., Ding, L., & Shu, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116610 · Cited by 12
Kabotyanski, K. E., Najera, R. A., Banks, G. P., Sharma, H., Provenza, N. R., Hayden, B. Y., Mathew, S. J., & Sheth, S. A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02951-7 · Cited by 12
Huang, X., Xi, C., Fang, Y., Ye, R., Wang, X., Zhang, S., Cui, Y., Guo, Y., Zhang, J., Ji, G., et al. (2025) · Depression and Anxiety · doi:10.1155/da/1767477 · Cited by 12
A narrative review on invasive brain stimulation for treatment-resistant depression
Dandekar, M. P., Díaz, A. P., Rahman, Z., da Silva, R. H., Nahas, Z. H., Aaronson, S. T., Selvaraj, S., Fenoy, A. J., Sanches, M., Soares, J. C., et al. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2021-1874 · Cited by 12
Chan, J. L., Carpentier, A. V., Middlebrooks, E. H., Okun, M. S., & Wong, J. K. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2289573 · Cited by 12
Deep Brain Stimulation as a Therapy for Alcohol Addiction
Münte, T. F., Heinze, H., & Visser-Vandewalle, V. E. R. M. (2012) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_207 · Cited by 12
Les thérapeutiques non médicamenteuses en psychiatrie
Székely, D. L., & Polosan, M. (2010) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2010.06.020 · Cited by 12
Deep Brain Stimulation—Possible Treatment Strategy for Pathologically Altered Body Weight?
Prinz, P., & Stengel, A. (2018) · Brain Sciences · doi:10.3390/brainsci8010019 · Cited by 12
- Role of the Endocannabinoid System in the Neurobiology of Suicide
Dwivedi, Y. (2012) · CRC Press eBooks · doi:10.1201/b12215-11 · Cited by 12
Yang, K., Long, H., Yuan, Y., Qi, S., Xu, B., Wang, K., & Song, Y. (2013) · Stereotactic and Functional Neurosurgery · doi:10.1159/000350036 · Cited by 12
Exploratory meta-analysis on deep brain stimulation in treatment-resistant depression
Smith, D. F. (2013) · Acta Neuropsychiatrica · doi:10.1017/neu.2014.22 · Cited by 12
The future of psychiatry: brain devices
Silva, J. A. C. E., & Steffen, R. E. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.010 · Cited by 12
Neuromodulation – ECT, rTMS, DBS
Synofzik, M., & Schlaepfer, T. E. (2010) · International library of ethics, law, and the new medicine/The international library of ethics, law, and the new medicine · doi:10.1007/978-90-481-8721-8_19 · Cited by 12
Self-citationNeural circuits mediating chronic stress: Implications for major depressive disorder
Guo, H., Ali, T., & Li, S. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111280 · Cited by 11
Vago, D. R., Epstein, J., Catenaccio, E., & Stern, E. R. (2011) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2011.01.003 · Cited by 11
Andrews, R. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05380.x · Cited by 11
Murakami, G., Nakamura, M., Takita, M., Ishida, Y., Ueki, T., & Nakahara, D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.115 · Cited by 11
The Retrograde Connections and Anatomical Segregation of the Göttingen Minipig Nucleus Accumbens
Meidahl, A. C., Orłowski, D., Sørensen, J. C. H., & Bjarkam, C. R. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00117 · Cited by 11
Doucette, W. T., Dwiel, L. L., Boyce, J. E., Simon, A. A., Khokhar, J. Y., & Green, A. I. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00336 · Cited by 11
Schumacher, A., Haegele, M., Spyth, J., & Moser, A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112277 · Cited by 11
Trapp, N. T., Xiong, W., & Conway, C. R. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_157 · Cited by 11
Pourahmad, R., Saleki, K., Esmaili, M., Abdollahi, A., Alijanizadeh, P., Zare, M., Banazadeh, M., & Ahmadi, M. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.05.008 · Cited by 11
Arsenault, D., Drouin‐Ouellet, J., Saint‐Pierre, M., Petrou, P., Dubois, M., Križ, J., Barker, R. A., Cicchetti, A., & Cicchetti, F. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.287243 · Cited by 11
Strong, D. R., Haber, S. N., Tyrka, A. R., Bernier, J. A., Rasmussen, S. A., & Greenberg, B. D. (2012) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318240acf5 · Cited by 11
Pandurangi, A. K., Bledowski, C., & Bledowski, J. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2011.11.009 · Cited by 11
Pathways of Translation: Deep Brain Stimulation
Gionfriddo, M. R., Greenberg, A. J., Wahegaonkar, A. L., & Lee, K. H. (2013) · Clinical and Translational Science · doi:10.1111/cts.12055 · Cited by 11
Modulation of CNS Functions by Deep Brain Stimulation: Insights Provided by Molecular Imaging
Boutet, A., Jain, M., Gwun, D., Rusjan, P., Neudorfer, C., Elias, G. J. B., Germann, J., Bilbily, A., Kucharczyk, W., Fasano, A. A., et al. (2020) · Springer eBooks · doi:10.1007/978-3-030-53168-3_46 · Cited by 11
Vandehey, N. T., Garell, P. C., Hampel, J. A., Murali, D., Smith, E. M., Davidson, R. J., Converse, A. K., Nickles, R. J., & Christian, B. T. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.08.033 · Cited by 11
Qualitative Approaches to the Study of Substance and Behavioral Addictions
Simpson, K. A., & Bluthenthal, R. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.013 · Cited by 10
Darrow, S. M., Pizzagalli, D. A., Smoski, M. J., Mathew, S. J., Nürnberger, J. I., Lisanby, S. H., Iosifescu, D. V., Murrough, J. W., Yang, H., Weiner, R. D., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.081 · Cited by 10
Metadata
- Authors
- Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V.
- Affiliations
- Johns Hopkins University (US)
- University Hospital Bonn (DE)
- University Hospital Cologne (DE)
- Corresponding author
- Schlaepfer, Thomas E
- Venue
- Neuropsychopharmacology
- Published
- 2007-04-11
- Volume
- 33
- Issue
- 2
- Pages
- 368-377
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2141467587
- Cited by
- 1,027
- References
- 61
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 36 · 2023: 42 · 2022: 36 · 2021: 54 · 2020: 81 · 2019: 52 · 2018: 54 · 2017: 45 · 2016: 51 · 2015: 73 · 2014: 75 · 2013: 66 · 2012: 78
- FWCI
- 41.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- deep brain stimulation, nucleus accumbens, anhedonia, reward system dysfunction, brain metabolism, FDG-PET, fronto-striatal network, treatment-resistant depression
- MeSH terms
- Depressive Disorder, Double-Blind Method, Humans, Philosophy, Reward, Time Factors, Deep Brain Stimulation, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
