Cited by 1,743Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.

STATs in oncogenesis

Bowman, Tammy, Garcia, Roy, Turkson, James, Jove, Richard·2000·Oncogene

DOI 10.1038/sj.onc.1203527

Open this paper in CoChat — free account

Abstract

Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs). In addition to their central roles in normal cell signaling, recent studies have demonstrated that diverse oncoproteins can activate specific STATs (particularly Stat3 and Stat5) and that constitutively-activated STAT signaling directly contributes to oncogenesis. Furthermore, extensive surveys of primary tumors and cell lines derived from tumors indicate that inappropriate activation of specific STATs occurs with surprisingly high frequency in a wide variety of human cancers. Together, these findings provide compelling evidence that aberrant STAT activation associated with oncogenesis is not merely adventitious but instead contributes to the process of malignant transformation. These studies are beginning to reveal the molecular mechanisms leading to STAT activation in the context of oncogenesis, and candidate genes regulated by STATs that may contribute to oncogenesis are being identified. Recent studies suggest that activated STAT signaling participates in oncogenesis by stimulating cell proliferation and preventing apoptosis. This review presents the evidence for critical roles of STATs in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling. Oncogene (2000).

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1203527

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Druker, B. J., Tamura, S., Buchdunger, E., Ohno-Jones, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. (1996) · Nature Medicine · doi:10.1038/nm0596-561 · Cited by 3,652
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656

Show all 152 references

Research works printed but not linked: 7

Gouilleux-Gruart V, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, Weber-Nordt R, Dusanter-Fourt I, Dreyfus F, Groner B and Prin L . 1996 Blood 87: 1692–1697 · DOI
Hallek M, Leif Bergsagel P and Anderson KC . 1998 Blood 91: 3–21 · DOI
Ho JM, Beattie BK, Squire JA, Frank DA and Barber DL . 1999 Blood 93: 4354–4364 · DOI
Liu RY, Fan C, Garcia R, Jove R and Zuckerman KS . 1999 Blood 93: 2369–2379 · DOI
Skorski T, Nieborowska-Skorska M, Wlodarski P, Wasik M, Trotta R, Kanakaraj P, Salomoni P, Antonyak M, Martinez R, Majewski M, Wong A, Perussia B and Calabretta B . 1998 Blood 91: 406–418 · DOI
Sun WH, Pabon C, Alsayed Y, Huang PP, Jandeska S, Uddin S, Platanias LC and Rosen ST . 1998 Blood 91: 570–576 · DOI
Wang YH, Wharton W, Garcia R, Kraker A, Jove R and Pledger WJ . 2000 Oncogene in press

Sorted by citations

Items 901–999 of 999

Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids
Kumar, A., & Bora, U. (2012) · Bioinformation · doi:10.6026/97320630008988 · Cited by 36
Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells
Chang, C. J., Chiang, C.-H., Song, W.-S., Tsai, S. K., Woung, L., Chang, C. H., Jeng, S.-Y., Tsai, C. Y., Hsu, C. C., Lee, H. F., et al. (2012) · Child s Nervous System · doi:10.1007/s00381-011-1672-x · Cited by 39
Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour
Chang, K., Wu, M., Jones, D., Chen, F., & Tseng, Y. (2006) · The Journal of Pathology · doi:10.1002/path.2041 · Cited by 35
Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy
Dufait, I., Valckenborgh, E. V., Menu, E., Escors, D., Ridder, M. D., & Breckpot, K. (2016) · Oncotarget · doi:10.18632/oncotarget.8311 · Cited by 36
Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis
WANG, H., FENG, H., & ZHANG, Y. (2016) · Neoplasma · doi:10.4149/neo_2016_406 · Cited by 38
GOLPH3 promotes glioma progression via facilitating JAK2–STAT3 pathway activation
Wu, S., Fu, J., Dong, Y. J., Yi, Q., Lu, D., Wang, W., Qi, Y., Yu, R., & Zhou, X. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2884-7 · Cited by 36
Signaling pathways modulated by miRNAs in breast cancer angiogenesis and new therapeutics
Hussen, B. M., Salihi, A. B., Abdullah, S. T., Rasul, M. F., Hidayat, H. J., Hajiesmaeili, M., & Ghafouri‐Fard, S. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153764 · Cited by 36
Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells
Mori, R., Xiong, S., Wang, Q., Tarabolous, C., Shimada, H., Panteris, E., Danenberg, K. D., Danenberg, P. V., & Pinski, J. (2008) · The Prostate · doi:10.1002/pros.20851 · Cited by 37
Modulation of the Interleukin-6 Receptor Subunit Glycoprotein 130 Complex and Its Signaling by LMO4 Interaction*
Novotny-Diermayr, V., Lin, B., Gu, L., & Cao, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500175200 · Cited by 40
Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis
Coletta, R. D., Jedlicka, P., Gutierrez‐Hartmann, A., & Ford, H. L. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000023587.40966.f6 · Cited by 36
Estrogen receptor-α regulates SOCS-3 expression in human breast cancer cells
Matthews, J. B., Almlöf, T., Kietz, S., Leers, J., & Gustafsson, J.-Å. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.057 · Cited by 39
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy
Hong, J. W., Xu, H., Yu, L., Zhuang, Y., Chen, X., Meng, Z., Zhu, J., Li, J., & Zhu, M. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01587-4 · Cited by 36
Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma
Brown, M. E., Bear, M. D., Rosol, T. J., Premanandan, C., Kisseberth, W. C., & London, C. A. (2015) · BMC Veterinary Research · doi:10.1186/s12917-015-0505-7 · Cited by 35
A novel role for signal transducer and activator of transcription 5b (STAT5b) in β1-integrin-mediated human breast cancer cell migration
Bernaciak, T. M., Zareno, J., Parsons, J. T., & Silva, C. M. (2009) · Breast Cancer Research · doi:10.1186/bcr2341 · Cited by 35
Role of Human Herpesvirus 8 Interleukin-6-Activated gp130 Signal Transducer in Primary Effusion Lymphoma Cell Growth and Viability
Cousins, E., & Nicholas, J. (2013) · Journal of Virology · doi:10.1128/jvi.02047-13 · Cited by 35
The Emerging Role of Suppressors of Cytokine Signaling (SOCS) in the Development and Progression of Leukemia
Keewan, E. F., & Matlawska‐Wasowska, K. (2021) · Cancers · doi:10.3390/cancers13164000 · Cited by 36
Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells
Chou, W., Wang, Y., Chen, K., Wu, J.-M., Liang, C.-L., & Juo, S. H. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.11.003 · Cited by 35
Structural basis for the binding of high affinity phosphopeptides to Stat3
McMurray, J. S. (2007) · Biopolymers · doi:10.1002/bip.20901 · Cited by 35
Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines
Gu, L., Chiang, K., Zhu, N., Findley, H. W., & Zhou, M. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.03.007 · Cited by 35
Tanshinone IIA induces TRAIL sensitization of human lung cancer cells through selective ER stress induction
Kim, E. O., Kang, S. E., Im, C. R., Lee, J., Ahn, K. S., Yang, W. M., Um, J., Lee, S., & Yun, M. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3441 · Cited by 36
Transcriptional Activation of Signal Transducer and Activator of Transcription (STAT) 3 and STAT5B Partially Mediate Homeobox A1-Stimulated Oncogenic Transformation of the Immortalized Human Mammary Epithelial Cell
Mohankumar, K. M., Perry, J. K., Kannan, N., Kohno, K., Gluckman, P. D., Emerald, B. S., & Lobie, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1320 · Cited by 35
STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer
Jiang, B., Zhu, Z. Z., Liu, F., Yang, L., Zhang, W. Y., Yuan, H. H., Wang, J., Hu, X., & Huang, G. (2011) · Genetics and Molecular Research · doi:10.4238/vol10-3gmr1071 · Cited by 34
Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis
Joliot, V., Cormier, F., Medyouf, H., Alcalde, H., & Ghysdael, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209480 · Cited by 34
The Intracellular Delivery of a Recombinant Peptide Derived from the Acidic Domain of PIAS3 Inhibits STAT3 Transactivation and Induces Tumor Cell Death
Borghouts, C., Tittmann, H., Delis, N., Kirchenbauer, M., Brill, B., & Groner, B. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0417 · Cited by 34
STAT3 as a therapeutic target for Epstein-Barr virus (EBV) – associated nasopharyngeal carcinoma
Ho, Y., Tsao, S., Zeng, M., & Lui, V. W. Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.052 · Cited by 36
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway
Nadiminty, N., Chun, J. Y., Hu, Y., Dutt, S. S., Lin, X., & Gao, A. C. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.119 · Cited by 34
Cross-talk between Phospho-STAT3 and PLCγ1 Plays a Critical Role in Colorectal Tumorigenesis
Zhang, P., Zhao, Y., Zhu, X., Sedwick, D., Zhang, X., & Wang, Z. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0147 · Cited by 34
T40214/PEI complex: A potent therapeutics for prostate cancer that targets STAT3 signaling
Weerasinghe, P., Li, Y., Guan, Y., Zhang, R., Tweardy, D. J., & Jing, N. (2008) · The Prostate · doi:10.1002/pros.20807 · Cited by 34
Adiponectin Receptor Expression in Human Malignant Tissues
Chou, S. H.-H., Tseleni‐Balafouta, S., Moon, H., Chamberland, J. P., Liu, X., Kavantzas, N., & Mantzoros, C. S. (2010) · Hormones and Cancer · doi:10.1007/s12672-010-0017-7 · Cited by 34
Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
Monnien, F., Zaki, H. M., Borg, C., Mougin, C., Bosset, J.-F., Mercier, M., Arbez‐Gindre, F., & Kantelip, B. M. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.076414 · Cited by 33
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling
Chou, D. H., Vetere, A., Choudhary, A., Scully, S. S., Schenone, M., Tang, A. J., Gomez, R. C., Burns, S. M., Lundh, M., Vital, T., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04284 · Cited by 34
Preparation and characterization of lipid nanoparticle/pDNA complexes for STAT3 downregulation and overcoming chemotherapy resistance in lung cancer cells
Kotmakçı, M., Çetintaş, V. B., & Kantarcı, A. G. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.04.034 · Cited by 35
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity
Zhou, Y., Yang, Y., Zhou, T., Li, B., & Wang, Z. (2021) · Aging and Disease · doi:10.14336/ad.2020.0919 · Cited by 37
Co‐culture of Head and Neck Squamous Cell Carcinoma Spheroids with Autologous Monocytes Predicts Prognosis
Kross, K. W., Heimdal, J. H., Olsnes, C., Olofsson, J. S., & Aarstad, H. J. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02072.x · Cited by 33
Solanum nigrum Unripe fruit fraction attenuates Adriamycin resistance by down-regulating multi-drug resistance protein (Mdr)-1 through Jak-STAT pathway
Jagadeeshan, S., David, D., Jisha, S. P., Manjula, S., & Nair, S. A. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1872-3 · Cited by 33
STAT6 knockdown using multiple siRNA sequences inhibits proliferation and induces apoptosis of human colorectal and breast cancer cell lines
Salguero‐Aranda, C., Sancho-Mensat, D., Canals-Lorente, B., Sultan, S., Reginald, A., & Chapman, L. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0207558 · Cited by 33
Morbid Obesity and Thyroid Cancer Rate. A Review of Literature
Masone, S., Velotti, N., Savastano, S., Filice, E., Serao, R., Vitiello, A., Berardi, G., Schiavone, V., & Musella, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091894 · Cited by 36
STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
Zhang, L., Nesvick, C. L., Day, C. A., Choi, J., Lu, V. M., Peterson, T. E., Power, E. A., Anderson, J. B., Hamdan, F. H., Decker, P. A., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac093 · Cited by 33
Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury
Magierowska, K., Korbut, E., Wójcik-Grzybek, D., Bakalarz, D., Śliwowski, Z., Cieszkowski, J., Szetela, M., Torregrossa, R., Whiteman, M., & Magierowski, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.051 · Cited by 33
STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells
Li, G., Wei, H., Chen, Z., Lv, S., Yin, C., & Wang, D. (2008) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9696-0 · Cited by 34
Human T‐cell leukemia virus type‐I Tax induces expression of interleukin‐6 receptor (IL‐6R): Shedding of soluble IL‐6R and activation of STAT3 signaling
Horiuchi, S., Yamamoto, N., Dewan, M. Z., Takahashi, Y., Yamashita, A., Yoshida, T., Nowell, M. A., Richards, P. J., Jones, S. A., & Yamamoto, N. (2006) · International Journal of Cancer · doi:10.1002/ijc.21918 · Cited by 33
STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma
Ouédraogo, Z. G., Müller‐Barthélémy, M., Kemeny, J., Dedieu, V., Biau, J., Khalil, T., Raoelfils, L. I., Granzotto, A., Pereira, B., Beaudoin, C., et al. (2016) · Brain Pathology · doi:10.1111/bpa.12254 · Cited by 33
Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics
Bahlawane, C., Eulenfeld, R., Wiesinger, M., Wang, J., Muller, A., Girod, A., Nazarov, P. V., Felsch, K., Vallar, L., Sauter, T., et al. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0096-8 · Cited by 33
Transcriptional Activity of the ΔNp63 Promoter Is Regulated by STAT3
Chu, W., Dai, P., Li, H., & Chen, J.-K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800183200 · Cited by 33
Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects
Barton, B. E., & Barton, B. E. (2012) · OncoTargets and Therapy · doi:10.2147/ott.s32559 · Cited by 32
Correlation of STAT1 with Apoptosis and Cell-Cycle Markers in Esophageal Squamous Cell Carcinoma
Zhang, Y., Zhang, Y., Yun, H., Lai, R. L., & Su, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113928 · Cited by 33
JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice.
Ignarro, R. S., Vieira, A. S., Sartori, C., Langone, F., Rogerio, F., & Parada, C. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.02.005 · Cited by 29
Roles of STAT3 in leukemia (Review)
Shi, Y., Zhang, Z., Qu, X., Zhu, X., Zhao, L., Wei, R., Guo, Q., Sun, L., Yin, X., Zhang, Y., et al. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4386 · Cited by 34
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
Gao, D., Jin, N., Fu, Y., Zhu, Y., Wang, Y., Wang, T., Chen, Y., Zhang, M., Xiao, Q., Huang, M., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113333 · Cited by 32
Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway
Luo, F., Lu, F., Qiu, M., Zhou, T., Ma, W., Luo, M., Zeng, K., Luo, Q., Pan, W., Zhang, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04042-7 · Cited by 32
Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF‐7 cells
Yuan, C., Chen, G., Jing, C., Liu, M., Liang, B., Gong, G., & Yu, M. Y. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22943 · Cited by 32
Combined treatment targeting HIF‐1α and Stat3 is a potent strategy for prostate cancer therapy
Reddy, K. R., Guan, Y., Qin, G., Zhou, Z., & Jing, N. (2011) · The Prostate · doi:10.1002/pros.21397 · Cited by 32
Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis
Macià, A., Vaquero, M., Gou-Fàbregas, M., Castelblanco, E., Valdivielso, J. M., Anerillas, C., Mauricio, D., Matías‐Guiu, X., Ribera, J., & Encinas, M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.161 · Cited by 33
Activation of a pro‐survival pathway IL‐6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin‐induced differentiation of C6 malignant glioma cells
Shu, M., Zhou, Y., Zhu, W., Wu, S., Zheng, X., & Yan, G. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.03.003 · Cited by 28
Histone Deacetylase Inhibitors Induce Cell Death Selectively in Cells That Harbor Activated kRasV12: The Role of Signal Transducers and Activators of Transcription 1 and p21
Klampfer, L., Huang, J., Shirasawa, S., Sasazuki, T., & Augenlicht, L. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0210 · Cited by 32
Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway
Yamashita, N., Kondo, M., Zhao, S., Li, W., Koike, K., Nemoto, K., & Kanno, Y. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.03.061 · Cited by 32
The nonsteroidal anti-inflammatory drug sulindac causes down-regulation of signal transducer and activator of transcription 3 in human oral squamous cell carcinoma cells.
Nikitakis, N. G., Hamburger, A. W., & Sauk, J. J. (2002) · PubMed · Cited by 32
Pharmacological updates of nifuroxazide: Promising preclinical effects and the underlying molecular mechanisms
Althagafy, H. S., El‐Aziz, M. K. A., Ibrahim, I. M., Abd‐alhameed, E. K., & Hassanein, E. H. M. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175776 · Cited by 35
Downregulation of signal transducer and activator of transcription 3 by sorafenib: A novel mechanism for hepatocellular carcinoma therapy
Hung, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15269 · Cited by 31
An Endoplasmic Reticulum Stress-Initiated Sphingolipid Metabolite, Ceramide-1-Phosphate, Regulates Epithelial Innate Immunity by Stimulating β-Defensin Production
Kim, Y., Park, K., Kim, J. Y., Seo, H. S., Shin, K., Lee, Y.-M., Holleran, W. M., Elias, P. M., & Uchida, Y. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00599-14 · Cited by 31
Potential Role for STAT3 Inhibitors in Glioblastoma
Jackson, C. M., Ruzevick, J., Amin, A. G., & Lim, M. K. (2012) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2012.04.002 · Cited by 31
MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling
Park, J., Kim, S., Joh, J. J., Remick, S. C., Miller, D. M., Yan, J., Kanaan, Z., Chao, J.-H., Krem, M. M., Basu, S. K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9759 · Cited by 31
Napabucasin, a novel inhibitor of STAT3, inhibits growth and synergises with doxorubicin in diffuse large B-cell lymphoma
Li, X., Wei, Y., & Wei, X. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.07.032 · Cited by 32
Organogenesis and tumorigenesis: Insight from the JAK/STAT pathway in the Drosophila eye
Wang, Y., & Huang, M. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22394 · Cited by 31
Deregulation of Interferon Signaling in Malignant Cells
Katsoulidis, E., Kaur, S., & Platanias, L. C. (2010) · Pharmaceuticals · doi:10.3390/ph3020406 · Cited by 39
Matrine suppresses cell growth of human chronic myeloid leukemia cells via its inhibition of the interleukin-6/Janus activated kinase/signal transducer and activator of transcription 3 signaling cohort
Ma, L., Zhu, Z., Jiang, L., Sun, X. Y., Lu, X., Zhou, M., Qian, S., & Li, J. (2015) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1007507 · Cited by 31
Multiparametric Flow Cytometric Analysis of Signal Transducer and Activator of Transcription 5 Phosphorylation in Immune Cell SubsetsIn vitroand following Interleukin-2 Immunotherapy
Varker, K. A., Kondadasula, S. V., Go, M. R., Lesinski, G. B., Ghosh-Berkebile, R., Lehman, A., Monk, J. P., Olencki, T. E., Kendra, K. L., & Carson, W. E. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1159 · Cited by 31
A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells
Sam, M., Elliott, B. E., & Mueller, C. R. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-69 · Cited by 31
Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity
Tarayrah, L., Li, Y., Gan, Q., & Chen, X. (2015) · Biology Open · doi:10.1242/bio.013961 · Cited by 31
Advances in Gene Therapy for Malignant Melanoma
Sotomayor, M. G., Yu, H., Antonia, S. J., Sotomayor, E. M., & Pardoll, D. M. (2002) · Cancer Control · doi:10.1177/107327480200900106 · Cited by 31
Antiapoptotic Signaling Pathways in Non–Small-Cell Lung Cancer: Biology and Therapeutic Strategies
Haura, E. B., Cress, W. D., Chellappan, S., Zheng, Z., & Bepler, G. (2004) · Clinical Lung Cancer · doi:10.3816/clc.2004.n.025 · Cited by 31
Integrin β3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3
Bhattacharya, S., Ray, R. M., & Johnson, L. R. (2006) · Biochemical Journal · doi:10.1042/bj20060256 · Cited by 31
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling
Lai, M.-J., Lee, H., Chuang, H., Chang, L., Tsai, A.-C., Chen, M.-C., Huang, H.-L., Wu, Y., Teng, C., Pan, S., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00659 · Cited by 30
STAT signaling in Dictyostelium development
Kawata, T. (2011) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2010.01243.x · Cited by 30
Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway
Obchoei, S., Sawanyawisuth, K., Wongkham, C., Kasinrerk, W., Yao, Q. C., Chen, C., & Wongkham, S. (2014) · Tumor Biology · doi:10.1007/s13277-014-2691-5 · Cited by 30
STAT3 Polymorphism Can Predict the Response to Interferon-α Therapy in Patients with Metastatic Renal Cell Carcinoma
Eto, M., Kamba, T., Miyake, H., Fujisawa, M., Kamai, T., Uemura, H., Tsukamoto, T., Azuma, H., Matsubara, A., Nishimura, K., et al. (2012) · European Urology · doi:10.1016/j.eururo.2012.09.052 · Cited by 30
In silico analysis of indole-3-carbinol and its metabolite DIM as EGFR tyrosine kinase inhibitors in platinum resistant ovarian cancer vis a vis ADME/T property analysis
Dash, R., Hosen, S. M. Z., Karim, M. R., Kabir, M. S. H., Hossain, M., Junaid, M., Islam, A., Paul, A., & Khan, M. F. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.501112 · Cited by 30
A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway
Zhang, Z., Mao, H., Du, X., Zhu, J., Xu, Y., Wang, S., Xu, X., Ji, P., Yu, Y., Cao, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6974 · Cited by 30
Hepatitis B virus X protein–induced SH2 domain–containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5–transketolase interaction
Zheng, Y., Ming, P., Zhu, C., Si, Y., Xu, S., Chen, A., Wang, J., & Zhang, B. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005739 · Cited by 30
Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential
Vempati, S., Reindl, C., Kaza, S. K., Kern, R., Malamoussi, T., Dugas, M., Mellert, G., Schnittger, S., Hiddemann, W., & Spiekermann, K. (2007) · Blood · doi:10.1182/blood-2006-10-053181 · Cited by 33
Binding Modes of Peptidomimetics Designed to Inhibit STAT3
Dhanik, A., McMurray, J. S., & Kavraki, L. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051603 · Cited by 29
The role of constitutively activated STAT3 in B16 melanoma cells
Pfeffer, L. M., Yang, C. H., Fan, M., & Yue, J. (2010) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s6657 · Cited by 28
Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance
Wolf, S. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i2.156 · Cited by 30
Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices
Chan, H. Y., Siu, M. K. Y., Zhang, H. J., Wong, E., Ngan, H., Chan, K. Y. K., & Cheung, A. (2008) · Histopathology · doi:10.1111/j.1365-2559.2008.03089.x · Cited by 31
Mutant p53 (G199V) Gains Antiapoptotic Function through Signal Transducer and Activator of Transcription 3 in Anaplastic Thyroid Cancer Cells
Kim, T. H., Lee, S. Y., Rho, J. H., Jeong, N. Y., Soung, Y. H., Jo, W. S., Kang, D.-Y., Kim, S.-H., & Yoo, Y. H. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0117 · Cited by 30
Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents
Maruoka, T., Kitanaka, A., Kubota, Y., Yamaoka, G., Kameda, T., Imataki, O., Dobashi, H., Bandoh, S., Kadowaki, N., & Tanaka, T. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4314 · Cited by 30
Molecular Biology of Oral Cavity Squamous Cell Carcinoma
Kupferman, M. E., & Myers, J. N. (2006) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2005.11.003 · Cited by 28
Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction
Mukherjee, T., Schäfer, U., & Zeidler, M. P. (2005) · Genetics · doi:10.1534/genetics.105.046904 · Cited by 30
The human hepatocyte growth factor (HGF) gene is transcriptionally activated by leukemia inhibitory factor through the Stat binding element
Tomida, M., & Saito, T. (2003) · Oncogene · doi:10.1038/sj.onc.1207190 · Cited by 31
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells
Anagnostopoulou, A., Vultur, A., Arulanandam, R., Cao, J., Turkson, J., Jove, R., Kim, J. S., Glenn, M. P., Hamilton, A. D., & Raptis, L. H. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.10.047 · Cited by 29
Self-citation
Through Induction of Juxtaposition and Tyrosine Kinase Activity of Jak1, X-Gene Product of Hepatitis B Virus Stimulates Ras and the Transcriptional Activation through AP-1, NF-κB, and SRE Enhancers
Kim, H., Lee, Y., Won, J., & Yun, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5496 · Cited by 30
Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of Interleukin 10 Receptor and CD20: Implications for Adjuvant Therapies
Yu, D., Dews, M., Park, A., Tobias, J. W., & Thomas‐Tikhonenko, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4197 · Cited by 34
Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia
Martínez‐Lostao, L., Briones, J., Forné, I., Martínez‐Gallo, M., Ferrer, B., Sierra, J., Rodriguez-Sanchez, J. L., & Juárez, C. (2004) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190400018398 · Cited by 29
Preclinical development and clinical studies of targeted JAK/STAT combined Anti-PD-1/PD-L1 therapy
Chen, M., & Wang, S.-L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111717 · Cited by 29
Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure
Zhu, X., Yuan, R., Hood, L., & Ao, P. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.01.004 · Cited by 29
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Chen, J. L., Li, J., Stadler, W. M., & Lussier, Y. A. (2011) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000178 · Cited by 29
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma
Miklóssy, G., Youn, U. J., Yue, P., Zhang, M., Chen, C.-H., Hilliard, T. S., Paladino, D., Li, Y., Choi, J. C.-B., Sarkaria, J. N., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00686 · Cited by 29
Self-citation
STAT3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure
Liu, X. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.147 · Cited by 33
Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer
Haviland, R., Eschrich, S., Bloom, G., Ma, Y., Minton, S., Jove, R., & Cress, W. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024923 · Cited by 19
Self-citation

Authors: Bowman, T., Garcia, R., Turkson, J., & Jove, R.
Affiliations: Moffitt Cancer Center (US)
University of South Florida (US)
ORCID: Turkson, James
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2474-2488
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203527
OpenAlex: W2024282024
Cited by: 1,743
References: 152
Citations by year: 2026: 16 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 39 · 2021: 48 · 2020: 44 · 2019: 45 · 2018: 59 · 2017: 63 · 2016: 58 · 2015: 104 · 2014: 80 · 2013: 82 · 2012: 89
FWCI: 7.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT, signal transducer and activator of transcription, carcinogenesis, STAT3, STAT5, malignant transformation, cytokine signaling, cell proliferation, apoptosis, cancer therapy targets, cancer cell lines
MeSH terms: Animals, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Neoplasms, Phosphorylation, Phosphoserine, Protein-Tyrosine Kinases, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Neoplastic, STAT1 Transcription Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

STATs in oncogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks