Cited by 1,743Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.

STATs in oncogenesis

Bowman, Tammy, Garcia, Roy, Turkson, James, Jove, Richard·2000·Oncogene

DOI 10.1038/sj.onc.1203527

Open this paper in CoChat — free account

Abstract

Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs). In addition to their central roles in normal cell signaling, recent studies have demonstrated that diverse oncoproteins can activate specific STATs (particularly Stat3 and Stat5) and that constitutively-activated STAT signaling directly contributes to oncogenesis. Furthermore, extensive surveys of primary tumors and cell lines derived from tumors indicate that inappropriate activation of specific STATs occurs with surprisingly high frequency in a wide variety of human cancers. Together, these findings provide compelling evidence that aberrant STAT activation associated with oncogenesis is not merely adventitious but instead contributes to the process of malignant transformation. These studies are beginning to reveal the molecular mechanisms leading to STAT activation in the context of oncogenesis, and candidate genes regulated by STATs that may contribute to oncogenesis are being identified. Recent studies suggest that activated STAT signaling participates in oncogenesis by stimulating cell proliferation and preventing apoptosis. This review presents the evidence for critical roles of STATs in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling. Oncogene (2000).

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1203527

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Druker, B. J., Tamura, S., Buchdunger, E., Ohno-Jones, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. (1996) · Nature Medicine · doi:10.1038/nm0596-561 · Cited by 3,652
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656

Show all 152 references

Research works printed but not linked: 7

Gouilleux-Gruart V, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, Weber-Nordt R, Dusanter-Fourt I, Dreyfus F, Groner B and Prin L . 1996 Blood 87: 1692–1697 · DOI
Hallek M, Leif Bergsagel P and Anderson KC . 1998 Blood 91: 3–21 · DOI
Ho JM, Beattie BK, Squire JA, Frank DA and Barber DL . 1999 Blood 93: 4354–4364 · DOI
Liu RY, Fan C, Garcia R, Jove R and Zuckerman KS . 1999 Blood 93: 2369–2379 · DOI
Skorski T, Nieborowska-Skorska M, Wlodarski P, Wasik M, Trotta R, Kanakaraj P, Salomoni P, Antonyak M, Martinez R, Majewski M, Wong A, Perussia B and Calabretta B . 1998 Blood 91: 406–418 · DOI
Sun WH, Pabon C, Alsayed Y, Huang PP, Jandeska S, Uddin S, Platanias LC and Rosen ST . 1998 Blood 91: 570–576 · DOI
Wang YH, Wharton W, Garcia R, Kraker A, Jove R and Pledger WJ . 2000 Oncogene in press

Sorted by citations

Items 301–400 of 999

RETRACTED: STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells
Fofaria, N. M., & Srivastava, S. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu233 · Cited by 132
Retracted
Adipose Tissue, Obesity and Adiponectin: Role in Endocrine Cancer Risk
Tumminia, A., Vinciguerra, F., Parisi, M., Graziano, M., Sciacca, L., Baratta, R., & Frittitta, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122863 · Cited by 132
Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3
Ren, Z., Cabell, L. A., Schaefer, T. S., & McMurray, J. S. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)01050-8 · Cited by 128
MiR-130b Is a Prognostic Marker and Inhibits Cell Proliferation and Invasion in Pancreatic Cancer through Targeting STAT3
Zhao, G., Zhang, J., Shi, Y., Qin, Q., Liu, Y., Wang, B., Tian, K., Deng, S., Li, X., Zhu, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073803 · Cited by 129
Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth
Lin, A., Schildknecht, A., Nguyen, L. T., & Ohashi, P. S. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.09.003 · Cited by 127
Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3
Mandal, P. K., Gao, F., Lü, Z., Ren, Z., Ramesh, R., Birtwistle, J. S., Kaluarachchi, K., Chen, X., Bast, R. C., Liao, W. S. ‐., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2000882 · Cited by 130
STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment
Laudisi, F., Cherubini, F., Monteleone, G., & Stolfi, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061787 · Cited by 133
The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion
Wright, J. H., Wang, X., Manning, G., LaMere, B. J., Le, P., Zhu, S., Khatry, D., Flanagan, P. M., Buckley, S. D., Whyte, D. B., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.6.2068-2082.2003 · Cited by 126
Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor
Coleman, Ren, Z., Mandal, P. K., Cameron, A. G., Dyer, G. A., Muranjan, S., Campbell, M. L., Chen, X., & McMurray, J. S. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050513m · Cited by 128
STAT3 expression in gastric cancer indicates a poor prognosis
Kim, D., Cha, S., Ahn, D., Kang, H., Kwon, C., Ko, K., Hwang, S., Park, P. J., Rim, K., & Hong, S. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05671.x · Cited by 125
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
Walker, S. R., Nelson, E. A., & Frank, D. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209775 · Cited by 125
Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis
Shah, N. G., Trivedi, T. I., Tankshali, R. A., Goswami, J. V., Jetly, D., Shukla, S. N., Shah, P. M., & Verma, R. J. (2009) · Head & Neck · doi:10.1002/hed.21126 · Cited by 124
Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
Huang, M., Dorsey, J. F., Epling‐Burnette, P. K., Nimmanapalli, R., Landowski, T. H., Mora, L. B., Niu, G., Sinibaldi, D., Bai, F., Kraker, A. J., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1206028 · Cited by 126
Self-citation
Antagonizing STAT3 Dimerization with a Rhodium(III) Complex
Ma, D., Liu, L., Leung, K., Chen, Y., Zhong, H., Chan, D. S., Wang, H., & Leung, C. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404686 · Cited by 125
A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion
Huang, W., Dong, Z., Wang, F., Peng, H., Liu, J., & Zhang, J. (2014) · ACS Chemical Biology · doi:10.1021/cb500071v · Cited by 125
VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance
Lee, Y. K., Shanafelt, T. D., Bone, N. D., Strege, A. K., Jelinek, D. F., & Kay, N. E. (2005) · Leukemia · doi:10.1038/sj.leu.2403667 · Cited by 125
Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents
Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q., & Zhou, J. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3003082 · Cited by 121
STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination
Jung, J. E., Kim, H. S., Lee, C. S., Shin, Y., Kim, Y.-N., Kang, G. H., Kim, T.-Y., Juhnn, Y., Kim, S. J., Park, J., et al. (2008) · Experimental & Molecular Medicine · doi:10.3858/emm.2008.40.5.479 · Cited by 126
FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease
Huang, F., Wang, Q., Guo, F., Zhao, Y., Ji, L., An, T., Song, Y., Liu, Y., He, Y., & Qin, G. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.002 · Cited by 123
Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model
Ling, X., Marini, F. C., Konopleva, M. Y., Schober, W. D., Shi, Y., Burks, J. K., Clise-Dwyer, K., Wang, R., Zhang, W., Yuan, X., et al. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0041-8 · Cited by 122
Regulation of Cell Proliferation, Apoptosis, and Transcription Factor Activities during the Promotion of Liver Carcinogenesis by Polychlorinated Biphenyls
Tharappel, J. C., Lee, E. Y., Robertson, L. W., Spear, B. T., & Glauert, H. P. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9360 · Cited by 120
RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth
Zhang, W., Zong, C. S., Hermanto, U., Lopez‐Bergami, P., Ronai, Z. A., & Wang, L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.413-424.2006 · Cited by 124
Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma
Ma, X.-T. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i11.1569 · Cited by 118
Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3
Ahmad, R., Raina, D., Meyer, C., & Kufe, D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3036 · Cited by 120
The combination of curcumin and 5-fluorouracil in cancer therapy
Wei, Y., Yang, P., Cao, S., & Zhao, L. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0979-x · Cited by 122
Auranofin blocks interleukin‐6 signalling by inhibiting phosphorylation of JAK1 and STAT3
Kim, N.-H., Lee, M.-Y., Park, S.-J., Choi, J.-S., Oh, M.-K., & Kim, I.-S. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02679.x · Cited by 125
Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3
Miyazaki, T., Bub, J. D., Uzuki, M., & Iwamoto, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.076 · Cited by 118
Tip60 Is a Co-repressor for STAT3
Xiao, H., Chung, J., Kao, H., & Yang, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210816200 · Cited by 122
Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.
Iavnilovitch, E., Groner, B., & Barash, I. (2002) · PubMed · Cited by 117
HTLV-1 p12I protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells
Nicot, C., Mulloy, J. C., Ferrari, M. G., Johnson, J. M., Fu, K., Fukumoto, R., Trovato, R., Fullen, J., Leonard, W. J., & Franchini, G. (2001) · Blood · doi:10.1182/blood.v98.3.823 · Cited by 116
Molecular aspects of development and regulation of endometriosis
Aznaurova, Y. B., M.B.Zhumataev, M. B. Z., Roberts, T. K., Aliper, A. M., & Zhavoronkov, A. A. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-50 · Cited by 116
Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1
Pandey, M. K., Sung, B., Ahn, K. S., & Aggarwal, B. B. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.052548 · Cited by 118
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells
Vultur, A., Cao, J., Arulanandam, R., Turkson, J., Jove, R., Greer, P. A., Craig, A. W., Elliott, B. E., & Raptis, L. H. (2004) · Oncogene · doi:10.1038/sj.onc.1207378 · Cited by 116
Self-citation
NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma
Han, S., Yun, H., Son, D.-J., Tompkins, V. S., Peng, L., Chung, S.-T., Kim, J., Park, E.-S., & Janz, S. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-97 · Cited by 120
Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas
Lee, T., Yeh, J., Waes, C. V., & Chen, Z. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0069 · Cited by 115
Cyclin D1 Represses STAT3 Activation through a Cdk4-independent Mechanism
Bienvenu, F., Gascan, H., & Coqueret, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100795200 · Cited by 115
Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines
Fossey, S. L., Bear, M. D., Kisseberth, W. C., Pennell, M. L., & London, C. A. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-125 · Cited by 115
Targeting constitutive and interleukin‐6‐inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)
Chakravarti, N., Myers, J. N., & Aggarwal, B. B. (2006) · International Journal of Cancer · doi:10.1002/ijc.21967 · Cited by 115
STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma
Coppo, P., Gouilleux‐Gruart, V., Huang, Y., Bouhlal, H., Bouamar, H., Bouchet, S., Perrot, C., Vieillard, V., Dartigues, P., Gaulard, P., et al. (2009) · Leukemia · doi:10.1038/leu.2009.91 · Cited by 116
Activation of Stat‐3 as one of the early events in tobacco chewing‐mediated oral carcinogenesis
Nagpal, J. K., Mishra, R., & Das, B. R. (2002) · Cancer · doi:10.1002/cncr.10499 · Cited by 113
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation
Laßmann, S., Schuster, I., Walch, A. K., Göbel, H., Jütting, U., Makowiec, F., Hopt, U. T., & Werner, M. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.035113 · Cited by 114
Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis
Kim, D. J., Chan, K. S., Sano, S., & DiGiovanni, J. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20342 · Cited by 115
Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1
Kunnumakkara, A. B., Nair, S. A., Sung, B., Pandey, M. K., & Aggarwal, B. B. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0154 · Cited by 115
Retracted
Role of let-7 family microRNA in breast cancer
Thammaiah, C. K., & Jayaram, S. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.10.003 · Cited by 113
A catch‐22: Interleukin‐22 and cancer
Hernández, P. P., Gronke, K., & Diefenbach, A. (2017) · European Journal of Immunology · doi:10.1002/eji.201747183 · Cited by 117
SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia
Chen, C., Tsay, W., Tang, J., Shen, H.-L., Lin, S., Huang, S., Yao, M., Chen, Y., Shen, M.-C., Wang, C., et al. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10222 · Cited by 113
Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis
Cai, D., Cao, J., Li, Z., Zheng, X., Yao, Y., Li, W., & Yuan, Z. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-102 · Cited by 112
Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis
Chan, K. S., Sano, S., Kataoka, K., Abel, E. L., Carbajal, S., Beltrán, L., Clifford, J. L., Peavey, M. C., Shen, J., & DiGiovanni, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210726 · Cited by 112
Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells
Simon, A. R., Takahashi, S., Severgnini, M., Fanburg, B. L., & Cochran, B. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00315.2001 · Cited by 115
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer‐derived CD133‐positive cells
Hsu, H., Huang, P., Chang, Y., Tzao, C., Chen, Y., Shih, H., Hung, S., Chen, Y., Tseng, L., & Chiou, S. (2011) · Cancer · doi:10.1002/cncr.25869 · Cited by 113
LIV-1 Promotes Prostate Cancer Epithelial-to-Mesenchymal Transition and Metastasis through HB-EGF Shedding and EGFR-Mediated ERK Signaling
Lue, H.-W., Yang, X., Wang, R., Qian, W., Xu, R. Z. H., Lyles, R. H., Osunkoya, A. O., Zhou, B. P., Vessella, R. L., Zayzafoon, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027720 · Cited by 112
Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian cancer via regulation of the STAT3 and PI3K/Akt signaling pathways
Zhou, B., Sun, C., Li, N., Shan, W., Lü, H., Guo, L., Guo, E., Xia, M., WENG, D., Li, M., et al. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3442 · Cited by 108
Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects
Burdelya, L., Kujawski, M., Niu, G., Zhong, B., Wang, T., Zhang, S., Kortylewski, M., Shain, K., Kay, H., Djeu, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.3925 · Cited by 131
Emerging drugs to treat squamous cell carcinomas of the head and neck
Fung, C., & Grandis, J. R. (2010) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2010.497754 · Cited by 110
STATs: An Old Story, Yet Mesmerizing.
Abroun, S., Saki, N., Ahmadvand, M., Asghari, F., Salari, F., & Rahim, F. (2015) · PubMed Central · doi:10.22074/cellj.2015.1 · Cited by 139
Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth.
Rivat, C., Rivat, C., Rodrigues-Ferreira, S., Rodrigues, S., Bruyneel, E. A., Erik, B., Piétu, G., Piétu, G., Robert, A., Amélie, R., et al. (2005) · PubMed · Cited by 110
Signal Transducers and Activators of Transcription-3 Binding to the Fibroblast Growth Factor Receptor Is Activated by Receptor Amplification
Dudka, A. A., Sweet, S. M. M., & Heath, J. K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3033 · Cited by 116
Antagonizing STAT3 Dimerization with a Rhodium(III) Complex
Ma, D., Liu, L., Leung, K., Chen, Y., Zhong, H., Chan, D. S., Wang, H., & Leung, C. (2014) · Angewandte Chemie · doi:10.1002/ange.201404686 · Cited by 109
A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3
Schust, J., & Berg, T. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.03.024 · Cited by 109
Loss of Stat5a delays mammary cancer progression in a mouse model
Ren, S. V., Cai, H. R., Li, M., & Furth, P. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205484 · Cited by 109
Mesothelin-Induced Pancreatic Cancer Cell Proliferation Involves Alteration of Cyclin E via Activation of Signal Transducer and Activator of Transcription Protein 3
Bharadwaj, U., Li, M., Chen, C., & Yao, Q. C. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0095 · Cited by 109
The Hepatitis E Virus ORF3 Protein Modulates Epidermal Growth Factor Receptor Trafficking, STAT3 Translocation, and the Acute-Phase Response
Chandra, V. K., Kar-Roy, A., Kumari, S., Mayor, S., & Jameel, S. (2008) · Journal of Virology · doi:10.1128/jvi.00403-08 · Cited by 108
Phase I study of OPB ‐51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies
Ogura, M., Uchida, T., Terui, Y., Hayakawa, F., Kobayashi, Y., Taniwaki, M., Takamatsu, Y., Naoe, T., Tobinai, K., Munakata, W., et al. (2015) · Cancer Science · doi:10.1111/cas.12683 · Cited by 110
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP‐1 in human multiple myeloma cells
Pandey, M. K., Sung, B., & Aggarwal, B. B. (2009) · International Journal of Cancer · doi:10.1002/ijc.25059 · Cited by 105
Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer
Sasi, W., Jiang, W. G., Sharma, A. K., & Mokbel, K. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-178 · Cited by 107
Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
Dai, X., Ahn, K. S., Kim, C., Siveen, K. S., Ong, T. H., Shanmugam, M. K., Li, F., Shi, J., Kumar, A. P., Wang, L. Z., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2014.12.008 · Cited by 107
H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17
Huang, Z., Lei, W., Hu, H., Zhang, H., & Zhu, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26530 · Cited by 107
Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer.
Widschwendter, A., Geymayer, S., Welte, T., Daxenbichler, G., Marth, C., & Doppler, W. (2002) · PubMed · Cited by 107
Opposite Regulation of Myc and p21 Transcription by STAT3 Proteins
Barré, B., Avril, S., & Coqueret, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210422200 · Cited by 108
Retracted
TPCA-1 Is a Direct Dual Inhibitor of STAT3 and NF-κB and Regresses Mutant EGFR-Associated Human Non–Small Cell Lung Cancers
Jing, N., Du, Y., Chen, X., Bai, Q., Wang, Y., Zhang, X., Zhu, N., Zhang, J., Hou, J., Wang, Q. L., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0464 · Cited by 109
Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity
Lufei, C., Koh, T. H., Uchida, T., & Cao, X. (2007) · Oncogene · doi:10.1038/sj.onc.1210567 · Cited by 106
Trophoblast invasion: tuning through LIF, signalling via Stat3
Poehlmann, T. G., Fitzgerald, J. S., Meißner, A., Wengenmayer, T., Schleußner, E., Friedrich, K., & Markert, U. R. (2005) · Placenta · doi:10.1016/j.placenta.2005.01.007 · Cited by 110
Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer
Höpfner, M., Schuppan, D., & Scherübl, H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.1 · Cited by 106
Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes
Macias, E., Rao, D., Carbajal, S., Kiguchi, K., & DiGiovanni, J. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.68 · Cited by 105
Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways
Pratheeshkumar, P., Son, Y., Divya, S. P., Roy, R. V., Hitron, J. A., Wang, L., Kim, D., Dai, J., Asha, P., Zhang, Z., et al. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.10.008 · Cited by 106
Molecular mechanisms involved in dendritic cell dysfunction in cancer
Tang, M., Diao, J., & Cattral, M. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2317-8 · Cited by 106
Interleukin 21: a cytokine/cytokine receptor system that has come of age
Leonard, W. J., Zeng, R., & Spolski, R. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0308149 · Cited by 122
KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway
Burger, M., Hartmann, T. N., Burger, J. A., & Schraufstätter, I. U. (2005) · Oncogene · doi:10.1038/sj.onc.1208442 · Cited by 101
Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein
Fletcher, S., Turkson, J., & Gunning, P. T. (2008) · ChemMedChem · doi:10.1002/cmdc.200800123 · Cited by 105
Self-citation
Signal transducer and activator of transcription 3 inhibitors: a patent review
Page, B. D. G., Ball, D. P., & Gunning, P. T. (2010) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.539205 · Cited by 103
Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
Chen, C.-L., Cen, L., Kohout, J., Hutzen, B., Chan, C., Hsieh, F.-C., Loy, A., Huang, V., Cheng, G., & Lin, J. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-78 · Cited by 125
Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
Wheeler, S., Suzuki, S., Thomas, S. M., Sen, M., Leeman‐Neill, R. J., Chiosea, S. I., Kuan, C.-T., Bigner, D. D., Gooding, W. E., Lai, S. Y., et al. (2010) · Oncogene · doi:10.1038/onc.2009.279 · Cited by 102
Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
Um, H. J., Min, K., Kim, D., & Kwon, T. K. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.08.133 · Cited by 102
MEN2A-RET-induced cellular transformation by activation of STAT3
Schuringa, J. J., Wojtachnio, K., Hagens, W. I., Vellenga, E., Buys, C. H. C. M., Hofstra, R. M. W., & Kruijer, W. (2001) · Oncogene · doi:10.1038/sj.onc.1204715 · Cited by 104
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Ren, Z. J., & Schaefer, T. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112438200 · Cited by 102
Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines
Li, L., & Shaw, P. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109962200 · Cited by 102
RARAfusion genes in acute promyelocytic leukemia: a review
Braekeleer, E. D., Douet‐Guilbert, N., & Braekeleer, M. D. (2014) · Expert Review of Hematology · doi:10.1586/17474086.2014.903794 · Cited by 107
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
Aksamitiene, E., Kholodenko, B. Ν., Kölch, W., Hoek, J. B., & Kiyatkin, A. B. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.05.006 · Cited by 102
Implication of STAT3 Signaling in Human Colonic Cancer Cells during Intestinal Trefoil Factor 3 (TFF3) – and Vascular Endothelial Growth Factor–Mediated Cellular Invasion and Tumor Growth
Rivat, C., Rodrigues-Ferreira, S., Erik, B., Piétu, G., Amélie, R., Redeuilh, G., Bracke, M., Gespach, C. P., & Attoub, S. (2005) · Cancer Research · doi:10.1158/0008-5472.195.65.1 · Cited by 122
Signal Transducer and Activator of Transcription 3 Is a Key Regulator of Keratinocyte Survival and Proliferation following UV Irradiation
Sano, S., Chan, K. S., Kira, M., Kataoka, K., Takagi, S., Tarutani, M., Itami, S., Kiguchi, K., Yokoi, M., Sugasawa, K., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4359 · Cited by 102
MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop
Ahmad, R., Rajabi, H. N., Kosugi, M., Joshi, M. D., Alam, M., Vasir, B., Kawano, T., Kharbanda, S. M., & Kufe, D. W. (2011) · Science Signaling · doi:10.1126/scisignal.2001426 · Cited by 105
Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells
Sakaguchi, M., Oka, M., Iwasaki, T., Fukami, Y., & Nishigori, C. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.45 · Cited by 103
Dasatinib: An Anti-Tumour Agent via Src Inhibition
Gnoni, A., Marech, I., Silvestris, N., Vacca, A., & Lorusso, V. (2011) · Current Drug Targets · doi:10.2174/138945011794751591 · Cited by 103
MSCs inhibit tumor progression and enhance radiosensitivity of breast cancer cells by down-regulating Stat3 signaling pathway
He, N., Kong, Y., Lei, X., Liu, Y., Wang, J., Xu, C., Wang, Y., Du, L., Ji, K., wang, Q., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0949-3 · Cited by 103
Honokiol inhibits epithelial—mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E‐cadherin axis
Avtanski, D. B., Nagalingam, A., Bonner, M. Y., Arbiser, J. L., Saxena, N. K., & Sharma, D. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.01.004 · Cited by 100
p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3
Lin, J., Tang, H., Jin, X., Jia, G., & Hsieh, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205426 · Cited by 101
Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX
Teng, T., Lin, B., Manser, E., Ng, D. C. H., & Cao, X. (2009) · Journal of Cell Science · doi:10.1242/jcs.057109 · Cited by 99
Intracellular signaling network as a prime chemopreventive target of (–)‐epigallocatechin gallate
Na, H., & Surh, Y. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500154 · Cited by 98
Cucurmin, anticancer, & antitumor perspectives: A comprehensive review
Imran, M., Ullah, A., Saeed, F., Nadeem, M., Arshad, M. U., & Suleria, H. A. R. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1252711 · Cited by 101
Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid
Galadari, S., Rahman, A. U., Pallichankandy, S., & Thayyullathil, F. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.08.006 · Cited by 97

Authors: Bowman, T., Garcia, R., Turkson, J., & Jove, R.
Affiliations: Moffitt Cancer Center (US)
University of South Florida (US)
ORCID: Turkson, James
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2474-2488
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203527
OpenAlex: W2024282024
Cited by: 1,743
References: 152
Citations by year: 2026: 16 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 39 · 2021: 48 · 2020: 44 · 2019: 45 · 2018: 59 · 2017: 63 · 2016: 58 · 2015: 104 · 2014: 80 · 2013: 82 · 2012: 89
FWCI: 7.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT, signal transducer and activator of transcription, carcinogenesis, STAT3, STAT5, malignant transformation, cytokine signaling, cell proliferation, apoptosis, cancer therapy targets, cancer cell lines
MeSH terms: Animals, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Neoplasms, Phosphorylation, Phosphoserine, Protein-Tyrosine Kinases, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Neoplastic, STAT1 Transcription Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

STATs in oncogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks