Cited by 1,743Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

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STATs in oncogenesis

Bowman, Tammy, Garcia, Roy, Turkson, James, Jove, Richard·2000·Oncogene

DOI 10.1038/sj.onc.1203527

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Abstract

Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs). In addition to their central roles in normal cell signaling, recent studies have demonstrated that diverse oncoproteins can activate specific STATs (particularly Stat3 and Stat5) and that constitutively-activated STAT signaling directly contributes to oncogenesis. Furthermore, extensive surveys of primary tumors and cell lines derived from tumors indicate that inappropriate activation of specific STATs occurs with surprisingly high frequency in a wide variety of human cancers. Together, these findings provide compelling evidence that aberrant STAT activation associated with oncogenesis is not merely adventitious but instead contributes to the process of malignant transformation. These studies are beginning to reveal the molecular mechanisms leading to STAT activation in the context of oncogenesis, and candidate genes regulated by STATs that may contribute to oncogenesis are being identified. Recent studies suggest that activated STAT signaling participates in oncogenesis by stimulating cell proliferation and preventing apoptosis. This review presents the evidence for critical roles of STATs in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling. Oncogene (2000).

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Authors: Bowman, T., Garcia, R., Turkson, J., & Jove, R.
Affiliations: Moffitt Cancer Center (US)
University of South Florida (US)
ORCID: Turkson, James
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2474-2488
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203527
OpenAlex: W2024282024
Cited by: 1,743
References: 152
Citations by year: 2026: 16 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 39 · 2021: 48 · 2020: 44 · 2019: 45 · 2018: 59 · 2017: 63 · 2016: 58 · 2015: 104 · 2014: 80 · 2013: 82 · 2012: 89
FWCI: 7.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT, signal transducer and activator of transcription, carcinogenesis, STAT3, STAT5, malignant transformation, cytokine signaling, cell proliferation, apoptosis, cancer therapy targets, cancer cell lines
MeSH terms: Animals, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Neoplasms, Phosphorylation, Phosphoserine, Protein-Tyrosine Kinases, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Neoplastic, STAT1 Transcription Factor

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