Cited by 1,743Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

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STATs in oncogenesis

Bowman, Tammy, Garcia, Roy, Turkson, James, Jove, Richard·2000·Oncogene

DOI 10.1038/sj.onc.1203527

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Abstract

Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs). In addition to their central roles in normal cell signaling, recent studies have demonstrated that diverse oncoproteins can activate specific STATs (particularly Stat3 and Stat5) and that constitutively-activated STAT signaling directly contributes to oncogenesis. Furthermore, extensive surveys of primary tumors and cell lines derived from tumors indicate that inappropriate activation of specific STATs occurs with surprisingly high frequency in a wide variety of human cancers. Together, these findings provide compelling evidence that aberrant STAT activation associated with oncogenesis is not merely adventitious but instead contributes to the process of malignant transformation. These studies are beginning to reveal the molecular mechanisms leading to STAT activation in the context of oncogenesis, and candidate genes regulated by STATs that may contribute to oncogenesis are being identified. Recent studies suggest that activated STAT signaling participates in oncogenesis by stimulating cell proliferation and preventing apoptosis. This review presents the evidence for critical roles of STATs in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling. Oncogene (2000).

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CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Druker, B. J., Tamura, S., Buchdunger, E., Ohno-Jones, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. (1996) · Nature Medicine · doi:10.1038/nm0596-561 · Cited by 3,652
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80011-4 · Cited by 1,638
Self-citation
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600
Essential role of Stat6 in IL-4 signalling
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
gp 130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES
Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,468
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465
A new protein containing an SH2 domain that inhibits JAK kinases
Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature · doi:10.1038/43213 · Cited by 1,408
New functional activities for the p21 family of CDK inhibitors.
LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., & Harlow, E. (1997) · Genes & Development · doi:10.1101/gad.11.7.847 · Cited by 1,402
STATs: Signal Transducers and Activators of Transcription
Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3801 · Cited by 1,323
Cytokine signal transduction
Kishimoto, T., Taga, T., & Akira, S. (1994) · Cell · doi:10.1016/0092-8674(94)90333-6 · Cited by 1,318
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Shimoda, K., van Deursent, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., et al. (1996) · Nature · doi:10.1038/380630a0 · Cited by 1,278
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Teglund, S., McKay, C., Schuetz, E. G., van Deursen, J. M., Stravopodis, D. J., Wang, D., Brown, M. P., Bodner, S. M., Grosveld, G. C., & Ihle, J. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81444-0 · Cited by 1,266
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
Kaplan, M. H., Sun, Y.-L., Hoey, T., & Grusby, M. J. (1996) · Nature · doi:10.1038/382174a0 · Cited by 1,240
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A., Sarawar, S. R., Carson, R. T., Sangster, M. Y., Vignali, D. A. A., Doherty, P. C., Grosveld, G. C., et al. (1996) · Nature · doi:10.1038/382171a0 · Cited by 1,183
Stat5a is mandatory for adult mammary gland development and lactogenesis.
Liu, X., Robinson, G. W., Wagner, K. U., Garrett, L., Wynshaw-Boris, A., & Hennighausen, L. (1997) · Genes & Development · doi:10.1101/gad.11.2.179 · Cited by 1,111
Structure and function of a new STAT-induced STAT inhibitor
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,040
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
Udy, G. B., Towers, R. P., Snell, R. G., Wilkins, R. J., Park, S.-H., Ram, P. A., Waxman, D. J., & Davey, H. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7239 · Cited by 991
Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein
Yu, C.-L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., & Jove, R. (1995) · Science · doi:10.1126/science.7541555 · Cited by 931
Self-citation
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
Meydan, N., Grunberger, T., Dadi, H., Shahar, M., Arpaia, E., Lapidot, Z., Leeder, J. S., Freedman, M. H., Cohen, A., Gazit, A., et al. (1996) · Nature · doi:10.1038/379645a0 · Cited by 896
Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 WAF1/CIP1 Mediated by STAT1
Chin, Y. E., Kitagawa, M., Su, W., You, Z.-H., Iwamoto, Y., & Fu, X.-Y. (1996) · Science · doi:10.1126/science.272.5262.719 · Cited by 816
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
Shuai, K., Horvath, C. M., Huang, L. H. T., Qureshi, S. A., Cowburn, D., & Darnell, J. E. (1994) · Cell · doi:10.1016/0092-8674(94)90357-3 · Cited by 807
A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase
Fry, D. W., Kraker, A. J., McMichael, A., Ambroso, L. A., Nelson, J. M., Leopold, W. R., Connors, R. W., & Bridges, A. J. (1994) · Science · doi:10.1126/science.8066447 · Cited by 806
Three-dimensional structure of the Stat3β homodimer bound to DNA
Becker, S., Groner, B., & Müller, C. W. (1998) · Nature · doi:10.1038/28101 · Cited by 802
A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia
Penard‐Lacronique, V., Boureux, A., Della-Valle, V., Poirel, H. A., Quang, C. T., Mauchauffé, M., Berthou, C., Lessard, M., Berger, R., Ghysdael, J., et al. (1997) · Science · doi:10.1126/science.278.5341.1309 · Cited by 796
Inhibition of Stat1-mediated gene activation by PIAS1
Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., & Shuai, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10626 · Cited by 765
Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging
van Lohuizen, M., Verbeek, S. J., Scheljen, B., Wientjens, E., van der Guidon, H., & Berns, A. J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90382-9 · Cited by 763
Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process
Hallek, M. J., Bergsagel, P. L., & Anderson, K. C. (1998) · Blood · doi:10.1182/blood.v91.1.3 · Cited by 750
Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA
Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J. E., Jr., & Kuriyan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81443-9 · Cited by 734
Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice
Socolovsky, M., Fallon, A. E. J., Wang, S., Brugnara, C., & Lodish, H. F. (1999) · Cell · doi:10.1016/s0092-8674(00)81013-2 · Cited by 695
A family of proteins that inhibit signalling through tyrosine kinase receptors
Kharitonenkov, A., Chen, Z., Sures, I., Wang, H., Schilling, J., & Ullrich, A. (1997) · Nature · doi:10.1038/386181a0 · Cited by 662
Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis
Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., & Hirano, T. (1996) · Immunity · doi:10.1016/s1074-7613(00)80501-4 · Cited by 652
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., & Jove, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2545 · Cited by 651
Self-citation
Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region
Cuypers, H. T. M., Selten, G. C. M., Quint, W. G. V., Zijlstra, M., Maandag, E. R., Boelens, W. C., van Wezenbeek, P. M. G. F., Melief, C. J. M., & Berns, A. J. M. (1984) · Cell · doi:10.1016/0092-8674(84)90309-x · Cited by 627
STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation
Chung, J., Uchida, E., Grammer, T. C., & Blenis, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6508 · Cited by 620
Stat3 Activation Is Required for Cellular Transformation by v- src
Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., & Darnell, J. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2553 · Cited by 614
Signaling Through the Hematopoietic Cytokine Receptors
Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., & Silvennoinen, O. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002101 · Cited by 612
Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
Migone, T.-S., Lin, J.-X., Cereseto, A., Mulloy, J. C., O'Shea, J. J., Franchini, G., & Leonard, W. J. (1995) · Science · doi:10.1126/science.7604283 · Cited by 557
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.
Bromberg, J., Horvath, C. M., Wen, Z., Schreiber, R. D., & Darnell, J. E., Jr. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7673 · Cited by 555
Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins
David, M., Petricoin, E., Benjamin, C. D., Pine, R. I., Weber, M. J., & Larner, A. C. (1995) · Science · doi:10.1126/science.7569900 · Cited by 543
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.Preprint
Horvath, C. M., Wen, Z., & Darnell, J. E., Jr. (1995) · Genes & Development · doi:10.1101/gad.9.8.984 · Cited by 537
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
Sano, S., Itami, S., Takeda, K., Tarutani, M., Yamaguchi, Y., Miura, H., Yoshikawa, K., Akira, S., & Takeda, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4657 · Cited by 519
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.
Grandis, J. R., Drenning, S. D., Chakraborty, A., Zhou, M. Y., Zeng, Q., Pitt, A. S., & Tweardy, D. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3785 · Cited by 507
P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members
Ilaria, R. L., & Etten, R. A. V. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31704 · Cited by 498
Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
van Lohuizen, M., Verbeek, S. J., Krimpenfort, P., Domen, J., Saris, C. J. M., Radaszkiewicz, T., & Berns, A. J. M. (1989) · Cell · doi:10.1016/0092-8674(89)90589-8 · Cited by 497
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A., & Kitamura, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4754 · Cited by 496
Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain
Xu, X. M., Sun, Y., & Hoey, T. (1996) · Science · doi:10.1126/science.273.5276.794 · Cited by 484
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
Carlesso, N., Frank, D. A., & Griffin, J. D. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.811 · Cited by 481
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase
Alvarez, E., Northwood, I. C., Gonzalez, F. A., Latour, D. A., Seth, A., Abate, C., Curran, T., & Davis, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98613-8 · Cited by 472
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.
Harrison, D. A., Binari, R. C., Nahreini, T. S., Gilman, M. Z., & Perrimon, N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07285.x · Cited by 469
IL‐10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3‐dependent and ‐independent pathways
O’Farrell, A.-M., Liu, Y., Moore, K. W., & Mui, A. L. ‐. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1006 · Cited by 440
Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
Shirogane, T., Fukada, T., Müller, J. M. M., Shima, D. T., Hibi, M., & Hirano, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80145-4 · Cited by 431
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.
Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Stein, R. B., & Rosen, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3041 · Cited by 415
Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation
Onishi, M., Nosaka, T., Misawa, K., Mui, A., Gorman, D. M., McMahon, M., Miyajima, A., & Kitamura, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3871 · Cited by 411
Identification of a Stat Gene That Functions in Drosophila Development
Yan, R., Small, S., Desplan, C., Dearolf, C. R., & Darnell, J. E., Jr. (1996) · Cell · doi:10.1016/s0092-8674(00)81287-8 · Cited by 409
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., & Hirano, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.63 · Cited by 401
Function of the c-Myc Oncogenic Transcription Factor
Dang, C. V., Resar, L. M. S., Emison, E. S., Kim, S., Li, Q., Prescott, J. E., Wonsey, D. R., & Zeller, K. I. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4686 · Cited by 391
Mechanisms of apoptosis avoidance in cancer
Reed, J. C. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199901000-00014 · Cited by 377
Signaling mechanisms through gp130: A model of the cytokine system
Hirano, T., Nakajima, K., & Hibi, M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)80005-1 · Cited by 375
marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs
Hou, X. S., Melnick, M. B., & Perrimon, N. (1996) · Cell · doi:10.1016/s0092-8674(00)81286-6 · Cited by 374
ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases
Olayioye, M. A., Beuvink, I., Horsch, K., Daly, J. M., & Hynes, N. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17209 · Cited by 373
STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
Caldenhoven, E., van Dijk, T. B., Solari, R., Armstrong, J., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., & de Groot, R. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13221 · Cited by 373
Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines
Cao, X., Tay, A., Guy, G. R., & Tan, Y. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1595 · Cited by 359
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice
Akira, S. (1999) · Stem Cells · doi:10.1002/stem.170138 · Cited by 350
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine‐dependent growth of hematopoietic cells
Matsumura, I., Kitamura, T., Wakao, H., Tanaka, H., Hashimoto, K., Albanese, C., Downward, J., Pestell, R. G., & Kanakura, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1367 · Cited by 332
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
Wen, Z. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.11.2062 · Cited by 330
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.
Maa, M. C., Leu, T. H., McCarley, D. J., Schatzman, R. C., & Parsons, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6981 · Cited by 330
Jak-STAT Signaling Induced by the v- abl oncogene
Danial, N. N., Pernis, A., & Rothman, P. B. (1995) · Science · doi:10.1126/science.7569929 · Cited by 325
An amino acid substitution in the Drosophila hopTum‐l Jak kinase causes leukemia‐like hematopoietic defects.
Luo, H. R., Hanratty, W. P., & Dearolf, C. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07127.x · Cited by 324
Regulation of STAT‐dependent pathways by growth factors and cytokines
Leaman, D. W., Leung, S., Li, X.-X., & Stark, G. R. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.14.9002549 · Cited by 318
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
Gouilleux-Gruart, V, Gouilleux, F., Desaint, C., Claisse, J., Capiod, J., Delobel, J., Weber-Nordt, R., Dusanter-Fourt, I., Dreyfus, F., Groner, B., et al. (1996) · Blood · doi:10.1182/blood.v87.5.1692.1692 · Cited by 316
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
Weber-Nordt, R., Egen, C., Wehinger, J., Ludwig, W. D., Gouilleux‐Gruart, V., Mertelsmann, R. H., & Finke, J. (1996) · Blood · doi:10.1182/blood.v88.3.809.809 · Cited by 314
Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
Barone, M. V., & Courtneidge, S. A. (1995) · Nature · doi:10.1038/378509a0 · Cited by 308
Negative regulation of the JAK/STAT pathway
Starr, R., & Hilton, D. J. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199901)21:1 · Cited by 287
EGF receptor in neoplasia and metastasis
Khazaie, K., Schirrmacher, V., & Lichtner, R. B. (1993) · Cancer and Metastasis Reviews · doi:10.1007/bf00665957 · Cited by 283
Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
Chai, S. K., NICHOLS, G. L., & Rothman, P. B. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.10.4720 · Cited by 281
Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines
Silva, M., Benito, A., Sanz, C., Prósper, F., Ekhterae, D., Núñez, G., & Fernández-Luna, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22165 · Cited by 277
Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis
Nieborowska-Skorska, M., Wasik, M. A., Słupianek, A., Salomoni, P., Kitamura, T., Calabretta, B., & Skórski, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.8.1229 · Cited by 275
Involvement of pp60c-src with two major signaling pathways in human breast cancer.
Luttrell, D. K., Lee, A., Lansing, T. J., Crosby, R. M., Jung, K., Willard, D., Luther, M., Rodriguez, M., Berman, J., & Gilmer, T. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.83 · Cited by 271
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
Takemoto, S., Mulloy, J. C., Cereseto, A., Migone, T.-S., Patel, B. K. R., Matsuoka, M., Yamaguchi, K., Takatsuki, K., Kamihira, S., White, J. D., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13897 · Cited by 271
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
Turkson, J., Bowman, T. L., Adnane, J., Zhang, Y., Djeu, J. Y., Sekharam, M., Frank, D. A., Holzman, L. B., Wu, J., Sebti, S. M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7519 · Cited by 259
Self-citation
Transformation of hematopoietic cell lines to growth‐factor independence and induction of a fatal myelo‐ and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
Schwaller, J., Frantsve‐Hawley, J., Aster, J. C., Williams, I. R., Tomasson, M. H., Ross, T. S., Peeters, P. J., Rompaey, L. V., Etten, R. A. V., Ilaria, R. L., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5321 · Cited by 245
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
Karni, R., Jove, R., & Levitzki, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202835 · Cited by 242
Self-citation
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.
Frank, D. A., Mahajan, S., & Ritz, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119869 · Cited by 241
Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies
Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R. S., Takasugi, T., Matsuyama, T., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.08008.x · Cited by 233
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice
Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.232 · Cited by 227
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases
Sengupta, T. K., Talbot, E. S., Scherle, P., & Ivashkiv, L. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11107 · Cited by 226
Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
Watson, C. J. E., & Miller, W. R. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.162 · Cited by 226
Serine Phosphorylation and Negative Regulation of Stat3 by JNK
Lim, C. P., & Cao, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.31055 · Cited by 225
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
Zhang, Q., Nowak, I. A., Vonderheid, E. C., Rook, A. H., Kadin, M. E., Nowell̀, P. C., Shaw, L. M. J., & Wasik, M. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9148 · Cited by 221
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
Nielsen, M., Kaltoft, K., Nordahl, M., Röpke, C., Geisler, C., Mustelin, T., Dobson, P., Svejgaard, A., & Ødum, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6764 · Cited by 220
Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents
Levitzki, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00066-7 · Cited by 214
Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)
Jain, N., Zhang, T., Fong, S., Lim, C. P., & Cao, X. (1998) · Oncogene · doi:10.1038/sj.onc.1202238 · Cited by 213
Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling
Garcia, R., & Jove, R. (1998) · Journal of Biomedical Science · doi:10.1007/bf02258360 · Cited by 206
Self-citation
Protein Kinase C δ Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner
Jain, N. K., Zhang, T., Kee, W. H., Li, W., & Cao, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24392 · Cited by 206
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.
Boulton, T. G., Zhong, Z.-H., Wen, Z., Darnell, J. E., Jr., Stahl, N., & Yancopoulos, G. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6915 · Cited by 201
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
de Groot, R. P., Raaijmakers, J. A. M., Lammers, J. J., Jove, R., & Koenderman, L. (1999) · Blood · doi:10.1182/blood.v94.3.1108.415k07_1108_1112 · Cited by 188
Self-citation
STAT proteins as novel targets for cancer therapy
Catlett-Falcone, R., Dalton, W. S., & Jove, R. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199911000-00010 · Cited by 185
Self-citation
Interferon-α Resistance in a Cutaneous T-Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression
Sun, W. H., Pabon, C., Alsayed, Y. M., Huang, P. P., Jandeska, S., Shahab Uddin, M. S., Platanias, L. C., & Rosen, S. T. (1998) · Blood · doi:10.1182/blood.v91.2.570 · Cited by 169
Cytosolic Tyrosine Dephosphorylation of STAT5
Yu, C., Jin, Y., & Burakoff, S. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.599 · Cited by 168
Interleukin‐2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.
Beadling, C., Ng, J., Babbage, J. W., & Cantrell, D. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00541.x · Cited by 167
IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line
Dumon, S., Santos, S. C. R., Debierre-Grockiego, F., Gouilleux‐Gruart, V., Petit, L., Boucheron, C., Mollat, P., Gisselbrecht, S., & Gouilleux, F. (1999) · Oncogene · doi:10.1038/sj.onc.1202796 · Cited by 158
Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation
Chaturvedi, P., Reddy, M. R., & Reddy, E. P. (1998) · Oncogene · doi:10.1038/sj.onc.1201972 · Cited by 145
STAT3 Is a Serine Kinase Target in T Lymphocytes
Ng, J., & Cantrell, D. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24542 · Cited by 141
The Functional Synergy Between IL-12 and IL-2 Involves p38 Mitogen-Activated Protein Kinase and Is Associated with the Augmentation of STAT Serine Phosphorylation
Gollob, J., Schnipper, C. P., Murphy, E. A., Ritz, J., & Frank, D. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4472 · Cited by 139
Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation
Yu, C., & Burakoff, S. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14017 · Cited by 129
Rational design of a receptor super‐antagonist of human interleukin‐6.
Savino, R., Ciapponi, L., Lahm, A., Demartis, A., Cabibbo, A., Toniatti, C., Delmastro, P., Altamura, S., & Ciliberto, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06931.x · Cited by 127
Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice
Breuer, M. L., Slebos, R. J. C., Verbeek, S. J., van Lohuizen, M., Wientjens, E., & Berns, A. J. M. (1989) · Nature · doi:10.1038/340061a0 · Cited by 126
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
Besser, D., Bromberg, J., Darnell, J. E., Jr., & Hanafusa, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1401 · Cited by 123
Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
Naka, T., Fujimoto, M., & Kishimoto, T. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01454-1 · Cited by 122
STAT Signaling in the Pathogenesis and Treatment of Cancer
Frank, D. A. (1999) · Molecular Medicine · doi:10.1007/bf03403538 · Cited by 118
Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins
Decker, T., & Kovarik, P. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050393 · Cited by 111
p16 and p21WAF1 Protein Expression in Melanocytic Tumors by Immunohistochemistry
Sparrow, L. E., Eldon, M. J., English, D. R., & Heenan, P. J. (1998) · American Journal of Dermatopathology · doi:10.1097/00000372-199806000-00006 · Cited by 105
Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase
Yu, C., Jove, R., & Burakoff, S. J. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.11.5206 · Cited by 105
Self-citation
Abrogation of Interleukin-3 Dependence of Myeloid Cells by the v-src Oncogene Requires SH2 and SH3 Domains Which Specify Activation of STATs
Chaturvedi, P., Sharma, S., & Reddy, E. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3295 · Cited by 104
Evidence for the involvement of pim‐2, a new common proviral insertion site, in progression of lymphomas.
Breuer, M., Cuypers, H., & Berns, A. (1989) · EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03434.x · Cited by 102
Growth Hormone Regulation of SIRP and SHP-2 Tyrosyl Phosphorylation and Association
Stofega, M. R., Wang, H., Ullrich, A., & Carter‐Su, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7112 · Cited by 100
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck
Lund, T. C., Garcia, R., Medveczky, M. M., Jove, R., & Medveczky, P. G. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6677-6682.1997 · Cited by 96
Self-citation
Fusion of the ets Transcription Factor TEL to Jak2 Results in Constitutive Jak-Stat Signaling
Ho, J. M.-Y., Beattie, B. K., Squire, J. A., Frank, D. A., & Barber, D. L. (1999) · Blood · doi:10.1182/blood.v93.12.4354 · Cited by 94
Stat3 Plays an Important Role in Oncogenic Ros- and Insulin-like Growth Factor I Receptor-induced Anchorage-independent Growth
Zong, C. S., Zeng, L., Jiang, Y., Sadowski, H. B., & Wang, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28065 · Cited by 91
Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines
Kuroki, M., & O’Flaherty, J. T. (1999) · Biochemical Journal · doi:10.1042/bj3410691 · Cited by 88
The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing
Skórski, T., Nieborowska-Skorska, M., Wlodarski, P. K., Wasik, M. A., Trotta, R., Kanakaraj, P., Salomoni, P., Antonyak, M., Martinez, R., Majewski, M., et al. (1998) · Blood · doi:10.1182/blood.v91.2.406 · Cited by 86
Constitutive Activation of JAK1 in Src-transformed Cells
Campbell, G. S., Yu, C., Jove, R., & Carter‐Su, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2591 · Cited by 85
Self-citation
Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells*
Wen, X., Lin, H. H., Shih, H.-M., Kung, H., & Ann, D. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.38204 · Cited by 80
Unique signal transduction of Eyk: constitutive stimulation of the JAK‐STAT pathway by an oncogenic receptor‐type tyrosine kinase.
Zong, C. S., Yan, R., August, A., Darnell, J. E., Jr., & Hanafusa, H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00829.x · Cited by 77
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase
Nelson, K. L., Rogers, J. A., Bowman, T. L., Jove, R., & Smithgall, T. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7072 · Cited by 74
Self-citation
Constitutive Activation of the JAK2/STAT5 Signal Transduction Pathway Correlates With Growth Factor Independence of Megakaryocytic Leukemic Cell Lines
Liu, R. Y., Fan, C. L., Garcia, R., Jove, R., & Zuckerman, K. S. (1999) · Blood · doi:10.1182/blood.v93.7.2369 · Cited by 70
Self-citation
Signal Transducer and Activator of Transcription-3 Serine Phosphorylation by Insulin Is Mediated by a Ras/Raf/MEK-Dependent Pathway
Ceresa, B. P., Horvath, C. M., & Pessin, J. E. (1997) · Endocrinology · doi:10.1210/endo.138.10.5266 · Cited by 64
Direct Interaction of Jak1 and v-Abl Is Required for v-Abl-Induced Activation of STATs and Proliferation
Danial, N. N., Losman, J. A., Lu, T., Yip, N. H., Krishnan, K., Krolewski, J. J., Goff, S. P., Wang, J. Y. J., & Rothman, P. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6795 · Cited by 63
The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells
Lund, T. C., Prator, P. C., Medveczky, M. M., & Medveczky, P. G. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1689-1694.1999 · Cited by 51
Prolonged STAT1 activation related to the growth arrest of malignant lymphoma cells by interferon-alpha.
Grimley, P., Fang, H., Rui, H., Petricoin, E. F., Ray, S., Dong, F., Fields, K., Hu, R., Zoon, K., Audet, S., et al. (1998) · Blood · doi:10.1182/blood.v91.8.3017.3017_3017_3027 · Cited by 42
Effect of IL-6 receptor antisense oligodeoxynucleotide on in vitro proliferation of myeloma cells.
Keller, E. T., & Ershler, W. B. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.4091 · Cited by 38
p53, p21(Waf1/Cip1) and cyclin D1 protein expression and prognosis in esophageal cancer *
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Expression of v-src in mammary epithelial cells induces transcription via STAT3
Smith, P. D., & CROMPTON, M. R. (1998) · Biochemical Journal · doi:10.1042/bj3310381 · Cited by 33
Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line
Murakami, Y., Nakano, S., Niho, Y., Hamasaki, N., & Izuhara, K. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199805)175:2 · Cited by 30
A small deletion in the 3′-untranslated region of the cyclin D1/PRAD1/bcl-1 oncogene in a patient with chronic lymphocytic leukemia
Hosokawa, Y., Suzuki, R., Joh, T., Maeda, Y., Nakamura, S., Kodera, Y., Arnold, A., & Seto, M. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980610)76:6 · Cited by 26
Expression of p21WAF1/CIP1 in Soft Tissue Sarcomas: A Comparative Immunohistochemical Study with p53 and Ki-67
Pindzola, J. A., Palazzo, J., Kovatich, A. J., Tuma, B., & Nobel, M. (1998) · Pathology - Research and Practice · doi:10.1016/s0344-0338(98)80127-1 · Cited by 21
Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-Erk signaling.
van Puijenbroek, A. V., van der Saag, P. T., & Coffer, P. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4576 · Cited by 15
Recent publications
(1995) · Aerobiologia · doi:10.1007/bf02447211 · Cited by 2
Untitled work
Rodriguez-Palmero, M. (1999) · doi:10.1002/(sici)1521-4141(199912)29:12
Untitled work
(1999) · doi:10.1002/(sici)1097-0215(19991112)83:4

Research works printed but not linked: 7

Gouilleux-Gruart V, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, Weber-Nordt R, Dusanter-Fourt I, Dreyfus F, Groner B and Prin L . 1996 Blood 87: 1692–1697 · DOI
Hallek M, Leif Bergsagel P and Anderson KC . 1998 Blood 91: 3–21 · DOI
Ho JM, Beattie BK, Squire JA, Frank DA and Barber DL . 1999 Blood 93: 4354–4364 · DOI
Liu RY, Fan C, Garcia R, Jove R and Zuckerman KS . 1999 Blood 93: 2369–2379 · DOI
Skorski T, Nieborowska-Skorska M, Wlodarski P, Wasik M, Trotta R, Kanakaraj P, Salomoni P, Antonyak M, Martinez R, Majewski M, Wong A, Perussia B and Calabretta B . 1998 Blood 91: 406–418 · DOI
Sun WH, Pabon C, Alsayed Y, Huang PP, Jandeska S, Uddin S, Platanias LC and Rosen ST . 1998 Blood 91: 570–576 · DOI
Wang YH, Wharton W, Garcia R, Kraker A, Jove R and Pledger WJ . 2000 Oncogene in press

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Authors: Bowman, T., Garcia, R., Turkson, J., & Jove, R.
Affiliations: Moffitt Cancer Center (US)
University of South Florida (US)
ORCID: Turkson, James
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2474-2488
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203527
OpenAlex: W2024282024
Cited by: 1,743
References: 152
Citations by year: 2026: 16 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 39 · 2021: 48 · 2020: 44 · 2019: 45 · 2018: 59 · 2017: 63 · 2016: 58 · 2015: 104 · 2014: 80 · 2013: 82 · 2012: 89
FWCI: 7.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT, signal transducer and activator of transcription, carcinogenesis, STAT3, STAT5, malignant transformation, cytokine signaling, cell proliferation, apoptosis, cancer therapy targets, cancer cell lines
MeSH terms: Animals, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Neoplasms, Phosphorylation, Phosphoserine, Protein-Tyrosine Kinases, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Neoplastic, STAT1 Transcription Factor

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