Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanová, E., Cooper, P. R., Nowak, N. J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81174-5 · Cited by 1,079

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 1,011

microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation

Mao, A., Liu, Y., Zhang, H., Di, C., & Sun, C. (2014) · DNA and Cell Biology · doi:10.1089/dna.2014.2401 · Cited by 38

The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation

di Masi, A., D’Apice, M. R., Ricordye, R., Tanzarella, C., & Novelli, G. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6149 · Cited by 38

Poly(ADP-ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Mammary Tumors

Tang, Y., Hamed, H. A., Poklepovic, A. S., Dai, Y., Grant, S., & Dent, P. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.078907 · Cited by 37

Sensing of dangerous DNA

Gasser, S., Zhang, W. Y. L., Tan, N. Y., Tripathi, S., Suter, M. A., Chew, Z. H., Khatoo, M., Ngeow, J. Y. Y., & Cheung, F. S. G. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.001 · Cited by 44

The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization

Henry, M. P., Hawkins, J. R., Boyle, J., & Bridger, J. M. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00623 · Cited by 42

MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates Colorectal Cancer Cell Growth and Apoptosis

Zhang, L., Lu, P., Yan, L., Yang, L., Wang, Y., Chen, J., Dai, J., Li, Y., Kang, Z., Bai, T., et al. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.02.003 · Cited by 39

The role of WRNIP1 in genome maintenance

Yoshimura, A., Seki, M., & Enomoto, T. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1282585 · Cited by 37

An Activation Force-based Affinity Measure for Analyzing Complex Networks

Guo, J. H., Guo, H., & Wang, Z. (2011) · Scientific Reports · doi:10.1038/srep00113 · Cited by 36

Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health?

Gallo, A., Landi, R., Rubino, V., Cerbo, A. D., Giovazzino, A., Palatucci, A. T., Centenaro, S., Guidetti, G., Canello, S., Cortese, L., et al. (2017) · PeerJ · doi:10.7717/peerj.3236 · Cited by 36

Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity

Moussa, R., Park, K. C., Kovačević, Ž., & Richardson, D. R. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.027 · Cited by 39

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia

Popp, H. D., Kohl, V., Naumann, N., Flach, J., Brendel, S., Kleiner, H., Weiß, C., Seifarth, W., Saußele, S., Hofmann, W., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041177 · Cited by 36

Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications

Oberle, C., & Blattner, C. (2010) · Current Genomics · doi:10.2174/138920210791110979 · Cited by 37

Double functions for the Mre11 complex during DNA double-strand break repair and replication

Borde, V., & Cobb, J. A. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.12.013 · Cited by 39

The ATM regulated DNA damage response pathway as a chemo- and radiosensitisation target

Alao, J. P. (2009) · Expert Opinion on Drug Discovery · doi:10.1517/17460440902835475 · Cited by 36

Chromatin Modifications Associated with DNA Double-strand Breaks Repair as Potential Targets for Neurological Diseases

Brochier, C., & Langley, B. C. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0210-9 · Cited by 41

DNA Damage and DNA Damage Responses in THP-1 Monocytes after Exposure to Spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin

Rakkestad, K. E., Skaar, I., Ansteinsson, V. E., Solhaug, A., Holme, J. A., Pestka, J. J., Samuelsen, J. T., Dahlman, H. J., Hongslo, J. K., & Becher, R. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq045 · Cited by 37

The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer

Yu, P., Zhu, X., Zhu, J., Han, Y., Zhang, H., Zhou, X. Y., Yang, L., Xia, Y., Zhang, C., & Kong, L. (2021) · Oncogene · doi:10.1038/s41388-021-01933-z · Cited by 35

Strategies involving STING pathway activation for cancer immunotherapy: Mechanism and agonists

Pan, X., Zhang, W., Guo, H., Wang, L., Wu, H., Ding, L., & Yang, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115596 · Cited by 36

CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair

Duquette, M. L., Zhu, Q., Taylor, E. R., Tsay, A. J., Shi, L. Z., Berns, M. W., & McGowan, C. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003050 · Cited by 39

Novel quinazoline HMJ‐30 induces U‐2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up‐regulation of ATM/p53 signaling pathway

Chiu, Y., Hour, M., Lu, C., Chung, J., Kuo, S., Huang, W., Chen, H., Jin, Y., & Yang, J. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21398 · Cited by 35

Direct Activation of ATM by Resveratrol under Oxidizing Conditions

Lee, J., Guo, Z., Myler, L. R., Zheng, S., & Paull, T. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097969 · Cited by 38

Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis

Mansoori, A. A., & Jain, S. K. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.12.4803 · Cited by 35

AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis

Yuan, D., Lai, J., Xu, P., Zhang, S., Zhang, J., Li, C., Wang, Y., Du, J., Liu, Y., & Yang, C. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.04.006 · Cited by 35

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN

Mazouzi, A., Stukalov, A., Müller, A. C., Chen, D., Wiedner, M., Prochazkova, J., Chiang, S., Schuster, M. K., Breitwieser, F. P., Pichlmair, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.077 · Cited by 36

PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells

Yuan, Z., Guo, W., Yang, J. H., Li, L., Wang, M., Lei, Y., Wan, Y., Zhao, X., Luo, N., Cheng, P., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.658419 · Cited by 34

Ataxia Telangiectasia Mutated Kinase Mediates NF-κB Serine 276 Phosphorylation and Interferon Expression via the IRF7-RIG-I Amplification Loop in Paramyxovirus Infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I. R., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R., & Brasier, A. R. (2014) · Journal of Virology · doi:10.1128/jvi.02458-14 · Cited by 35

hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes

Mahajan, K. N. (2015) · Oncogene · doi:10.1038/onc.2015.321 · Cited by 34

ZnO nanoparticles-associated mitochondrial stress-induced apoptosis and G2/M arrest in HaCaT cells: a mechanistic approach

Vallabani, N. V. S., Sengupta, S., Shukla, R. K., & Kumar, A. (2019) · Mutagenesis · doi:10.1093/mutage/gez017 · Cited by 34

Genistein Enhances Radiosensitivity of Human Hepatocellular Carcinoma Cells by Inducing G2/M Arrest and Apoptosis

Yan, H., Jiang, J., Du, A., Gao, J., Zhang, D., & Song, L. (2020) · Radiation Research · doi:10.1667/rr15380.1 · Cited by 34

Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage

Chesnokova, V., Zonis, S., Apostolou, A. P., Estrada, H. Q., Knott, S., Wawrowsky, K., Michelsen, K. S., Ben-Shlomo, A., Barrett, R. J., Gorbunova, V., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110068 · Cited by 34

Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining

Jessulat, M., Malty, R. H., Nguyen‐Tran, D., Deineko, V., Aoki, H., Vlasblom, J., Omidi, K., Jin, K., Minić, Z., Hooshyar, M., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00007-15 · Cited by 34

Regulation of signaling pathways by β‐elemene in cancer progression and metastasis

Qureshi, M. Z., Attar, R., Romero, M. A., Sabitaliyevich, U. Y., Nurmurzayevich, S. B., Öztürk, Ö. A., Hanna‐Wakim, L., Lin, X., Özbey, Ü., Yelekenova, A. B., et al. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28624 · Cited by 34

Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1

Kobayashi, J., Tauchi, H., Chen, B., Bruma, S., Tashiro, S., Matsuura, S., Tanimoto, K., Chen, D. J., & Komatsu, K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.109 · Cited by 34

Soft Cysteine Signaling Network: The Functional Significance of Cysteine in Protein Function and the Soft Acids/Bases Thiol Chemistry That Facilitates Cysteine Modification

Wible, R. S., & Sutter, T. R. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00428 · Cited by 33

ATM in breast and brain tumors: a comprehensive review

Mehrdad, A. E., & Mehdipour, P. (2018) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2018.0022 · Cited by 34

LRRK2 interacts with ATM and regulates Mdm2–p53 cell proliferation axis in response to genotoxic stress

Chen, Z., Cao, Z., Zhang, W., Gu, M., Zhou, Z., Li, B., Li, J., Tan, E., & Zeng, L. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx337 · Cited by 34

Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells

Ivanov, V. N., Wu, J., Wang, T. J. C., & Hei, T. K. (2019) · Oncotarget · doi:10.18632/oncotarget.26582 · Cited by 32

Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis

Ye, P., Zhang, M., Fan, S., Zhang, T., Fu, H., Su, X., Gavine, P. R., Liu, Q., & Yin, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143207 · Cited by 31

Inhibitory effect of black tea pigments, theaflavin-3/3′-gallate against cisplatin-resistant ovarian cancer cells by inducing apoptosis and G1 cell cycle arrest

Pan, H., Wang, F., Rankin, G. O., Rojanasakul, Y., Tu, Y., & Chen, Y. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4145 · Cited by 32

Basic transcription factor 3 is involved in gastric cancer development and progression

Liu, Q. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i28.4495 · Cited by 31

DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging

Lee, W. H., Nguyen, P. K. P., Fleischmann, D., & Wu, J. C. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw206 · Cited by 31

Heritable sperm chromatin epigenetics: a break to remember†

Meyer, R. G., Ketchum, C. C., & Meyer‐Ficca, M. L. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox137 · Cited by 32

Contribution of ATM and ATR kinase pathways to p53‐mediated response in etoposide and methyl methanesulfonate induced DNA damage

Sun, B., Ross, S. M., Rowley, S. M., Adeleye, Y. A., & Clewell, R. A. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22070 · Cited by 30

Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA

Ka, H. I., Lee, S., Han, S., Jeong, A. L., Park, J. Y., Joo, H. J., Soh, S., Park, D., & Yang, Y. D. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0268-1 · Cited by 30

A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis

Jacobs, C., Huang, Y., Masud, T., Lu, W., Westfield, G., Giblin, W., & Sekiguchi, J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq524 · Cited by 31

Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Sarkar, A. K., Stellrecht, C. M., Vangapandu, H. V., Ayres, M., Kaipparettu, B. A., Park, J. H., Balakrishnan, K., Burks, J. K., Pandita, T. K., Hittelman, W. N., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.234385 · Cited by 30

Martini: using literature keywords to compare gene sets

Soldatos, T. G., O’Donoghue, S. I., Satagopam, V., Jensen, L. J., Brown, N. P., Barbosa-Silva, A., & Schneider, R. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp876 · Cited by 29

POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway

Weng, T., & Koh, C.-G. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.443 · Cited by 29

R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1

Marabitti, V., Valenzisi, P., Lillo, G., Malacaria, E., Palermo, V., Pichierri, P., & Franchitto, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031547 · Cited by 29

The DNA Double-Strand Break Repair in Glioma: Molecular Players and Therapeutic Strategies

Maksoud, S. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02915-2 · Cited by 29

DMAP1 is an essential regulator of ATM activity and function

Penicud, K., & Behrens, A. (2013) · Oncogene · doi:10.1038/onc.2012.597 · Cited by 32

Cell and molecular response to IORT treatment

Minafra, L., & Bravatà, V. (2014) · Nova Science Publishers (Nova Science Publishers, Inc.) · doi:10.21037/2092 · Cited by 29

Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy

Nowak, D., Toriellec, É. L., Stern, M., Kawamata, N., Akagi, T., Dyer, M. J. S., Hofmann, W. K., Ogawa, S., & Koeffler, H. P. (2009) · Haematologica · doi:10.3324/haematol.2008.001347 · Cited by 29

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

Cheng, A. N., Fan, C., Lo, Y.-K., Kuo, C., Wang, H., Lien, I.-H., Lin, S., Chen, C., Jiang, S. S., Chang, I., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17126-2 · Cited by 29

The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy

Hehlgans, S., Storch, K., Lange, I., & Cordes, N. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.08.023 · Cited by 29

Cellular Response to Ionizing Radiation: A MicroRNA Story.

Halimi, M., Asghari, S. M., Sariri, R., Moslemi, D., & Parsian, H. (2012) · Europe PMC (PubMed Central) · Cited by 28

Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses

Jacobs, K. M., Misri, S., Meyer, B., Raj, S., Zobel, C. L., Sleckman, B. P., Hallahan, D. E., & Sharma, G. G. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-01-0017 · Cited by 28

The MRE11 complex: An important source of stress relief

Rein, K., & Stracker, T. H. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.10.010 · Cited by 29

Elevated Oxidative Stress and DNA Damage in Cortical Neurons of Chemotherapy Patients

Torre, M., Dey, A., Woods, J. K., & Feany, M. Β. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab074 · Cited by 28

DNA Damage Response and Cell Cycle Regulation in Pluripotent Stem Cells

Chen, A. C. H., Peng, Q., Fong, S. W., Lee, K. C., Yeung, W. S. B., & Lee, Y. L. (2021) · Genes · doi:10.3390/genes12101548 · Cited by 28

Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage

Ganesan, S., Nteeba, J., & Keating, A. F. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.10.004 · Cited by 27

Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells

Fukazawa, T., Tanimoto, K., Shrestha, L., Imura, T., Takahashi, S., Sueda, T., Hirohashi, N., Hiyama, E., & Yuge, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219363 · Cited by 27

New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

Reddy, M. V. B., Shen, Y., Yang, J., Hwang, T., Bastow, K. F., Qian, K., Lee, K., & Wu, T.-S. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.02.004 · Cited by 27

Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum

Dar, I., Yosha, G., Elfassy, R., Galron, R., Wang, Z., Shiloh, Y., & Barzilai, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204172 · Cited by 26

Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression

Xu, J., Xiao, X., Yan, B., Yuan, Q., Dong, X., Du, Q., Zhang, J., Shan, L., Ding, Z., Zhou, L., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02468-3 · Cited by 27

Targeting ATR Pathway in Solid Tumors: Evidence of Improving Therapeutic Outcomes

Mavroeidi, D., Georganta, A., Panagiotou, Ε., Syrigos, K., & Souliotis, V. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052767 · Cited by 26

A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

Boswell, Z. K., Rahman, S., Canny, M. D., & Latham, M. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-19908-8 · Cited by 25

Understanding the DNA double-strand break repair and its therapeutic implications

Ray, U., & Raghavan, S. C. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103177 · Cited by 27

Interleukin enhancer‐binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma

Zhang, X., Bustos, M. A., Groß, R., Ramos, R. I., Takeshima, T., Mills, G. B., Yu, Q., & Hoon, D. S. �. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.608 · Cited by 26

Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells

Yang, X., Ching, Y.-P., Zhou, Y., Chiu, J., Chen, F., & He, Q. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.08.014 · Cited by 25

Rho GTPases in cancer radiotherapy and metastasis

Zeng, R., Zheng, C., Chen, W., Xu, L., & Li, E. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09923-5 · Cited by 25

Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality

Sanese, P., Fasano, C., Buscemi, G., Bottino, C., Corbetta, S., Fabini, E., Silvestri, V., Valentini, V., Disciglio, V., Forte, G., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101604 · Cited by 25

A Collaborative Effort to Define Classification Criteria forATMVariants in Hereditary Cancer Patients

Feliubadaló, L., Moles‐Fernández, A., Santamariña, M., Sánchez, A. T., López‐Novo, A., Porras, L.-M., Blanco, A., Capellá, G., de la Hoya, M., Molina, I. J., et al. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa250 · Cited by 25

RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases

Willbanks, A. R., Wood, S., & Cheng, J. X. (2021) · Genes · doi:10.3390/genes12050627 · Cited by 26

Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

Wu, W., Ma, B., Ye, H., Wang, T., Wang, X., Yang, J., Wei, Y., Zhu, J., & Chen, L. (2016) · Oncotarget · doi:10.18632/oncotarget.10739 · Cited by 24

Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha‐galactosidase A (GLA) enzymes

Squillaro, T., Antonucci, I., Alessio, N., Esposito, A. A., Cipollaro, M., Melone, M. A. B., Peluso, G., Stuppia, L., & Galderisi, U. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25807 · Cited by 25

Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis

Wang, M.-J., Huang, H., Chiu, T., Chang, H., & Wu, H.-R. (2019) · Cells · doi:10.3390/cells9010022 · Cited by 24

Mechanistic Links Between ATM and Histone Methylation Codes During DNA Repair

Xu, Y., Xu, C., & Price, B. D. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387665-2.00010-9 · Cited by 23

The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis

Afroz, S., Garg, R., Fodje, M. N., & den Hurk, S. V. D. L. (2018) · Journal of Virology · doi:10.1128/jvi.00773-18 · Cited by 23

Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers

Cheng, Y., Li, W., Gui, R., Wang, C., Song, J., Wang, Z., Wang, X., Shen, Y., Wang, Z., & Hao, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.671247 · Cited by 22

Sterigmatocystin-Induced DNA Damage Triggers G2 Arrest via an ATM/p53-Related Pathway in Human Gastric Epithelium GES-1 Cells In Vitro

Zhang, D., Cui, Y., Shen, H., Xing, L., Cui, J., Wang, J., & Zhang, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065044 · Cited by 24

Clinical interpretation of pathogenic ATM and CHEK2 variants on multigene panel tests: navigating moderate risk

DePersia, A., Blazer, K. R., Stoll, J., Jones, M., Weipert, C. M., Nielsen, S. M., Kupfer, S. S., Weitzel, J. N., & Olopade, O. I. (2018) · Familial Cancer · doi:10.1007/s10689-018-0070-x · Cited by 22

Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model

Grolmusz, V. K., Chen, J., Emond, R., Cosgrove, P. A., Pflieger, L. T., Nath, A., Moos, P. J., & Bild, A. H. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01337-1 · Cited by 22

Genotoxicity and Mutagenicity - Mechanisms and Test Methods

Soloneski, S., & Larramendy, M. L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84992 · Cited by 22

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

Limbo, O., Moiani, D., Kertokalio, A., Wyman, C., Tainer, J. A., & Russell, P. R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks954 · Cited by 22

Recent advances in the genomic and molecular biology of Giardia

Ortega‐Pierres, M. G., Jex, A. R., Ansell, B. R. E., & Svärd, S. G. (2017) · Acta Tropica · doi:10.1016/j.actatropica.2017.09.004 · Cited by 23

Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective

Smart, D. J. (2008) · Toxicology · doi:10.1016/j.tox.2008.08.023 · Cited by 21

Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes

Nail, A. N., McCaffrey, L. M., Banerjee, M., Cardoso, A. P. F., & States, J. C. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116042 · Cited by 20

Non-apoptotic programmed cell death with paraptotic-like features in bleomycin-treated plant cells is suppressed by inhibition of ATM/ATR pathways or NtE2F overexpression

Smetana, O., Široký, J., Houlné, G., Opatrný, Z., & Chabouté, M. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err439 · Cited by 20

Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases

Guadagno, E., DIVITIIS, O. D., Solari, D., Borrelli, G., Bracale, U. M., Somma, A. D., Cappabianca, P., & De, M. D. B. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0562-9 · Cited by 20

Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors

Carranza, D., Torres‐Rusillo, S., Ceballos-Pérez, G., Blanco-Jimenez, E., Muñoz-López, M., Garcia-Perez, J. L., & Molina, I. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02703 · Cited by 20

Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome

Lochab, S., Singh, Y. P., Sengupta, S., & Nandicoori, V. K. (2020) · eLife · doi:10.7554/elife.51466 · Cited by 21

Differential effect of hypoxia on etoposide‐induced DNA damage response and p53 regulation in different cell types

Sermeus, A., Rebucci, M., Fransolet, M., Flamant, L., Desmet, D., Delaive, E., Arnould, T., & Michiels, C. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24409 · Cited by 20

The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining

Tsai, F.-L., & Kai, M. (2014) · Cell Cycle · doi:10.4161/15384101.2014.958386 · Cited by 19

Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells

Mordasini, V., Ueda, S., Aslandogmus, R., Berger, C., Gysin, C., Hühn, D., Sartori, A. A., Bernasconi, M., & Nadal, D. (2016) · Oncotarget · doi:10.18632/oncotarget.14120 · Cited by 19

Irradiation of Mesenchymal Stromal Cells With Low and High Doses of Alpha Particles Induces Senescence and/or Apoptosis

Alessio, N., Esposito, G., Galano, G., Rosa, R. D., Anello, P., Peluso, G., Tabocchini, M. A., & Galderisi, U. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25961 · Cited by 19

TREC/KREC levels in children with ataxia-telangiectasia

Boyarchuk, O. R., Makukh, H., Kostyuchenko, L. V., Yarema, N., Haiboniuk, I., Kravets, V. S., Shulhai, О. М., & Tretiak, B. I. (2021) · Immunologic Research · doi:10.1007/s12026-021-09216-1 · Cited by 19

DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda

Hlavová, M., Čížková, M., Vítová, M., Bišová, K., & Zachleder, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019626 · Cited by 19

Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain

Kirshner, M., Galron, R., Frenkel, D., Mandelbaum, G., Shiloh, Y., Wang, Z., & Barzilai, A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9643-y · Cited by 20

Radiation-Induced Organizing Pneumonia: A Characteristic Disease that Requires Symptom-Oriented Management

Otani, K., Seo, Y., & Ogawa, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020281 · Cited by 19

ATM activation by DNA double-strand breaks through

Lee, J., & Paull, T. T. (2016)

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Characterization of the mechanisms of ATM activation by the MRN complex and DNA

Lee, J. H. (2005) · Texas ScholarWorks (Texas Digital Library)

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762