Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanová, E., Cooper, P. R., Nowak, N. J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81174-5 · Cited by 1,079

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 1,011

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985

P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

Schultz, L. B., Chehab, N. H., Malikzay, A., & Halazonetis, T. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1381 · Cited by 916

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damagePreprint

Kim, S., Xu, B., & Kastan, M. B. (2002) · Genes & Development · doi:10.1101/gad.970602 · Cited by 593

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578

The ATM-mediated DNA-damage response: taking shape

Shiloh, Y. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.05.004 · Cited by 556

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

Savitsky, K., Sfez, S., Tagle, D. A., Ziv, Y., Sartiel, A., Collins, F. S., Shiloh, Y., & Rotman, G. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.11.2025 · Cited by 535

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 535

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Stracker, T. H., Carson, C. T., & Weitzman, M. D. (2002) · Nature · doi:10.1038/nature00863 · Cited by 522

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 519

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

Rappold, I., Iwabuchi, K., Date, T., & Chen, J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.613 · Cited by 503

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482

The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K.-I., & Karnitz, L. M. (2007) · Genes & Development · doi:10.1101/gad.1547007 · Cited by 478

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1599 · Cited by 477

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., & Khanna, K. (2000) · Nature Genetics · doi:10.1038/75508 · Cited by 468

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

You, Z., Chahwan, C., Bailis, J. M., Hunter, T. R., & Russell, P. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5363-5379.2005 · Cited by 449

p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation

Takekawa, M., Adachi, M., Nakahata, A., Nakayama, I., Itoh, F., Tsukuda, H., Taya, Y., & Imai, K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6517 · Cited by 419

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

Luo, G., Yao, M. S., Bender, C. F., Mills, M., Bladl, A. R., Bradley, A., & Petrini, J. H. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7376 · Cited by 415

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 412

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Zhu, J., Petersen, S., Tessarollo, L., & Nussenzweig, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00019-7 · Cited by 385

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

Anderson, L., Henderson, C., & Adachi, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1719-1729.2001 · Cited by 367

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

Shreeram, S., Demidov, O. N., Hee, W. K., Yamaguchi, H., Onishi, N., Kek, C., Timofeev, O. N., Dudgeon, C., Fornace, A. J., Anderson, C. W., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.010 · Cited by 358

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

Xiao, Y. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.2985 · Cited by 316

FAT: a novel domain in PIK-related kinases

Bosotti, R., Isacchi, A., & Sonnhammer, E. L. L. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01563-2 · Cited by 313

NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain

Kobayashi, J., Tauchi, H., Sakamoto, S., Nakamura, A., Morishima, K.-I., Matsuura, S., Kobayashi, T., Tamai, K., Tanimoto, K., & Komatsu, K. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01259-9 · Cited by 306

ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismPreprint

Nakada, D., Matsumoto, K., & Sugimoto, K. (2003) · Genes & Development · doi:10.1101/gad.1099003 · Cited by 306

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 303

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 294

Interaction of FANCD2 and NBS1 in the DNA damage response

Nakanishi, K., Taniguchi, T., Ranganathan, V., New, H. V., Moreau, L. A., Stotsky, M., Mathew, C. G., Kastan, M. B., Weaver, D. T., & D’Andrea, A. D. (2002) · Nature Cell Biology · doi:10.1038/ncb879 · Cited by 275

Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

Goodarzi, A. A., Jonnalagadda, J. C., Douglas, P., Young, D., Ye, R., Moorhead, G. B. G., Lees‐Miller, S. P., & Khanna, K. K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600455 · Cited by 269

A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein

Foray, N., Marot, D., Gabriel, A., Randrianarison-Huetz, V., Carr, A. M., Perricaudet, M., Ashworth, A., & Jeggo, P. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg274 · Cited by 266

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 248

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

Sun, Y., Jiang, X., Chen, S., & Price, B. D. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.092 · Cited by 236

The Mre11 complex and ATM: collaborating to navigate S phase

Petrini, J. H. J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00091-0 · Cited by 233

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1270 · Cited by 227

Involvement of Human MOF in ATM Function

Gupta, A. K. D., Sharma, G. G., Young, C. S. H., Agarwal, M., Smith, E. R., Paull, T. T., Lucchesi, J. C., Khanna, K. K., Ludwig, T., & Pandita, T. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5292-5305.2005 · Cited by 225

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

Maser, R. S., Zinkel, R. A., & Petrini, J. H. J. (2001) · Nature Genetics · doi:10.1038/86920 · Cited by 219

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., & Nussenzweig, A. (2006) · Nature · doi:10.1038/nature05112 · Cited by 209

Chk2 Activation Dependence on Nbs1 after DNA Damage

Buscemi, G., Savio, C., Zannini, L., Miccichè, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5214-5222.2001 · Cited by 201

Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

Desai-Mehta, A., Cerosaletti, K. M., & Concannon, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2184-2191.2001 · Cited by 196

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

Mochan, T. A., Venere, M., DiTullio, R. A., & Halazonetis, T. D. (2003) · PubMed · Cited by 192

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

Gatei, M. H., Zhou, B. S., Hobson, K., Scott, S. P., Young, D., & Khanna, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011681200 · Cited by 190

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

Xu, B., O’Donnell‐Luria, A., Kim, S., & Kastan, M. B. (2002) · PubMed · Cited by 189

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationPreprint

Ali, A., Zhang, J., Bao, S., Liu, I., Otterness, D. M., Dean, N. M., Abraham, R. T., & Wang, X.-F. (2004) · Genes & Development · doi:10.1101/gad.1176004 · Cited by 175

BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

Fabbro, M., Savage, K. I., Hobson, K., Deans, A. J., Powell, S. N., McArthur, G. A., & Khanna, K. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405372200 · Cited by 169

The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity

Tauchi, H., Kobayashi, J., Morishima, K.-I., Matsuura, S., Nakamura, A., Shiraishi, T., Ito, E., Masnada, D., Delia, D., & Komatsu, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000578200 · Cited by 156

Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection

Shirata, N., Kudoh, A., Daikoku, T., Tatsumi, Y., Fujita, M., Kiyono, T., Sugaya, Y., Isomura, H., Ishizaki, K., & Tsurumi, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500976200 · Cited by 141

The Haploinsufficient Tumor Suppressor p18 Upregulates p53 via Interactions with ATM/ATR

Park, B.-J., Kang, J. W., Lee, S., Choi, S., Shin, Y. K., Ahn, Y. H., Choi, Y. H., Choi, D., Lee, K. S., & Kim, S. (2005) · Cell · doi:10.1016/j.cell.2004.11.054 · Cited by 135

Adenovirus Type 5 E4orf3 Protein Targets the Mre11 Complex to Cytoplasmic Aggresomes

Araujo, F. D., Stracker, T. H., Carson, C. T., Lee, D. V., & Weitzman, M. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11382-11391.2005 · Cited by 128

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Stracker, T. H., Morales, M., Couto, S. S., Hussein, H., & Petrini, J. H. J. (2007) · Nature · doi:10.1038/nature05740 · Cited by 126

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

Girard, P.-M., Riballo, E., Begg, A. C., Waugh, A., & Jeggo, P. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205596 · Cited by 123

Rad50 Adenylate Kinase Activity Regulates DNA Tethering by Mre11/Rad50 Complexes

Bhaskara, V., Dupré, A., Lengsfeld, B. M., Hopkins, B. B., Chan, A., Lee, J., Zhang, X., Gautier, J., Zakian, V. A., & Paull, T. T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.028 · Cited by 123

Residual Ataxia Telangiectasia Mutated Protein Function in Cells from Ataxia Telangiectasia Patients, with 5762ins137 and 7271T→G Mutations, Showing a Less Severe Phenotype

Stewart, G. S., Last, J. I. K., Stanković, T., Kingsbury, N., Kidd, A., Byrd, P. J., & Taylor, A. M. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103160200 · Cited by 107

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

Costanzo, V., Paull, T., Gottesman, M., & Gautier, J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020110 · Cited by 106

Regulation of Mre11/Rad50 by Nbs1

Lee, J., Ghirlando, R., Bhaskara, V., Hoffmeyer, M. R., Gu, J. H., & Paull, T. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308705200 · Cited by 103

The Rad50 Signature Motif: Essential to ATP Binding and Biological Function

Moncalián, G., Lengsfeld, B. M., Bhaskara, V., Hopfner, K., Kärcher, A., Alden, E., Tainer, J. A., & Paull, T. T. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.11.026 · Cited by 101

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1

Xia, Z., Morales, J. C., Dunphy, W. G., & Carpenter, P. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007665200 · Cited by 96

ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro

Kozlov, S., Gueven, N., Keating, K. E., Ramsay, J., & Lavin, M. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300003200 · Cited by 91

SV40 T antigen interacts with Nbs1 to disrupt DNA replication controlPreprint

Wu, X., Avni, D., Chiba, T., Feng, Y., Zhao, Q., Lin, Y., Heng, H. H., & Livingston, D. M. (2004) · Genes & Development · doi:10.1101/gad.1182804 · Cited by 90

ATMIN defines an NBS1‐independent pathway of ATM signalling

Kanu, N., & Behrens, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601733 · Cited by 90

Active Role for Nibrin in the Kinetics of Atm Activation

Cerosaletti, K. M., Wright, J. A., & CONCANNON, P. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1691-1699.2006 · Cited by 88

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

Difilippantonio, S., Celeste, A., Kruhlak, M. J., Lee, Y., Difilippantonio, M. J., Feigenbaum, L., Jackson, S. P., McKinnon, P. J., & Nussenzweig, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070319 · Cited by 87

NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage Response

Shang, Y. L., Bodero, A. J., & Chen, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210749200 · Cited by 82

The p18 component of the multisynthetase complex shares a protein motif with the β and γ subunits of eukaryotic elongation factor 1

Quevillon‐Chéruel, S., & Mirande, M. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01005-8 · Cited by 82

Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

McConnell, J. L., Gomez, R. J., McCorvey, L. R. A., Law, B. K., & Wadzinski, B. E. (2007) · Oncogene · doi:10.1038/sj.onc.1210406 · Cited by 80

Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation

Cerosaletti, K. M., & Concannon, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211689200 · Cited by 74

Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

Zhao, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf612 · Cited by 72

Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

Becker, E., Meyer, V., Madaoui, H., & Guérois, R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl075 · Cited by 65

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Lee, J. H., Xu, B., Lee, C. H., Ahn, J.-Y., Song, M. S., Lee, H., Canman, C. E., Lee, J., Kastan, M. B., & Lim, D. (2003) · PubMed · Cited by 65

DNA repair: The Nijmegen breakage syndrome protein

Featherstone, C., & Jackson, S. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70392-6 · Cited by 64

Interaction between Protein Phosphatase 5 and the A subunit of Protein Phosphatase 2A

Lubert, E. J., Hong, Y., & Sarge, K. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106906200 · Cited by 64

Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association

Young, D. B., Jonnalagadda, J. C., Gatei, M. H., Jans, D. A., Meyn, M. S., & Khanna, K. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411689200 · Cited by 54

ATM-dependent Dissociation of B55 Regulatory Subunit from Nuclear PP2A in Response to Ionizing Radiation

Guo, C. Y., Brautigan, D. L., & Larner, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110092200 · Cited by 43

The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer

Smith, J., Tho, L. M., Xu, N., & Gillespie, D. A. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00003-0 · Cited by 1,331

Double-strand break repair: 53BP1 comes into focus

Panier, S., & Boulton, S. J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3719 · Cited by 1,168

Alternative lengthening of telomeres: models, mechanisms and implications

Cesare, A. J., & Reddel, R. R. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2763 · Cited by 1,107

DNA repair mechanisms in dividing and non-dividing cells

Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

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